[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"vasoplegic-syndrome-of-cardiac-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:vasoplegic-syndrome-of-cardiac-surgery":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100597532","mic-mac-micro--and-macrocirculatory-assessment-during-cardiac-surgery-in-patients-at-risk-of-vasoplegic-syndrome-a-prospective-study-100597532",false,"NCT07059715","Mic Mac: Micro- and Macrocirculatory Assessment During Cardiac Surgery in Patients at Risk of Vasoplegic Syndrome: A Prospective Study.","Mic Mac Study: A Prospective Study of Hemodynamic Coherence in Vasoplegic Syndrome After Cardiopulmonary Bypass","MicMac","Inclusion Criteria:\n\nHave at least 3 point of the following risk factors for post-body circulation vasoplegic syndrome:\n\n* Acute or chronic heart failure with left ventricular ejection fraction\\\u003C 40% (1 pt)\n* Complex cardiac surgery ( 2 pts)\n* Cardiovascular risk factors with a EuroSCORE\\> 4% (1 pt)\n* Chronic Kidney Disease Stage 4\n* Type 2 Diabetes Mellitus\n* Pre-operative heparin treatment\n* Hypothyroidism\n* Anti-hypertensive treatments including an ACE inhibitor, an angiotensin II receptor antagonist, a beta-blocker or Sacubitril\n\nExclusion Criteria:\n\n* Heart transplantation\n* Pre-operative hemodynamic instability\n* Pregnant women\n* Age \\\u003C18\n* Pre-existing sepsis\n* Extracorporeal circulation support\n* Heartmate\u002FImpella\u002FCarmat patient\n* Hypothalamo-hypophyseal pathologies\n* Adrenal insufficiency\n* Anuric patient\n* Guardianship\u002F curatorship\n* Lack of social security coverage\n* Opposition to clinical research by patients or their families",true,"ALL","18 Years",{"count":21,"type":22},50,"ESTIMATED","OBSERVATIONAL","This research focuses on understanding the vasoplegic syndrome after cardiac surgery under extracorporeal circulation and in the aftermath of your surgery in the ICU.\n\nThe investigators evaluate variations in a number of clinical and biological parameters during cardiac surgery and in the 48 hours following resuscitation. In addition to all the monitors investigators usually use to monitor vital parameters during this type of procedure, investigators use sensors placed on the skin at the earlobe and palm of the hand to assess the quality of blood circulating in the body.\n\nThe investigators would like to know if these observations help us to better understand the vasoplegic syndrome (persistent drop in blood pressure requiring the administration of medication to maintain normal blood pressure), a known but poorly understood complication following cardiac surgery under extracorporeal circulation. Extracorporeal circulation is the pump that keeps the blood circulating in your body when the heart is stopped while the surgeon works on the heart.",[26],"Vasoplegic Syndrome of Cardiac Surgery",[28,29,30],"vasoplegia syndrome","post cardiopulmonary bypass","cardiac surgery","RECRUITING","2025-07-10",{"date":34,"type":35},"2025-07-11","ACTUAL",{"date":37,"type":35},"2025-02-10",{"date":39,"type":22},"2026-12-31",{"name":41,"class":42},"European Georges Pompidou Hospital","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":58,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":43},"100587931","phase-4-inotropic-effects-of-vasopressin-versus-noradrenaline-in-patients-with-vasoplegic-syndrome-after-cardiac-surgery-100587931","NCT06934798","Inotropic Effects of Vasopressin Versus Noradrenaline In Patients With Vasoplegic Syndrome After Cardiac Surgery","INVASC","Inclusion Criteria:\n\n* Age over 18.\n* Patients undergoing coronary artery bypass grafting, valve surgery or both, with a diagnosis of vasoplegic syndrome in the immediate postoperative period (\\\u003C24 hours), defined as mean arterial pressure \\\u003C 65 mmHg (measured using an invasive blood pressure catheter) and resistance to fluid replacement - at least 1000ml of crystalloids.\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding.\n* Aortic surgery.\n* Surgeries to correct congenital heart disease.\n* Heart transplants.\n* Emergency surgery.\n* Use of vasopressor therapy in the preoperative period.\n* Presence of a ventricular assist device other than an intra-aortic balloon in the postoperative period.\n* Severe hyponatremia in the postoperative period (serum sodium less than 130mEq\u002Fl).\n* Postoperative acute coronary syndrome.\n* Mesenteric ischemia in the postoperative period.\n* History of Raynaud's disease.\n* History of neoplasia.",{"count":52,"type":22},350,"INTERVENTIONAL",[55],"PHASE4","This is a randomized, double-blind clinical trial designed to compare the inotropic effects of vasopressin versus norepinephrine in patients who develop vasoplegic syndrome in the immediate postoperative period following cardiac surgery.\n\nVasoplegic syndrome is characterized by severe hypotension due to systemic vasodilation, despite adequate fluid resuscitation and preserved or elevated cardiac output. Vasopressors are essential in restoring hemodynamic stability in this context; however, their impact on myocardial performance remains uncertain. While norepinephrine is the standard first-line agent, vasopressin has shown potential benefits, including reduced catecholamine exposure and fewer adverse cardiovascular effects.\n\nThis study aims to assess changes in cardiac output and other echocardiographic and hemodynamic parameters after administration of either vasopressin or norepinephrine. The findings are expected to contribute to optimizing vasopressor selection in vasoplegic patients after cardiac surgery and improving clinical outcomes.",[26],[59,60,61],"Shock Cardiogenic","Postoperative Complications","Cardiac Surgical Procedures","2025-04-25",{"date":64,"type":35},"2025-04-30",{"date":66,"type":35},"2024-04-01",{"date":68,"type":22},"2025-07-30",{"name":70,"class":42},"University of Sao Paulo"]