[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"vasopressor-therapy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:vasopressor-therapy":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100645156","hemodynamic-laboratory-and-clinical-outcomes-of-hemoadsorption-therapy-an-observational-study-at-flr-ferenc-hospital-using-longitudinal-data-100645156",false,"NCT07679555","Hemodynamic, Laboratory, and Clinical Outcomes of Hemoadsorption theraPy: an obsErvational Study at Flór Ferenc Hospital Using Longitudinal Data","Hemodynamic, Laboratory, and Clinical Outcomes of Hemoadsorption theraPy: an obsErvational Study at Flór Ferenc Hospital Using Longitudinal Data (HOPE-FUL)","HOPE-FUL","Inclusion Criteria:\n\n* \\>18 years;\n* CytoSorb or Efferon LPS hemoadsorption treatment,\n* with available relevant pre- and post-treatment clinical and laboratory data\n\nExclusion Criteria:\n\n* age under 18 years\n* missing key demographic or outcome data;\n* unknown treatment type or timing;\n* data unavailable for legal or ethical reasons.","ALL","18 Years",{"count":20,"type":21},60,"ESTIMATED","OBSERVATIONAL","This single-center retrospective observational cohort study aims to evaluate the clinical, hemodynamic, and laboratory effects of adjunctive hemoadsorption therapy in critically ill adult patients treated in the Intensive Care Unit of Flór Ferenc Hospital, Hungary, between January 1, 2020, and May 31, 2026. Patients who received CytoSorb or Efferon LPS hemoadsorption therapy will be included.\n\nThe study will assess changes in vasopressor requirements, hemodynamic parameters, inflammatory biomarkers, liver function tests, tissue perfusion markers, and oxygenation following hemoadsorption treatment. Clinical outcomes, including intensive care unit length of stay, ICU mortality, and 28-day and 90-day mortality, will also be evaluated. Data will be collected retrospectively from anonymized medical records, and no study-related interventions will be performed.",[25,26],"Hemoadsorption","Vasopressor Therapy",[28,29,30,31,32,33,34],"hemoadsorption","CytoSorb","Efferon LPS","Vasoactive Inotropic Score","Vasopressor Dependency Index","Shock reversal time","Biomarkers","RECRUITING","2026-06-25",{"date":38,"type":39},"2026-07-01","ACTUAL",{"date":41,"type":39},"2020-01-01",{"date":43,"type":21},"2026-09-30",{"name":45,"class":46},"Pest County Flór Ferenc Hospital","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":47},"100624544","enteral-versus-parenteral-nutrition-during-recovery-after-shock-100624544","NCT07411014","Enteral Versus Parenteral Nutrition During Recovery After Shock","Enteral Versus Parenteral Nutrition During Early Recovery in the Critically Ill After Shock: A Prospective, Multicenter, Open-label, Randomized Controlled Study","Screening Criteria:\n\n* Subjects must be at least 19 years of age at the time of screening.\n* Subjects must be admitted to the intensive care unit (ICU).\n* Subjects must be receiving vasopressor therapy for shock.\n* Subjects must have a documented history of maximum vasopressor requirement with a vasopressor-inotropic score (VIS) of 12 or greater, calculated as follows:\n\nVIS = dopamine dose (µg\u002Fkg\u002Fmin) + dobutamine dose (µg\u002Fkg\u002Fmin) + 10 × milrinone dose (µg\u002Fkg\u002Fmin) + 100 × epinephrine dose (µg\u002Fkg\u002Fmin) + 100 × norepinephrine dose (µg\u002Fkg\u002Fmin) + 10,000 × vasopressin dose (U\u002Fkg\u002Fmin)\n\nInclusion Criteria:\n\n* Subjects must meet all screening criteria.\n* Subjects must have central venous access suitable for the administration of parenteral nutrition (PN).\n* Subjects must demonstrate a decreasing vasopressor requirement, defined as a current VIS of 12 or less at the time of enrollment.\n\nExclusion Criteria:\n\n* Subjects with contraindications to enteral nutrition (EN) or parenteral nutrition (PN) at the time of enrollment will be excluded.\n* Subjects requiring specific nutritional management, including but not limited to long-term home enteral nutrition, long-term parenteral nutrition, or a diagnosis of refeeding syndrome, will be excluded.\n* Subjects who are pregnant or breastfeeding will be excluded.\n* Subjects with severe comorbid conditions associated with an estimated life expectancy of less than three months will be excluded.\n* Subjects with a documented do-not-resuscitate (DNR) order will be excluded.\n* Subjects with active gastrointestinal bleeding will be excluded.\n* Subjects who have undergone gastrointestinal surgery within one month prior to enrollment will be excluded.\n* Subjects currently participating in another randomized controlled trial comparing enteral nutrition and parenteral nutrition will be excluded.","19 Years",{"count":57,"type":21},1150,"INTERVENTIONAL",[60],"NA","This study compares enteral nutrition and parenteral nutrition in critically ill adult patients recovering from shock while receiving decreasing doses of vasopressors in the intensive care unit.\n\nEligible patients will be randomly assigned to receive either enteral or parenteral nutrition during the early recovery phase of shock.\n\nThe study aims to determine whether enteral nutrition improves clinical outcomes, including ICU mortality and ICU-acquired infections, compared with parenteral nutrition.",[63,64,65,26],"Shock","Critical Illness","Nutritional Support",[67,68,69,70,71,63],"Enteral Nutrition","Parenteral Nutrition","Critically Ill Patients","Shock Recovery","Vasopressor Weaning","NOT_YET_RECRUITING","2026-02-13",{"date":75,"type":39},"2026-02-18",{"date":77,"type":21},"2026-02-01",{"date":79,"type":21},"2029-12-31",{"name":81,"class":46},"Samsung Medical Center"]