[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"vasospasm-coronary\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:vasospasm-coronary":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,49,81],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100460207","coronary-microvascular-dysfunction-assessments-in-myocardial-infarction-with-non-obstructive-coronary-arteries-100460207",false,"NCT05272618","Coronary Microvascular Dysfunction Assessments in Myocardial Infarction With Non-Obstructive Coronary Arteries","Clinical Relevance of Coronary Microvascular Dysfunction Assessments in Myocardial Infarction With Non-Obstructive Coronary Arteries","CMD-MINOCA","Inclusion Criteria:\n\n* Subject with age ≥19 years and acute myocardial infarction\n\n  * Rise and\u002For fall of cardiac troponin with one level \\>99 percentile plus ischemic signs\u002Fsymptoms\n\n    * Subject with non-obstructive coronary arteries\n  * \\\u003C50% diameter stenosis or\n  * fractional flow reserve (FFR) \\>0.80 ③ Subject without previous history of coronary artery disease\n\n    * Subject who performed invasive coronary angiography within 24 hours after presentation ⑤ Subject who eligible for invasive and non-invasive coronary physiologic assessment\n\nExclusion Criteria:\n\n* Subject with obstructive coronary arteries\n\n  * Subject with alternate diagnosis including sepsis, pulmonary embolism, myocarditis, Takotsubo syndrome, spontaneous coronary dissection, and other cardiomyopathies.\n\n    * Subject with cardiogenic shock or cardiac arrest ④ Subject who has non-cardiac co-morbid conditions with life expectancy \\\u003C1 year ⑤ Subject or lactating women ⑥ Subject unable to provide consent","ALL","19 Years",{"count":20,"type":21},150,"ESTIMATED","12 Months","OBSERVATIONAL","To compare clinical outcomes of myocardial infarction with non-obstructive coronary arteries (MINOCA) according to the coronary microvascular dysfunction (CMD), evaluated by optical coherence tomography (OCT), invasive and non-invasive coronary physiologic assessment.",[26,27,28],"Myocardial Infarction","Coronary Microvascular Dysfunction","Vasospasm, Coronary",[30,31,32,33,34,35],"MINOCA","Coronary physiology","Cardiac PET","CFR","IMR","OCT","RECRUITING","2026-05-08",{"date":39,"type":40},"2026-05-12","ACTUAL",{"date":42,"type":40},"2022-02-14",{"date":44,"type":21},"2030-12-31",{"name":46,"class":47},"Chonnam National University Hospital","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":68,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":77,"leadSponsor":79,"locationsCount":4},"100627470","comprehensive-invasive-physiological-evaluation-of-obstructive-coronary-artery-disease-100627470","NCT07449052","Comprehensive Invasive Physiological Evaluation of Obstructive Coronary Artery Disease","Inclusive Invasive Physiological Assessment in Angina Syndromes - Obstructive Coronary Artery Disease","Inclusion Criteria:\n\n* Patients \\>18 years of age\n* Hemodynamically relevant obstructive coronary artery disease (as assessed by pressure wire evaluation) in the left anterior descending coronary artery amenable to percutaneous coronary intervention at the discretion of the operator.\n\nExclusion Criteria:\n\n* Prior coronary artery bypass graft surgery.\n* Stenosis \\>90% in the target vessel or a stenosis deemed unsafe for pressure wire instrumentation\n* Known severe left ventricular dysfunction (left ventricular ejection fraction by any imaging modality)\n* Severe valvular disease\n* Renal impairment (estimated glomerular filtration rate \\\u003C30mL\u002Fmin)\n* Contra-indications for the use of adenosine or acetylcholine\n* Expected inability to conform to the clinical follow-up\n* Unable or unwilling to use the ORBITA-app\n* Life expectancy of less than 12 months.","18 Years",{"count":58,"type":21},450,"INTERVENTIONAL",[61],"NA","The goal of this clinical trial is to test whether adding coronary function testing and starting targeted medical treatment for identified vasomotor disorders will also improve angina symptoms and quality of life in patients with obstructive coronary artery disease who undergo percutaneous coronary intervention. The main question it aims to answer is:\n\nDoes performing coronary function testing in patients with obstructive coronary artery disease who undergo percutaneous coronary intervention lead to better relieve of angina symptoms and improvement in quality of life?\n\nResearchers will compare this group undergoing coronary function testing with a control group who will solely undergo percutaneous coronary intervention.\n\nParticipants will:\n\n* Undergo percutaneous coronary intervention and coronary function testing in the intervention arm\n* Undergo percutaneous coronary intervention in the control arm",[64,65,66,28,67],"Coronary Artery Disease (CAD)","Obstructive Coronary Artery Disease","Coronary Microvascular Dysfunction (CMD)","Stable Angina Pectoris",[69,70,71],"Coronary Function Testing","Percutaneous Coronary Intervention","Stable Angina","NOT_YET_RECRUITING","2026-04-30",{"date":75,"type":40},"2026-05-01",{"date":75,"type":21},{"date":78,"type":21},"2029-03-01",{"name":80,"class":47},"UMC Utrecht",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":88,"targetDuration":4,"studyType":59,"phases":90,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":4},"100618852","comprehensive-diagnostic-assessment-of-coronary-endothelial-function-impairment-and-vasospasm-with-continuous-thermodilution-in-patients-with-suspected-coronary-microvascular-and-vasomotor-dysfunction-100618852","NCT07337005","CompREhensive Diagnostic Assessment of Coronary Endothelial Function Impairment and Vasospasm With CoNtinuous ThErmodilution in Patients With Suspected Coronary Microvascular and Vasomotor Dysfunction","REDEFINE-CMD","Inclusion Criteria:\n\n1. Patients with symptoms suggestive of angina.\n2. Evidence of unobstructed coronary arteries on invasive or non-invasive coronary angiography (coronary stenosis \\\u003C50% and \u002For FFR \\>0.80).\n3. Above the age of 18.\n4. The subject has been informed of the nature of the study, agrees to its provisions and has signed written informed consent.\n\nExclusion Criteria:\n\n1. Pregnancy.\n2. Contraindication to angiography and\u002For physiological assessment with adenosine or acetylcholine.\n3. Previous coronary artery bypass graft (CABG).\n4. Moderate to severe valvular heart disease.",{"count":89,"type":21},100,[61],"The goal of this observational study is to learn more about the diagnosis of coronary endothelium function and coronary vasospasm using a dedicated invasive protocol in patients who has angina without obstruction in their main heart arteries. The main question it aims to answer is the feasibility, reproducibility, and safety of this invasive protocol:\n\nDoes this invasive protocol diagnose coronary endothelial dysfunction and vasospasm without issues?\n\nParticipants already having invasive coronary angiogram and physiological studies will undergo additional physiological measurements during the same procedure.\n\nParticipants will enrol in a symptoms and quality of life questionnaire using dedicated questionnaires and a mobile application to assess the burden of their symptoms before and after the invasive procedure and up to 12 months follow up.\n\nA subset of participants will undergo a repeat set of these measurements to assess reproducibility of the invasive protocol.\n\nA subset of the participants will also undergo a cardiac MRI to assess correlation with the invasive protocol measurements.",[66,28],"2026-01-07",{"date":95,"type":40},"2026-01-13",{"date":97,"type":21},"2025-12-15",{"date":99,"type":21},"2027-12",{"name":101,"class":47},"Mid and South Essex NHS Foundation Trust"]