[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"vasospasm\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:vasospasm":39},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,53],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100487581","vascular-lab-resource-vlr-biorepository-100487581",false,"NCT05628948","Vascular Lab Resource (VLR) Biorepository","Vascular Lab Resource (VLR) Biorepository Study","Inclusion Criteria:\n\n1. 18 years or older\n2. Subjects capable of providing informed consent document\n3. Subjects with diagnosed with or at risk for cardiovascular and metabolic diseases\n\nExclusion Criteria:\n\n1. Known life expectancy of ≤ 6 months at the time of enrollment\n2. Known current pregnancy\n3. Severe Anemia (last documented hemoglobin \\\u003C 7.0 g\u002FdL)","ALL","18 Years",{"count":19,"type":20},500,"ESTIMATED","OBSERVATIONAL","This is a study of biomarkers obtained from prospectively collected subject samples and their correlation with cardiovascular and metabolic diseases. The purpose of this initiative is to develop an enduring tool to allow for collaborative research between clinicians at Cleveland Clinic Main Campus and basic scientists at the Lerner Research Institute. This collaboration will allow resources to be available to clinical and basic researchers alike. This tool will enable research of vascular disease in the Vascular Lab and will leverage this valuable asset to the fullest extent to allow for interdepartmental collaboration.",[24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39],"Cardiovascular Diseases","Metabolic Disease","Peripheral Artery Disease","Carotid Disease","Aneurysmal Disease","Venous Disease","Thrombosis","Lymphedema","Lipedema","Non-Atherosclerotic Chronic Arterial Occlusive Disease","Vasculitis","Fibromuscular Dysplasia","Arterial Dissection","May-Thurner Syndrome","Thoracic Outlet Syndrome","Vasospasm","RECRUITING","2025-12-15",{"date":43,"type":44},"2025-12-19","ACTUAL",{"date":46,"type":44},"2019-11-14",{"date":48,"type":20},"2031-06-30",{"name":50,"class":51},"The Cleveland Clinic","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":69,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":82},"100541420","treatment-of-vasospasm-of-aneurysmal-subarachnoid-hemorrhage-with-intrathecal-nicardipine---fast-it-trial-100541420","NCT06329635","Treatment of Vasospasm of Aneurysmal Subarachnoid Hemorrhage With Intrathecal Nicardipine - FAST-IT Trial","Trial of Treatment of Vasospasm Associated With Aneurysmal Subarachnoid Hemorrhage With Intrathecal Injection of Nicardipine: a Multi-center, Prospective, Double-blinded, Randomized Controlled Trial","Inclusion criteria:\n\n1. Age 18-80.\n2. Spontaneous SAH confirmed by head CT.\n3. Saccular brain aneurysm is identified and treated, either surgically or endovascularly.\n4. SAH Fisher grade \\>1 or modified Fisher grade \\>0.\n5. EVD placed for acute hydrocephalus, or LD placed for draining bloody CSF as deemed necessary by the treating physician.\n6. Any clinical scenario leading to the diagnosis of possible vasospasm, which includes:\n\n   1. Mean flow velocity of MCA \\>120, or Lindegaard Ratio ( LR ) \\> 3.\n   2. Any intracranial artery including MCA, ACA, PCA, and BA, TCD showed an upward trend of mean flow velocity for 2 consecutive days (\\>25cm\u002Fs\u002Fday).\n   3. Clinical deterioration including mental status change (GCS score decrease \\> 2) and focal neurological deficit unable to be attributed to other known neurological reasons.\n   4. Evidence of vasospasm on CTA or DSA, or ischemic change by CTP, MRI.\n7. Within 14 days of onset of SAH.\n8. Informed consent obtained from the patient or family member.\n\nExclusion criteria:\n\n1. Hunt-Hess Grade 5 or WFNS Grade 5 (no clinical improvement after EVD placement for acute hydrocephalus).\n2. Bacterial or distal aneurysms without subarachnoid hemorrhage in the basal cisterns.\n3. The treating physician determines that the culprit aneurysm has not been fully repaired, with a very high likelihood of rebleeding in the near term.\n4. History of head trauma within the past 3 months.\n5. Any recent brain disease within 3 months, such as tumors, stroke, epilepsy, vasculitis, arteriovenous malformation, hydrocephalus, etc.\n6. History of psychiatric disorders or seizures within 3 months.\n7. Severe concurrent medical conditions.\n8. Pregnant women or those of childbearing potential with a positive urine or serum β-human chorionic gonadotropin (HCG) test.\n9. Lactating women.\n10. Life expectancy of less than 1 year prior to aSAH onset.\n11. Pre-morbid mRS score \\>1.\n12. Participation in another randomized clinical trial that may confound the evaluation of this study.","80 Years",{"count":62,"type":20},396,"INTERVENTIONAL",[65],"NA","To investigate whether patients with cerebral vasospasm associated with aneurysmal subarachnoid hemorrhage have a better prognosis with intrathecal nicardipine injection via extraventricular drainage or lumbar drainage.",[68,39],"Aneurysmal Subarachnoid Hemorrhage",[68,39,70,71,72],"Delayed cerebral ischemia","Nicardipine","Intrathecal injection","2025-09-02",{"date":75,"type":44},"2025-09-08",{"date":77,"type":44},"2024-05-27",{"date":79,"type":20},"2026-05",{"name":81,"class":51},"The Affiliated Hospital Of Guizhou Medical University",28]