[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"velopharyngeal-insufficiency\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:velopharyngeal-insufficiency":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,46,79,114],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100521661","etiological-study-of-persistent-velopharyngeal-insufficiency-in-children-with-operated-velopalatine-cleft-by-analysis-of-velopharyngeal-motor-skills-in-static-and-dynamic-mri-100521661",false,"NCT06072495","Etiological Study of Persistent Velopharyngeal Insufficiency in Children With Operated Velopalatine Cleft by Analysis of Velopharyngeal Motor Skills in Static and Dynamic MRI","FENTIRM","Inclusion Criteria:\n\n* Children aged 7 to 12 years with Isolated cleft lip\n* isolated velopalatal cleft\n* Without a diagnosis of syndromic cleft or Pierre Robin sequence\n* French speaking, and French is the native language\n* Operated with a cheiloplasty (for cleft lip) or an intravelar Veloplasty (according to Sommerlad) at the Amiens University Hospital\n* Whose follow-up is done at the Amiens University Hospital\n\nExclusion Criteria:\n\n* Refusal of the parents and\u002For the patient\n* With a contraindication to MRI\n* Whose follow-up was initiated in another center and\u002For whose surgery was performed in another center\n* Whose surgical schedule has not been followed\n* Patient with severe neurological or neuropsychiatric disorders or Severe speech and language delay not related to the cleft anatomy\n* Patients treated with fixed, non-removable orthodontic treatment.","ALL","7 Years","12 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","Velopharyngeal insufficiency is defined as the inability of the soft palate to isolate the nasopharynx from the oropharynx. It is a frequent sequela in patients with a velopalatine cleft despite anatomical restoration of the soft palate by intravelar veloplasty at 6 months. If rehabilitation by a speech therapist is not successful, a pharyngoplasty can be discussed. In the last ten years, MRI was used in dynamic and static way, to analyzed velopharyngeal muscles, in particular Levator Veli Palatini. MRI could be used to identify the etiology of VPI in those patients, and thus allow personalized rehabilitation and surgical management. The aim of this study is to examine the differences in velopharyngeal motricity as well as velar muscles morphology, positioning, and symmetry of children with repaired cleft palate with different degrees of severity of velopharyngeal insufficiency (VPI), and children with labial cleft (noncleft palate anatomy).",[27,28,29],"Velopharyngeal Insufficiency","Real Time MRI","Cleft Palate",[27,31,32],"real time MRI","Cleft palate","RECRUITING","2026-06-12",{"date":36,"type":37},"2026-06-15","ACTUAL",{"date":39,"type":37},"2024-11-06",{"date":41,"type":21},"2026-06",{"name":43,"class":44},"Centre Hospitalier Universitaire, Amiens","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":63,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":45},"100613242","velopharyngeal-dysfunction-in-head--neck-cancer-patients-pilot-study-100613242","NCT07264036","Velopharyngeal Dysfunction in Head & Neck Cancer Patients, Pilot Study","Injectable Augmentation Outcomes in Post-Radiation Head and Neck Cancer Patients With Velopharyngeal Dysfunction","Inclusion Criteria:\n\nEnglish-speaking adults (≥18 years) History of head and neck cancer treated with surgical resection, chemoradiation, or both Presence of perceptual hypernasality on clinical assessment\n\nExclusion Criteria:\n\nPre-existing or suspected non-cancer-related causes of velopharyngeal dysfunction Contraindications to pharyngeal wall augmentation Requirement for more intensive active cancer surveillance Planned future surgical or medical treatments to the pharynx that would interfere with participation","18 Years",{"count":55,"type":21},20,[24],"Some head and neck cancer survivors develop velopharyngeal dysfunction (VPD), a problem with closure between the soft palate and throat that can cause nasal-sounding speech, food or liquid leaking into the nose, difficulty swallowing, and reduced quality of life. This study aims to better understand VPD in this population and to evaluate whether pharyngeal wall augmentation (plumping up the back wall of the throat) can improve speech and swallowing.\n\nParticipants will undergo a multidisciplinary assessment including physical examination, flexible nasolaryngoscopy, speech recording and acoustic analysis, nasometry, clinical swallowing evaluation, and fiberoptic endoscopic evaluation of swallowing (FEES).\n\nAim 1: Determine the prevalence, severity, and functional impact of VPD in head and neck cancer survivors.\n\nAim 2: Assess the feasibility and usefulness of advanced diagnostic tools for VPD.\n\nThe investigators hypothesize that high nasalance scores (\\>1 SD above normal) will accurately predict VPD with at least 75% positive predictive value and will correlate with worse communication-related quality of life (CPIB).\n\nThe investigators also hypothesize that participants with VPD will have more pharyngeal residue or nasal regurgitation on FEES, and that these findings will be associated with lower swallowing-related quality of life (SWAL-QOL).\n\nAim 3: Evaluate the effectiveness of pharyngeal wall augmentation injections for improving speech intelligibility and swallowing function.\n\nThe investigators expect that this treatment will lead to measurable changes in both objective assessments and patient-reported outcomes. The results will help improve diagnosis and management of VPD in head and neck cancer survivors.",[27,59,60,61,62],"Head and Neck Cancer","Survivorship","Dysphagia","Speech Disorder",[64,65,66,67,68,69],"velopharyngeal dysfunction","hypernasal speech","pharyngeal wall augmentation","nasometry","head and neck cancer","survivorship","2026-04-27",{"date":72,"type":37},"2026-04-28",{"date":74,"type":37},"2026-03-24",{"date":76,"type":21},"2027-07-01",{"name":78,"class":44},"Vanessa Torrecillas",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":86,"sex":16,"minAge":53,"maxAge":4,"enrollmentInfo":87,"targetDuration":89,"studyType":90,"phases":4,"briefSummary":91,"conditions":92,"keywords":96,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":45},"100616085","velopharyngeal-insufficiency-after-maxillomandibular-advancement-osteotomy-in-obstructive-sleep-apnea-patients-100616085","NCT07301021","Velopharyngeal Insufficiency After Maxillomandibular Advancement Osteotomy in Obstructive Sleep Apnea Patients","VPIMMA","Inclusion Criteria:\n\n* Age \\> 18 years\n* Mild to severe OSA\n* Indication for MMA for OSA treatment\n\nExclusion Criteria:\n\n* patients who underwent other adjunctive procedures at the time of MMA (e.g., multipiece le Fort osteotomy, TMJ reconstruction\n* Previous history of orthognathic surgery\n* Previous history of orthognathic surgery\n* Previous history of oropharyngeal surgery (UPPP or multi-level surgery)\n* Cleft palate and syndromic patients\n* Neuromusculair diseases which causes VPI, dysphagia or dysarthria\n* Incapacity",true,{"count":88,"type":21},28,"2 Years","OBSERVATIONAL","The aim of this study is to gain insight into the development of velopharyngeal insufficiency (VPI) in patients who have undergone maxillomandibular advancement osteotomy (MMA) as a treatment for obstructive sleep apnea syndrome (OSAS). A speech therapist evaluates nasality, speech, and swallowing before and after the surgery.",[27,93,94,95],"Swallowing","Nasality","Speech",[97,98,99,100,101,102,103],"maxillomandibular advancement","obstructive sleep apnea","velopharyngeal insufficiency","speech therapy","swallowing","nasality","speech","NOT_YET_RECRUITING","2026-03-18",{"date":107,"type":37},"2026-03-20",{"date":109,"type":21},"2026-05-01",{"date":111,"type":21},"2027-12-01",{"name":113,"class":44},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)",{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":16,"minAge":121,"maxAge":122,"enrollmentInfo":123,"targetDuration":4,"studyType":22,"phases":124,"briefSummary":125,"conditions":126,"keywords":131,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":45},"100477077","expiratory-muscle-strength-training-for-hypernasal-speech-in-children-100477077","NCT05492266","Expiratory Muscle Strength Training for Hypernasal Speech in Children","Expiratory Muscle Strength Training as a Non-surgical Option for Velopharyngeal Dysfunction: A Randomized-controlled Trial","Inclusion Criteria:\n\n* Pittsburgh weighted speech scores of 5 or greater\n* Ages 5-17 years\n\nExclusion Criteria:\n\n* CAPS-A-AM hypernasality score \\\u003C2\n* Previous speech surgery (e.g. palatoplasty or pharyngeal flap)\n* Speech surgery scheduled within the next 56 days\n* Unable or unwilling to perform the tests and exercises outlined in the study","5 Years","17 Years",{"count":20,"type":21},[24],"When the soft palate does not move enough because of a cleft palate or for unknown reasons, this can lead to a speech difference called velopharyngeal insufficiency. The purpose of this research study is to test if soft palate exercises using a hand help breathing device will help improve the ability of the soft palate to close the area between the throat and nose and help improve speech.",[27,127,128,129,130],"Velopharyngeal Incompetence Due to Cleft Palate","Inadequate Velopharyngeal Closure","Palatopharyngeal Incompetence","Hypernasality",[29,132],"Speech Intelligibility","2025-07-17",{"date":135,"type":37},"2025-07-22",{"date":137,"type":37},"2025-03-03",{"date":139,"type":21},"2027-11",{"name":141,"class":44},"Noel Jabbour"]