[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"venous-insufficiency-chronicperipheral\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:venous-insufficiency-chronicperipheral":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100638728","impact-of-chronic-venous-insufficiency-on-outcomes-after-total-knee-arthroplasty-100638728",false,"NCT07577141","Impact of Chronic Venous Insufficiency on Outcomes After Total Knee Arthroplasty","The Impact of Chronic Venous Insufficiency on Postoperative Outcomes and Wound Healing After Total Knee Arthroplasty: A Prospective Observational Study","VENOUS-TKA","Inclusion Criteria:\n\n* Patients undergoing primary total knee arthroplasty\n* Age ≥ 50 years\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Revision TKA\n* Peripheral arterial disease (ABI \\\u003C 0.9)\n* Active infection\n* History of deep vein thrombosis within 6 months\n* Immunosuppressive therapy\n* Severe uncontrolled diabetes mellitus",true,"ALL","50 Years","80 Years",{"count":22,"type":23},100,"ESTIMATED","OBSERVATIONAL","Total knee arthroplasty (TKA) is an effective treatment for end-stage knee osteoarthritis; however, postoperative complications-particularly wound healing problems-remain a significant concern. Chronic venous insufficiency (CVI) is associated with venous hypertension, impaired microcirculation, and tissue hypoxia, which may negatively affect wound healing and increase complication rates.\n\nThis prospective observational cohort study aims to evaluate the impact of preoperative CVI on postoperative outcomes following TKA. Patients will be assessed preoperatively using the CEAP classification and Doppler ultrasonography to identify and stratify venous insufficiency.\n\nParticipants will be followed for 12 months postoperatively. The primary outcome will be wound healing complications in the early postoperative period. Secondary outcomes will include functional outcomes assessed by the Knee Society Score (KSS), patient-reported outcomes using the WOMAC score, and overall complication rates.\n\nThe findings of this study are expected to clarify the role of venous insufficiency as a potential risk factor in TKA and may contribute to improved preoperative risk stratification and postoperative management strategies.",[27,28,29],"Total Knee Anthroplasty","Venous Insufficiency (Chronic)(Peripheral)","Doppler Ultrasound Diagnosis",[31,32,33,34],"total knee arthroplasty","chronic venous insufficiency","doppler","wound","NOT_YET_RECRUITING","2026-05-12",{"date":38,"type":39},"2026-05-18","ACTUAL",{"date":41,"type":23},"2026-06",{"date":43,"type":23},"2027-06",{"name":45,"class":46},"SB Istanbul Education and Research Hospital","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":18,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":70,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":86},"100602421","effect-of-photobiomodulation-on-healing-of-venous-leg-ulcers-100602421","NCT07123285","Effect of Photobiomodulation on Healing of Venous Leg Ulcers","Effect of Photobiomodulation on the Healing of Venous Ulcers in the Lower Limbs","Inclusion Criteria:\n\n* Patients of both sexes;\n* Individuals with venous ulcers in the lower limbs for at least three weeks that have not healed;\n* Age between 18 and 85 years;\n* Residents of Lençóis Paulista or nearby regions.\n\nExclusion Criteria:\n\n* Patients with ulcers of non-venous etiology;\n* Pregnant women;\n* Presence of severe arterial disease in the lower limbs.","18 Years","85 Years",{"count":57,"type":23},96,"INTERVENTIONAL",[60],"NA","This randomized, controlled, double-blind clinical trial will evaluate the efficacy of photobiomodulation (PBM) combined with compression therapy in the healing of venous ulcers (VUs) in the lower limbs. A total of 96 participants will be allocated into two groups: Experimental Group (PBM + compression) and Control Group (sham PBM + compression). Treatments will be administered twice weekly for 16 weeks (32 sessions). The primary outcome will be complete wound healing. Secondary outcomes include changes in ulcer area and volume, pain (VAS), quality of life (SF-36), clinical severity (VCSS), wound quality (Bates-Jensen Scale), infrared thermography, and treatment costs. Data will be analyzed using ANOVA or Kruskal-Wallis, chi-square or Fisher's exact test, and Kaplan-Meier survival analysis, with a significance level of p \\\u003C 0.05.",[63,28,64,65,66,67,68,69],"Venous Disease","Venous Insufficiency of Leg","Venous Leg Ulcer (VLU)","Venous Leg Ulcer","Venous Hypertension Ulcers","Varicose Ulcers","Varicose Ulcer of Lower Limb",[71,72,73,74,75,76],"venous ulcers","varicose ulcers","photobiomodulation","lasers","phototherapy","venous leg ulcer","2026-04-27",{"date":79,"type":39},"2026-04-29",{"date":81,"type":23},"2026-05",{"date":83,"type":23},"2027-07",{"name":85,"class":46},"University of Nove de Julho",1]