[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ventilated-patient-in-intensive-care\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ventilated-patient-in-intensive-care":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,39,65],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100639527","effectiveness-of-diaphragmatic-function-and-parasternal-intercostal-muscles-functions-as-predictors-for-successful-weaning-from-mechanical-ventilation-100639527",false,"NCT07630662","Effectiveness of Diaphragmatic Function and Parasternal Intercostal Muscles Functions as Predictors for Successful Weaning From Mechanical Ventilation","Ultrasound Evaluation of Diaphragmatic Functions and Parasternal Intercostal Muscle Thickening Fraction as Predictors of Successful Weaning From Mechanical Ventilation.","Inclusion Criteria:\n\n* 1\\. Adult patients more than 18 years old. 2. Patient on mechanical ventilation more than 48 hours.\n\nExclusion Criteria:\n\n* 1\\. Declining to give a written informed consent. 2. Diaphragmatic paralysis or injury","ALL","18 Years",{"count":19,"type":20},77,"ESTIMATED","2 Days","OBSERVATIONAL","Critically ill patients frequently develop respiratory muscle dysfunction that may contribute to difficult and prolonged weaning from mechanical ventilation. that is besides complications such as barotrauma, ventilator-acquired pneumonia, accumulation of secretions, and lung atelectasis.\n\nThe ultrasound estimation of parasternal intercostal muscle and diaphragmatic functions is a method to evaluate if there is a good chance of weaning outcomes.",[25],"Ventilated Patient in Intensive Care","RECRUITING","2026-06-02",{"date":29,"type":30},"2026-06-05","ACTUAL",{"date":32,"type":30},"2026-01-01",{"date":34,"type":20},"2026-08-01",{"name":36,"class":37},"Ain Shams University","OTHER",1,{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":47,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":49,"conditions":50,"keywords":51,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":38},"100630619","variation-in-viscoelastic-properties-of-pulmonary-mucus-in-patients-undergoing-mechanical-ventilation-100630619","NCT07490028","Variation in Viscoelastic Properties of Pulmonary Mucus in Patients Undergoing Mechanical Ventilation","Study of the Variation in Viscoelastic Properties of Pulmonary Mucus in Patients Undergoing Mechanical Ventilation With or Without NIV","RHEOREA","Inclusion Criteria:\n\n* Adult patients (\\> 18 years old)\n* Hospitalised in the intensive care unit of the CHIAP\n* Placed on mechanical ventilation, regardless of the length of hospitalisation before and after\n* French-speaking patients, able to understand the study information leaflet\n* No objection from the patient\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding women\n* Patients deprived of their liberty, under guardianship or curatorship",{"count":48,"type":20},20,"Ventilator-associated pneumonia (VAP) is defined as an infection of the lung parenchyma in patients undergoing invasive mechanical ventilation for at least 48 hours. It is one of the types of pneumonia acquired in intensive care units (ICUs) and is one of the most common infections in this population, representing a major complication.\n\nThe diagnosis of VAP is based on three main criteria: clinical suspicion, adiological imaging, and microbiological cultures of the lower respiratory tract. However, these elements have significant limitations.\n\nNew rapid diagnostic techniques, such as multiplex polymerase chain reaction (PCR), can quickly identify pathogens and resistance mechanisms in just a few hours. These promising tools could reduce the time to initiate targeted treatment while limiting the excessive use of antibiotics. However, no single tool is currently accurate enough to diagnose VAP, and diagnosis is based on a combination of factors.\n\nToday, scores exist that can be used to assess the probability of PAVM, such as the CIPS. These are useful tools but lack specificity. The clinical, biological and radiological criteria used to calculate the score can also be observed in other pathologies. Thus, although they are sensitive to the detection of PAVM, they are often insufficient to establish a definitive diagnosis. They must be supplemented by other diagnostic approaches, such as microbiological cultures and more detailed imaging examinations, to obtain a more accurate assessment.\n\nIt is also essential to mention the importance of gaining a better understanding of the lung microbiome. Indeed, it appears to play a central role not only in the pathophysiology of MVAP, but also in its diagnosis and management.\n\nThe work of Fromentin et al. shows that it is possible to observe dysbiosis associated with a loss of microbial diversity and the onset of certain pulmonary infections. Thus, structural variations in mucus could reflect changes in the pulmonary microbiome.\n\nIt is therefore essential to remember that mucus plays an essential protective role in the respiratory tract by trapping particles, bacteria and pathogens, while facilitating their transport thanks to its viscoelastic properties. However, in mechanically ventilated patients, these mucociliary clearance mechanisms are often impaired, promoting the accumulation of secretions, bacterial proliferation and, ultimately, the onset of MVAP.\n\nThe work of Patarin and Giovanna and al. suggests that biochemical and microbiological changes in mucus could be a criterion for initiating treatment in recurrent pulmonary infections in patients with chronic obstructive pulmonary disease (COPD) or cystic fibrosis. These observations suggest the potential value of early characterisation of mucus in ventilated patients in order to detect additional diagnostic clues that would enable rapid and appropriate treatment.",[25],[52,53,54,55],"viscoelastic properties","mucus","mechanical ventilation","ventilator-associated pneumonia","2026-03-19",{"date":58,"type":30},"2026-03-24",{"date":60,"type":30},"2025-03-08",{"date":62,"type":20},"2026-03",{"name":64,"class":37},"Centre Hospitalier Intercommunal Aix-Pertuis",{"id":66,"slug":67,"hasResults":11,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":4,"eligibilityCriteria":71,"healthyVolunteers":11,"sex":16,"minAge":72,"maxAge":4,"enrollmentInfo":73,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":38},"100628870","the-rapid-shallow-breathing-index-rsbi-is-a-widely-used-predictor-for-weaning-patients-from-mechanical-ventilation-this-study-aims-to-determine-the-predictive-value-of-rsbi-measurements-for-extubation-success-in-mechanically-ventilated-icu-patients-100628870","NCT07467265","The Rapid Shallow Breathing Index (RSBI) is a Widely Used Predictor for Weaning Patients From Mechanical Ventilation This Study Aims to Determine the Predictive Value of RSBI Measurements for Extubation Success in Mechanically Ventilated ICU Patients","Rapid Shallow Index as Successfully Predictor of Outcome of Extubating","Inclusion Criteria:\n\n* • Adults \\> 22 years.\n\n  * Mechanically ventilated patients meeting extubation readiness:\n\n    * FiO₂ ≤ 0.4, PEEP ≤ 8 cmH₂O, PaO₂\u002FFiO₂ ≥ 200 mmHg.\n    * Respiratory rate ≤ 35 breaths\u002Fmin, pH \\> 7.30.\n    * Hemodynamic stability (HR ≤ 120 bpm, SBP 90-160 mmHg).\n    * Glasgow Coma Scale \\>10, adequate cough reflex.\n  * Includes postoperative, elective\u002Femergency reintubation, and tracheostomized patients.\n\nExclusion Criteria:\n\n* Age \\\u003C22 years.\n* Refusal of informed consent.\n* Altered mental status (e.g., traumatic brain injury).\n* Hemodynamic instability or deep sedation (RASS ≤ -2).","22 Years",{"count":74,"type":20},70,"Early extubation in ICU patients is crucial for reducing complications of prolonged ventilation, including morbidity and mortality. The Rapid Shallow Breathing Index (RSBI) is a widely used predictor for weaning patients from mechanical ventilation. This study aims to determine the predictive value of RSBI measurements for extubation success in mechanically ventilated ICU patients",[25,77],"Failure of Extubation",[79],"RSBI.VAP.success of extubation","2026-03-11",{"date":82,"type":30},"2026-03-13",{"date":84,"type":30},"2026-03-01",{"date":86,"type":20},"2026-09-01",{"name":36,"class":37}]