[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ventilation-during-resuscitation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ventilation-during-resuscitation":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100588279","phase-3-the-application-of-positive-end-expiratory-pressure-in-out-of-hospital-cardiac-arrest-the-lazarus-peep-trial-100588279",false,"NCT06939335","The Application of Positive End-Expiratory Pressure in Out-of-Hospital Cardiac Arrest: The Lazarus-PEEP Trial.","Lazarus-PEEP","Inclusion Criteria:\n\n1. Age: Adults aged 18 years and older.\n2. Type of Cardiac Arrest: Patients who have experienced a non-traumatic out-of-hospital cardiac arrest.\n3. CPR Administration: Patients receiving cardiopulmonary resuscitation from an advanced life support (ALS) team.\n4. Intubation and Ventilation: Patients who are intubated and ventilated during resuscitation efforts.\n\nExclusion Criteria:\n\n1. Cardiac arrest in patient younger than 18 years of age.\n2. Traumatic cardiac arrest, including drowning, penetrating or blunt injury, and burns.\n3. Immediate Return of Spontaneous Circulation (ROSC): Patients who achieve ROSC before intubation and initiation of intubation.\n4. Pregnancy.\n5. Mechanical ventilation during arrest: patients already receiving mechanical ventilation at the moment of cardiac arrest, due to reasons other than their arrest, will be excluded.\n6. Do Not Resuscitate (DNR) Orders: Patients with existing DNR orders or any advanced directive indicating that CPR should not be performed.\n7. Failure to intubate: if intubation is unsuccessful, ventilation by any means (MBV, SGA) should take priority over the study protocol, and the patient is excluded.\n8. Enrolment in Other Studies: Patients currently enrolled in another interventional clinical trial that could interfere with the outcomes of this study.","ALL","18 Years",{"count":19,"type":20},132,"ESTIMATED","INTERVENTIONAL",[23],"PHASE3","The goal of this clinical trial is to learn whether using Positive End-Expiratory Pressure (PEEP) during cardiopulmonary resuscitation (CPR) improves outcomes for adults who experience out-of-hospital cardiac arrest, a condition where the heart suddenly stops beating. PEEP is used during ventilation, which may enhance oxygen levels by keeping the airways open throughout CPR.\n\nThis study aims to determine if using PEEP during CPR helps restart the heart more effectively, improves survival rates, and enhances survival with good neurologic outcomes after a cardiac arrest compared to standard CPR without PEEP.\n\nResearchers will randomly assign participants to one of two groups: one receiving CPR with PEEP set at 5 cm of water pressure and the other receiving standard CPR without PEEP. Participants will be treated by emergency medical teams trained in advanced life support, and specialised sensors will measure airflow and airway pressure during resuscitation.\n\nAdditionally, the study will evaluate potential side effects associated with PEEP, such as increased pressure within the chest or lung injuries. Findings from this trial will guide recommendations on the usage of PEEP in standard CPR practices to potentially improve patient outcomes.",[26,27,28,29],"Cardiac Arrest (CA)","Out-of-hospital Cardiac Arrest (OHCA)","Positive End-expiratory Pressure (PEEP)","Ventilation During Resuscitation","RECRUITING","2026-01-20",{"date":33,"type":34},"2026-01-21","ACTUAL",{"date":36,"type":34},"2025-04-25",{"date":38,"type":20},"2027-02-01",{"name":40,"class":41},"University Hospital, Ghent","OTHER",7,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":21,"phases":53,"briefSummary":55,"conditions":56,"keywords":57,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":4},"100584135","intra-arrest-ventilation-in-human-cadavers-ii-100584135","NCT06885398","Intra Arrest Ventilation in Human Cadavers II","Intra-Arrest-Ventilation - a Prospective Randomized Trial in Human Cadavers II","Inclusion Criteria:\n\n* more than 18 years of age\n\nExclusion Criteria:\n\n* Adult respiratory distress syndrome (ARDS)\n* Severe lung or thoracic injuries\n* Pneumothorax\n* Abnormal airways\n* Tracheostoma\n* severe aspirations",true,{"count":52,"type":20},3,[54],"NA","The study investigates the influence of three types of ventilation mode by using Bi-Level positive airway pressure (pinsp 20 mbar, PEEP 5, AF 10\u002Fmin) with two different types of ventilators ( Medumat vs. MeduVENT ), Continuous positive airway pressure (PEEP 5, AF 10\u002Fmin, ASB 10) and Chest Compression Synchronized Ventilation (pInsp = 30 vs. 60 mbar; respiratory rate = chest compression rate, PEEP 5) with regard to achieving a sufficient tidal volume and the tightness of various supraglottic airway devices (laryngeal mask, i-Gel-laryngeal mask, laryngeal tube) and endotracheal intubation.",[29],[58,59,60,61,62,63,64],"Cardiac arrest","Airway management","Cadaver","Heart diseases","Heart arrest","Death","cardiovascular diseases","NOT_YET_RECRUITING","2025-03-17",{"date":68,"type":34},"2025-03-20",{"date":70,"type":20},"2025-04-01",{"date":72,"type":20},"2025-12-30",{"name":74,"class":41},"Muehlenkreiskliniken, MKK"]