[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ventilation-mechanical\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ventilation-mechanical":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,44,73,106],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100644174","surveillance-of-neonatal-endotracheal-tube-colonisation-100644174",false,"NCT07664449","Surveillance of Neonatal Endotracheal Tube Colonisation","Surveillance Study of Endotracheal Tube Microbial Colonisation in Neonatal Intensive Care Units","NETT","Inclusion Criteria:\n\n* Infant of any gestational age (22 weeks gestation and upwards) who is expected to be intubated for more than 12 hours\n* All infants must have verbal or written informed consent from the parent\u002Fcarer\n* All infants must have a realistic prospect of survival as determined by the attending clinical team\n\nExclusion Criteria:\n\n* Infants that are not for active resuscitation\n* Infants that are undergoing end-of-life care\n* In situations where consent is not possible or provided",true,"ALL",{"count":20,"type":21},80,"ESTIMATED","OBSERVATIONAL","Babies in neonatal intensive care units (NICUs) sometimes need help breathing using a breathing tube (endotracheal tube, or ETT) connected to a breathing machine (ventilator). Over time, bacteria and other substances can build up on the inside of these tubes. This build-up may contribute to infections, inflammation, or breathing problems, but we do not fully understand how often this occurs or what is present within the tubes used in UK NICUs.\n\nThis surveillance study will collect breathing tubes that have been removed from babies who have been ventilated for more than 12 hours as part of their normal clinical care. No additional procedures or interventions will be performed on babies, and the tubes would otherwise be discarded.\n\nResearchers will examine the used tubes and any respiratory secretions (mucus) associated with them. Laboratory testing will identify any bacteria or other microorganisms present and analyse the chemical composition that has accumulated within the tubes and respiratory secretions. By studying these samples, we hope to better understand how breathing tubes become colonised over time and how this may relate to infection and lung health in newborn babies.\n\nThis study aims to identify the microorganisms that colonises ETT and map them in a contemporary UK neonatal cohort.\n\nThe information gained from this study may help improve infection surveillance, guide future research, and support the development of strategies to reduce complications associated with mechanical ventilation in vulnerable newborn infants.",[25,26],"Ventilation, Mechanical","Ventilation-Associated Pneumonia",[28,29,30,31],"ventilation","endotracheal tube colonisation","neonatal","biofilm colonisation","NOT_YET_RECRUITING","2026-06-17",{"date":35,"type":36},"2026-06-24","ACTUAL",{"date":38,"type":21},"2026-07",{"date":40,"type":21},"2028-03",{"name":42,"class":43},"University of Nottingham","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":18,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":72},"100606410","association-between-eit-and-ct-during-peep-titration-in-patients-with-acute-respiratory-failure-100606410","NCT07175194","Association Between EIT and CT During PEEP Titration in Patients With Acute Respiratory Failure","Association Between the \"Best\" Positive End-Expiratory Pressure Identified With Electrical Impedance Tomography and the Potential for Hyperinflation and Collapse Assessed With Lung Computed Tomography in Mechanically Ventilated Patients With Acute Respiratory Failure","TAC-EIT-20-5","Inclusion Criteria:\n\n* Adults (≥18 years of age) admitted to our Unit with ARF treated with mechanical ventilation\n* The patient undergoes a lung CT and EIT to guide the setting of PEEP as part of our routine clinical practice\n\nExclusion Criteria:\n\n* The patient cannot undergo a lung CT and\u002For EIT as judged by the attending physician (for instance, transport to the radiology unit may be considered too risky if the patient is extremely severe, or using EIT may be contraindicated because of the presence of a pacemaker)\n* Pregnancy (as this condition alters the respiratory physiology)","18 Years",{"count":54,"type":21},30,"This observational study will analyze data already collected by the investigators as part of their routine clinical practice from patients with acute respiratory failure (ARF) treated with mechanical ventilation. The study itself does not require any specific intervention.\n\nMechanical ventilation can save the lives of patients with ARF. However, if used improperly, it can exacerbate lung disease and worsen outcomes (Slutsky et al.).\n\nDespite decades of animal and clinical research, it remains unclear how to establish the positive end-expiratory pressure (PEEP) during mechanical ventilation to reduce the risk of lung damage. Several methods have been suggested, but none have consistently proven superior to the others (Sahetya et al.).\n\nAs part of their routine clinical practice, the investigators study the responses to different PEEP levels of patients with ARF undergoing mechanical ventilation by integrating information from various techniques, each examining different aspects of lung morphology and physiology. The methods the investigators use include lung computed tomography (CT) and electrical impedance tomography (EIT). Lung CT is the reference technique for measuring the morphological response to PEEP (Gattinoni et al.). It quantifies the volume of the hyperinflated and non-aerated lung, both of which are related to the risk of mechanical ventilation causing damage (Slutsky et al.). Lung EIT monitors the functional response to PEEP in terms of changes in regional compliance across different PEEP levels. Allegedly, an increase in compliance when PEEP is decreased reveals overdistention, the functional correlate of (worrisome) hyperinflation, at the higher PEEP. A decrease in compliance when PEEP is decreased signals new collapse, the functional correlate of (worrisome) loss of aeration (Franchineau et al.).\n\nIn the Unit where the investigators work, patients with ARF treated with mechanical ventilation are routinely studied as follows. First, a lung CT with a PEEP of 20 cmH2O and then of 5 cmH2O is obtained. Thereafter, a decremental PEEP test is performed with the EIT, where PEEP is decreased from 20 cmH2O down to 5 cmH2O in steps of 2 or 3 cmH2O. Finally, results are analyzed and compared offline.\n\nAt the lung CT, decreasing PEEP from 20 to 5 cmH2O is always associated with some decrease in the volume of the hyperinflated lung and some increase in the volume of the non-aerated lung. However, the magnitude of these two effects varies among individuals, and the net response may be defined as the difference between those two competing effects. If the decrease in the volume of the hyperinflated lung is greater than the increase in the volume of the non-aerated lung, the overall response (i.e., less hyperinflation) can be considered positive. PEEP should then be set closer to 5 than to 20 cmH2O. Diversely, if the decrease in the volume of the hyperinflated lung is smaller than the increase in the volume of the non-aerated lung, the overall response (i.e., more loss of aeration) can be considered negative. PEEP should then be set closer to 20 cmH2O (Protti et al.). Similarly, at the lung EIT, decreasing PEEP from 20 to 5 cmH2O is always associated with compliance improvement in some regions (i.e., less overdistension) and worsening in others (i.e., more collapse). Again, the magnitude of these two opposite effects varies among individuals. According to most experts on lung EIT, PEEP should be set at the level where both overdistension and collapse are minimized (the so-called \"best\" PEEP) (Jonkman et al.).\n\nLung CT requires transfer to the radiology unit, exposure of the patient to radiation, and complex analysis offline. By contrast, lung EIT is virtually risk-free, and analysis can be performed using an automatic algorithm. Nevertheless, lung EIT is less well validated than lung CT. For instance, the assumption that a decrease in compliance in response to a decrease in PEEP is due to new collapse has been questioned (Protti et al., Chiumello et al., Menga et al.). So far, lung CT remains the reference technique for studying individual responses to PEEP, while lung EIT requires further validation.\n\nThis study aims to verify whether the \"best\" PEEP identified using lung EIT is strongly associated with the net response assessed using lung CT, when PEEP is decreased from 20 to 5 cmH2O in patients with ARF treated with mechanical ventilation. If so, this would strengthen the rationale for using the lung EIT (which is safer and simpler than the lung CT) to set PEEP.",[57,25],"Acute Hypoxemic Respiratory Failure",[59,60,61],"Positive End-Expiratory Pressure","Computed Tomography","Electrical Impedance Tomography","RECRUITING","2026-05-17",{"date":65,"type":36},"2026-05-19",{"date":67,"type":36},"2025-11-01",{"date":69,"type":21},"2027-06",{"name":71,"class":43},"Istituto Clinico Humanitas",1,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":18,"minAge":52,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":94,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":105},"100579076","phase-3-prophylaxis-against-early-ventilator-associated-infections-in-acute-brain-injury-100579076","NCT06819592","PRophylaxis Against Early VENTilator-associated Infections in Acute Brain Injury","PRophylaxis Against Early VENTilator-associated Infections to Reduce Mortality in Mechanically Ventilated Intensive Care Unit (ICU) Patients With Acute Brain Injuries: a Phase 3 Randomised, Double Blind, Parallel Group, Placebo-controlled Two-side Superiority Trial","PREVENT-NEURO","Inclusion Criteria:\n\n1. ≥ 18 years of age\n2. Receiving invasive mechanical ventilation\n3. The requirement for mechanical ventilation is because of an acute brain injury due to intracranial haemorrhage, ischaemic stroke, cerebral venous sinus thrombosis, subarachnoid haemorrhage, suspected hypoxic ischaemic encephalopathy post cardiac arrest, or traumatic brain injury.\n4. Admitted to an ICU or is anticipated to be admitted to an ICU\n\nExclusion Criteria:\n\n1. Endotracheal intubation was more than 12 hours ago\n2. Hospital admission was more than 72 hours ago\n3. Anticipated inability to deliver trial intervention within 90 minutes of randomisation\n4. Documented use of antibiotic therapy in the week prior to hospitalisation\n5. Currently receiving antibiotic therapy, or intention to prescribe antibiotic therapy, excluding cephazolin for peri-operative prophylaxis\n6. Any contraindication to receiving ceftriaxone\n7. Known or suspected pregnancy\n8. Death within 90 days is deemed inevitable due to the current illness or intercurrent medical conditions\n9. Previously enrolled in the PREVENT-NEURO trial.",{"count":82,"type":21},3300,"INTERVENTIONAL",[85],"PHASE3","This research is about whether treatment with a commonly used antibiotic can prevent infections in airway and lungs and improves the chance of surviving, if it is given soon after patients commence mechanical ventilation when they have been admitted to hospital with an acute severe brain injury.\n\nAn acute severe brain injury can occur as a result of a stroke, a traumatic injury or due to lack of oxygen to the brain that happens as a result of a cardiac arrest.\n\nPatients who are unconscious after an acute severe brain injury often need assistance to breath adequately, and this assistance is given by a breathing tube, connected to a mechanical ventilator. This treatment is an emergency medical treatment. The breathing tube is inserted into the patients' airway by either their mouth or neck. For patients who need assistance with their breathing from a mechanical ventilator, infections in the airways and lungs, known as pneumonia, are a common complication. Everyone naturally has bacteria in their mouth, esophagus and stomach. Clinicians think that during the process of inserting the breathing tube, small amounts of these bacteria can be introduced into the airways and lung when people are unconscious following an acute severe brain injury, or during the process of placing the breathing tube into the airways. These bacteria are now in a place they aren't meant to be and can cause an infections in the airways and lungs known as pneumonia.\n\nThe purpose of this research is to see if giving one dose of a common antibiotic can prevent patients developing pneumonia, which is associated with having a breathing tube inserted and being on a ventilator, improving the chance of recovery following the acute severe brain injury and ultimately improving the chance of surviving.\n\nWhen patients have a known infection, current guidelines are to treat them with antibiotics. Antibiotics work to kill the bacteria causing the infection. When a patient has an infection in their lungs, they often need to stay on the mechanical ventilator for longer. While current practice is to give patients with a proven infection in their airways and lungs (pneumonia) antibiotics, it is unknown if giving an antibiotic to patients to prevent these infections before they show signs of pneumonia may lead to better outcomes.",[88,89,90,91,92,25,93],"All-cause Mortality","Quality of Life","Disability, Intellectual","Neurological Disorder","Acute Brain Injury","Intensive Care Medicine",[92,95],"Mechanical Ventilation","2026-02-16",{"date":98,"type":36},"2026-02-19",{"date":100,"type":36},"2025-10-30",{"date":102,"type":21},"2029-12",{"name":104,"class":43},"The George Institute",9,{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":18,"minAge":52,"maxAge":113,"enrollmentInfo":114,"targetDuration":116,"studyType":22,"phases":4,"briefSummary":117,"conditions":118,"keywords":120,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":72},"100586136","pleural-strain-by-speckle-tracking-ultrasound-feasibility-and-driving-pressure-associations-100586136","NCT06911450","Pleural Strain by Speckle-Tracking Ultrasound: Feasibility and Driving Pressure Associations","Quantification of Pleural Longitudinal Strain by Speckle-Tracking Ultrasound: Feasibility and Associations With Driving Pressure in Mechanically Ventilated Patients","Phase 1: Feasibility Assessment in Non-Mechanically Ventilated Patients\n\nInclusion Criteria:\n\n* Adult patients (≥18 years) admitted to the ICU with an APACHE II score \\>8.\n* Non-mechanically ventilated patients (either spontaneously breathing or receiving only non-invasive oxygen therapy).\n\nExclusion Criteria:\n\n* History of thoracic surgery or trauma.\n* Presence of pneumothorax or chest trauma (e.g., rib fractures, flail chest).\n* Pregnancy or age \\\u003C18 years.\n* Refusal to participate by the patient or legal representative.\n* Poor ultrasound image quality (e.g., unclear pleural visualization).\n\nPhase 2: Feasibility Assessment in Mechanically Ventilated Patients\n\nInclusion Criteria:\n\n* Adult patients (≥18 years) admitted to the ICU with an APACHE II score \\>8.\n* Receiving invasive mechanical ventilation for \\>24 hours.\n\nExclusion Criteria:\n\n* History of thoracic surgery or trauma.\n* Presence of pneumothorax or chest trauma (e.g., rib fractures, flail chest).\n* Pregnancy or age \\\u003C18 years.\n* Requirement for high-frequency oscillatory ventilation.\n* Poor ultrasound image quality (e.g., pleural motion obscured by pleural effusion).\n\nPhase 3: Correlation Analysis of Strain and Driving Pressure in Mechanically Ventilated Patients\n\nInclusion Criteria:\n\n* Adult patients (≥18 years) admitted to the ICU with an APACHE II score \\>8.\n* Receiving invasive mechanical ventilation for \\>24 hours.\n* Tolerance to stepwise driving pressure adjustments (10, 15, and 20 cmH₂O, maintained for 10 minutes each).\n\nExclusion Criteria:\n\n* History of thoracic surgery or trauma.\n* Presence of pneumothorax, chest trauma (e.g., rib fractures, flail chest), or significant patient-ventilator asynchrony.\n* Pregnancy or age \\\u003C18 years.\n* Requirement for high-frequency oscillatory ventilation.\n* Hemodynamic instability (mean arterial pressure \\[MAP\\] \\\u003C65 mmHg or requiring high-dose vasopressors).\n* Severe hypoxemia (PaO₂\u002FFiO₂ \\\u003C100 mmHg), precluding safe adjustment of driving pressure.\n* Poor ultrasound image quality (e.g., loss of pleural strain signal).","75 Years",{"count":115,"type":21},75,"28 Days","What is this study about? This research aims to test a new ultrasound technology called \"speckle tracking\" to measure how much the lining of your lungs (pleura) stretches during breathing, especially if you're on a breathing machine (ventilator). Doctors want to see if this technology can help them adjust ventilator settings more safely, reducing the risk of lung damage.\n\nWhy is this important? Lung protection: Patients on ventilators, especially those with severe lung problems (like ARDS or pneumonia), need careful settings. Too much pressure from the ventilator can harm the lungs.\n\nBetter monitoring: Current tools can't easily measure lung stretching at the bedside. This ultrasound method might offer a simple, painless way to check lung health in real time.\n\nWho can join? Included: Adults (18+ years) in the ICU with serious illness (assessed by a standard score called APACHE II \\>8), whether on a ventilator or not.\n\nExcluded: People with recent chest surgery, broken ribs, nerve\u002Fmuscle diseases, or pregnancy (to avoid risks and ensure accurate measurements).\n\nWhat will happen during the study?\n\nUltrasound scans:\n\nA small probe will be placed gently on your chest for 5-10 minutes. The machine will record videos of your lung movements during breathing. This is painless and uses no radiation.\n\nMeasurements:\n\nDoctors will repeat the scan twice (10 minutes apart) to check consistency. For ventilator patients, scans will be done at different pressure settings to see how lung stretching changes.\n\nHow will this help me or others? Direct benefit: You'll receive detailed monitoring of your lung function, which may help doctors personalize your care.\n\nFuture benefit: If successful, this technology could help doctors worldwide adjust ventilators more safely, reducing complications for ICU patients.\n\nIs my information safe? All data (scans, medical records) will be anonymized and stored securely. Participation is voluntary, and you can withdraw anytime without affecting your treatment.\n\nWho is conducting the study? Led by Dr. Xu Qiancheng and the ICU team at Yijishan Hospital, Wannan Medical College.\n\nExperts in ultrasound and critical care will ensure the study is safe and scientifically rigorous.",[25,119],"ARDS (Acute Respiratory Distress Syndrome)",[121,122,95,123,124],"Speckle-Tracking Ultrasound","Pleural Longitudinal Strain","Ventilator-Induced Lung Injury (VILI)","Lung Strain","2025-03-28",{"date":127,"type":36},"2025-04-04",{"date":129,"type":36},"2024-12-05",{"date":131,"type":21},"2025-05-31",{"name":133,"class":43},"First Affiliated Hospital of Wannan Medical College"]