[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ventilation-perfusion-mismatch\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ventilation-perfusion-mismatch":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,50,85],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":33,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100555503","ventilator-pressure-and-optimization-of-compliance-and-hemodynamics-100555503",false,"NCT06512935","Ventilator Pressure and Optimization of Compliance and Hemodynamics","Ventilator Pressure and Optimization of Compliance and Hemodynamics: VPOCH Trial","VPOCH","Inclusion Criteria:\n\nPreterm infants with recovering respiratory distress syndrome (RDS) who were born at a gestational age \\\u003C 34 weeks and are receiving respiratory support via conventional mechanical ventilation or on HFJV.\n\n* Post-natal age \\> 7 days and less than 1 month (outside golden week protocol)\n* Gestational age ≥ 21 weeks and ≤ 34 week\n* Infants with written informed consent obtained from legal guardian\n\nExclusion Criteria:\n\n* Blood culture-positive sepsis\n* Congenital anomalies affecting respiration\n* Cyanotic or ductal-dependent congenital heart disease\n* Newborns who are considered too unstable for study enrolment per neonatology attending\n* Newborns on pressors or steroids for maintaining cardiac output\n* Non-invasive ventilation or newborn with significant BPD (bronchopulmonary dysplasia) with pulmonary hypertension (HTN)\n* Open skin wounds or abrasions on the chest wall.","ALL","7 Days","30 Days",{"count":21,"type":22},24,"ESTIMATED","INTERVENTIONAL",[25],"NA","In preterm infants \\\u003C 34 weeks' gestation at birth receiving respiratory support with invasive positive pressure ventilation, the positive end-expiratory pressure (PEEP) of best compliance will increase the cardiac output and improve oxygenation. This study may emphasize using point-of-care echocardiography along with electrical impedance tomography (EIT) to optimize ventilator settings in preterm infants.\n\nInfants will be randomized to a 4-hour crossover period of increasing and decreasing PEEP in random order from baseline to determine compliance, oxygenation, and cardiac hemodynamics at each step using echocardiography (ECHO) and EIT measurements. There will be a 15-minute washout period after changes prior to data collection.",[28,29,30,31,32],"Bronchopulmonary Dysplasia","Pulmonary Hypertension Due to Lung Diseases and Hypoxia","Extreme Prematurity","Ventilator Lung; Newborn","Ventilation Perfusion Mismatch",[34,35,36],"Respiratory distress syndrome","ventilation mechanics in newborn","cardiac hemodynamics newborn","RECRUITING","2026-05-06",{"date":40,"type":41},"2026-05-11","ACTUAL",{"date":43,"type":22},"2026-08-01",{"date":45,"type":22},"2027-06-30",{"name":47,"class":48},"University of Alabama at Birmingham","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":17,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":23,"phases":62,"briefSummary":63,"conditions":64,"keywords":69,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":4},"100616312","effects-of-inspiratory-vs-expiratory-breath-hold-on-lung-perfusion-measured-by-eit-saline-indicator-method-a-self-controlled-study-100616312","NCT07303972","Effects of Inspiratory vs Expiratory Breath-Hold on Lung Perfusion Measured by EIT Saline Indicator Method: A Self-Controlled Study","Electrical Impedance Tomography Saline Indicator Technique for Assessing Differences in Lung Perfusion Between Inspiratory and Expiratory Breath-Hold Phases: A Prospective Self-Controlled Study","Inclusion Criteria:\n\n* Age 18 to 65 years\n* Able to provide written informed consent\n* Able to perform standardized inspiratory and expiratory breath-hold maneuvers for at least 8 seconds\n* No known acute cardiopulmonary disease\n* Suitable for noninvasive electrical impedance tomography monitoring and intravenous saline administration\n\nExclusion Criteria:\n\n* Known severe cardiopulmonary disease (e.g., advanced chronic obstructive pulmonary disease, severe pulmonary hypertension, or heart failure)\n* Hemodynamic instability or clinically significant cardiac arrhythmia\n* Contraindication to intravenous saline administration or fluid bolus\n* Pregnancy or breastfeeding\n* Skin conditions or chest wall abnormalities preventing proper placement of EIT electrodes",true,"18 Years","65 Years",{"count":61,"type":22},100,[25],"This study aims to compare lung perfusion distribution between inspiratory breath-hold and expiratory breath-hold phases using the saline indicator method combined with electrical impedance tomography (EIT). A self-controlled crossover design will be used in which each participant undergoes both breath-hold conditions with standardized rapid intravenous saline injections. The primary objective is to evaluate changes in global and regional pulmonary perfusion under different lung volume states. The findings may improve understanding of perfusion redistribution with lung inflation and support optimized ventilatory strategies in clinical practice.",[65,66,67,68],"Lung Perfusion","Respiratory Physiology","Electrical Impedance Tomography","Ventilation-Perfusion Mismatch",[67,65,70,71,72,73,74],"Saline Indicator","Breath-Hold","Inspiratory \u002F Expiratory Phases","Regional Perfusion","Ventilation-Perfusion Matching","NOT_YET_RECRUITING","2025-12-23",{"date":78,"type":41},"2025-12-26",{"date":80,"type":22},"2026-01-01",{"date":82,"type":22},"2028-01-01",{"name":84,"class":48},"Shanghai Zhongshan Hospital",{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":4,"eligibilityCriteria":91,"healthyVolunteers":11,"sex":17,"minAge":58,"maxAge":4,"enrollmentInfo":92,"targetDuration":94,"studyType":95,"phases":4,"briefSummary":96,"conditions":97,"keywords":100,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":49},"100480404","change-in-the-phase-iii-slope-of-the-volumetric-capnography-by-prone-positioning-in-acute-respiratory-distress-syndrome-100480404","NCT05535543","Change in the Phase III Slope of the Volumetric Capnography by Prone Positioning in Acute Respiratory Distress Syndrome","Assessment of the Effects of Prone Positioning Among ARDS Patients on Ventilation Homogenization by the Phase Iii Slope of the Volumetric Capnography","Inclusion Criteria:\n\n* ARDS criteria met\n* intubated and mechanically ventilated as a result of respiratory failure\n* PaO2\u002FFiO2 \\\u003C200\n\nExclusion Criteria:\n\n* age older than 18\n* Chronic pulmonary disease, pneumothoraces, intraabdominal hypertension (\\> 12 mmHg), pregnancy, not expected to survive \\>24 hours, hemodynamic instability",{"count":93,"type":22},60,"1 Day","OBSERVATIONAL","This study evaluates the effects of prone positioning on homogenization of ventilation.",[98,32,99],"Acute Respiratory Distress Syndrome","Respiratory Failure",[98,101,102,103],"Volumetric Capnography","phase iii slope","prone","2024-07-02",{"date":106,"type":41},"2024-07-03",{"date":108,"type":41},"2022-09-06",{"date":110,"type":22},"2025-02-28",{"name":112,"class":48},"Istanbul University - Cerrahpasa"]