[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ventilation-therapy-complications\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ventilation-therapy-complications":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,49,74,98,119],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100400773","structural-modification-in-supraglottic-airway-device-100400773",false,"NCT04498598","Structural Modification In Supraglottic Airway Device","Structural Modification In Supraglottic Airway Device Enhances Exchange Between Supraglottic & Endotracheal Ventilation Modes","Inclusion Criteria:\n\n1. Adult patients\n2. scheduled for a general anesthesia procedure with ETT \\& muscle relaxation\n\nExclusion Criteria:\n\n1. Patients who are not able to consent\n2. Non English Speaking\n3. History of difficult airway\n4. Physical exam of airway which suggests difficulty in airway management or need to use special equipment\n5. BMI \\>35\n6. Gastroesophageal reflux disease\n7. Anesthetic plan other than general anesthesia\n8. Emergency procedures","ALL","18 Years","100 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"NA","The proposed A\u002FZ modification of a supraglottic airway (SGA) incorporates an opening in the SGA body that enables access to the endotracheal tube (ETT) through the body of the SGA without the need of using an exchange catheter, thus enabling an ETT to move in the body of the SGA and convert a supraglottic to endotracheal ventilation. In its original form an adaptor made from same material currently used in the endotracheal tubes can make ventilation through the proposed airway device possible in exactly the same manner of a conventional SGA currently used. This adapter also known as the R-piece can be replaced with an ETT. The modification also allows placement of SGA over an existing ETT to convert and endotracheal (ET) to supraglottic (SG) mode of ventilation without the need to use an exchange catheter.",[27,28,29,30],"Airway Complication of Anesthesia","Ventilation Therapy; Complications","Hypoxia","Hypoventilation",[32,33,34,35],"Airway Management","Oxygenation and Ventilation","Airway Devices","Supraglottic Airway","RECRUITING","2026-05-01",{"date":39,"type":40},"2026-05-07","ACTUAL",{"date":42,"type":40},"2020-09-30",{"date":44,"type":21},"2026-08-24",{"name":46,"class":47},"The Cleveland Clinic","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":17,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":73},"100367724","clinical-decision-support-tool-in-pards-pilot-study-100367724","NCT04068012","Clinical Decision Support Tool in PARDS Pilot Study","A Computerized Decision Support Tool for Ventilator Management in Pediatric Acute Respiratory Distress Syndrome Pilot Study","Inclusion Criteria:\n\n* Children \\> 1 month of age and \\>44 weeks gestation and ≤ 18 years of age AND\n* Supported on mechanical ventilation with pulmonary parenchymal disease (i.e. Pediatric Acute Respiratory Distress Syndrome (PARDS)) with Oxygen Saturation Index (OSI) ≥ 5) or Oxygenation Index (OI) ≥ 4 AND\n* Who are within 72 hours of initiation of invasive mechanical ventilation AND\n* Who are anticipated to require \\>72 hours mechanical ventilation.\n\nExclusion Criteria:\n\n* Conditions on enrollment that preclude conventional methods of weaning (i.e., status asthmaticus, severe lower airway obstruction, bronchiolitis, critical airway, Extra Corporeal Life Support (ECLS), intubation for Upper Airway Obstruction, Do Not Resuscitate orders, severe chronic respiratory failure, spinal cord injury above lumbar region, cyanotic heart disease (unrepaired or palliated)) OR\n* Conditions precluding the use of permissive hypercapnia or hypoxemia (i.e. intracranial hypertension, severe pulmonary hypertension)\n* Primary Attending physician refuses to enroll the patient","1 Month",{"count":58,"type":21},180,[24],"Previous clinical trials in adults with acute respiratory distress syndrome (ARDS) have demonstrated that ventilator management choices can improve Intensive Care Unit (ICU) mortality and shorten time on mechanical ventilation. This study seeks to scale an established Clinical Decision Support (CDS) tool to facilitate dissemination and implementation of evidence-based research in mechanical ventilation of infants and children with pediatric ARDS (PARDS).\n\nThis will be accomplished by using CDS tools developed and deployed in Children's Hospital Los Angeles (CHLA) which are based on the best available pediatric evidence, and are currently being used in an NHLBI funded single center randomized controlled trial (NCT03266016, PI: Khemani). Without CDS, there is significant variability in ventilator management of PARDS patients both between and within Pediatric ICUs (PICUs), but clinicians are willing to accept CDS recommendations. The CDS tool will be deployed in multiple PICUs, targeting enrollment of up to 180 children with PARDS. Study hypotheses:\n\n1. The CDS tool in will be implementable in nearly all participating sites\n2. There will be \\> 80% compliance with CDS recommendations and\n3. The investigators can implement automatic data capture and entry in many of the ICUs\n\nOnce feasibility of this CDS tool is demonstrated, a multi-center validation study will be designed, which seeks to determine whether the CDS can result in a significant reduction in length of mechanical ventilation (LMV).",[28,62,63],"Ventilator-Induced Lung Injury","Ards","2026-04-09",{"date":66,"type":40},"2026-04-14",{"date":68,"type":40},"2020-12-01",{"date":70,"type":21},"2027-07-01",{"name":72,"class":47},"Children's Hospital Los Angeles",8,{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":83,"phases":4,"briefSummary":84,"conditions":85,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":48},"100399707","lung-barometric-measurements-in-normal-and-in-respiratory-distressed-lungs-100399707","NCT04484727","\"Lung Barometric Measurements in Normal And in Respiratory Distressed Lungs\"","LUNAR","Inclusion Criteria:\n\n* Patients above18 years\n* ASA 1-3\n* Planned\u002Facute ventilator treatment in ICU or OR\n\nExclusion Criteria:\n\n* Patients under 18 years\n* ASA 4 and above\n* severe COPD\u002Femphysema\u002Fheart failure\n* PEEP\\>16 and\u002For FiO2 \\>80%\n* elevated intracranial pressure\n* defect coagulation\n* non-treated known or suspected pneumothorax",{"count":82,"type":21},200,"OBSERVATIONAL","Little is known about how lung mechanics are affected during the very early phase after starting mechanical ventilation. Since the conventional method of measuring esophageal pressure is complicated, hard to interpret and expensive, there are no studies on lung mechanics on intensive care patients directly after intubation, during the first hours of ventilator treatment and forward until the ventilator treatment is withdrawn. Published studies have collected data using the standard methods from day 1 to 3 of ventilator treatment for respiratory system mechanics, i.e. the combined mechanics of lung and chest wall. Consequently, information on lung mechanical properties during the first critical hours of ventilator treatment is missing and individualization of ventilator care done on the basis of respiratory system mechanics, which are not representative of lung mechanics on an individual patient basis. We have developed a PEEP-step method based on a change of PEEP up and down in one or two steps, where the change in end-expiratory lung volume ΔEELV) is determined and lung compliance calculated as ΔEELV divided by ΔPEEP (CL = ΔEELV\u002FΔPEEP). This simple non-invasive method for separating lung and chest wall mechanics provides an opportunity to enhance the knowledge of lung compliance and the transpulmonary pressure. After the two-PEEP-step procedure, the PEEP level where transpulmonary driving pressure is lowest can be calculated for any chosen tidal volume.\n\nThe aim of the present study in the ICU is to survey lung mechanics from start of mechanical ventilation until extubation and to determine PEEP level with lowest (least injurious) transpulmonary driving pressure during ventilator treatment. The aim of the study during anesthesia in the OR, is to survey lung mechanics in lung healthy and identify patients with lung conditions before anesthesia, which may have an increased risk of postoperative complications.",[62,86,87,28,88],"Ventilatory Failure","Ventilator Lung","Ventilator Associated Pneumonia","2025-03-13",{"date":91,"type":40},"2025-03-17",{"date":93,"type":40},"2022-05-01",{"date":95,"type":21},"2026-12-31",{"name":97,"class":47},"Göteborg University",{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":106,"targetDuration":4,"studyType":22,"phases":108,"briefSummary":109,"conditions":110,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":117,"locationsCount":48},"100527054","study-to-investigate-an-association-between-brain-activity-and-tidal-volume-in-humans-batman-100527054","NCT06142773","Study to Investigate an Association Between Brain Activity and Tidal Volume in Humans (BATMAN)","Study to Investigate an Association Between Brain Activity and Tidal Volume in Humans (BATMAN) - a Pilot Study","BATMAN","Inclusion Criteria:\n\n1. Patients scheduled to undergo an MRI scan of their head under general anesthesia\n2. Age \\> 18 years\n\nExclusion Criteria:\n\n1. Stroke, and\u002For brain tumor in the regions of interest that has not been diagnosed before the MRI scan\n2. Previous medical history of dementia\n3. Previous medical history of brain surgery\n4. Acute or chronic spinal cord Injury\n5. Previous Vagotomy\n6. Phrenic nerve injury",{"count":107,"type":21},10,[24],"The communication between the lungs and the brain has drawn a lot of attention recently. Animal studies have shown that the breathing cycle is coupled with brain activity, showing that the greater the volume of air delivered to the lungs via a breathing machine greater the brain activity and also the greater the injury to the brain cells.\n\nThere is no study in humans that investigates the physiological communication between the volume of air delivered to the lungs and brain activity. This is important because really sick patients receive breathing assistance using breathing machines to keep their oxygen levels within a normal range. Although these machines are life-saving tools, they might result in brain cell injury, leading to cognitive impairment. So, establishing the existence of a physiological communication between the volume of air delivered using these breathing machines and brain activity is the first step to investigating therapies to prevent brain cell injury due to the use of breathing machines to assist breathing.",[28],"2025-03-03",{"date":113,"type":40},"2025-03-06",{"date":115,"type":40},"2023-11-30",{"date":95,"type":21},{"name":118,"class":47},"University Health Network, Toronto",{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":4,"eligibilityCriteria":125,"healthyVolunteers":126,"sex":16,"minAge":127,"maxAge":128,"enrollmentInfo":129,"targetDuration":4,"studyType":22,"phases":131,"briefSummary":132,"conditions":133,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":48},"100563127","comparing-different-startegies-of-positive-pressure-ventilation-in-children-100563127","NCT06612125","Comparing Different Startegies of Positive Pressure Ventilation in Children","Comparison of Positive Pressure Ventilation Strategies in Young Children Undergoing Laparoscopic Inguinal Hernia Repair With Laryngeal Mask Airway: A Prospective Randomized Study","Inclusion Criteria:\n\n1. age between 1 and 5 years.\n2. patient scheduled for laparoscopic inguinal hernia repair.\n3. American Society of Anesthesiologists classification of physical status of I-II.\n\nExclusion Criteria:\n\n1. cardiopulmonary disease.\n2. severe hepatorenal dysfunction.\n3. history of upper respiratory tract infection 2 weeks before the operation.\n4. overweight \\[more than 20% of standard body weight\\].\n5. neuromuscular disease.\n6. anticipated difficult airway.\n7. hiatus hernia or gastroesophageal reflux disease.",true,"1 Year","5 Years",{"count":130,"type":21},78,[24],"The most basic modes of mechanical ventilation are volume-controlled ventilation (VCV) and pressure-controlled ventilation (PCV). VCV guarantees a target volume of ventilation using a constant flow, but may lead to high peak airway pressure (Ppeak) during the gas insufflation . In PCV mode, on the other hand,",[28],"2025-01-08",{"date":136,"type":40},"2025-01-09",{"date":138,"type":40},"2024-10-01",{"date":140,"type":21},"2025-03-30",{"name":142,"class":47},"Beni-Suef University"]