[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ventilation-therapy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ventilation-therapy":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,43,71,105,129,155],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100538137","initiation-of-noninvasive-ventilation-in-als-patients-with-chronic-respiratory-insufficiency-100538137",false,"NCT06286917","Initiation of Noninvasive Ventilation in ALS Patients With Chronic Respiratory Insufficiency","InNIVALS","Inclusion Criteria:\n\n* ALS diagnosed by a neurology and\n* chronic respiratory insufficiency or significant respiratory muscle weakness caused by ALS\n\nExclusion Criteria:\n\n* impaired cognition to give informed consent to participation\n* contraindication to NIV therapy\n* another severe disease with a prognosis of less than one year\n* ventilation via an artificial airway, tracheostomy","ALL","18 Years","99 Years",{"count":20,"type":21},120,"ESTIMATED","INTERVENTIONAL",[24],"NA","This research will study whether noninvasive ventilation (NIV) used to treat chronic respiratory insufficiency in patients with amyotrophic lateral sclerosis (ALS) can be initiated as successfully in the outpatient setting as in the conventional inpatient setting, and what the costs of these alternative initiation methods are.",[27,28,29],"Ventilation Therapy","ALS","Chronic Respiratory Failure","RECRUITING","2026-01-23",{"date":33,"type":34},"2026-01-27","ACTUAL",{"date":36,"type":34},"2024-03-05",{"date":38,"type":21},"2029-12",{"name":40,"class":41},"Tampere University","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":4},"100608232","impact-of-home-non-invasive-ventilation-in-patients-with-chronic-obstructive-pulmonary-disease-discharged-from-assiut-university-hospital-100608232","NCT07198880","Impact of Home Non Invasive Ventilation in Patients With Chronic Obstructive Pulmonary Disease Discharged From Assiut University Hospital","Inclusion Criteria:\n\n* Patients more than 18 year old.\n* Severe COPD (classified as GOLD stage Ⅲ and IV), confirmed by FEV₁\u002FFVC \\\u003C 70% and FEV₁ \\\u003C 50% of the predicted value. (9)\n* Persistent hypercapnia (PaCO₂ ≥ 60 mmHg ≥2 weeks after resolution of acute exacerbation and compliant on optimal medical therapy with or without long term oxygen therapy\n\nExclusion Criteria:\n\n* Other significant respiratory disorders (e.g,history suggestive OSA, Body Mass Index more than 30, pneumothorax, bullous lung disease, advanced interstitial lung diseases , restrictive thoracic wall diseases , neuromuscular disease).\n* Undergone intubation or tracheostomy prior to NIV initiation during the last 2 months.\n* Those using addictive narcotic medications.\n* Comorbidities and diseases that might confound survival outcomes (e.g., malignancy, advanced hepatic or renal diseases).\n* Pregnancy\n* Refusal or Inability to tolerate NIV during initiation and adaptation phase.\n* Expected Poor compliance (patients deemed unlikely to adhere to nightly NIV use such as no family support, severe frailty).\n* Withdrawal criteria: stopping bipap or medical treatment, voluntary withdrawal by the participant, failure to attend scheduled visits, and significant clinical deterioration requiring alternative management during the study period","80 Years",{"count":51,"type":21},40,[24],"This study aims to evaluate the impact of long-term home non-invasive ventilation (NIV) on patients with COPD",[55,56,27,57,58,59,60],"COPD","COPD (Chronic Obstructive Pulmonary Disease)","Non Invasive Ventilation (NIV)","BiPAP","Hypercapnia","Long Term Oxygen Therapy","NOT_YET_RECRUITING","2025-09-27",{"date":64,"type":34},"2025-09-30",{"date":66,"type":21},"2026-01-01",{"date":68,"type":21},"2028-01-01",{"name":70,"class":41},"Assiut University",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":82,"conditions":83,"keywords":87,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":104},"100580402","peep-vs-zeep-in-out-of-hospital-cardiac-arrest-100580402","NCT06836830","PEEP vs. ZEEP in Out-of-Hospital-Cardiac-Arrest","Peri-Arrest Ventilation With Positive End-Expiratory-Pressure vs. Zero End-Expiratory-Pressure in Out-of-Hospital-Cardiac-Arrest","PerAVent","Inclusion Criteria:\n\n* Adults \\>= 18 years\n* non-traumatic OHCA\n* mechanical ventilation via airway device\n\nExclusion Criteria:\n\n* Patients \\\u003C 18 years,\n* traumatic cause of OHCA,\n* no cardiac arrest, withholding of resuscitation (e.g. Do-Not-Resuscitate orders)",{"count":80,"type":21},600,[24],"Out-of-hospital cardiac arrest (OHCA) remains a major cause of mortality, with low survival probabilities to hospital discharge. Despite the frequent use of airway management and mechanical ventilation during resuscitation, there is limited evidence regarding the optimal ventilation strategy to improve oxygen delivery and patient outcomes. The present study aims to investigate the effects of positive-end-expiratory-pressure (PEEP) set at 5 mbar compared to zero-end-expiratory-pressure (ZEEP) on the return of spontaneous-circulation (ROSC) in adult patients with OHCA.",[27,84,85,86],"PEEP, Occult","CPR","Cardiac Arrest (CA)",[88,89,90,91,92,93,94,85],"Cardiac Arrest","Positive End-Expiratory Pressure","Zero End-Expiratory Pressure","Ventilation","Randomized Controlled Trial","Emergency Medicine","Resuscitation","2025-08-05",{"date":97,"type":34},"2025-08-06",{"date":99,"type":34},"2025-06-01",{"date":101,"type":21},"2026-10-31",{"name":103,"class":41},"Muehlenkreiskliniken, MKK",3,{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":112,"targetDuration":4,"studyType":22,"phases":114,"briefSummary":115,"conditions":116,"keywords":117,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":42},"100508665","early-mobilisation-and-relational-touch-practice-on-intubated-patients-of-intensive-care-unit-100508665","NCT05903378","Early Mobilisation and Relational Touch Practice on Intubated Patients of Intensive Care Unit","TORE-BDL","Inclusion Criteria:\n\nAdult patient ventilated invasively for at least 48 hours, RASS between 0 and -1 with early mobilization prescribed but not performed.\n\nExclusion Criteria:\n\n* Patient needing help from another person to mobilizing\n* Patient with an unstable fracture\n* Patient with a recent laparotomy (less than 10 days)\n* Patient under judicial protection measures\n* Patient on catecholamines\n* Pregnant or breastfeeding woman\n* Non-communicating patient due to neuropsychiatric pathology\n* Patient benefiting from a process of palliative care or moribund patient whose estimated life expectancy is less than 30 days\n* Strict bed rest order\n* Fraction inspired oxygen (FIO2) \\>50%\n* Body mass index \\> 40 Kg\u002Fm2\n* Patient having an epidural with motor impairment.",{"count":113,"type":21},100,[24],"41.3% of patients hospitalized in intensive care express feeling anxiety when they are systematically questioned. Ventilatory weaning is one of the moments of anxiety for the patient. While being conscious he must tolerate invasive ventilation. The early mobilization of patients in intensive care must be started early, within 24-48 hours, after the patient wakes up. Early mobilization is part of the weaning process from invasive mechanical ventilation in intensive care. It is recommended to reduce it to use relaxation therapies. Several studies have assessed the impact of relational touch in conscious or unconscious patients in intensive care. The SRLF consensus conference in 2010 recommends the use of massage for anxiolytic purposes.\n\nThis study aims to assess the impact of relational touch versus standard care on anxiety during the first bedside session, in intubated intensive care patients ventilated for at least 48 hours and presenting with RASS (Richmond agitation sedation scale). ) from 0 to -1.\n\nThe study will aussi assess the impact of relational touch versus standard care on the following patient parameters:\n\n* Evaluation of caregiver anxiety with the Spielberger inventory before and after the session\n* Increasing the duration of the bedside session;\n* Variations in pain, assessed by the Behavioral Pain Scale (BPS) at the end of the session;\n* The level of agitation\u002Fvigilance at the beginning and at the end of the session with the Richmond agitation-sedation scale (RASS);\n* Induced variations in blood pressure;\n* Induced variations in oxygen saturation;\n* The variations induced on the respiratory rate;\n* The variations induced on the heart rate;\n* The need to prescribe psychotropic drugs on the day of the first bedside;\n* Reduction in the number of days of invasive mechanical ventilation between the first bedside session and discharge from intensive care unit (maximum D28 after the first bedside session).\n\nThis is a national, multicenter, cluster, randomized, controlled trial with 4-stage stepped-wedge design (1:1:1:1 randomization), phase III, superiority, open-label, comparing systematic practice relational touch by the paramedical team during bedside sessions, versus standard care (without relational touch).\n\nThe benefit is above all for the patient with a better experience of bedside sessions and a reduction in ventilation time, therefore bed rest, leading to a reduction in decubitus complications. The expected economic benefit involves the reduction of decubitus complications and therefore their cost and the reduction of hospitalization times in intensive care.",[27],[27,118,119],"ICU","relational touch","2025-04-04",{"date":122,"type":34},"2025-04-06",{"date":124,"type":21},"2025-12",{"date":126,"type":21},"2026-06",{"name":128,"class":41},"Assistance Publique - Hôpitaux de Paris",{"id":130,"slug":131,"hasResults":11,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":135,"eligibilityCriteria":136,"healthyVolunteers":11,"sex":16,"minAge":137,"maxAge":138,"enrollmentInfo":139,"targetDuration":4,"studyType":22,"phases":141,"briefSummary":142,"conditions":143,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":42},"100568626","high-flow-nasal-cannula-for-stabilization-of-extremely-premature-infants-100568626","NCT06683677","High Flow Nasal Cannula for Stabilization of Extremely Premature Infants","High Flow Nasal Cannula is Appropriate Alternative for Stabilization of Extremely Premature Infants: a Prospective Observational Study","SIMPLSAFE2","Inclusion Criteria:\n\n* Preterm infants born between 25+0 and 27+6 gestational weeks\n* Weight above 500 grams\n\nExclusion Criteria:\n\n* Previable rupture of membranes,\n* Congenital malformations previable\n* Acute intrauterine hypoxia.","0 Minutes","2 Minutes",{"count":140,"type":21},60,[24],"A prospective observational study evaluates the safety and efficacy of using High-Flow Nasal Cannula to stabilize extremely preterm infants immediately after birth. Following placental transfusion, high flow nasal cannula at 6-8 l\u002Fmin is administered along with intermittent tactile stimulation. Criteria for switching to other interventions like continuous positive airway pressure or positive pressure ventilation are set for cases of persistent bradycardia or low Saturation of oxygen (SpO2).",[144,27,145],"Premature Infant","High Flow Nasal Canula","2024-11-12",{"date":148,"type":34},"2024-11-14",{"date":150,"type":21},"2024-12-01",{"date":152,"type":21},"2029-07-01",{"name":154,"class":41},"Charles University, Czech Republic",{"id":156,"slug":157,"hasResults":11,"nctId":158,"briefTitle":159,"officialTitle":160,"acronym":4,"eligibilityCriteria":161,"healthyVolunteers":162,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":163,"targetDuration":4,"studyType":22,"phases":165,"briefSummary":166,"conditions":167,"keywords":168,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":42},"100552989","cerebral-blood-flow-helmet-vs-oronasal-mask-during-continuous-positive-airway-pressure-ventilation-100552989","NCT06480253","Cerebral Blood Flow: Helmet vs Oronasal Mask During Continuous Positive Airway Pressure Ventilation","Variation of Cerebral Blood Flow Depending on the Interface Chosen During Continuous Positive Airway Pressure Ventilation","Inclusion Criteria:\n\n* Age ≥ 18 years,\n* Ability to give informed consent\n\nExclusion Criteria:\n\n* known cardiac pathologies\n* known pulmonary pathologies\n* known vascular pathologies\n* history of concussion\n* history of headache",true,{"count":164,"type":21},19,[24],"In this trial the investigators will evaluate blood flow in common carotid artery of healthy subjects treated with Continuous Positive Airway Pressure (CPAP) Ventilation, comparing two different devices: oronasal mask versus Helmet. The hypothesis is that Helmet CPAP reduces carotid flow compared to oronasal mask.",[27],[169],"Continuous Positive Airway Pressure","2024-06-24",{"date":172,"type":34},"2024-06-28",{"date":174,"type":21},"2024-07-01",{"date":176,"type":21},"2024-07-31",{"name":178,"class":41},"Papa Giovanni XXIII Hospital"]