[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ventilation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ventilation":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,48,79,105,125],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100637544","manual-versus-autoflow-ventilation-during-anesthesia-inducton-in-geriatric-patients-100637544",false,"NCT07582913","Manual Versus Autoflow Ventilation During Anesthesia Inductıon in Geriatric Patients","Effects of Manual Versus Autoflow Ventilation During Anesthesia Induction on Cerebral and Peripheral Oxygenation in Geriatric Patients","Inclusion Criteria:\n\n* Patients aged 65 years and older.\n* Patients scheduled to undergo elective surgery requiring endotracheal intubation under general anesthesia.\n* Patients with an American Society of Anesthesiologists (ASA) physical status of I, II, or III.\n* Volunteer patients who are willing to participate and provide written informed consent.\n\nExclusion Criteria:\n\n* Patients with severe heart failure or severe pulmonary disease.\n* Patients with a presence or history of brain tumors or cerebrovascular accidents (CVA\u002Fstroke).\n* Patients with impaired cooperation or cognitive dysfunction (e.g., dementia, delirium, Alzheimer's disease).\n* Patients with a known history or preoperative prediction of a difficult airway.\n* Patients with a known allergy to the monitoring sensor materials.","ALL","65 Years",{"count":19,"type":20},106,"ESTIMATED","INTERVENTIONAL",[23],"NA","The objective of this study is to compare the effects of manual ventilation and AutoFlow ventilation, administered during the induction of general anesthesia, on cerebral (s-rSO₂) and peripheral (somatic) oxygenation (p-rSO₂) in geriatric patients.",[26,27,28,29,30],"Cerebral Oxygenation","Peripheral Oxygenation","Geriatrics","Ventilation","Near-Infrared Spectroscopy",[28,30,32,33,34,35],"Cerebral Oximetry","Cerebral Autoregulation","Mask Ventilation","Autoflow","RECRUITING","2026-05-13",{"date":39,"type":40},"2026-05-15","ACTUAL",{"date":37,"type":40},{"date":43,"type":20},"2026-12-05",{"name":45,"class":46},"Ankara City Hospital Bilkent","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":21,"phases":59,"briefSummary":60,"conditions":61,"keywords":66,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100593956","wise-choices-in-the-intensive-care-unit-100593956","NCT07013175","Wise Choices in the Intensive Care Unit","WIse CHoices in the Intensive Care Unit, a Cluster Randomized Registry Based Clinical Trial","WICH-ICU","Inclusion Criteria:\n\n* Patients 18 years or older, treated in Swedish ICU's\n\nExclusion Criteria:\n\n* Patients under the age of 18 years","18 Years",{"count":58,"type":20},10000,[23],"Aim: to evaluate if the Choosing Wisely campaign can be introduced without harming critically ill patients.\n\nBackground: Each year, around 45,000 patients are admitted to Sweden's 81 ICUs (intensive care units), costing 6-7 billion SEK (6% of total healthcare expenditure). The high costs of health care are partly attributable to overuse of diagnostic tests. Up to 30% of these tests lead to treatments that provide no benefit for patients, some of them may even be harmful(1-3). To improve quality of care while combating this problem of cost, the American Board of Internal Medicine Foundation developed the Choosing Wisely Campaign, tasking professional societies to develop lists of top five medical services patients and physicians should question. Patients in the ICU, can especially benefit from this paradigm shift. They are subjected to multiple testing on a daily - sometimes hourly - basis, therefore this field of medicine responded to the campaign quickly. Two sets of top-five-lists of tests and interventions that can be questioned have been published(4 5).\n\nIn multiple countries, including Sweden, the Choosing Wisely campaign is gathering traction among critical care physicians and is on the verge of being introduced. It is both common-sensical and will save money, so health care leaders are positive. However, the investigators have an opportunity, and a duty, to assess the evidence; can the Choosing Wisely campaign be introduced without harming ICU patients?\n\nThe present study thus aims to evaluate the introduction of the Choosing Wisely campaign in the context of the ICU. Is this change of care strategy associated with changes in 30-day-mortality? Secondary outcomes include ICU length of stay, use of non-invasive- or invasive mechanical ventilation and continuous renal replacement therapy. This is a registry-based cluster randomized controlled study (R-RCT), targeting Swedish ICU's across multiple regions. Primary and secondary outcomes will be retrieved from the Swedish Intensive care Register (SIR), making ICU participation easier and less costly.",[62,29,63,64,65],"Critical Illness","Outcome","Dialysis","Acute Kidney Injury",[67,68],"critical illness","choosing wisely","2025-11-24",{"date":71,"type":40},"2025-12-02",{"date":73,"type":40},"2025-11-03",{"date":75,"type":20},"2027-12-31",{"name":77,"class":46},"Karolinska Institutet",2,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":86,"enrollmentInfo":87,"targetDuration":89,"studyType":90,"phases":4,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":47},"100602158","the-role-of-oxygen-reserve-index-ori-in-apneic-ventilation-100602158","NCT07119866","The Role of Oxygen Reserve Index (ORi) in Apneic Ventilation","The Role of Oxygen Reserve Index (ORi) Monitoring in Optimizing Apneic Ventilation for Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n* 18-60 years\n* ASA 1-2\n* Mallampati score \\\u003C2\n* Scheduled for elective laparoscopic cholecystectomy under general anesthesia\n\nExclusion Criteria:\n\n* \\\u003C18 and \\>60 years\n* ASA 3-4\n* Initial ORI value below 0.24","60 Years",{"count":88,"type":20},60,"1 Day","OBSERVATIONAL","Background: The Oxygen Reserve Index (ORI) is a non-invasive parameter utilizing multi-wavelength pulse co-oximetry. ORI can provide early warnings of deteriorating oxygenation before changes are reflected in SpO₂ levels. This study aimed to investigate the feasibility of non-ventilated intubation in patients undergoing cholecystectomy as a means to achieve safe intubation without nasogastric tube placement, with reduced trauma and cost, and improved time efficiency.",[93,94,29,95],"Oxygen Reserve Index","Apnea","Body Mass Index","NOT_YET_RECRUITING","2025-08-06",{"date":99,"type":40},"2025-08-13",{"date":101,"type":20},"2025-08-07",{"date":103,"type":20},"2025-08-30",{"name":45,"class":46},{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":4,"enrollmentInfo":111,"targetDuration":4,"studyType":21,"phases":113,"briefSummary":114,"conditions":115,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":47},"100584883","adhere-lpv-advancing-delivery-of-high-quality-evidence-based-respiratory-efforts-in-lung-protective-ventilation-100584883","NCT06895148","ADHERE-LPV Advancing Delivery of High-Quality Evidence-Based Respiratory Efforts in Lung-Protective Ventilation","Inclusion Criteria:\n\n* Aged 18 and over\n* Requires mechanical ventilation\n\nExclusion Criteria:\n\n* The patient opted out of research\n* The mode ordered does not require a set tidal volume\n* Requires ECMO prior to ICU admission\n* Data during the use of ECMO\n* Hospitalization was for an elective surgery\n* The duration of mechanical ventilation was less than 12 hours (these are not the patients that would benefit from LPV)\n* Admission code documentation of Do Not Intubate. While rare, in situations where a patient was intubated but whose preferences are contradictory to the current care, mechanical ventilation is managed differently while undergoing goals of care conversations.\n* Height was documented as less than 4 feet given the PBW formula was not validated below this height.",{"count":112,"type":20},1125,[23],"This study is a cluster randomized trial across 10 hospitals, stratified by hospital size (hospitals with greater than 100 mechanically ventilated patients a year will be classified as large, while those with 100 or fewer will be classified as small). Randomization will occur at the hospital level, ensuring an even distribution of large and small hospitals between study arms. Hospitals assigned to the intervention group will implement an EHR-based strategy designed to enhance adherence to lung-protective ventilation (LPV) for a 9-month intervention period, after which the strategy will be rolled out to all hospitals. The intervention focuses on modifying the ventilator order within the Electronic Health Record (EHR) to encourage default settings aligned with LPV principles. This study design allows for comparison of patient outcomes before and after implementation within each hospital while also enabling simultaneous comparisons between hospitals that have and have not yet received the intervention. The cluster randomization approach is necessary, given the order is controlled at the hospital level.",[29],"2025-07-07",{"date":118,"type":40},"2025-07-09",{"date":120,"type":40},"2025-07-01",{"date":122,"type":20},"2026-07-16",{"name":124,"class":46},"University of Minnesota",{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":132,"sex":16,"minAge":133,"maxAge":17,"enrollmentInfo":134,"targetDuration":4,"studyType":21,"phases":136,"briefSummary":137,"conditions":138,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":47},"100558153","effects-of-different-anesthesia-machine-modalities-on-bariatric-surgery-patients-a-prospective-randomized-controlled-study-100558153","NCT06547411","Effects of Different Anesthesia Machine Modalities on Bariatric Surgery Patients: a Prospective Randomized Controlled Study","Effects of Different Ventilation Modes on Intracranial Pressure and Carbon Dioxide Partial Pressure During Bariatric Surgery: a Prospective, Randomized, Controlled Study","Inclusion Criteria:\n\n* Patients scheduled for elective bariatric surgery.\n* Age between 16 and 65 years.\n* Continuous weight gain for more than 5 years with a BMI ≥ 35.\n* ASA-PS (American Society of Anesthesiologists Physical Status) categorization of Grade II or III.\n\nExclusion Criteria:\n\n* Patients who were dependent on alcohol or opioids.\n* Patients with severe mental or intellectual disabilities.\n* Patients with severe ocular conditions, such as ocular trauma, optic nerve tumors, or those wearing ocular prostheses.",true,"16 Years",{"count":135,"type":20},90,[23],"The goal of this clinical trial is to explore the clinical significance and value of the PRVC ventilation mode in Bariatric Surgery Patients. The main questions it aims to answer are：\n\n* Do different ventilation patterns affect intracranial pressure and partial pressure of carbon dioxide in bariatric surgery patients?\n* Does PRVC mode reduce intracranial pressure and partial pressure of carbon dioxide in bariatric surgery patients?\n* Whether intracranial pressure can be quickly measured by monitoring a patient's optic nerve sheath diameter (ONSD)？ Researchers randomized bariatric surgery patients into PC, VC, and PRVC groups for comparison, looking at breathing mechanics, PaCO2, and ICP.\n\nParticipants will:\n\n* take PC mode ventilation, VC mode ventilation, and PRVC mode ventilation\n* monitor Respiratory mechanics, PaCO2, and ONSD",[29,139,140,141],"Bariatric Surgery","Intracranial Pressure","Carbon Dioxide","2025-02-28",{"date":144,"type":40},"2025-03-05",{"date":146,"type":40},"2024-03-01",{"date":148,"type":20},"2025-03-30",{"name":150,"class":46},"Yu-Long Jia"]