[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ventilator-acquired-pneumonia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ventilator-acquired-pneumonia":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,81],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100611846","clustervap-multicentre-proteomic-endotyping-of-ventilator-associated-pneumonia-100611846",false,"NCT07245888","ClusterVAP: Multicentre Proteomic Endotyping of Ventilator-associated Pneumonia","Endotyping of Ventilator-associated Pneumonia With Proteomics on Bronchoalveolar Lavage for Improved Diagnosis, the ClusterVAP Study","ClusterVAP","Inclusion Criteria:\n\nAdult patients (≥18 years) admitted to an intensive care unit (ICU). Receiving invasive mechanical ventilation. Undergoing bronchoalveolar lavage (BAL) or mini-BAL on clinical indication for suspected lower respiratory tract infection.\n\nNew or worsening clinical signs compatible with lower respiratory tract infection within the preceding 24 hours, defined as the treating clinician's suspicion plus at least one of:\n\nBody temperature \\>38 °C or \\\u003C36 °C. Visually purulent tracheal secretions. Signs of reduced oxygenation (e.g., increased FiO₂ and\u002For decreased arterial pO₂, increased positive end-expiratory pressure or driving pressure).\n\nRequest for chest radiograph to investigate infection or new infiltrate. Initiation of antibiotic therapy targeting lower respiratory tract infection.\n\nExclusion Criteria:\n\nBAL or mini-BAL performed solely for screening without suspicion of infection. Concurrent enrolment in the VAPmarkers study (reserved for external validation).\n\nAge \\\u003C18 years. Any condition that, in the opinion of the investigator, would preclude safe participation or confound study objectives.","ALL","18 Years",{"count":20,"type":21},400,"ESTIMATED","OBSERVATIONAL","Ventilator-associated pneumonia (VAP) is a common and serious infection in patients receiving mechanical ventilation in intensive care units. Current diagnostic methods are imprecise, leading to unnecessary antibiotic use and delayed treatment. The ClusterVAP study aims to identify biologically and clinically distinct subgroups of patients with suspected VAP by analyzing proteins in bronchoalveolar lavage (BAL) fluid using advanced proteomic techniques. This multicentre observational study will enroll approximately 400 adult patients from intensive care units in Sweden, France, Portugal, Denmark, and the United Kingdom. BAL or mini-BAL samples collected for clinical reasons will be analyzed to define \"pneumoclusters\" and explore their association with patient outcomes. The study will also identify candidate biomarkers that could support future diagnostic tools. No experimental treatments are given; all patients receive standard care. Results may improve diagnostic accuracy and guide personalized treatment strategies for critically ill patients.",[25,26],"Ventilator Acquired Pneumonia","Mechanical Ventilation Complication",[28,29,30],"VAP","endotyping","mini-BAL","RECRUITING","2026-06-25",{"date":34,"type":35},"2026-06-30","ACTUAL",{"date":37,"type":35},"2026-05-01",{"date":39,"type":21},"2027-12",{"name":41,"class":42},"Region Skane","OTHER",4,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":80},"100615991","evidence-based-nursing-to-reduce-adverse-events-regarding-ventilator-associated-pneumonia-pressure-injuries-and-central-line-bloodstream-infection-in-intensive-care-unit-in-bangladesh-100615991","NCT07299799","Evidence-Based Nursing to Reduce Adverse Events Regarding Ventilator Associated Pneumonia, Pressure Injuries and Central Line Bloodstream Infection in Intensive Care Unit in Bangladesh","Evidence-Based Nursing to Reduce Adverse Events Regarding Ventilator Associated Pneumonia, Pressure Injuries and Central Line Bloodstream Infection in Intensive Care Unit: A Quasi-experimental Study in Bangladesh","EBP in Nursing","Trial 1 \\& 2-\n\nInclusion Criteria:\n\nNurse\n\n* who is a registered nurse in Bangladesh.\n* who agrees to participate in this study and the EBP training.\n* who will stay at the ICU for 6 months. Patient\n* Irrespective of age and sex, participants must be at least 18 years old\n* Legal guardian of a patient consent to participation in the study\n\nExclusion Criteria:\n\nNurse\n\n* Who will not directly involve patient care in ICU. Patient\n* No exclusion criteria",true,{"count":54,"type":21},272,"INTERVENTIONAL",[57],"NA","Quality of care is crucial for preventing adverse events such as infection in the intensive care units (ICUs). The most common ICU-acquired infections include pneumonia such as Ventilator Associated Pneumonia (VAP), Pressure Ulcer (PU), Medical Device Related Pressure Ulcer (MDRPU), and Central Line-Associated Bloodstream Infection (CLABSI). VAP, PU, and MDRPU are significant indicators of the quality of care, while CLABSI is a critical marker of healthcare quality in ICUs, as it is largely preventable through strict adherence to infection control protocols.\n\nVAP is a lung infection that occurs in patients receiving mechanical ventilation for more than 48 hours. A PU is defined as localized damage to the skin or underlying tissue caused solely by pressure, while MDRPUs may also result from friction or pressure from medical devices or other objects. CLABSI is a severe infection caused by improperly inserted or maintained central venous catheters, which underscores the need for stringent catheter management protocols.",[25,60,61,62],"Central Line Associated Blood Stream Infections (CLABSI)","Pressure Ulcer (PU)","Medical Device Related Pressure Ulcer (MDRPU)",[64,65,66,67,68,69],"evidence based practice","Nurses competency","Ventilator Associated Pneumonia","Pressure Ulcer","Central Line Bloodstream Infection","Medical Device Related Pressure Ulcer","NOT_YET_RECRUITING","2026-02-10",{"date":73,"type":35},"2026-02-11",{"date":75,"type":21},"2026-02-15",{"date":77,"type":21},"2026-05-30",{"name":79,"class":42},"Hiroshima University",2,{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":89,"targetDuration":4,"studyType":55,"phases":91,"briefSummary":92,"conditions":93,"keywords":98,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":113},"100248593","simple-mechanical-device-to-control-pressure-in-the-balloon-of-the-endotracheal-tube-to-prevent-ventilator-acquired-pneumonia-100248593","NCT02514655","Simple Mechanical Device to Control Pressure in the Balloon of the Endotracheal Tube to Prevent Ventilator-acquired Pneumonia","Role of a Simple Mechanical Device of Pressure Control in the Balloon of the Endotracheal Tube to Prevent Ventilator-acquired Pneumonia","PAV-PROTECT","Inclusion Criteria:\n\n* Patients aged ≥18 years\n* Patients admitted in the ICU, mechanically ventilated and whose trachea was intubated by the oral route using tubes with catheter polyvinyl chloride \"high-volume low pressure\" and of standard shape tubes Intubation indication is decided by the physicians in charge according to the usual criteria of respiratory, neurological and \u002For hemodynamic failure\n* With an expected duration of mechanical ventilation \\> 48 hours\n\nExclusion Criteria:\n\n* Patients intubated by nasotracheal route\n* Patients with tracheotomy before admission\n* Patients intubated with a polyurethane balloon catheter or a polyvinyl chloride balloon catheter of conical shape\n* Previously intubated patients for \\> 48 hours before their possible recruitment\n* Moribund patients (terminal illness or care-limiting decision)\n* Minors protected or incapacitated patients\n* Patients with recently diagnosed ENT cancer\n* Patients with facial, thoracic, spinal or upper airway trauma\n* Patients burned, intoxicated by fire fumes or caustic ingestion\n* Patient pregnant or breastfeeding (or with known positive urine pregnancy test before inclusion)\n* Patient intubated with a subglottic suction tube\n* Unaffiliated patients to a social security\n* Patients included in any other scientific study that may interfere with the outcome criteria of this study. This includes any other study on tracheal intubation or mechanical ventilation, if the use of the pressure control device may interfere with its endpoint.",{"count":90,"type":21},500,[57],"Hypothesis: Nosten® device is able to reduce the time of underinflated balloon and removes excess pressure. This device may thus reduce the risk of ventilator-acquired pneumonia (VAP) and early tracheal lesions resulting from intubation with decreased discomfort, morbidity, and nursing workload.\n\nThe main objective of the investigators is to show that Nosten® device is more effective than monitoring and manual inflation of the balloon of the tracheal tube to prevent VAP occurrence.",[94,95,96,97],"Mechanical Ventilation","Tracheal Intubation","Ventilator-acquired Pneumonia","Intubation -Related Tracheal Lesions",[99,100,101,102,103],"Tracheal intubation","Cuff pressure","Ventilator-acquired pneumonia","Intensive care unit","Tracheal injuries","2025-06-19",{"date":106,"type":35},"2025-06-25",{"date":108,"type":35},"2015-08-15",{"date":110,"type":21},"2026-12-31",{"name":112,"class":42},"Assistance Publique - Hôpitaux de Paris",1]