[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ventilator-dependent\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ventilator-dependent":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,51],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100627161","effects-of-mobilization-using-a-powered-lower-limb-exoskeleton-with-prolonged-mechanical-ventilation-100627161",false,"NCT07445035","Effects of Mobilization Using a Powered Lower-limb Exoskeleton With Prolonged Mechanical Ventilation","Physiological and Functional Adaptations Associated With Robot-assisted Lower-limb Activity in Ventilator-dependent Hospitalized Patients","Inclusion Criteria:\n\n* Able to maintain a seated position for at least 1 minute.\n* The participant or their legal representative is able to sign the informed consent form.\n\nExclusion Criteria:\n\n* Inability to follow instructions.\n* Intubation\u002Ftracheostomy prior to current admission.\n* Diagnosis of severe left heart failure.\n* Diagnosis of neuromuscular disorders.\n* Unable to stand.\n* Complete paralysis of the lower extremities.\n* Presence of unhealed ulcers in the lower extremities.\n* Deep vein thrombosis of the lower extremities.\n* Lower-limb amputation.\n* Severe hypertension\n* Severe cardiac conditions\n* Severe bilateral joint disorders\n* Severe pain while standing\n* Severe osteoporosis\n* Lower-limb fracture\n* Ongoing epileptic seizure","ALL","45 Years","65 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study aims to evaluate the effects of powered lower-limb exoskeleton-assisted training on lower limb strength, respiratory parameters, 28-day ventilator-free days, and length of hospital stay in patients with prolonged mechanical ventilation admitted to a Respiratory Care Center. The goal is to provide clinical evidence for integrating rehabilitation and respiratory care in this patient population.",[27,28,29,30,31],"Prolonged Mechanical Ventilation","Ventilator Weaning","Ventilator Dependent","Exoskeleton Device","Exercise Training",[33,34,35,36,37],"prolonged mechanical ventilation","ventilator weaning","lower limb muscle strengthening","exoskeleton robot","exercise training","RECRUITING","2026-06-29",{"date":41,"type":42},"2026-07-01","ACTUAL",{"date":44,"type":42},"2026-06-26",{"date":46,"type":21},"2026-12-31",{"name":48,"class":49},"Fu Jen Catholic University","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":22,"phases":62,"briefSummary":63,"conditions":64,"keywords":65,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":50},"100544377","short-effects-of-simt-and-em-in-prolonged-mechanically-ventilated-patients-100544377","NCT06368089","Short Effects of SIMT and EM in Prolonged Mechanically Ventilated Patients","Short Effects of Speci|c Inspiratory Muscle Training and Early Mobilization in Prolonged Mechanically Ventilated Patients","Inclusion Criteria:\n\n* Patients with respiratory diseases who have been on mechanical ventilation for more than 48 hours and are ready to be weaned off or undergoing weaning trials with continuous positive airway pressure (CPAP) or synchronized intermittent mandatory ventilation (SIMV).\n* The PaO2\u002FFiO2 ratio is ≥ 150-200, with FiO2 ≤ 0.4-0.5 and PEEP ≤ 5-8 cmH2O, and a pH \\> 7.3 in blood plasma.\n* The age range is between 40 and 80 years old.\n* Patients exhibit good self-awareness and cooperation in training (Riker score of 4).\n* They can understand and communicate in Thai\n\nExclusion Criteria:\n\n* Clinical instability (HR \\> 120 beats\u002Fminute, RR \\> 30 breaths\u002Fminute, SatO2 \\< 90%, SBP \\> 140 mmHg or \\< 90 mmHg)\n* Patients who can be extubated and use non-invasive ventilation only or successfully extubated within the first 24 hours.\n* Patients with altered mental status (Glasgow Coma Score \\< 10) and inability to cooperate with training (Riker score \\< 4 or \\> 4)\n* Patients with limitations or contraindications such as inability to adjust the bed to a 45-degree angle or sit on the side of the bed, such as those with spinal cord injuries or recent head surgeries.\n* History of hemoptysis, pneumothorax\n* History of neuromuscular diseases causing muscle weakness and decreased sensation.\n* Patients with excessive cardiac stimulation (\\> 5 micrograms per kilogram per minute)\n* Heart rate \\> 140 beats per minute\n* Hemoglobin levels \\< 8-10 grams per deciliter\n* Patients with difficult airway issues.","40 Years","80 Years",{"count":61,"type":21},46,[24],"Using mechanical ventilation for more than 18 hours can affect respiratory muscle and postural muscle control, making it difficult to wean off the ventilator and reducing mobility. The aim of this study is to:\n\n1. Compare the effects of respiratory muscle strength training and early mobilization on dynamic lung compliance and maximum inspiratory pressure before and after a 7-day training period.\n2. Compare the success rate of weaning and the duration of weaning between the respiratory muscle strength training and the early mobilization program.",[29],[66,67,68,69,70],"Specific inspiratory muscle training","Early mobilization","Lung compliance","Prolong mechanical ventilation","Weaning outcome","2024-11-04",{"date":73,"type":42},"2024-11-06",{"date":75,"type":42},"2024-05-06",{"date":77,"type":21},"2026-03",{"name":79,"class":49},"Prince of Songkla University"]