[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ventilator-induced-lung-injury-vili\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ventilator-induced-lung-injury-vili":68},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":29,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":4},"100634623","bedside-lung-ultrasound-to-monitor-lung-recruitment-in-obese-patients-100634623",false,"NCT07542093","Bedside Lung Ultrasound to Monitor Lung Recruitment in Obese Patients","Use of Bedside Lung Ultrasound to Monitor Lung Recruitment Maneuvers During Mechanical Ventilation in Obese Patients","Inclusion Criteria:\n\n* Adult patients aged \\>18 years\n* BMI ≥ 33 kg\u002Fm² (morbid obesity)\n* Intubated and receiving invasive mechanical ventilation for any indication (elective surgery, respiratory failure, post-operative ICU admission)\n* Expected duration of mechanical ventilation ≥ 6 hours\n* Hemodynamically stable at enrollment: Mean Arterial Pressure (MAP) ≥ 65 mmHg without escalating vasopressor support\n* SpO₂ ≥ 85% on current ventilator settings\n* Written informed consent obtained from patient or legal guardian\n\nExclusion Criteria:\n\n* Known or suspected pneumothorax or bullous emphysema (contraindication to recruitment maneuvers)\n* Severe hemodynamic instability: MAP \\\u003C 60 mmHg or requiring high-dose vasopressors (norepinephrine \\> 0.3 mcg\u002Fkg\u002Fmin)\n* Active bronchopleural fistula\n* Recent thoracic or cardiac surgery (within 48 hours) where high airway pressures are contraindicated\n* Raised intracranial pressure (ICP) or known severe traumatic brain injury\n* Confirmed ARDS with PaO₂\u002FFiO₂ ratio \\\u003C 100 mmHg (severe ARDS, where recruitment strategy differs significantly)\n* Chest wall deformity or subcutaneous emphysema that precludes reliable lung ultrasound assessment\n* Refusal of consent","ALL","18 Years",{"count":19,"type":20},45,"ESTIMATED","OBSERVATIONAL","Patients with morbid obesity who require a breathing machine (mechanical ventilator) in the Intensive Care Unit (ICU) frequently experience partial lung collapse. This happens because the extra weight of the chest and abdomen presses on the lungs, reducing their capacity and making it difficult to maintain adequate oxygen levels. To address this, doctors often perform a standard lung recruitment maneuver, which involves temporarily increasing the air pressure from the ventilator to gently pop open the collapsed lung areas. However, standard bedside monitoring tools make it difficult to see exactly how well the different regions of the lungs are reopening.\n\nThis prospective observational study aims to evaluate the use of Bedside Lung Ultrasound (LUS), which is a safe, radiation-free imaging tool, to monitor how well the lungs respond to these maneuvers in real-time.\n\nDuring the study, researchers will use a standardized 12-zone ultrasound scan to examine the lungs of mechanically ventilated adult patients (BMI ≥ 33 kg\u002Fm²) before, during, and after a step-by-step lung recruitment maneuver. By calculating a \"Total Lung Ultrasound Score,\" the medical team can directly visualize and measure the transition from collapsed tissue to normal, aerated lung tissue. Furthermore, the ultrasound will be used during a step-down pressure phase to help identify the patient's \"optimal PEEP\" (Positive End-Expiratory Pressure), which is the exact customized pressure needed to keep the lungs open after the maneuver is complete, thereby improving oxygenation and minimizing the risk of lung injury.",[24,25,26,27,28],"Morbid Obesity","Obesity","Respiratory Failure","Atelectasis","Ventilator-Induced Lung Injury (VILI)",[30,31,32,33,34,35,36],"Lung Ultrasound (LUS)","Lung Ultrasound Score","Lung Recruitment Maneuvers (LRM)","Mechanical Ventilation","Positive End-Expiratory Pressure (PEEP)","Optimal PEEP","Decremental PEEP Titration","NOT_YET_RECRUITING","2026-04-14",{"date":40,"type":41},"2026-04-21","ACTUAL",{"date":43,"type":20},"2026-05",{"date":45,"type":20},"2027-06",{"name":47,"class":48},"Assiut University","OTHER",{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":69,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":84},"100596169","biphasic-positive-airway-pressure-ventilation-versus-flow-controlled-ventilation-in-burn-patients-100596169","NCT07041957","Biphasic Positive Airway Pressure Ventilation Versus Flow-Controlled Ventilation in Burn Patients","Biphasic Positive Airway Pressure Ventilation Versus Flow-Controlled Ventilation in Burn Patients: A Monocentric, Randomized Controlled, Parallel Group Trial","BIFLOWBURN","Inclusion Criteria:\n\n* Body weight ≥ 40 kg\n* Invasive ventilation time ≤ 24 hours before admission to the burn ICU or indication for intubation and invasive ventilation within 48 hours after admission to the burn ICU\n* Estimated (further) invasive ventilation time ≥ 24 hours\n* Intervention start within 48 hours after admission to the burn ICU\n* Establishment of a central venous line and invasive blood pressure monitoring as part of the intensive care therapy before the intervention start\n* Signed informed consent from the participant, legal guardian, next of kin in incompetent patients, or an intensivist in charge and independent from the Trial Management Committee in incompetent patients without a representative of the patients will\n\nExclusion Criteria:\n\n* Participation in another interventional trial\n* Duration of invasive ventilation \\> 24 hours at the time point of admission to the burn ICU\n* Estimated (further) invasive ventilation time \\\u003C 24 hours\n* Patients being treated in the burn ICU for (suspected) severe skin reactions such as Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN)\n* Lack of consent from the participant, legal guardian, next of kin, or intensivist in charge to participate in the study","80 Years",{"count":59,"type":20},24,"INTERVENTIONAL",[62],"NA","The goal of this clinical trial is to learn if the new ventilation mode flow-controlled ventilation (FCV) is a more protective mode of ventilation for adult patients after severe burn injury. The main question it aims to answer is:\n\nDoes FCV reduce the mechanical power (a key determinant of ventilator-induced lung injury) compared to conventional pressure-controlled ventilation (PCV) during ventilation of patients with burn injury?\n\nResearchers will compare FCV with PCV for up to 70 hours of ventilation to see if the mechanical power is reduced during ventilation of participants being in need of ventilation after severe burn injury.\n\nVentilation of participants will be controlled by either FCV or PCV. Group-specific ventilation will have the following characteristics:\n\n* FCV: Control of airway flows during inspiration and expiration, use of individualized lower and upper airway pressures and no fixed values for the volumes being inspired and expired (tidal volumes)\n* PCV: No control of airway flows during expiration, use of individualized lower airway pressures and upper airway pressures for a fixed tidal volume during each breath (6-8 ml\u002Fkg ideal body weight)\n\nIn total, at least 24 participants in need of ventilation after severe burn injury will be ventilated either with FCV (12 participants) or PCV (12 participants) for up to 70 hours.\n\nDuring ventilation mechanical power is computed according to certain ventilation parameters. Additionally, we evaluate organ functions of the cardiovascular systems, the lungs and other organs during and after the group-specific ventilation.",[65,66,67,68],"Burn Injury","Inhalational Injury","Pulmonary Complications","Ventilator-induced Lung Injury (VILI)",[70,71,72,73,74],"Flow-controlled ventilation","Pressure-controlled ventilation","Mechanical Power","Dissipated Energy","Ventilator-induced lung injury","2025-06-18",{"date":77,"type":41},"2025-06-27",{"date":79,"type":20},"2025-07",{"date":81,"type":20},"2028-06",{"name":83,"class":48},"University Hospital Bergmannsheil Bochum",1]