[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ventilator-induced-lung-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ventilator-induced-lung-injury":59},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,17,0,[8,42,83,109,139,165,187,214,238,258,285,307,329,352,374,405,429],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":4},"100644563","mechanical-power-during-different-ventilation-modes-in-laparoscopic-surgery-100644563",false,"NCT07670494","Mechanical Power During Different Ventilation Modes in Laparoscopic Surgery","Comparison of Mechanical Power in Pressure-Regulated Volume Control and Volume-Controlled Ventilation Modes During Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n* Patients undergoing elective laparoscopic cholecystectomy surgery.\n* Patients between 18 and 75 years of age.\n* American Society of Anesthesiologists (ASA) physical status I, II or III.\n* Body Mass Index (BMI) between 18.5 and 35 kg\u002Fm².\n* Voluntary written informed consent for participation.\n\nExclusion Criteria:\n\n* History of significant chronic obstructive pulmonary disease (COPD) or asthma.\n* Previous lung resection or major thoracic surgery.\n* Heavy smokers (more than 20 cigarettes per day).\n* Presence of spontaneous breathing effort during mechanical ventilation.\n* Conversion from laparoscopic surgery to open surgery during the procedure.\n* Emergency surgery cases.\n* Known pregnancy.",true,"ALL","18 Years",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study investigates how different breathing machine (ventilator) settings affect the energy delivered to the lungs during surgery. Mechanical power is a measure of this energy, and high levels can sometimes lead to lung irritation. In clinical practice, a mode called Pressure-Regulated Volume Control (PRVC) is often used because it lowers the \"peak\" pressure in the airways, which is generally thought to be safer. However, doctors have noticed that even though the peak pressure goes down in PRVC mode, the total mechanical power displayed on the monitor might actually increase compared to the standard Volume-Controlled Ventilation (VCV) mode. In this study, patients undergoing gallbladder surgery will be monitored using both ventilation modes in a random order. The researchers will compare the machine-calculated mechanical power for both modes to see if the perceived benefit of lower peak pressure in PRVC actually results in lower overall energy transfer to the lungs.",[27,28,29],"Laparoscopic Cholecystectomy","Mechanical Ventilation","Ventilator-Induced Lung Injury","NOT_YET_RECRUITING","2026-06-26",{"date":33,"type":34},"2026-06-30","ACTUAL",{"date":36,"type":21},"2026-07-01",{"date":38,"type":21},"2026-08-12",{"name":40,"class":41},"Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital","OTHER",{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":53,"conditions":54,"keywords":60,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":82},"100644735","personalized-ventilator-settings-for-patients-on-ecmo-100644735","NCT07673250","Personalized Ventilator Settings for Patients on ECMO","Personalized Ventilator Settings for Patients on ECMO (PEEPECMO)","PEEPECMO","1. History of Lung or Cardiac Transplantation, or definite bridge to transplantation\n2. Patient is not committed to full support\n3. Treating clinician refusal, or unwillingness to commit to controlled therapeutics (Esophageal Pressure Guided Positive End-Expiratory Pressure and neuromuscular blockade)\n4. Inability to get informed consent from the patient or legally authorized representative (LAR)\n5. Patients with contraindications to esophageal balloon placement or inability to successfully place an esophageal balloon will have personalized PEEP determined by electrical impedance tomography.\n\n   a. Contraindications include recently treated or bleeding varices, esophageal stricture, hematemesis, esophageal trauma, recent esophageal surgery or other contraindication for nasogastric tube placement, or severe coagulopathy.\n6. Severe barotrauma that requires lower mean airway pressure (i.e., PEEP) per the treating physician.\n7. Patients who are pregnant or prisoners.\n8. Has been on V-V ECMO \\> 72 hours.",{"count":51,"type":21},62,[24],"While mechanical ventilation can be used to sustain life in those with lung injury, it, can further worsen lung injury or prevent lung healing resulting in high morbidity and mortality as seen in Acute Respiratory Distress Syndrome (ARDS).\n\nUsing extracorporeal membrane oxygenation (ECMO), the highest level of life support also known as the heart-lung machine, investigators may minimize injury from mechanical ventilation to allow the lungs to heal; however, the optimal ventilator strategies while on ECMO are unknown. This study will evaluate personalized ventilator strategy compared to standard of care ventilation.",[55,56,57,58,59],"Acute Respiratory Distress Syndrome (ARDS)","Extracorporeal Membrane Oxygenation","Respiratory Failure Patients Treated With ECMO","Respiratory Failure, ICU","Ventilator Induced Lung Injury",[61,62,63,64,65,66,67,68,69,70,71,72],"Respiratory failure","ARDS","Acute Respiratory Distress Syndrome","ECMO","Pneumonia","Lung injury","Influenza","COVID","Viruses","Personalized ventilator settings","Positive end expiratory pressure","PEEP","2026-06-22",{"date":75,"type":34},"2026-06-29",{"date":77,"type":21},"2026-09-01",{"date":79,"type":21},"2031-06-30",{"name":81,"class":41},"University of California, San Diego",1,{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":91,"targetDuration":4,"studyType":22,"phases":93,"briefSummary":94,"conditions":95,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":4},"100643194","a-study-of-the-determinants-of-neurological-outcomes-in-patients-with-acute-respiratory-distress-syndrome-100643194","NCT07629973","A Study of the Determinants of Neurological Outcomes in Patients With Acute Respiratory Distress Syndrome","Etude Des déterminants de l'évolution NEUrologique Des Patients Ayant présenté un Syndrome de Détresse Respiratoire aiguë","NEURDS","Inclusion Criteria:\n\n* Adult patient\n* Patient admitted to the intensive care unit less than 48 hours ago\n* Patient diagnosed with mild, moderate or severe ARDS according to the Berlin classification based on the PaO₂\u002FFiO₂ ratio, with a minimum PEEP set at 5 cmH₂O (16), of pulmonary aetiology:\n\n  * Mild ARDS: 200 \\\u003C PaO₂\u002FFiO₂ \\\u003C 300 mmHg\n  * Moderate ARDS: 100 \\\u003C PaO₂\u002FFiO₂ \\\u003C 200 mmHg\n  * Severe ARDS: PaO₂\u002FFiO₂ \\\u003C 100 mmHg\n* Patients fitted with an oesophageal pressure measurement catheter (Nutrivent, Sidam, San Giacomo Roncole, Italy)\n* Patients registered with or covered by a social security scheme\n* Free and informed consent from the patient or a trusted relative (where the patient is unable to give consent).\n\nExclusion Criteria:\n\n* Patients with a history of central nervous system disorders resulting in cognitive impairment\n* Patients on ECMO\n* Patients admitted for symptomatic central nervous system disorders\n* Patients admitted for acute respiratory distress syndrome following cardiorespiratory arrest.\n* Patients being treated for a psychiatric condition, chronic heavy drinkers, or those undergoing long-term treatment with benzodiazepines, antidepressants or antipsychotics.\n* Pregnant, breastfeeding or labouring patients\n* Individuals subject to a legal protection order\n* Individuals receiving compulsory psychiatric care\n* Individuals deprived of their liberty by judicial or administrative decision",{"count":92,"type":21},150,[24],"Acute respiratory distress syndrome (ARDS) is characterized by pathological pulmonary edema caused by direct or indirect damage to the alveolar-capillary membrane.\n\nIts management relies on etiological treatment, invasive mechanical ventilation, and the use of sedatives and neuromuscular blockers, depending on the patient's condition.\n\nImprovements in patient care have led to an improved prognosis. However, in-hospital mortality remains high (between 35% and 45%). Notably, morbidity among surviving patients is very high and is largely dominated by neuropsychological sequelae. Attention and executive function disorders, confusion, disorientation, or memory impairment are thus found in 70 to 100% of patients following ARDS. These disorders are still present in 46 to 80% of surviving patients one year after ARDS and in 20% of them five years later.\n\nAlthough essential to treatment, mechanical ventilation carries a risk of significant complications. Beyond the risk of infection and complications related to sedation and neuromuscular blockade, the use of mechanical ventilation is associated with a risk of ventilator-induced lung injury (VILI).\n\nThe use of so-called protective ventilation reduces the risk of VILI and improves patient outcomes. However, analysis of relevant physiological parameters shows that the risk of VILI may still exist even when ventilator settings comply with recommendations and the concept of protective ventilation. Driving pressure (which represents Strain) is a good marker of VILI; it represents the distension of the lung with each breath relative to the initial lung volume. Values above 14 cmH₂O are associated with high mortality in patients with ARDS. Inspiratory transpulmonary pressure represents Stress-that is, the pressure that distends the alveoli at the end of inspiration-and is also associated with the risk of VILI. Finally, mechanical power represents the amount of energy delivered to the lung by the ventilator and has been validated as a marker of VILI. The advantage of mechanical power over the other indices described is that it incorporates all components that can lead to VILI.\n\nAmong the various sources of neurological damage during ARDS, inflammatory processes appear to play a major role. Numerous inflammatory mediators (TNF-α, IL-6, IL-8, IL-1β) are secreted during ARDS, and animal studies have demonstrated a link between inflammation and hippocampal damage. Furthermore, cerebral ischemic lesions, exacerbated by systemic inflammation and endothelial activation leading to coagulation activation with thrombus formation, may also contribute to the development of cognitive impairments.\n\nIn addition to the inflammatory processes associated with ARDS, mechanical ventilation itself may have a significant impact on neuroinflammatory damage. Recently, the term \"ventilator-associated brain injury\" (VABI) has been proposed to describe these secondary neurological lesions induced by mechanical ventilation. Studies in mouse and pig models have demonstrated a relationship between the dose and duration of VILI, apoptosis, neuroinflammation, and neuronal damage. An animal study in mice also showed an association between the duration of mechanical ventilation and the onset of cognitive impairments.\n\nDuring brain injury, proteins and neurotransmitters are released and serve as biomarkers of brain damage. Elevated plasma levels of S100B protein indicate astrocyte damage caused by traumatic, anoxic-ischemic, or inflammatory mechanisms. It correlates with neurological prognosis following cardiac arrest, in ischemic or hemorrhagic strokes, in neurodegenerative diseases, and in patients with traumatic brain injury.\n\nClinical studies have shown a negative correlation between elevated S100B protein levels, the MoCA (Montreal Cognitive Assessment) score, and the MMSE (Mini-mental state evaluation ) in patients with OSA (Obstructive Sleep Apnea) or COPD (chronic obstructive pulmonary disease), respectively, indicating an association between this protein and cognitive impairment.\n\nThe investigators therefore hypothesize that mechanical ventilation associated with high mechanical power is linked to a significant risk of brain injury, reflected by elevated serum S100B protein levels and the presence of neurocognitive disorders long after ARDS.",[55,96,97,59,98],"s100b","Mechanical Power","Transpulmonary Pressure","2026-06-09",{"date":101,"type":34},"2026-06-10",{"date":103,"type":21},"2026-10-17",{"date":105,"type":21},"2029-10-23",{"name":107,"class":108},"University Hospital, Angers","OTHER_GOV",{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":116,"targetDuration":4,"studyType":22,"phases":118,"briefSummary":119,"conditions":120,"keywords":124,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":82},"100638113","height-measurement-procedures-influence-the-risk-of-ventilator-induced-lung-injury-in-ards-100638113","NCT07595926","Height Measurement Procedures Influence the Risk of Ventilator-induced Lung Injury in ARDS","SIZE-ARDS","Inclusion Criteria:\n\n* Adult patient\n* Mechanical ventilation on volumetric mode\n* Sedated and curarized patient\n* Diagnosis of ARDS according to the Berlin criteria\n* Diagnosis of ARDS \\\u003C 48 hours\n* Signed informed consent\n* Affiliation with a social security or health insurance scheme\n\nExclusion Criteria:\n\n* Patient opposing the use of his\u002Fher data for research purposes.\n* Contraindication to placement of an esophageal balloon catheter (e.g., esophageal fistula, esophageal varices).\n* Contraindication to strict supine positioning for height measurement (e.g., proven or suspected intracranial hypertension with intracranial pressure \\>18 mmHg).\n* Impossibility of measuring height with the reference method (stadiometer) due to deformity or amputation of both lower limbs.\n* Patient under guardianship or curatorship, or deprived of liberty.\n* Pregnant or postpartum patient, or patient currently breastfeeding.",{"count":117,"type":21},39,[24],"Acute respiratory distress syndrome is characterized by heterogeneous lung injury, with dependent regions often collapsed and non-dependent regions relatively well-aerated, forming the so called \"baby lung.\" Mechanical ventilation, while essential, can induce additional lung injury (VILI) via overdistension (baro\u002Fvolutrauma) or repetitive alveolar collapse (atelectrauma). Protective ventilation strategies with low tidal volumes (VT 6-8 mL\u002Fkg predicted body weight, PBW) reduce mortality, but their efficacy relies on accurate PBW estimation, which is derived from patient height. In critical care, height measurement is often challenging, and common methods such as visual estimation or tape measurement can be inaccurate, leading to inappropriate VT settings and increased risk of lung stress and VILI. Alternative methods, including heel-to-knee distance and laser measurement, may offer more precise PBW estimation, yet their impact on lung mechanics in ARDS remains unexplored. This study addresses the knowledge gap by evaluating whether differences in height measurement methods significantly affect lung stress, tidal volume distribution, and ventilatory mechanics in ARDS patients.\n\nPatients' heights will be measured using five methods (stadiometer, visual, tape, laser, heel-to knee). Corresponding PBW and tidal volumes (VT = 6 mL\u002Fkg PBW) will be calculated and applied in randomized order, each for 30 minutes. Lung stress, ventilatory mechanics, gas exchange, and regional ventilation distribution will be assessed for each VT setting, preceded by a short alveolar recruitment maneuver. During the study, continuous monitoring of hemodynamics and oxygenation will be performed.\n\nVentilatory parameters including plateau pressure, driving pressure, and transpulmonary pressures will be recorded. Electrical impedance tomography will assess regional tidal volume distribution. Each patient's participation is limited to approximately two hours with no further follow-up.",[63,29,121,122,123],"Tidal Volume","Predicted Body Weight","Height",[125,126,127,128,129],"acute respiratory distress syndrome","ventilator-induced lung injury","tidal volume","predicted body weight","height","2026-05-12",{"date":132,"type":34},"2026-05-19",{"date":134,"type":21},"2026-05",{"date":136,"type":21},"2028-05",{"name":138,"class":41},"Centre Hospitalier Universitaire, Amiens",{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":4,"eligibilityCriteria":145,"healthyVolunteers":11,"sex":17,"minAge":146,"maxAge":18,"enrollmentInfo":147,"targetDuration":4,"studyType":22,"phases":149,"briefSummary":150,"conditions":151,"keywords":4,"overallStatus":154,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":164},"100367724","clinical-decision-support-tool-in-pards-pilot-study-100367724","NCT04068012","Clinical Decision Support Tool in PARDS Pilot Study","A Computerized Decision Support Tool for Ventilator Management in Pediatric Acute Respiratory Distress Syndrome Pilot Study","Inclusion Criteria:\n\n* Children \\> 1 month of age and \\>44 weeks gestation and ≤ 18 years of age AND\n* Supported on mechanical ventilation with pulmonary parenchymal disease (i.e. Pediatric Acute Respiratory Distress Syndrome (PARDS)) with Oxygen Saturation Index (OSI) ≥ 5) or Oxygenation Index (OI) ≥ 4 AND\n* Who are within 72 hours of initiation of invasive mechanical ventilation AND\n* Who are anticipated to require \\>72 hours mechanical ventilation.\n\nExclusion Criteria:\n\n* Conditions on enrollment that preclude conventional methods of weaning (i.e., status asthmaticus, severe lower airway obstruction, bronchiolitis, critical airway, Extra Corporeal Life Support (ECLS), intubation for Upper Airway Obstruction, Do Not Resuscitate orders, severe chronic respiratory failure, spinal cord injury above lumbar region, cyanotic heart disease (unrepaired or palliated)) OR\n* Conditions precluding the use of permissive hypercapnia or hypoxemia (i.e. intracranial hypertension, severe pulmonary hypertension)\n* Primary Attending physician refuses to enroll the patient","1 Month",{"count":148,"type":21},180,[24],"Previous clinical trials in adults with acute respiratory distress syndrome (ARDS) have demonstrated that ventilator management choices can improve Intensive Care Unit (ICU) mortality and shorten time on mechanical ventilation. This study seeks to scale an established Clinical Decision Support (CDS) tool to facilitate dissemination and implementation of evidence-based research in mechanical ventilation of infants and children with pediatric ARDS (PARDS).\n\nThis will be accomplished by using CDS tools developed and deployed in Children's Hospital Los Angeles (CHLA) which are based on the best available pediatric evidence, and are currently being used in an NHLBI funded single center randomized controlled trial (NCT03266016, PI: Khemani). Without CDS, there is significant variability in ventilator management of PARDS patients both between and within Pediatric ICUs (PICUs), but clinicians are willing to accept CDS recommendations. The CDS tool will be deployed in multiple PICUs, targeting enrollment of up to 180 children with PARDS. Study hypotheses:\n\n1. The CDS tool in will be implementable in nearly all participating sites\n2. There will be \\> 80% compliance with CDS recommendations and\n3. The investigators can implement automatic data capture and entry in many of the ICUs\n\nOnce feasibility of this CDS tool is demonstrated, a multi-center validation study will be designed, which seeks to determine whether the CDS can result in a significant reduction in length of mechanical ventilation (LMV).",[152,29,153],"Ventilation Therapy; Complications","Ards","RECRUITING","2026-04-09",{"date":157,"type":34},"2026-04-14",{"date":159,"type":34},"2020-12-01",{"date":161,"type":21},"2027-07-01",{"name":163,"class":41},"Children's Hospital Los Angeles",8,{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":171,"eligibilityCriteria":172,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":173,"targetDuration":4,"studyType":175,"phases":4,"briefSummary":176,"conditions":177,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":4},"100617222","physiological-effects-of-controlled-vs-assisted-ventilation-during-moderate-to-severe-ards-pearl-study-100617222","NCT07315815","Physiological Effects of Controlled vs. Assisted Ventilation During Moderate-to-severe ARDS (PEARL Study)","Physiological Effects of Controlled vs. Assisted Ventilation During Moderate-to-severe Acute Respiratory Distress Syndrome (PEARL Study)","PEARL","Inclusion Criteria:\n\n* Intubated patients fulfilling moderate-to-severe ARDS (ratio of arterial partial pressure of oxygen to fraction of inspired oxygen.\n* Undergoing assisted ventilation as per clinical decision\n\nExclusion Criteria:\n\n* refusal to participate, age younger than 18 years old, pregnancy\n* contraindication to EIT use (e.g., presence of pacemaker or automatic implantable cardioverter defibrillator), impossibility to place the EIT belt in the right position (e.g., presence of surgical wounds dressing), and any contraindication to the insertion of a nasogastric tube (e.g., recent upper-gastrointestinal surgery, esophageal varices).",{"count":174,"type":21},20,"OBSERVATIONAL","Background:\n\nIn patients with acute hypoxemic respiratory failure or ARDS, mechanical ventilation is often required. Two common strategies are pressure support ventilation (PSV), which allows spontaneous breathing, and volume-controlled ventilation (VCV), which delivers fixed tidal volumes. Although PSV can improve comfort, strong inspiratory efforts may cause excessive lung inflation and increase the risk of ventilator-induced lung injury (VILI). In contrast, VCV with muscle paralysis ensures full control over tidal volume and driving pressure, potentially offering better lung protection.\n\nHypothesis:\n\nThe study will help determine whether a controlled ventilation strategy - with or without volume adjustments and with or without muscle paralysis - provides superior lung protection compared to PSV in hypoxemic patients with intense inspiratory effort.\n\nMethods:\n\nThis prospective physiological study will be performed in the ICU of Fondazione Policlinico Universitario A. Gemelli (Rome, Italy) and will include 20 moderate to severe ARDS patients. Each patient will undergo four 30-minute ventilation phases:\n\nPSV with clinical PEEP;\n\nVCV at 6 ml\u002Fkg predicted body weight (PBW);\n\nVCV with muscle paralysis and Vt equal to PSV;\n\nVCV with muscle paralysis and Vt adjusted to keep driving pressure ≤14 cmH₂O.\n\nDuring each phase, data on gas exchange, respiratory mechanics, inspiratory effort, and regional ventilation (via electrical impedance tomography) will be collected.\n\nEndpoints:\n\nPrimary: Regional tidal volume distribution during VCV vs. PSV.\n\nSecondary: Transpulmonary driving pressure, dorsal ventilation fraction, and pendelluft occurrence.\n\nExpected Impact:\n\nBy comparing assisted and controlled ventilation under different conditions, the study aims to clarify which strategy better balances patient comfort, effective ventilation, and lung protection in ARDS patients with high respiratory drive.",[29],"2026-02-09",{"date":180,"type":34},"2026-02-11",{"date":182,"type":21},"2026-03-01",{"date":184,"type":21},"2027-04-01",{"name":186,"class":41},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS",{"id":188,"slug":189,"hasResults":11,"nctId":190,"briefTitle":191,"officialTitle":192,"acronym":193,"eligibilityCriteria":194,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":195,"targetDuration":4,"studyType":22,"phases":197,"briefSummary":198,"conditions":199,"keywords":202,"overallStatus":154,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":209,"completionDateStruct":210,"leadSponsor":212,"locationsCount":82},"100556553","inspiratory-effort-targeted-pressure-support-ventilation-it-psv-trial-100556553","NCT06526598","Inspiratory Effort-Targeted Pressure Support Ventilation (IT-PSV) Trial","A Cluster Randomized Trial on Inspiratory Effort-Based Pressure Support Adjustment Strategy in Patients Undergoing Assisted Mechanical Ventilation","IT-PSV","Mechanically ventilated patients, who are admitted to the ICU with acute hypoxic respiratory failure, will be consecutively screened daily at 08:00-10:00 morning rounds.\n\nInclusion criteria:\n\n1. PSV initiated during the last 24 hours;\n2. Mechanical ventilation expected to be required for at least 24-48 h by responsible physicians;\n3. The partial pressure of oxygen in arterial blood (PaO2)\u002Finspired oxygen fraction (FiO2) ≤ 300 mmHg (measuring at clinical FiO2 and positive end-expiratory pressure PEEP);\n4. No sedation or stable sedation with Richmond Agitation Sedation Scale (RASS) of -2 to +1 or Riker's Sedation-Agitation Scale (SAS) of 3 to 4.\n\nExclusion criteria included:\n\n1. Age younger than 18 years old;\n2. Initiation of PSV before ICU admission;\n3. Duration of mechanical ventilation longer than 7 days before enrollment;\n4. History of neuromuscular diseases;\n5. Clinical suspicion of increased intracranial pressure;\n6. Extracorporeal support;\n7. Moribund conditions;\n8. Refusal by the ICU physicians or the patient.",{"count":196,"type":21},619,[24],"The Inspiratory effort-Targeted Pressure Support Ventilation (IT-PSV) is a cluster randomized controlled trial. Its main aim is to determine whether an inspiratory effort-targeted pressure support setting strategy, compared to the traditional tidal volume and respiratory rate target, can improve clinical outcomes in adult participants undergoing pressure support ventilation.\n\nThe investigators propose a physiological-oriented assisted ventilation management that, if found effective, could potentially change the clinical practice for mechanical ventilation.",[200,201,29],"Critical Care","Acute Hypoxic Respiratory Failure",[203,204,205],"pressure support ventilation","pressure muscle index","inspiratory effort","2026-01-19",{"date":208,"type":34},"2026-01-21",{"date":206,"type":34},{"date":211,"type":21},"2027-02-28",{"name":213,"class":41},"Capital Medical University",{"id":215,"slug":216,"hasResults":11,"nctId":217,"briefTitle":218,"officialTitle":219,"acronym":220,"eligibilityCriteria":221,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":222,"targetDuration":4,"studyType":22,"phases":224,"briefSummary":225,"conditions":226,"keywords":4,"overallStatus":154,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":231,"startDateStruct":232,"completionDateStruct":234,"leadSponsor":235,"locationsCount":237},"100538848","open-lung-protective-extubation-following-general-anesthesia-100538848","NCT06296173","Open Lung Protective Extubation Following General Anesthesia","Open Lung Protective Extubation Following General Anesthesia: the OLEXT-3 Trial","OLEXT-3","Inclusion Criteria:\n\n* Adult patients (18 years of age or over)\n* Elective intra-abdominal surgery under general anesthesia.\n* Moderate or high risk of postoperative pulmonary complication according to the ARISCAT score (score of 26 or more)\n* Planned postoperative hospitalization\n\nExclusion Criteria:\n\n* Expected or known difficult intubation according to the treating anesthesiologist\n* Postoperative mechanical ventilation (planned or unplanned)\n* General anesthesia performed outside the main operating room",{"count":223,"type":21},270,[24],"Perioperative respiratory complications are a major source of morbidity and mortality. Postoperative atelectasis plays a central role in their development. Protective \"open lung\" mechanical ventilation aims to minimize the occurrence of atelectasis during the perioperative period. Randomized controlled studies have been performed comparing various \"open lung\" ventilation protocols, but these studies report varying and conflicting effects. The interpretation of these studies is complicated by the absence of imagery supporting the pulmonary impact associated with the use of different ventilation strategies. Imaging studies suggest that the gain in pulmonary gas content in \"open lung\" ventilation regimens disappears within minutes after the extubation. Thus, the potential benefits of open-lung ventilation appear to be lost if, at the time of extubation, no measures are used to keep the lungs well aerated. Recent expert recommendations on good mechanical ventilation practices in the operating room conclude that there is actually no quality study on extubation.\n\nExtubation is a very common practice for anesthesiologists as part of their daily clinical practice. It is therefore imperative to generate evidence on good clinical practice during anesthetic emergence in order to potentially identify an effective extubation strategy to reduce postoperative pulmonary complications.",[227,228,229,29,230],"Intra-abdominal Surgery","Anesthesia","Lung Injury","Atelectasis",{"date":208,"type":34},{"date":233,"type":34},"2024-10-08",{"date":184,"type":21},{"name":236,"class":41},"Centre hospitalier de l'Université de Montréal (CHUM)",4,{"id":239,"slug":240,"hasResults":11,"nctId":241,"briefTitle":242,"officialTitle":243,"acronym":4,"eligibilityCriteria":244,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":245,"targetDuration":4,"studyType":175,"phases":4,"briefSummary":247,"conditions":248,"keywords":4,"overallStatus":154,"whyStopped":4,"lastUpdateSubmitDate":250,"lastUpdatePostDateStruct":251,"startDateStruct":253,"completionDateStruct":255,"leadSponsor":257,"locationsCount":82},"100316913","a-new-ultrasonographic-tool-to-assess-pulmonary-strain-in-the-icu-100316913","NCT03405779","A New Ultrasonographic Tool to Assess Pulmonary Strain in the ICU","A Pilot Study of a New Ultrasonographic Tool to Assess Regional Pulmonary Strain in Mechanically Ventilated Patients Suffering From Pulmonary Diseases in an Intensive Care Setting.","Inclusion Criteria:\n\n* Adult intensive care patients under mechanical ventilation suffering from a pulmonary disease with a static lung compliance of less than 40 mL\u002Fcm H2O.\n\nExclusion Criteria:\n\n* Obesity (Body Mass Index superior to 30 kg\u002Fm2)\n* Previous thoracic procedure (chest tube, thoracotomy, thoracoscopy)\n* Intra-abdominal pressure inferior to 15 mm Hg (if available)\n* Previous participation to the study",{"count":246,"type":21},10,"The primary objective of the study is to create a small dataset of regional pulmonary strain values in patients suffering from pulmonary diseases under mechanical ventilation in an intensive care setting.\n\nHypothesis: The analysis of lung ultrasonographic sequences using speckle-tracking allows the determination of local pleural strain in 4 predetermined pulmonary areas in mechanically ventilated patients suffering from pulmonary diseases.",[249,29],"Mechanical Ventilation Complication","2025-09-12",{"date":252,"type":34},"2025-09-18",{"date":254,"type":34},"2018-03-12",{"date":256,"type":21},"2026-02-01",{"name":236,"class":41},{"id":259,"slug":260,"hasResults":11,"nctId":261,"briefTitle":262,"officialTitle":263,"acronym":264,"eligibilityCriteria":265,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":266,"targetDuration":4,"studyType":22,"phases":268,"briefSummary":269,"conditions":270,"keywords":275,"overallStatus":154,"whyStopped":4,"lastUpdateSubmitDate":276,"lastUpdatePostDateStruct":277,"startDateStruct":279,"completionDateStruct":281,"leadSponsor":283,"locationsCount":82},"100492233","electrical-activity-of-the-diaphragm-and-respiratory-mechanics-during-nava-100492233","NCT05689476","Electrical Activity of the Diaphragm and Respiratory Mechanics During NAVA","Evaluation of the Relationship Between Electrical Activity of the Diaphragm and Respiratory Mechanics During Neurally Adjusted Ventilatory Assist in Lung Transplant Patients and in Patients Affected by Acute Respiratory Failure.","NAVAMECH","Inclusion Criteria:\n\n* Age \\> 18 y.o.\n* Admission to ICU for post-operative monitoring after LTx or acute respiratory failure needing invasive mechanical ventilation\n* Presence of spontaneous breathing activity\n* Sedation titrated to a target RASS between 0 and -2\n* Written informed consent obtained\n\nExclusion Criteria:\n\n* Contraindication to nasogastric tube insertion (gastroesophageal surgery in the previous 3 months, gastroesophageal bleeding in the previous 30 days, history of esophageal varices, facial trauma)\n* Increased risk of bleeding with nasogastric tube insertion, due to severe coagulation disorders and severe thrombocytopenia ( i.e., INR \\> 2 and platelets count \\\u003C 70.000\u002Fmm3)\n* Severe hemodynamic instability (noradenaline \\> 0.3 μg\u002Fkg\u002Fmin and\u002For use of vasopressin)\n* Postoperative extracorporeal respiratory support (ECMO)\n* Pre-operative reconditioning of the transplanted lungs by means of ex-vivo lung perfusion (EVLP)\n* Lung retransplantation\n* Failure to obtain a stable EAdi signal",{"count":267,"type":21},40,[24],"Protective ventilatory strategy should be applied to reduce ventilator-induced lung injury (VILI) after Lung Transplantation (LTx) or in case of acute respiratory failure requiring invasive mechanical ventilation. Neurally Adjusted Ventilatory Assist (NAVA) is an assisted ventilation mode in which respiratory support is coordinated by the electrical activity of the diaphragm (EAdi). Aim of the study is to assess the physiological relationship between neural respiratory drive, as assessed by EAdi, and tidal volume, driving pressure, and mechanical power, at different levels of ventilatory assist, in the absence of pulmonary vagal afferent feedback or during acute respiratory failure. Additional parameters will be collected: Pmus, Pocc, transpulmonary pressure etc.",[271,272,273,29,274],"Work of Breathing","Lung Transplantation","Neurally Adjusted Ventilatory Assist","Acute Respiratory Failure (ARF)",[229,29,273],"2025-07-01",{"date":278,"type":34},"2025-07-08",{"date":280,"type":34},"2022-12-27",{"date":282,"type":21},"2025-12-27",{"name":284,"class":41},"University of Padova",{"id":286,"slug":287,"hasResults":11,"nctId":288,"briefTitle":289,"officialTitle":289,"acronym":290,"eligibilityCriteria":291,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":292,"targetDuration":4,"studyType":175,"phases":4,"briefSummary":294,"conditions":295,"keywords":4,"overallStatus":154,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":299,"startDateStruct":301,"completionDateStruct":303,"leadSponsor":305,"locationsCount":82},"100594297","inspiratory-work-of-breathing-before-and-after-extubation-100594297","NCT07017608","Inspiratory Work of Breathing Before and After Extubation","INTEGRATION","Inclusion Criteria:\n\n* Adult patients intubated and ventilated\n\nExclusion Criteria:\n\n* Contraindication for esophageal catheter insertion: upper gastrointestinal surgery within prior 6 weeks, actively bleeding esophageal varices\n* Bronchopleural fistula\n* Contraindication for electrical impedance tomography: chest burns, skin lesions in the thorax, chest wall bandaging limiting electrode placement, unstable spinal lesions or fractures\n* Pregnancy",{"count":293,"type":21},67,"Critically ill patients who (1) are not able to maintain their airway, (2) cannot breathe on their own, or (3) both, are ones who often require tracheal intubation and support from a breathing machine (mechanical ventilator). When the patient is ready to be liberated from the mechanical ventilator because the initial insult for intubation has been resolved, the patient is screened using the readiness to wean test in preparation for extubation. As the patient passes this screening, a spontaneous breathing test (SBT) is initiated. Currently, there are many debates surrounding which SBT technique is most favorable. At Toronto General Hospital, the clinical team uses a zero-end expiratory pressure (ZEEP) trial. Once the patient successfully passes their SBT they are then extubated.\n\nThe patient will undergo a spontaneous breathing trial of continuous positive airway pressure (CPAP) of 5 cmH2O and ZEEP, in which time the investigators will be using a new technology called electrical impedance tomography (EIT), to study and compare the end expiratory lung volume (EELV); investigators will use an esophageal catheter to measure and monitor pressures in the lung, and also assess the patient's work of breathing. This will be repeated once the patient has been extubated safely.",[296,29,297],"Lung Transplant; Complications","Ventilator Associated Pneumonia","2025-06-03",{"date":300,"type":34},"2025-06-12",{"date":302,"type":34},"2020-09-01",{"date":304,"type":21},"2026-12",{"name":306,"class":41},"University Health Network, Toronto",{"id":308,"slug":309,"hasResults":11,"nctId":310,"briefTitle":311,"officialTitle":312,"acronym":4,"eligibilityCriteria":313,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":314,"enrollmentInfo":315,"targetDuration":4,"studyType":175,"phases":4,"briefSummary":317,"conditions":318,"keywords":4,"overallStatus":154,"whyStopped":4,"lastUpdateSubmitDate":320,"lastUpdatePostDateStruct":321,"startDateStruct":323,"completionDateStruct":325,"leadSponsor":327,"locationsCount":237},"100590422","electrical-impedance-tomography-based-prognostic-model-for-ards-100590422","NCT06967207","Electrical Impedance Tomography-Based Prognostic Model for ARDS","Electrical Impedance Tomography-Based Prognostic Model for ARDS: A Multicenter, Prospective, Observational Study","Inclusion Criteria:\n\n1. Meet the new 2023 ARDS global definition;\n2. Age 18-80 years\n\nExclusion Criteria:\n\n1. Expected death within 24 hours of screening;\n2. Metastatic cancer (active malignancy with distant metastases);\n3. Severe psychiatric disorders;\n4. Pregnancy or postpartum status;\n5. Pneumothorax or moderate to large pleural effusion without adequate drainage;\n6. Chronic respiratory failure;\n7. Patients with pulmonary embolism or pulmonary hypertension;\n8. Heart failure patients: EF \\\u003C50% or NYHA class III or IV;\n9. Patient\u002Ffamily refusal to participate;\n10. Participation in another interventional trial within 3 months prior to enrollment","80 Years",{"count":316,"type":21},625,"This multicenter, prospective, observational study aims to develop and validate an EIT-based prognostic model for ARDS. By focusing on the pathophysiological characteristics of ARDS and the causes of ventilator-induced lung injury, the investigators intend to establish a prognostic model that reveals lung injury and heterogeneity, enabling risk stratification and guiding individualized treatment.",[55,319],"Ventilator-induced Lung Injury","2025-05-10",{"date":322,"type":34},"2025-05-13",{"date":324,"type":34},"2025-04-15",{"date":326,"type":21},"2027-12-31",{"name":328,"class":41},"XiaoJing Zou,MD",{"id":330,"slug":331,"hasResults":11,"nctId":332,"briefTitle":333,"officialTitle":334,"acronym":4,"eligibilityCriteria":335,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":336,"targetDuration":4,"studyType":22,"phases":337,"briefSummary":338,"conditions":339,"keywords":342,"overallStatus":154,"whyStopped":4,"lastUpdateSubmitDate":344,"lastUpdatePostDateStruct":345,"startDateStruct":347,"completionDateStruct":349,"leadSponsor":350,"locationsCount":82},"100588071","eit-guided-ventilator-settings-in-ahrf-100588071","NCT06936618","EIT-Guided Ventilator Settings in AHRF","Using Electrical Impedance Tomography-Guided Ventilator Settings to Reduce Mechanical Power in Acute Hypoxemic Respiratory Failure : An Exploratory Study","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Diagnosed with acute hypoxemic respiratory failure within 48 hours\n* Expected to require invasive mechanical ventilation ≥ 48 hours\n* On mechanical ventilation within 24 hours\n* Deep sedation and neuromuscular blockade\n\nExclusion Criteria:\n\n* Pregnancy\n* Body mass index (BMI) \\> 40 kg\u002Fm2\n* Contraindications to using electrical impedance tomography, including\n* Presence of a pacemaker or automatic implantable cardioverter-defibrillator (AICD)\n* Inability to place the belt due to presence of surgical wounds dressing, thoracic or spinal cord trauma, recent thoracic surgery, etc.\n* High risk for PEEP titration\n* Hemodynamic instability defined as mean arterial pressure \\\u003C 65 mmHg despite optimization of fluid status and\u002For use of vasopressors\n* Unstable cardiac arrhythmias\n* Presence of lung bullae greater than 2 cm in diameter, identified on chest X-ray\n* Presence of pneumothorax or pneumomediastinum\n* Right-sided heart failure or severe pulmonary hypertension\n* Neurologic conditions associated with a risk of intracranial hypertension\n* Use of extracorporeal membrane oxygenation (ECMO)\n* Severe chronic respiratory disease, defined as follows: requiring home oxygen therapy, or previous lung function showing (FEV1 less than 20 ml\u002Fkg PBW, or FEV1\u002FFVC less than 50% predicted value), or chronic hypercapnia (PaCO2 greater than 45 mmHg) and\u002For chronic hypoxemia (PaO2 less than 55 mmHg) on FIO2 = 0.21, or radiographic x-ray evidence of any chronic over-inflation or chronic interstitial infiltration, or chronic restrictive, obstructive, neuromuscular, chest wall or pulmonary vascular disease resulting in severe exercise restriction (unable to climb stairs or perform household duties, secondary polycythemia, severe pulmonary hypertension with mean pulmonary arterial pressure greater than 40 mmHg)\n* Decision to withhold life-sustaining treatment or palliative care.\n* Moribund status with an expected survival of less than 24 hours.\n* Refusal to provide informed consent",{"count":5,"type":21},[24],"This exploratory study aims to investigate the effect of Electrical Impedance Tomography (EIT)-guided ventilator settings on mechanical power in patients with acute hypoxemic respiratory failure (AHRF), including both ARDS and non-ARDS conditions. Mechanical power, a key factor associated with ventilator-induced lung injury (VILI), will be measured before and after EIT-guided PEEP titration. The study will evaluate feasibility and changes in lung mechanics, gas exchange, and EIT parameters. A total of 17 patients requiring invasive mechanical ventilation will be enrolled at Siriraj Hospital, Mahidol University.",[340,55,97,59,341],"Acute Hypoxemic Respiratory Failure","Electrical Impedance Tomography (EIT)",[343],"Acute Hypoxemic Respiratory Failure; Electrical Impedance Tomography; Mechanical Power, Ventilator-induced lung injury","2025-04-22",{"date":346,"type":34},"2025-04-27",{"date":348,"type":34},"2024-12-17",{"date":304,"type":21},{"name":351,"class":41},"Mahidol University",{"id":353,"slug":354,"hasResults":11,"nctId":355,"briefTitle":356,"officialTitle":356,"acronym":357,"eligibilityCriteria":358,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":359,"targetDuration":4,"studyType":175,"phases":4,"briefSummary":361,"conditions":362,"keywords":4,"overallStatus":154,"whyStopped":4,"lastUpdateSubmitDate":365,"lastUpdatePostDateStruct":366,"startDateStruct":368,"completionDateStruct":370,"leadSponsor":372,"locationsCount":82},"100399707","lung-barometric-measurements-in-normal-and-in-respiratory-distressed-lungs-100399707","NCT04484727","\"Lung Barometric Measurements in Normal And in Respiratory Distressed Lungs\"","LUNAR","Inclusion Criteria:\n\n* Patients above18 years\n* ASA 1-3\n* Planned\u002Facute ventilator treatment in ICU or OR\n\nExclusion Criteria:\n\n* Patients under 18 years\n* ASA 4 and above\n* severe COPD\u002Femphysema\u002Fheart failure\n* PEEP\\>16 and\u002For FiO2 \\>80%\n* elevated intracranial pressure\n* defect coagulation\n* non-treated known or suspected pneumothorax",{"count":360,"type":21},200,"Little is known about how lung mechanics are affected during the very early phase after starting mechanical ventilation. Since the conventional method of measuring esophageal pressure is complicated, hard to interpret and expensive, there are no studies on lung mechanics on intensive care patients directly after intubation, during the first hours of ventilator treatment and forward until the ventilator treatment is withdrawn. Published studies have collected data using the standard methods from day 1 to 3 of ventilator treatment for respiratory system mechanics, i.e. the combined mechanics of lung and chest wall. Consequently, information on lung mechanical properties during the first critical hours of ventilator treatment is missing and individualization of ventilator care done on the basis of respiratory system mechanics, which are not representative of lung mechanics on an individual patient basis. We have developed a PEEP-step method based on a change of PEEP up and down in one or two steps, where the change in end-expiratory lung volume ΔEELV) is determined and lung compliance calculated as ΔEELV divided by ΔPEEP (CL = ΔEELV\u002FΔPEEP). This simple non-invasive method for separating lung and chest wall mechanics provides an opportunity to enhance the knowledge of lung compliance and the transpulmonary pressure. After the two-PEEP-step procedure, the PEEP level where transpulmonary driving pressure is lowest can be calculated for any chosen tidal volume.\n\nThe aim of the present study in the ICU is to survey lung mechanics from start of mechanical ventilation until extubation and to determine PEEP level with lowest (least injurious) transpulmonary driving pressure during ventilator treatment. The aim of the study during anesthesia in the OR, is to survey lung mechanics in lung healthy and identify patients with lung conditions before anesthesia, which may have an increased risk of postoperative complications.",[29,363,364,152,297],"Ventilatory Failure","Ventilator Lung","2025-03-13",{"date":367,"type":34},"2025-03-17",{"date":369,"type":34},"2022-05-01",{"date":371,"type":21},"2026-12-31",{"name":373,"class":41},"Göteborg University",{"id":375,"slug":376,"hasResults":11,"nctId":377,"briefTitle":378,"officialTitle":379,"acronym":380,"eligibilityCriteria":381,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":382,"enrollmentInfo":383,"targetDuration":4,"studyType":22,"phases":385,"briefSummary":386,"conditions":387,"keywords":392,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":396,"lastUpdatePostDateStruct":397,"startDateStruct":399,"completionDateStruct":401,"leadSponsor":403,"locationsCount":237},"100541796","ventilation-of-the-extremely-premature-infants-optimized-by-dead-space-washout-100541796","NCT06334523","Ventilation of the Extremely Premature Infants Optimized by Dead Space Washout","Open Randomised Study of Conventional Ventilation Optimised by Dead Space Washout in Extremely Premature Infants","Volem","Inclusion Criteria:\n\n* Gestational Age at birth between 23 weeks gestation + 0 days and 26 weeks gestation + 6days\n* Age between 0 and 7 days of life\n* Need for intubation and mechanical ventilation before day 8 of life\n* Availability of the Research-associated medical devices\n* Beneficiary of a social security system (in France: CMU or securité sociale)\n* Parental consent for their infant to participate in this trial\n\nExclusion Criteria:\n\n* Known Severe Congenital Malformation (potential life-threatening malformation)\n* Known Preexisting Severe Intraventricular Haemorrhage (grade 3 or 4) and\u002For other brain abnormality that can alter life prognosis\n* Known Genetic Disorder (potential life-threatening malformation)\n* Preexistent mechanical ventilation for a duration of more than 12 hours\n* Participation in another interventional research trial before inclusion","7 Days",{"count":384,"type":21},144,[24],"The Continuous Tracheal Gas Insufflation (CTGI) is a ventilation option of conventional mechanical ventilation that is used to reduce or even eliminate the dead space caused by respiratory prostheses. This objective is of particular interest in the smallest preterm infants, where the volume of anatomical dead space due to prostheses is little different from the tidal volume. The principle of this option is to continuously blow an additional flow of 0.2 L\u002Fminute at the tip of the endotracheal tube to purge expired CO2 trapped in the prostheses, to have a CO2-free volume of gas available for subsequent insufflation.\n\nThe goal of this clinical trial is to learn if Continuous Tracheal Gas Insufflation (CTGI) works to reduce ventilatory dependence in preterm infants after mechanical ventilation. It will also learn about the safety of CTGI. The main questions it aims to answer are:\n\n* Does Continuous Tracheal Gas Insufflation (CTGI) reduce the number of days of non-invasive ventilation in extremely preterm infants who needed mechanical ventilation?\n* Does Continuous Tracheal Gas Insufflation (CTGI) reduce the age at the weaning of any ventilatory support and\u002For oxygen supplementation.\n\nResearchers will compare the clinical outcome of patients mechanically ventilated with the CTGI-device to the outcome of patients ventilated without the CTGI device, to see if the CTGI ventilation works to reduce ventilation dependence.\n\nParticipants will:\n\n• Be mechanically ventilated using CTGI (if randomly assigned in the CTGI-group), for the entire endotracheal ventilation period during their stay in the neonatal intensive care unit.",[388,389,390,391,29],"Extremely Low Birthweight Infant","Continuous Tracheal Gas Insufflation","Medical Device","Lung Protection",[393,394,29,395],"lung protection","extremely low birthweight infant","mechanical ventilation","2025-02-03",{"date":398,"type":34},"2025-02-05",{"date":400,"type":21},"2025-02-13",{"date":402,"type":21},"2029-04-03",{"name":404,"class":41},"Centre Hospitalier Intercommunal Creteil",{"id":406,"slug":407,"hasResults":11,"nctId":408,"briefTitle":409,"officialTitle":410,"acronym":4,"eligibilityCriteria":411,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":412,"targetDuration":4,"studyType":22,"phases":413,"briefSummary":414,"conditions":415,"keywords":418,"overallStatus":154,"whyStopped":4,"lastUpdateSubmitDate":420,"lastUpdatePostDateStruct":421,"startDateStruct":423,"completionDateStruct":425,"leadSponsor":427,"locationsCount":82},"100560064","non-invasive-phrenic-nerve-stimulation-in-ards-patient-100560064","NCT06572280","Non-invasive Phrenic Nerve Stimulation in ARDS Patient","Non-invasive Phrenic Nerve Stimulation in ARDS Patients - a Feasibility Study","Inclusion Criteria:\n\n1. Adult ARDS patients undergoing controlled mechanical ventilation\n2. The duration of endotracheal intubation \\\u003C 48 hrs\n\nExclusion Criteria:\n\n1. Neurological condition affecting motor neuron or muscle (e.g. ALS)\n2. Paralysis of the phrenic nerve\n3. Proven or suspected spinal cord injury\n4. Conditions that limit diaphragm movement\n5. Patients with Implanted cardiac support systems (pacemaker, implanted defibrillator)\n6. Patients with implanted medical pumps\n7. Pregnancy\n8. Patients with skin lesions, infections or strictures in throat\u002Fneck area\n9. Patients with metallic implants\n10. Refusal to sign informed consent",{"count":246,"type":21},[24],"Reduced diaphragmatic activity during mechanical ventilation can lead to diaphragmatic disuse atrophy, atelectasis, increased lung stress and strain, and hemodynamic impairment. This, in turn, may prolong the duration of mechanical ventilation, make weaning more difficult, and even increase mortality. Synchronizing phrenic nerve stimulation to promote diaphragmatic activity may prevent ventilator-induced lung injury and ventilator-induced diaphragm dysfunction, thereby improving patient outcomes. Surgically implanted phrenic nerve stimulation has been used in certain neurological disorders, but the effects of percutaneous non-invasive synchronized phrenic nerve stimulation in patients with ARDS undergoing mechanical ventilation remain unclear and require further investigation.",[416,29,417],"ARDS, Human","Diaphragm Injury",[62,419,395],"diaphragm injury","2024-08-25",{"date":422,"type":34},"2024-08-27",{"date":424,"type":34},"2024-08-01",{"date":426,"type":21},"2025-01-30",{"name":428,"class":41},"Southeast University, China",{"id":430,"slug":431,"hasResults":11,"nctId":432,"briefTitle":433,"officialTitle":434,"acronym":4,"eligibilityCriteria":435,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":436,"targetDuration":4,"studyType":175,"phases":4,"briefSummary":438,"conditions":439,"keywords":4,"overallStatus":154,"whyStopped":4,"lastUpdateSubmitDate":440,"lastUpdatePostDateStruct":441,"startDateStruct":443,"completionDateStruct":445,"leadSponsor":447,"locationsCount":82},"100544366","mechanism-study-of-ventilator-induced-lung-injury-in-elderly-people-100544366","NCT06367946","Mechanism Study of Ventilator-Induced Lung Injury in Elderly People.","Mechanism Study Under the Role of Tissue Kallikrein-related Peptidase 8 (KLK8)-Induced Senescence of Pulmonary Vascular Endothelial Cells in Ventilator-induced Lung Injury in Elderly People.","Inclusion Criteria:\n\n1. Lung tissues from patients with different ages:\n\n   Patients undergoing elective general anesthesia surgery; Patients undergoing partial lung resection with mechanical ventilation; American Society of Anesthesiology (ASA) grade 2-3;\n2. Peripheral blood from patients with different ages and duration of mechanical ventilation:\n\nPatients undergoing elective general anesthesia surgery with mechanical ventilation; ASA grade 2-3;\n\nExclusion Criteria:\n\n1. Lung tissues from patients with different ages:\n\n   Patients with chronic lung diseases (asthma, chronic obstructive pulmonary disease (COPD), pulmonary heart disease, etc.); Patients with human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), or receiving immunotherapy; Patients who have recently suffered from pneumonia; Recent history of mechanical ventilation; Patients with thrombotic diseases; Children and pregnant women.\n2. Peripheral blood from patients with different ages and duration of mechanical ventilation:\n\nPatients with chronic lung diseases (asthma, COPD, pulmonary heart disease, etc.); Smoking patients; Patients with hypertension\u002Fdiabetes\u002Fcoronary heart disease; Patients with HIV, HBV, HCV, HDV, or receiving immunotherapy; Patients who have recently suffered from pneumonia; Recent history of mechanical ventilation; Patients with thrombotic diseases; Children and pregnant women.",{"count":437,"type":21},1000,"1. We collect lung tissues from patients with different ages and confirm that KLK8 expression is positively correlated with age.\n2. We collect peripheral blood from patients with different ages and duration of mechanical ventilation to explore the correlation between the degree of endothelial\u002Fepithelial damage, age and duration of mechanical ventilation.",[29],"2024-04-11",{"date":442,"type":34},"2024-04-16",{"date":444,"type":34},"2023-06-01",{"date":446,"type":21},"2027-06-30",{"name":448,"class":41},"Xinhua Hospital, Shanghai Jiao Tong University School of Medicine"]