[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ventilator-lung-newborn\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ventilator-lung-newborn":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,50,79,114,139],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":33,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100555503","ventilator-pressure-and-optimization-of-compliance-and-hemodynamics-100555503",false,"NCT06512935","Ventilator Pressure and Optimization of Compliance and Hemodynamics","Ventilator Pressure and Optimization of Compliance and Hemodynamics: VPOCH Trial","VPOCH","Inclusion Criteria:\n\nPreterm infants with recovering respiratory distress syndrome (RDS) who were born at a gestational age \\\u003C 34 weeks and are receiving respiratory support via conventional mechanical ventilation or on HFJV.\n\n* Post-natal age \\> 7 days and less than 1 month (outside golden week protocol)\n* Gestational age ≥ 21 weeks and ≤ 34 week\n* Infants with written informed consent obtained from legal guardian\n\nExclusion Criteria:\n\n* Blood culture-positive sepsis\n* Congenital anomalies affecting respiration\n* Cyanotic or ductal-dependent congenital heart disease\n* Newborns who are considered too unstable for study enrolment per neonatology attending\n* Newborns on pressors or steroids for maintaining cardiac output\n* Non-invasive ventilation or newborn with significant BPD (bronchopulmonary dysplasia) with pulmonary hypertension (HTN)\n* Open skin wounds or abrasions on the chest wall.","ALL","7 Days","30 Days",{"count":21,"type":22},24,"ESTIMATED","INTERVENTIONAL",[25],"NA","In preterm infants \\\u003C 34 weeks' gestation at birth receiving respiratory support with invasive positive pressure ventilation, the positive end-expiratory pressure (PEEP) of best compliance will increase the cardiac output and improve oxygenation. This study may emphasize using point-of-care echocardiography along with electrical impedance tomography (EIT) to optimize ventilator settings in preterm infants.\n\nInfants will be randomized to a 4-hour crossover period of increasing and decreasing PEEP in random order from baseline to determine compliance, oxygenation, and cardiac hemodynamics at each step using echocardiography (ECHO) and EIT measurements. There will be a 15-minute washout period after changes prior to data collection.",[28,29,30,31,32],"Bronchopulmonary Dysplasia","Pulmonary Hypertension Due to Lung Diseases and Hypoxia","Extreme Prematurity","Ventilator Lung; Newborn","Ventilation Perfusion Mismatch",[34,35,36],"Respiratory distress syndrome","ventilation mechanics in newborn","cardiac hemodynamics newborn","RECRUITING","2026-05-06",{"date":40,"type":41},"2026-05-11","ACTUAL",{"date":43,"type":22},"2026-08-01",{"date":45,"type":22},"2027-06-30",{"name":47,"class":48},"University of Alabama at Birmingham","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":61,"briefSummary":62,"conditions":63,"keywords":67,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":75,"leadSponsor":77,"locationsCount":49},"100596778","baby-abs-abdominal-binder-study-100596778","NCT07049900","Baby ABS (Abdominal Binder Study)","Baby ABS (Abdominal Binder Study) : Impact of Abdominal Binder Use on Abdominal Wall Development in Premature Infants Requiring CPAP Support","Inclusion Criteria:\n\n* Premature viable neonates with corrected gestational age of 26-31 weeks\n* Anticipated to require non-invasive continuous positive pressure ventilation including bCPAP, CPAP, and NAVA CPAP for a minimum of 2 weeks either on their first trial of CPAP or after extubation.\n\nExclusion Criteria:\n\n* Outside of gestational age at birth\n* Umbilical lines\n* Genetic condition or neuromuscular anomaly\n* Known abdominal anomaly\n* Non-viable neonates and neonates with uncertain viability who are not anticipated to be able to survive with standard NICU care.\n* Surgical intervention on the abdominal wall, such as gastroschisis or history of surgical NEC\n* Compromised skin integrity of abdominal wall\n* Any condition in the opinion of the investigator that would risk the data integrity or collection of the study","26 Weeks","31 Weeks",{"count":60,"type":22},40,[25],"The primary outcome of this study is to determine if the use of the FDA-approved DandleLion NeoBellyBand increases the thickness of the rectus abdominis muscle in premature babies receiving continuous positive pressure ventilation, leading to infants reaching full oral feedings at an earlier corrected gestational age.",[64,65,31,66],"Premature","Premature Lungs","Rectus Abdominis",[68,69,70],"bCPAP","CPAP","NAVA CPAP","2025-09-22",{"date":73,"type":41},"2025-09-26",{"date":71,"type":41},{"date":76,"type":22},"2027-02-28",{"name":78,"class":48},"University of Minnesota",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":17,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":23,"phases":91,"briefSummary":94,"conditions":95,"keywords":98,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":113},"100518101","phase-2-caffeine-as-an-adjuvant-therapy-for-late-preterm-infants-with-respiratory-distress-100518101","NCT06026163","Caffeine as an Adjuvant Therapy for Late Preterm Infants With Respiratory Distress","Caffeine for Late Preterm Infants: A Double Blind Randomized Controlled Trial","CAT\u002FLPT","Inclusion Criteria:\n\n* Newborn infants at gestational age 34 0\u002F7 through 36 6\u002F7\n* Presented with respiratory distress\n* Require respiratory support in the form of any of the following :\n\nA) Invasive mechanical ventilation, B) Non-invasive positive pressure ventilation, C) Nasal cannula with FIO2 requirement over 50% to keep pre-ductal saturation between 90-95%.\n\nExclusion Criteria:\n\n1 - Late preterm admitted for non-respiratory etiologies 2- Late preterm infants requiring nasal cannula on less than 50% FIO2 by 4 hours of age as they are less likely to require respiratory support for a long time.\n\n3- Newborn infants with congenital malformations and chromosomal anomalies. 4- Infants with echocardiographic evidence of PPHN requiring medical intervention.\n\n5- Late preterm with history of maternal substance abuse","1 Day","3 Days",{"count":90,"type":22},134,[92,93],"PHASE2","PHASE3","Use of caffeine citrate in late-preterm infants with respiratory distress is questionable. Oliphant and colleagues found in a recently published study that caffeine therapy use in late-preterm infants at a loading dose of 20 and 40 mg\u002Fkg and maintenance dose of 10 and 20 mg\u002Fkg\u002Fday reduces the incidence of intermittent hypoxia events by 61 and 67% respectively.\n\nThe investigators hypothesized that caffeine will improve respiratory drive, prevent apnea, shorten the hospital stay and improve arousal state in late preterm infants.\n\nThe investigators aim to study the effect of caffeine citrate on late preterm babies as regard duration of respiratory support, duration of hospital stay, respiratory morbidity, incidence and frequency of apnea.",[96,97,31],"Prematurity","Respiratory Disease",[99,100,101,102],"caffeine","preterm","newborn","respiratory support","2025-06-24",{"date":105,"type":41},"2025-06-27",{"date":107,"type":41},"2023-10-12",{"date":109,"type":22},"2028-01-01",{"name":111,"class":112},"Ministry of Health, Saudi Arabia","OTHER_GOV",2,{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":121,"enrollmentInfo":122,"targetDuration":4,"studyType":23,"phases":124,"briefSummary":126,"conditions":127,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":49},"100474164","phase-4-the-caffeine-therapy-in-the-fetal-to-neonatal-transition-100474164","NCT05454332","The Caffeine Therapy in the Fetal to Neonatal Transition","The Caffeine Therapy in the Fetal to Neonatal Transition in Preterms","Inclusion Criteria:\n\n* Premature newborns with birth weight less than 1250 grams\n* Who are not intubated in the delivery room\n\nExclusion Criteria:\n\n* Premature newborns from other hospitals\n* Presence of a major congenital malformation or genetic syndrome","2 Hours",{"count":123,"type":22},50,[125],"PHASE4","Introduction: The caffeine is used in the treatment for apnea of prematurity and it has several positive effects in the neurodevelopment of preterm babies. There are innumerable observational studies suggesting that initiating caffeine in the first hours of life may offer more benefits in the reduction of the necessity of intubation and in ventilation time. It is necessary to expand further research on the best time to start caffeine, which may improve the quality of care for premature infants.\n\nObjective: To evaluate the benefits of caffeine administration in the first two hours of life compared to administration at 24 hours of life in premature patients on noninvasive mechanical ventilation with birth weights less than 1250 grams.\n\nMethodology: Preterm newborn patients with birth weight \\\u003C 1250 grams born at Hospital de Clínicas de Porto Alegre who are not intubated in the delivery room will be included. Patients will be randomized into two groups. One arm of the study will receive caffeine at 2 hours of age and the other arm will receive caffeine at 24 hours of age (control). Patients in the control group will receive 0.9% SF at 2 hours of life in order to keep the study blinded. The following outcomes will be evaluated: need for intubation, time on invasive and non-invasive mechanical ventilation, BPD, necrotizing enterocolitis, need for ROP treatment, PDA with hemodynamic repercussions, peri-intraventricular hemorrhage, leukomalacia and death. The sample size calculation is 50 patients, 25 in each arm.\n\nExpected Results: It is expected to find a 43% reduction in the need for intubation in preterm infants who receive caffeine in the first two hours of life compared to administration at 24 hours of life. It is also expected to find a reduction in mechanical ventilation time, in addition to a possible reduction in negative outcomes associated with prematurity.",[128,129,31],"Mechanical Ventilation Complication","Caffeine","2025-03-27",{"date":132,"type":41},"2025-04-02",{"date":134,"type":41},"2022-04-27",{"date":136,"type":22},"2026-08-30",{"name":138,"class":48},"Hospital de Clinicas de Porto Alegre",{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":4,"eligibilityCriteria":145,"healthyVolunteers":146,"sex":17,"minAge":147,"maxAge":148,"enrollmentInfo":149,"targetDuration":4,"studyType":23,"phases":151,"briefSummary":152,"conditions":153,"keywords":155,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":49},"100558369","evaluation-of-nasal-non-invasive-ventilation-in-management-of-neonates-with-respiratory-distress-using-lung-ultrasound-100558369","NCT06550219","Evaluation of Nasal Non Invasive Ventilation in Management of Neonates With Respiratory Distress Using Lung Ultrasound","Evaluation of Nasal Non Invasive Ventilation Modalities in Management of Neonates With Respiratory Distress Using Lung Ultrasound","Inclusion Criteria: Preterm \\\u003C37 wk. gestational age admitted to the NICU with spontaneous breathing and clinical manifestations of RD (tachypnea, nasal flaring, intercostal and subcostal retraction and or grunting).\n\nExclusion Criteria:\n\n1. Obvious major congenital abnormalities.\n2. Any of the baby intubated for resuscitation or for other reasons.\n3. Neonates need invasive mechanical ventilation.\n4. Pulmonary hemorrhage.\n5. Severe cardiovascular instability.\n6. Cardiopulmonary arrest needing prolonged resuscitation.\n7. Birth asphyxia (one-minute Apgar score ≤ 3).\n8. Major cardiac diseases (not including patent ductus arteriosus).",true,"1 Hour","24 Hours",{"count":150,"type":22},30,[25],"This study aims to evaluate the effect of non-invasive ventilation (nIPPV)\n\n, (nCPAP), and nasal high flow cannula (NHFC) as a primary mode of ventilation in preterm neonates \\\u003C37 gestational week with moderate to severe RD using LUS as regard: I. Primary outcomes: Duration of non-Invasive ventilation. II. Secondary outcomes: Evaluation LUS over the 1 st 7 days of life or weaning from ventilation. Need for intubation and invasive ventilation. Duration of respiratory support. Need for surfactant. Oxygen saturation index and oxygen index. Broncho-pulmonary dysplasia; grade. Duration of hospital stay",[154,31],"Preterm",[156,157],"preterm infants","non-invasive ventilation","2025-02-03",{"date":160,"type":41},"2025-02-04",{"date":162,"type":41},"2024-11-20",{"date":164,"type":22},"2025-11-01",{"name":166,"class":48},"Alexandria University"]