[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ventilator-lung\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ventilator-lung":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,41,76,101,131,160,184,210,238,265,291],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100538856","mechanical-ventilation-in-surgical-patients-100538856",false,"NCT06296277","Mechanical Ventilation in Surgical Patients","Management of Mechanical Ventilation During Surgery: an International, Multicenter, and Observational Data Registry","MEET VENUS","Inclusion Criteria:\n\n* Adults; and\n* Receiving intraoperative IMV (via tracheal intubation, or supraglottic device ) during general anesthesia for surgery\n\nExclusion Criteria:\n\n* Receiving intraoperative IMV outside of an operating room; and\n* Receiving intraoperative IMV during extracorporeal life support","ALL","18 Years",{"count":20,"type":21},10000,"ESTIMATED","OBSERVATIONAL","This is an investigator-initiated, international, multicenter, prospective, cross-sectional study that aims to 1) describe the incidence and types of postoperative pulmonary complications (PPCs), 2) describe patient demographics, baseline characteristics, and intraoperative ventilation management, 3) describe the occurrence of intraoperative adverse events (IAEs), and 4) their associations with PPCs, 5) assess the practice of intraoperative mechanical ventilation.\n\nPatients will be eligible for participation if: 1) adult and 2) receiving intraoperative ventilation during general anesthesia for surgery. Patients receiving ventilation outside of an operating room as well as patients receiving intraoperative ventilation during extracorporeal life support will be excluded",[25,26,27],"Surgery","Ventilator Lung","Postoperative Complications","RECRUITING","2026-05-25",{"date":31,"type":32},"2026-05-28","ACTUAL",{"date":34,"type":32},"2026-03-01",{"date":36,"type":21},"2027-08-31",{"name":38,"class":39},"Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":50,"phases":51,"briefSummary":53,"conditions":54,"keywords":59,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":4},"100538192","cpap-in-patients-with-severe-obesity-after-anesthesia-100538192","NCT06287632","CPAP in Patients With Severe Obesity After Anesthesia","Assessment of Cardiopulmonary Function in Response to Continuous Positive Airway Pressure in Patients With Severe Obesity After Anesthesia","Inclusion Criteria:\n\n1. Adult patients (≥ 18 years old) scheduled for elective non-cardiothoracic surgery requiring general anesthesia with an endotracheal tube\n2. Planned admission to the post-anesthesia care unit (PACU) after surgery\n3. BMI ≥ 40 kg\u002Fm2\n4. At the time of baseline measurements in the PACU, patients meet the following criteria:\n\n   * Receiving ≤ 6 liters of supplemental nasal cannula oxygen\n   * Alert as defined by a Richmond Agitation Sedation Scale of 0 or -1\n   * Oriented to person, place, and time\n\nExclusion Criteria:\n\n1. Pregnancy, suspected pregnancy or less than six weeks postpartum Known or current pneumothorax\n2. Hemodynamic instability at the time of study assessment in the PACU defined as:\n\n   * systolic blood pressure \\\u003C90 mmHg or \\>180 mmHg\n   * mean blood pressure \\\u003C60 or \\>130 mmHg\n   * Any use of intravenous vasoactive agent\n   * heart rate \\\u003C 50 or \\> 120 beats per minute\n3. Respiratory insufficiency in PACU defined as:\n\n   * Respiratory rate \\> 30\n   * Oxygen saturation \\\u003C 92%\n   * Receiving \\> 6 liters of supplemental oxygen\n4. Known chronic lung disease requiring supplemental oxygen at home\n5. Known systolic heart dysfunction (left ventricular ejection fraction ≤ 30%)\n6. Contraindication for esophageal catheter placement:\n\n   * Known esophageal varices\n   * Known bacterial sinusitis\n   * Recent esophageal, nasopharyngeal, or laryngeal trauma or surgery\n   * Known coagulopathy: including history of thrombocytopenia defined as platelet count \\\u003C50,000; presence of hemophilia; known genetic disorder of coagulation (e.g.,deficits of protein C, protein S, von Willebrand factor) or oral and subcutaneous anticoagulation treatment (e.g., heparin, warfarin, and or other oral anticoagulants)\n7. Contraindication for electrical impedance tomograph belt placement:\n\n   * Pacemaker and\u002For internal cardiac defibrillator\n   * Chest skin injury\n8. Concern for study inclusion by the perioperative nurse or anesthesia team",{"count":49,"type":21},60,"INTERVENTIONAL",[52],"NA","The goal of this study is to compare two continuous positive airway pressure (CPAP) settings on heart and lung function in patients with severe obesity after anesthesia. The main questions it aims to answer are:\n\n1. Does a recruitment maneuver and CPAP set to intrathoracic pressure (ITP) improve cardiopulmonary function compared to standard CPAP settings in patients with severe obesity after anesthesia?\n2. Does the location of adipose tissue influence the response to CPAP settings in patients with severe obesity after anesthesia?\n\nParticipants will undergo monitoring of their intrathoracic pressure using an esophageal catheter. In the recovery area after anesthesia, participants will receive two CPAP settings, each for 20 minutes.\n\n* Intervention 1: Recruitment maneuver and CPAP will set to the level of intrathoracic pressure\n* Intervention 2: CPAP set to home settings (if OSA is present) or between 8-10 cmH20 (if OSA is not present).",[55,56,57,58,26],"Obesity, Abdominal","Anesthesia Morbidity","Apnea, Obstructive Sleep","Atelectases, Postoperative Pulmonary",[60,61,62,63,64,65],"clinical trial","crossover studies","continuous positive airway pressure","electrical impedance tomography","esophageal pressure monitoring","transthoracic echocardiography","NOT_YET_RECRUITING","2025-11-17",{"date":69,"type":32},"2025-11-18",{"date":71,"type":21},"2026-06",{"date":73,"type":21},"2027-06",{"name":75,"class":39},"Massachusetts General Hospital",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":100},"100557745","weaning-from-mechanical-ventilation-in-patients-with-acute-brain-injury-100557745","NCT06542107","Weaning From Mechanical Ventilation in Patients With Acute Brain Injury","Prediction of Weaning for Patients With Acute Brain Injury Undergoing Mechanical Ventilation","Inclusion Criteria:\n\n* acute brain injury\n* age \\>=18 years\n* invasive mechanical ventilation for at least 24 hours\n\nExclusion Criteria:\n\n* tracheostomized before ICU admission\n* pregnant or lactation\n* with cervical spinal cord injury\n* decision to receive palliative care within 24 hours of ICU admission",{"count":84,"type":21},406,"Acute brain injury (ABI) patients frequently necessate intubation and invasive mechanical ventilation (IMV). While some ABI patients are capable of breathing spontaneously, which is one of the main criteria of extubation and weaning. However, the rate of extubation failure was significantly higher in ABI patients compared with non-neurological critical care patients. In patients who have failed one or several trials of extubation, tracheostomy is recommend according to the latest ESICM consensus. Tracheostomy can enhance comfort, improve pulmonary hygiene and decrease sedation requirement, which could facilitate the liberation from ventilator.\n\nNumerous studies have explored the causes of weaning failure and provide various predictive models in guiding extubation and tracheostomy. Yet, due to limitations of such as small sample size or a lack of external validation, there is paucity of practical weaning algorithm tailored for ABI patients. The liberation from IMV in ABI patients still remains challenging with poor level of evidence in current guidelines or expert consensus.\n\nWe aim to describe the weaning outcomes in ABI patients, and further investigate the potential predictors of weaning success in ABI patients.",[26,87],"Acute Brain Injury",[89,90,91],"mechanical ventilation","acute brain injury","weaning","2025-11-14",{"date":69,"type":32},{"date":95,"type":32},"2024-08-06",{"date":97,"type":21},"2025-12-31",{"name":99,"class":39},"Southeast University, China",2,{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":107,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":17,"minAge":109,"maxAge":110,"enrollmentInfo":111,"targetDuration":4,"studyType":50,"phases":113,"briefSummary":114,"conditions":115,"keywords":117,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":129,"locationsCount":40},"100543865","driving-pressure-guided-lung-protective-ventilation-100543865","NCT06361420","Driving Pressure-guided Lung Protective Ventilation","The Efficacy of Driving Pressure-guided Lung Protective Ventilation in Surgical Repair of Acute Type A Aortic Dissection: an Open-label, Randomized Control Clinical Trial","DPV","Inclusion Criteria:\n\n1. Able to sign Informed Consent and Release of Medical Information Forms;\n2. Age ≥ 14 years and ≤ 70 years old;\n3. Being confirmed the diagnosis by chest computed tomography angiography and receiving the surgical repair of acute type A aortic dissection.\n\nExclusion Criteria:\n\n1. Age \\\u003C 14 years or \\> 70 years old;\n2. Sepsis before surgery;\n3. Chronic pulmonary disease including lung infection or asthma requiring long-term pharmacotherapy;\n4. History of lung tumor;\n5. Obstructive sleep apnea hypopnea syndrome requiring long-term noninvasive mechanical ventilation support;\n6. Heart failure requiring catecholamines or invasive mechanical ventilation support;\n7. Body mass index \\> 30 Kg·m-2;\n8. Being reluctance to participate this study.","14 Years","70 Years",{"count":112,"type":21},43,[52],"The study, named as \"The Efficacy of Driving Pressure-guided Lung Protective Ventilation in Surgical Repair of Acute Type A Aortic Dissection: an open-label, randomized control clinical trial\", aims to investigate whether driving pressure-guided lung protective ventilation can reduce postoperative oxygenation function in patients who have undergone surgical repair of acute type A aortic dissection. The primary outcomes is the incidence of postoperative hypoxemia (a partial pressure of arterial oxygen to inspiratory oxygen fraction ratio less than 300 mm Hg or a peripheral blood oxygen saturation less than 93% at any concentration of inspiratory oxygen) within 7 days after the surgery.",[116,26],"Hypoxemia",[118,119,120,121,122],"Driving Pressure","Lung Protective Ventilation","Aortic Dissection","Hypoxia","Postoperative Pulmonary Complications","2025-08-06",{"date":125,"type":32},"2025-08-11",{"date":127,"type":32},"2024-01-26",{"date":97,"type":21},{"name":130,"class":39},"Yong Lin, PhD",{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":17,"minAge":138,"maxAge":139,"enrollmentInfo":140,"targetDuration":4,"studyType":50,"phases":142,"briefSummary":143,"conditions":144,"keywords":149,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":100},"100495084","integrated-echocardiography-and-chest-ultrasound-assessment-of-lung-recruitment-in-preterm-infants-100495084","NCT05726578","Integrated Echocardiography and Chest Ultrasound Assessment of Lung Recruitment in Preterm Infants","Integrated Echocardiography and Chest Ultrasound Assessment of Lung Recruitment in Preterm Infants Using High Frequency Ventilation","Inclusion Criteria:\n\n* Infants will be enrolled if they are 32 to 37 weeks of gestational age, have respiratory distress (RD) in the first 24 h of life, intubated and have invasive respiratory support using HFOV. Signs of RD are tachypnea (respiratory rate \\> 60\u002Fmin), grunting, nasal flaring, chest retraction, and need of oxygen supplementation or other respiratory support.\n\nExclusion Criteria:\n\n1. Known major congenital anomalies including congenital heart diseases.\n2. Fetal hydrops.\n3. Babies with congenital heart diseases","1 Hour","3 Days",{"count":141,"type":21},72,[52],"The primary aim of this work is to evaluate the role of high frequency oscillatory ventilation (HFOV) in recruitment of lung in preterm newborns 32 to 37 weeks gestational age with moderate to severe respiratory distress. The secondary aim is to evaluate the role of chest ultrasound in monitoring of lung recruitment in comparison to routine chest x ray in those babies. Also cardiac hemodynamics will be assesed using functional echocardiography.",[26,145,146,147,148],"Echocardiography","Chest Ultrasound","High Frequency Ventilation","Lung Recruitment",[150],"Premature infants","2025-05-24",{"date":153,"type":32},"2025-05-28",{"date":155,"type":32},"2024-07-01",{"date":157,"type":21},"2025-07-01",{"name":159,"class":39},"Alexandria University",{"id":161,"slug":162,"hasResults":11,"nctId":163,"briefTitle":164,"officialTitle":164,"acronym":165,"eligibilityCriteria":166,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":167,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":169,"conditions":170,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":40},"100399707","lung-barometric-measurements-in-normal-and-in-respiratory-distressed-lungs-100399707","NCT04484727","\"Lung Barometric Measurements in Normal And in Respiratory Distressed Lungs\"","LUNAR","Inclusion Criteria:\n\n* Patients above18 years\n* ASA 1-3\n* Planned\u002Facute ventilator treatment in ICU or OR\n\nExclusion Criteria:\n\n* Patients under 18 years\n* ASA 4 and above\n* severe COPD\u002Femphysema\u002Fheart failure\n* PEEP\\>16 and\u002For FiO2 \\>80%\n* elevated intracranial pressure\n* defect coagulation\n* non-treated known or suspected pneumothorax",{"count":168,"type":21},200,"Little is known about how lung mechanics are affected during the very early phase after starting mechanical ventilation. Since the conventional method of measuring esophageal pressure is complicated, hard to interpret and expensive, there are no studies on lung mechanics on intensive care patients directly after intubation, during the first hours of ventilator treatment and forward until the ventilator treatment is withdrawn. Published studies have collected data using the standard methods from day 1 to 3 of ventilator treatment for respiratory system mechanics, i.e. the combined mechanics of lung and chest wall. Consequently, information on lung mechanical properties during the first critical hours of ventilator treatment is missing and individualization of ventilator care done on the basis of respiratory system mechanics, which are not representative of lung mechanics on an individual patient basis. We have developed a PEEP-step method based on a change of PEEP up and down in one or two steps, where the change in end-expiratory lung volume ΔEELV) is determined and lung compliance calculated as ΔEELV divided by ΔPEEP (CL = ΔEELV\u002FΔPEEP). This simple non-invasive method for separating lung and chest wall mechanics provides an opportunity to enhance the knowledge of lung compliance and the transpulmonary pressure. After the two-PEEP-step procedure, the PEEP level where transpulmonary driving pressure is lowest can be calculated for any chosen tidal volume.\n\nThe aim of the present study in the ICU is to survey lung mechanics from start of mechanical ventilation until extubation and to determine PEEP level with lowest (least injurious) transpulmonary driving pressure during ventilator treatment. The aim of the study during anesthesia in the OR, is to survey lung mechanics in lung healthy and identify patients with lung conditions before anesthesia, which may have an increased risk of postoperative complications.",[171,172,26,173,174],"Ventilator-Induced Lung Injury","Ventilatory Failure","Ventilation Therapy; Complications","Ventilator Associated Pneumonia","2025-03-13",{"date":177,"type":32},"2025-03-17",{"date":179,"type":32},"2022-05-01",{"date":181,"type":21},"2026-12-31",{"name":183,"class":39},"Göteborg University",{"id":185,"slug":186,"hasResults":11,"nctId":187,"briefTitle":188,"officialTitle":189,"acronym":4,"eligibilityCriteria":190,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":191,"targetDuration":4,"studyType":50,"phases":192,"briefSummary":193,"conditions":194,"keywords":197,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":201,"lastUpdatePostDateStruct":202,"startDateStruct":204,"completionDateStruct":206,"leadSponsor":208,"locationsCount":40},"100575213","a-pilot-trial-of-pressure-muscle-index-targeted-psv-trial-100575213","NCT06769360","A Pilot Trial of Pressure Muscle Index-Targeted PSV Trial","A Pragmatic Pilot Trial Evaluating Inspiratory Pressure Adjustment Based on Pressure Muscle Index in Patients Undergoing Pressure Support Ventilation","Inclusion Criteria:\n\n1. PSV initiated during the last 24 hours, whether transition from controlled modes or primary initiation;\n2. Mechanical ventilation expected to be required for at least 24-48 hours by responsible physicians;\n3. The partial pressure of oxygen in arterial blood (PaO2)\u002Finspired oxygen fraction (FiO2) ≤ 300 mmHg (measuring at clinical FiO2 and positive end-expiratory pressure \\[PEEP\\]);\n4. No sedation or stable sedation with Richmond Agitation Sedation Scale (RASS) of -2 to +1 or Riker's Sedation-Agitation Scale (SAS) of 3 to 4.\n\nExclusion Criteria:\n\n1. Age younger than 18 years old;\n2. Initiation of PSV before ICU admission;\n3. Duration of mechanical ventilation longer than 7 days before enrollment;\n4. History of neuromuscular diseases;\n5. Clinical suspicion of increased intracranial pressure;\n6. Presentation with pneumothorax and\u002For bronchopleural fistula;\n7. Extracorporeal support;\n8. Moribund conditions;\n9. Refusal by the ICU physicians or the patient.",{"count":49,"type":21},[52],"Pressure support ventilation (PSV) is one of the most frequently used ventilator modes in the intensive care unit (ICU). The successful implementation of PSV depends on matching the patient's inspiratory effort with the ventilator support. In clinical practice, the pressure support level is usually set and adjusted according to tidal volume (VT) and respiratory rate (RR). However, these parameters may not fully represent the patient's effort. Previous studies have shown that pressure muscle index (PMI), which is measured as the difference between the peak and plateau airway pressure during an end-inspiratory airway occlusion, could reliably determine the low and high inspiratory effort during PSV.\n\nHowever, the comparative effectiveness of these two pressure support level setting strategies remains uncertain. Our aim is to explore clinical and implementation factors relevant to a future definitive randomized controlled trial to evaluate PMI - and VT\u002FRR - pressure support level setting strategies. The Inspiratory effort-targeted pressure support ventilation pragmatic pilot trial will test clinician adherence and to explore clinical outcomes.\n\nTwo centers are included in a pragmatic sequential cluster crossover pilot trial. We enrolled all eligible adults with acute respiratory failure requiring mechanical ventilation admitted to ICU. The pressure support level setting strategy was assigned according to the epoch. The first trial epoch will be assigned to VTRR - pressure support level setting strategy for 4 weeks. The washout week between the two epochs will be 4 weeks. Then sequentially, it will be crossed over to PMI - pressure support level setting strategy for 4 weeks.\n\n* In the VT\u002FRR-targeted group, the pressure support is adjusted to obtain a VT between 6 and 8 ml\u002Fkg PBW and RR between 20 and 35 breaths\u002Fmin until day 28 or death or performance of spontaneous breathing trial (SBT).\n* In the PMI-targeted group, the pressure support is adjusted according to PMI between 0 and 2 cmH2O until day 28 or death or performance of SBT.\n\nWe will also survey clinicians to understand potential facilitators and barriers to conducting a definitive randomized trial.",[195,196,26],"Critical Care","Acute Hypoxic Respiratory Failure",[198,199,200],"pressure support ventilation","pressure muscle index","inspiratory effort","2025-02-05",{"date":203,"type":32},"2025-02-07",{"date":205,"type":32},"2025-01-20",{"date":207,"type":21},"2025-04",{"name":209,"class":39},"Capital Medical University",{"id":211,"slug":212,"hasResults":11,"nctId":213,"briefTitle":214,"officialTitle":215,"acronym":216,"eligibilityCriteria":217,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":218,"enrollmentInfo":219,"targetDuration":4,"studyType":50,"phases":221,"briefSummary":222,"conditions":223,"keywords":224,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":229,"lastUpdatePostDateStruct":230,"startDateStruct":232,"completionDateStruct":234,"leadSponsor":236,"locationsCount":40},"100529802","i-asv-in-cardiac-surgery-100529802","NCT06178510","I-ASV in Cardiac Surgery","POStoperative INTELLiVENT-adaptive Support VEntilation in Cardiac Surgery Patients II (POSITiVE II) - a Randomized Clinical Trial","POSITiVE II","Inclusion Criteria:\n\n* 1\\. aged \\> 18 years of age;\n* 2\\. scheduled for elective cardiac surgery; and\n* 3\\. expected to receive postoperative ventilation in the ICU for \\> 2 hours.\n\nExclusion Criteria:\n\n1. any emergency or semi-elective surgery (precluding informed written consent);\n2. any surgery other than CABG, valve replacement or repair, or a combination (i.e., patients planned for surgery for congenital heart disease, or scheduled for heart transplantation are excluded);\n3. enrolled in another interventional trail;\n4. no written informed consent obtained;\n5. history of recent pneumectomy or lobectomy;\n6. history of COPD with oxygen at home;\n7. body mass index \\> 35;\n8. preoperative forced expiratory volume in the first second (FeV1)\u002Fforced vital capacity (VC) \\\u003C 50% (if available);\n9. preoperative arterial oxygen partial pressure (PaO2) \\\u003C 60 mm Hg (at room air);\n10. preoperative arterial carbon dioxide partial pressure (PaCO2) \\> 50 mm Hg;\n11. preoperative left ventricular ejection fraction \\\u003C 30% (if available);\n12. preoperative systolic pulmonary artery pressure \\> 60 mm Hg (if available);\n13. preoperative left ventricular mechanical support, e.g., Impella®; or\n14. preoperative use of veno-venous or veno-arterial extracorporeal support\n\n    At the end of surgery, patients are additionally excluded if a patient:\n15. cannot be weaned from the extracorporeal support; or\n16. unexpectedly needs implementation of an assist device","120 Years",{"count":220,"type":21},328,[52],"'POStoperative INTELLiVENT-adaptive support VEntilation in cardiac surgery patients II (POSITiVE II) is an investigator-initiated, international, multicenter, parallel, randomized clinical trial in patients after cardiac surgery.",[26],[225,226,227,228],"Adaptative Support Ventilation","INTELLiVENT","Cardiac Surgery","Workload","2024-10-31",{"date":231,"type":32},"2024-11-04",{"date":233,"type":32},"2024-05-31",{"date":235,"type":21},"2025-12",{"name":237,"class":39},"Medical University of Vienna",{"id":239,"slug":240,"hasResults":11,"nctId":241,"briefTitle":242,"officialTitle":243,"acronym":4,"eligibilityCriteria":244,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":245,"targetDuration":4,"studyType":50,"phases":247,"briefSummary":248,"conditions":249,"keywords":250,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":257,"startDateStruct":259,"completionDateStruct":261,"leadSponsor":263,"locationsCount":40},"100553241","respiratory-mechanics-measurement-of-ventilated-patients-through-low-frequency-oscillometry-technique-100553241","NCT06483529","Respiratory Mechanics Measurement of Ventilated Patients Through Low-frequency Oscillometry Technique","Respiratory Mechanics Measurement of Ventilated Patients Through Low-frequency Oscillometry Technique, an Explorative Study","Inclusion Criteria:\n\n* intubation\n* Controlled ventilation with an intention to continue controlled ventilation for the following 4 hours.\n* Richmond agitation sedation scale of -4 or less\n* Hemodynamically stable patient with either\n\n  * unchanged vasopressor dose administration for at least 60 minutes before the start of the measurements\n  * no vasopressor need and no vasopressor initiated within 60 minutes of measurements\n* No planned intervention in the coming 2 hours\n* Survival for at least 48 hours\n* Protective ventilation (inspired oxygen concentration≤60%, plateau pressure ≤30 cmH2O , driving pressure≤ 15cmH2O)\n* PEEP (Positive End Expiratory Pressure) ≤10\n\nExclusion Criteria:\n\n* assist ventilation\n* Ventilator asynchronies\n* Intermittent spontaneous breathing\n* nitric oxide therapy\n* presence of an extra corporeal membrane oxygenation device\n* Ventilation is not possible within the lower and upper inflection point of the low flow pressure volume curve.\n* Unstable right heart failure\n* Unstable lung embolism\n* Standard of care without Sedline® or invasive arterial catheter\n* Do not reanimate code of 2, 3 or 4\n* Subjects who are healthy, minors, pregnant women, patients in emergency situation\n* Outside the age range 18 to 84 years",{"count":246,"type":21},21,[52],"Respiratory failure has historically been one of the most important causes for admittance of patients to the critical care unit. This problem was the most important reason during the COVID-19 pandemic. Following the evolution of the physiology of the lung has therefore been the number one concern during these challenging times in the intensive care unit (ICU). Respiratory oscillometry (RO) identifies the lung impedance by applying small pressure oscillations onto the breathing or ventilation. Information about the respiratory mechanics can be extracted out of this impedance, including the resistance (R) and compliance (C) of the lung. The VUB developed a robust, patient safe RO measurement protocol that delivers high quality measurements with the least possible interference with the patient's breathing\u002Fventilation. The technique challenges current state-of-the-art techniques also aiming at identifying R and C of the respiratory system (not exclusively RO). The RO measurement protocol is in line with the technical standards of the ERS (European Respiratory Society) and has been successfully and safely tested on emulators and some parts on test subjects. The clinical investigation aims at a powered equivalence investigation between the RO measurement protocol and a standard of care dynamic compliance estimate on invasive ventilated patients. As secondary objectives, the feasibility of the RO techniques will be investigated during pressure support ventilation and the RO estimates will also be compared with other accepted respiratory mechanics estimation tools. To enable the investigation, a RO algorithm is developed, and a RO measurement extension is implemented in the DemcAir® ventilation system of Demcon. This was a fully tested ventilator that received a CE mark under the previous MDD regulation. However, Demcon, which produces ventilator parts for other commercial partners, removed the label to avoid competition with their partners. The ventilator will only execute the protocol on demand and save the data on an USB stick available in the ventilator. At any time, the RO measurement procedure can be stopped, and the ventilator will return to its initial ventilation. The USB stick is used to transport the data to a separate (VUB) laptop where the data processing is done.",[26],[251,252,253,254,255,256],"oscillometry","intensive care unit","intubated patients","compliance","resistance","impedance",{"date":258,"type":32},"2024-07-03",{"date":260,"type":32},"2023-09-18",{"date":262,"type":21},"2024-12-31",{"name":264,"class":39},"Universitair Ziekenhuis Brussel",{"id":266,"slug":267,"hasResults":11,"nctId":268,"briefTitle":269,"officialTitle":270,"acronym":4,"eligibilityCriteria":271,"healthyVolunteers":11,"sex":17,"minAge":272,"maxAge":4,"enrollmentInfo":273,"targetDuration":4,"studyType":50,"phases":275,"briefSummary":277,"conditions":278,"keywords":280,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":282,"lastUpdatePostDateStruct":283,"startDateStruct":285,"completionDateStruct":287,"leadSponsor":289,"locationsCount":40},"100527031","phase-3-sglt2-inhibitors-in-patients-with-adhf-during-ventilator-weaning-100527031","NCT06142474","SGLT2 Inhibitors in Patients With ADHF During Ventilator Weaning","The Potential Beneficial Effects of SGLT2 Inhibitors in Patients With Acute Decompensated Heart Failure During Ventilator Weaning: a Prospective Multicenter Cohort Study.","Inclusion Criteria:\n\n1. Patients aged ≥20 years\n2. Currently hospitalized for the primary diagnosis of acute HF (de novo or decompensated chronic HF) in HFrEF patients (LVEF≤40%)\n3. Meet the stabilization criteria:\n\n   A. Systolic BP ≥100mm Hg and no symptoms of hypotension in the preceding 6 hours B. No increase in i.v. diuretic dose for 6 hours prior to randomization C. No i.v. vasodilators including nitrates within the last 6 hours prior to randomization D. No i.v. inotropic drugs for 24 hours prior to randomization\n4. Elevated N-terminal proB-type natriuretic peptide (NT-proBNP) or BNP:\n\n   A. Without atrial fibrillation (AF): NT-proBNP ≥1600 pg\u002FmL or BNP ≥400 pg\u002FmL B. With AF: NT-proBNP ≥2400 pg\u002FmL or BNP ≥600 pg\u002FmL\n5. Patients were intubated for at least 24 hour with ventilator settings allowing to initiate the weaning process \\[SpO2 \\> 90% or PaO2\u002FFiO2 ≥ 150 mmHg with a fraction of inspired oxygen (FiO2) ≤ 40% and a positive end-expiratory pressure (PEEP) ≤ 8 cmH2O\\].\n\nExclusion Criteria:\n\n1. Decision to withdraw life support\n2. Cardiogenic shock\n3. Hospitalization for HF (HHF) triggered by acute myocardial infarction (AMI) or pulmonary embolism\n4. Planned or previous (within 30 days) cardiovascular revascularization or major cardiac surgery\u002Fintervention\u002Fdevice implantation\n5. Prior acute coronary syndrome, AMI, stroke or transient ischemic accident within 90 days\n6. Estimated glomerular filtration rate (eGFR) of less than 30 ml per minute per 1.73 m2 of body-surface area\n7. Type 1 diabetes mellitus\n8. Poorly controlled type 2 diabetes mellitus (a glycated hemoglobin level above 10.5%)\n9. Uncontrolled urinary tract infection","20 Years",{"count":274,"type":21},450,[276],"PHASE3","This study will explore the potential benefits of sodium-glucose cotransporter 2 (SGLT2) inhibitors in preventing cardiac ischemia and cardiopulmonary edema in patients with acute decompensated heart failure during weaning from ventilators.",[279,26],"Heart Failure Acute",[279,281],"Ventilator","2023-11-16",{"date":284,"type":32},"2023-11-21",{"date":286,"type":32},"2022-10-10",{"date":288,"type":21},"2030-10-09",{"name":290,"class":39},"National Taiwan University Hospital",{"id":292,"slug":293,"hasResults":11,"nctId":294,"briefTitle":295,"officialTitle":296,"acronym":4,"eligibilityCriteria":297,"healthyVolunteers":11,"sex":17,"minAge":298,"maxAge":299,"enrollmentInfo":300,"targetDuration":302,"studyType":22,"phases":4,"briefSummary":303,"conditions":304,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":308,"completionDateStruct":310,"leadSponsor":312,"locationsCount":40},"100449590","assessment-of-process-and-outcome-of-protocol-based-weaning-from-mechanical-ventilation-in-the-medical-patients-100449590","NCT05134467","Assessment of Process and Outcome of Protocol-based Weaning From Mechanical Ventilation in the Medical Patients","Prospective, Single-center, Observational Study on the Assessment of Process and Outcome of Protocol-based Weaning From Mechanical Ventilation in the Medical Patients","Inclusion Criteria:\n\n* All consecutive adult patients receiving mechanical ventilation for at least two calendar days in medical intensive care units\n\nExclusion Criteria:\n\n* None","19 Years","99 Years",{"count":301,"type":21},1000,"6 Months","This is a prospective, single-center, observational study to describe characteristics of weaning process and factors associated with duration of weaning and its outcomes in all consecutive adult (aged 19 years and older) patients receiving mechanical ventilation for at least two calendar days in medical intensive care units since November 2017. Details of the patients' weaning process and spontaneous breathing trial (SBT) in addition to clinical, laboratory, and outcome data will be collected in a specified format on the day of the assessment by respiratory care practitioners.",[26],"2021-11-19",{"date":307,"type":32},"2021-11-26",{"date":309,"type":32},"2017-11-01",{"date":311,"type":21},"2029-09-30",{"name":313,"class":39},"Samsung Medical Center"]