[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ventilator-weaning\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ventilator-weaning":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,51,80,116,142,173,208],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100627161","effects-of-mobilization-using-a-powered-lower-limb-exoskeleton-with-prolonged-mechanical-ventilation-100627161",false,"NCT07445035","Effects of Mobilization Using a Powered Lower-limb Exoskeleton With Prolonged Mechanical Ventilation","Physiological and Functional Adaptations Associated With Robot-assisted Lower-limb Activity in Ventilator-dependent Hospitalized Patients","Inclusion Criteria:\n\n* Able to maintain a seated position for at least 1 minute.\n* The participant or their legal representative is able to sign the informed consent form.\n\nExclusion Criteria:\n\n* Inability to follow instructions.\n* Intubation\u002Ftracheostomy prior to current admission.\n* Diagnosis of severe left heart failure.\n* Diagnosis of neuromuscular disorders.\n* Unable to stand.\n* Complete paralysis of the lower extremities.\n* Presence of unhealed ulcers in the lower extremities.\n* Deep vein thrombosis of the lower extremities.\n* Lower-limb amputation.\n* Severe hypertension\n* Severe cardiac conditions\n* Severe bilateral joint disorders\n* Severe pain while standing\n* Severe osteoporosis\n* Lower-limb fracture\n* Ongoing epileptic seizure","ALL","45 Years","65 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study aims to evaluate the effects of powered lower-limb exoskeleton-assisted training on lower limb strength, respiratory parameters, 28-day ventilator-free days, and length of hospital stay in patients with prolonged mechanical ventilation admitted to a Respiratory Care Center. The goal is to provide clinical evidence for integrating rehabilitation and respiratory care in this patient population.",[27,28,29,30,31],"Prolonged Mechanical Ventilation","Ventilator Weaning","Ventilator Dependent","Exoskeleton Device","Exercise Training",[33,34,35,36,37],"prolonged mechanical ventilation","ventilator weaning","lower limb muscle strengthening","exoskeleton robot","exercise training","RECRUITING","2026-06-29",{"date":41,"type":42},"2026-07-01","ACTUAL",{"date":44,"type":42},"2026-06-26",{"date":46,"type":21},"2026-12-31",{"name":48,"class":49},"Fu Jen Catholic University","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":62,"conditions":63,"keywords":67,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":50},"100636871","combined-predictive-value-of-rsbi-and-cally-index-in-predicting-weaning-success-in-icu-patients-100636871","NCT07571317","Combined Predictive Value of RSBI and CALLY Index in Predicting Weaning Success in ICU Patients","Combined Predictive Value of Rapid Shallow Breathing Index (RSBI) and CRP-Albumin-Lymphocyte (CALLY) Indices in Predicting the Success of Weaning From Mechanical Ventilation in Intensive Care Patients: A Prospective Observational Study","Inclusion Criteria:\n\n* Patients aged 18 years and older\n* Patients who have received invasive mechanical ventilation for at least 24 hours in the general intensive care unit.\n\nPatients who meet standard clinical weaning criteria (e.g., hemodynamic stability with minimal or no vasopressor support, adequate cough reflex, absence of excessive airway secretions).\n\nPatients deemed ready for a Spontaneous Breathing Trial by the attending physician.\n\nExclusion Criteria:\n\n* Patients under the age of 18.\n* Patients with a known or detected pregnancy.\n* Patients with a diagnosis of malignancy.\n* Patients with neuromuscular diseases that could impair respiratory effort or muscle strength assessments (e.g., Myasthenia Gravis, Amyotrophic Lateral Sclerosis, Guillain-Barré syndrome).","18 Years",{"count":60,"type":21},105,"OBSERVATIONAL","The primary objective of this prospective observational study is to evaluate the effectiveness of combining the Rapid Shallow Breathing Index (RSBI) and CRP-Albumin-Lymphocyte (CALLY) index to predict weaning success in adult patients within the intensive care unit. While weaning from mechanical ventilation is a critical clinical step, existing physiological metrics like RSBI do not fully capture a patient's inflammatory or nutritional status. This research introduces the CALLY index calculated as the ratio of the patient's immuno-nutritional reserve (Albumin and Lymphocytes) to systemic inflammation (CRP) as a complementary metabolic marker. By tracking approximately 105 participants at Basaksehir Cam and Sakura City Hospital, the study monitors weaning success over both a 48 hour and a 7 day period to identify both immediate and late phase extubation failures. The ultimate goal is to provide a more holistic prediction model that potentially reduces re-intubation rates and improves clinical outcomes by accurately identifying the optimal time for ventilator removal.",[64,65,28,66],"Critical Illness","Respiratory Insufficiency","Weaning Failure of Mechanical Ventilation",[68,34,69,70],"mechanical ventilation","Systemic Inflammation","CRP-Albumin-Lymphocyte Ratio","2026-05-06",{"date":73,"type":42},"2026-05-11",{"date":75,"type":21},"2026-05-04",{"date":77,"type":21},"2026-07-31",{"name":79,"class":49},"Istanbul University - Cerrahpasa",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":88,"enrollmentInfo":89,"targetDuration":91,"studyType":61,"phases":4,"briefSummary":92,"conditions":93,"keywords":101,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":5},"100600524","a-new-tool-for-extubation-readiness-in-mechanically-ventilated-patients-readiness-for-extubation-score-100600524","NCT07098611","A New Tool for Extubation Readiness in Mechanically Ventilated Patients: Readiness for EXtubation Score","A New Tool for Extubation Readiness in Mechanically Ventilated Patients: Readiness for EXtubation Score (REXs STUDY)","REXs","Inclusion Criteria:\n\n\\- Patients who are in the weaning process from mechanical ventilation after being connected to invasive mechanical ventilation in the intensive care unit.\n\nExclusion Criteria:\n\n* Patients without legal guardian consent.\n* Tracheostomized patients.\n* Patients enrolled in other studies.\n* Individuals with diaphragmatic pacers.\n* Pregnant patients.","89 Years",{"count":90,"type":21},470,"6 Weeks","Liberation from mechanical ventilation involves three steps: weaning, readiness assessment, and extubation. Readiness is determined using clinical criteria such as improvement of the underlying condition, hemodynamic stability, and adequate respiratory effort. Successful extubation is defined as not requiring invasive support within 48 hours. Due to the complexity of ICU patients, various clinical parameters and multi-component scores have been developed to predict extubation success. This study aims to develop and evaluate a multi-component score, the Readiness for EXtubation score (REXs), to predict extubation readiness in ICU patients under invasive mechanical ventilation.",[28,94,95,96,97,98,99,100],"Respiration, Artificial","Respiratory Failure","Extubation Readiness","Extubation Failure","Extubation Succeeded","Intensive Care Patients Invasively Ventilated","Weaning Invasive Mechanical Ventilation",[68,102,103,104,105,106],"extubation","weaning","readiness","prediction","score","2026-04-29",{"date":109,"type":42},"2026-05-05",{"date":111,"type":42},"2025-06-15",{"date":113,"type":21},"2026-12-30",{"name":115,"class":49},"Medipol University",{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":4,"eligibilityCriteria":122,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":4,"enrollmentInfo":123,"targetDuration":125,"studyType":61,"phases":4,"briefSummary":126,"conditions":127,"keywords":129,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":50},"100540823","weaning-ventilator-using-heart-lung-and-diaphragm-ultrasound-100540823","NCT06321848","Weaning Ventilator Using Heart, Lung And Diaphragm Ultrasound","The Predictive Value Of Heart, Lung And Diaphragm Ultrasound For Ventilator Weaning Outcome Of Surgical Intensive Care Patients","Inclusion Criteria:\n\n* Age \\>= 18\n* The duration of postoperative mechanical ventilation \\>= 48 hours\n\nExclusion Criteria:\n\n* Patient had a diagnosis of progressive neuromuscular diseases\n* Patient had a history of cardiovascular or respiratory disease who depend on a ventilator at home (COPD, severe bronchial asthma)\n* Patients had thoracic surgery or mitral valve surgery.",{"count":124,"type":21},190,"30 Days","Postextubation distress is detrimental to the prognosis of critically ill patients with successful spontaneous breathing trial. Failure to wean is known to be connected with heart, lung, and diaphragm problems. The aim of this study was to investigate how a composite model comprising diaphragm, lung, and heart ultrasonography indications could predict the weaning outcome.\n\nMethods: Ultrasonic features of the diaphragm, heart, and lungs are going to be collected along with clinical data about the patients. Either the successful weaning group or the failed weaning group is going to comprised the patients. Multivariate logistic regression analysis is going to be used to identify the variables that may be associated with the likelihood of weaning failure. A multiindicator combination model is going to be developed to increase the predictive accuracy after the possible indicators' accuracy in foretelling the weaning outcome was assessed.",[28,128],"Ultrasound",[130,131,132,34],"echocardiography","lung ultrasound","diaphragm ultrasound","2026-02-01",{"date":135,"type":42},"2026-02-03",{"date":137,"type":42},"2024-04-22",{"date":139,"type":21},"2026-04",{"name":141,"class":49},"Hanoi Medical University",{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":148,"eligibilityCriteria":149,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":4,"enrollmentInfo":150,"targetDuration":4,"studyType":22,"phases":152,"briefSummary":153,"conditions":154,"keywords":155,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":172},"100554461","instrumental-respiratory-physiotherapy-in-difficult-to-wean-icu-patients-100554461","NCT06499389","Instrumental Respiratory Physiotherapy in Difficult-to-wean ICU Patients","Randomized Controlled Trial Evaluating the Impact of Intensive, Instrumental and Early Respiratory Physiotherapy on Peak Expiratory Flow in Mechanically Ventilated Patients With ICU-acquired Muscle Weakness","PHYSIO WEAN","Inclusion Criteria:\n\n* Patient 18 years or more, affiliated to a social security system\n* Patients on invasive mechanical ventilation for 48 hours or more\n* Failure of at least one mechanical ventilation weaning test (spontaneous breathing trial, SBT)\n* First successful SBT on the day of eligibility assessment\n* Medical Research Council (MRC) score \\\u003C 48 and\u002For cough strength ≤ 2 on the 6-point Likert scale\n\nExclusion Criteria:\n\n* Recent brain injury (\\\u003C 3 months, stroke, cardiopulmonary arrest)\n* Delirium tremens (Cushman score \\> 7)\n* Chronic neuromuscular pathology\n* Patient under continuous intravenous sedation\n* Patient unresponsive to simple commands and Richmond Agitation and Sedation Scale (RASS) score \\\u003C -2 or \\> +1\n* FiO2: Inspired Oxygen Fraction\\> 50%, percutaneous, O2: oxygen saturation \\\u003C 88%, positive end-expiratory pressure \\> 5 centimeter of water (cmH2O) or respiratory rate ≥ 35 min-1\n* Vasopressor catecholamine at a dose \\> 0.5 μg\u002Fkg\u002Fmin\n* Tracheostomized patient\n* Undrained pneumothorax\n* Pulmonary emphysema (identified as antecedent in medical record)\n* Uncontrolled hemoptysis\n* Surgery \\\u003C 3 months of esophagus and\u002For the ear, nose and throat (ENT) sphere\n* Pregnancy or lactating\n* Patient deprived of liberty by judicial or administrative decision\n* Patient under guardianship or curatorship\n* Patient already included in the same study or in another study sharing the same primary endpoint",{"count":151,"type":21},50,[24],"Difficult ventilatory weaning is associated with a 20% mortality rate. 40% of these patients will develop intensive care unit (ICU)-acquired neuromyopathy, associated with reduced cough strength and a 4-fold increase in the risk of reintubation. The objective measure of cough strength is peak expiratory flow (PEF). Instrument-assisted coughing is a respiratory physiotherapy technique capable of significantly increasing PEF in chronic neuromuscular patients and draining bronchial secretions.\n\nThe objective of the study is to determine whether an early, systematic, instrumental, intensive respiratory physiotherapy strategy in patients with difficult ventilatory weaning and ICU-acquired neuromyopathy significantly improves PEF immediately prior to extubation, compared with a conventional, protocolized management strategy.",[28],[156,68,157,158,159,160,102,161,162],"critical care","ventilatory weaning","peak cough expiratory flow","cough strength","mechanical cough","reintubation","chest physiotherapy","2026-01-16",{"date":165,"type":42},"2026-01-20",{"date":167,"type":42},"2025-03-18",{"date":169,"type":21},"2027-05-01",{"name":171,"class":49},"Hospices Civils de Lyon",3,{"id":174,"slug":175,"hasResults":11,"nctId":176,"briefTitle":177,"officialTitle":178,"acronym":4,"eligibilityCriteria":179,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":4,"enrollmentInfo":180,"targetDuration":182,"studyType":61,"phases":4,"briefSummary":183,"conditions":184,"keywords":190,"overallStatus":198,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":206,"locationsCount":4},"100602202","comparison-of-diaphragm-ultrasound-and-rsbi-for-predicting-weaning-success-in-mechanically-ventilated-icu-patients-100602202","NCT07120438","Comparison of Diaphragm Ultrasound and RSBI for Predicting Weaning Success in Mechanically Ventilated ICU Patients","Comparison Between Diaphragmatic Ultrasound and Rapid Shallow Breathing Index (RSBI) in Predicting Weaning Success in Patients on Mechanical Ventilation for More Than 48 Hours in the ICU of Dr. Sardjito Hospital, Yogyakarta","Inclusion Criteria:\n\n1. Patients who have been on mechanical ventilation for more than 48 hours\n2. Adult patients aged ≥18 years\n3. Patients who meet the criteria for hemodynamic stability for weaning\n4. Patients or their families have provided written informed consent\n5. Patients with FiO₂ \\\u003C 50%, PEEP level \\\u003C 5 cm H₂O, respiratory rate \\\u003C 30 breaths per minute, PaO₂\u002FFiO₂ \\> 200, and GCS \\> 13\n6. Patients who have successfully completed the Spontaneous Awakening Trial (SAT) and Spontaneous Breathing Trial (SBT)\n\nExclusion Criteria:\n\n1. Patients with neuromuscular disorders, anatomical abnormalities of the diaphragm, or diaphragmatic palsy\n2. Patients with a history of severe thoracic trauma affecting diaphragm function on one or both sides\n3. Pregnancy",{"count":181,"type":21},55,"2 Days","The goal of this observational study is to evaluate the predictive value of diaphragmatic ultrasound compared to the Rapid Shallow Breathing Index (RSBI) in determining weaning success among mechanically ventilated patients in the ICU for more than 48 hours.\n\nThe main question it aims to answer is:\n\nWhich is more effective in predicting weaning success: diaphragmatic ultrasound (including Diaphragmatic Excursion \\[DE\\] and Diaphragm Thickening Fraction \\[DTF\\]) or RSBI, in patients ventilated \\>48 hours in the ICU of Dr. Sardjito General Hospital, Yogyakarta?\n\nParticipants will be adult ICU patients who are undergoing weaning from mechanical ventilation after more than 48 hours. Before extubation, each participant will undergo diaphragmatic ultrasound assessment to measure DE and DTF, along with RSBI measurement. The predictive accuracy of these parameters will be evaluated by comparing them with the actual weaning outcomes.\n\nSecondary objectives include:\n\n1. Assessing whether diaphragmatic ultrasound is associated with a higher weaning success rate than RSBI.\n2. Evaluating the correlation between DE values and successful weaning.\n3. Determining the optimal cutoff values of DE and DTF as predictors of weaning failure.\n4. Analyzing the incidence of weaning failure in patients who do not meet optimal diaphragm function criteria.\n5. Identifying DE and DTF thresholds that may help reduce the risk of reintubation.",[28,185,186,187,188,189],"Mechanical Ventilation","Respiratory Insufficiency Requiring Mechanical Ventilation","Weaning From Mechanical Ventilation","Weaning From Mechanical Ventilation in Care Unit","Intensive Care Unit Patients",[191,192,193,194,195,196,197],"Diaphragmatic Ultrasound","Rapid Shallow Breathing Index","Diaphragm Thickening Fraction","Diaphragm Excursion","Weaning Prediction","ICU","Weaning Failure","NOT_YET_RECRUITING","2025-08-06",{"date":201,"type":42},"2025-08-13",{"date":203,"type":21},"2025-08",{"date":205,"type":21},"2026-03",{"name":207,"class":49},"Gadjah Mada University",{"id":209,"slug":210,"hasResults":11,"nctId":211,"briefTitle":212,"officialTitle":212,"acronym":213,"eligibilityCriteria":214,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":4,"enrollmentInfo":215,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":217,"conditions":218,"keywords":230,"overallStatus":198,"whyStopped":4,"lastUpdateSubmitDate":231,"lastUpdatePostDateStruct":232,"startDateStruct":234,"completionDateStruct":236,"leadSponsor":238,"locationsCount":50},"100566342","study-of-sleep-quality-in-the-intensive-care-unit-and-association-with-weaning-from-invasive-ventilation-in-patients-with-chronic-obstructive-bronchopneumopathy-100566342","NCT06653933","Study of Sleep Quality in the Intensive Care Unit and Association with Weaning from Invasive Ventilation in Patients with Chronic Obstructive Bronchopneumopathy.","SLEECOP","Inclusion Criteria:\n\n* Patients diagnosed with COPD according to the GOLD criteria.\n* Mechanical ventilation by endotracheal tube and mechanical ventilation for \\> 24 hours.\n* Withdrawal of treatment with continuous sedation and\u002For neuroleptics.\n* Adequate recovery with Glasgow Coma Scale ≥ 8.\n\nExclusion Criteria:\n\n* Patients with central nervous system damage or neuromuscular pathology.\n* Pregnant or postpartum patients.\n* Patients or their relatives who object to participating in the study.",{"count":216,"type":21},42,"Patients admitted in ICU may require invasive mechanical ventilation, using a mechanical ventilator and an endotracheal tube.\n\nIn ICU, a prolonged duration of invasive mechanical ventilation may be responsible for ventilator-induced lung injury, pulmonary infection, prolonged administration of sedation, neuromyopathy and prolonged length of stay. The goal of the ICU healthcare teams is therefore to reduce the duration of invasive mechanical ventilation as much as possible.\n\nICU patients have many sleep disturbances: sleep fragmentation, sleep stage changes, changes in sleep architecture. These sleep disturbances are due to sedation and analgesia, delirium, patient care activities, noise and altered day-night cycles.\n\nChronic obstructive pulmonary disease (COPD) is a common respiratory disease. COPD complicates the management of invasive mechanical ventilation, particularly weaning of this invasive mechanical ventilation and extubation (removal of the intubation tube).\n\nTo reduce the risk of reintubation, it is recommended that a weaning test is performed prior to extubation. The purpose of this test is to simulate the conditions of breathing without the help of a ventilator after extubation. If the weaning test is successful, the patient can theoretically be extubated.\n\nThere are several causes associated with extubation failure, but studies suggest that sleep deprivation or poor sleep quality in the nights before extubation is one of them. In addition, patients with COPD often have chronic sleep disturbances or induced by their stay in the ICU (asthenia, bed rest, anxiety, sedation, etc.).\n\nThe aim of our study will be to compare the sleep characteristics of COPD patients with a failed weaning test and those with a successful test. Our hypothesis is that patients with a failed weaning test will have more sleep disturbances in the period of 72 hours before the weaning test.",[219,220,221,222,28,223,224,225,226,227,228,229],"COPD","COPD Exacerbation","Ventilated Patients","Ventilator-Associated Pneumonia (VAP)","Weaning of Mechanical Ventilation","Sleep Quality","Sleep Disorders, Circadian Rhythm","Sleep Disorders","Failure, Respiratory","ICU Hospitalization","ICU Sedation",[219,224,223],"2024-10-21",{"date":233,"type":42},"2024-10-23",{"date":235,"type":21},"2025-01-01",{"date":237,"type":21},"2027-07-01",{"name":239,"class":49},"University Hospital, Grenoble"]