[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ventilatory-failure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ventilatory-failure":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,41,74,96],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100380679","investigating-health-related-quality-of-life-in-patients-with-chronic-respiratory-failure-100380679",false,"NCT04236726","Investigating Health Related Quality of Life in Patients With Chronic Respiratory Failure","CRF-QoL","Inclusion Criteria:\n\nDiagnosed with chronic respiratory failure receiving any of:\n\n* Non-invasive ventilation\n* Prolonged mechanical ventilation\n* Mechanical insufflation-exsufflation therapy\n\nExclusion Criteria:\n\n* Aged \\\u003C18\n* Significant physical or psychiatric co-morbidity that would prevent compliance with trial protocol","ALL","18 Years",{"count":19,"type":20},200,"ESTIMATED","OBSERVATIONAL","To determine the quality of life of patients living with chronic respiratory failure and the impact interventions have on it.",[24,25,26,27],"Chronic Obstructive Pulmonary Disease","Respiratory Failure","Neuromuscular Diseases","Ventilatory Failure","RECRUITING","2026-06-03",{"date":31,"type":32},"2026-06-04","ACTUAL",{"date":34,"type":32},"2019-12-19",{"date":36,"type":20},"2026-12-31",{"name":38,"class":39},"Guy's and St Thomas' NHS Foundation Trust","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":49,"targetDuration":51,"studyType":21,"phases":4,"briefSummary":52,"conditions":53,"keywords":57,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":40},"100571147","predicting-failure-of-non-invasive-ventilatory-support-using-non-invasive-monitoring-in-non-intubated-patients-with-acute-hypoxemic-respiratory-failure-or-post-extubation-failure-the-prevision-study-100571147","NCT06716463","PREdicting Failure of Non-inVasIve Ventilatory Support Using Non-invaSIve mONitoring in Non-intubated Patients With Acute Hypoxemic Respiratory Failure or Post-extubation Failure. The PREVISION Study","PREdicting Failure of Non-inVasIve Ventilatory Support Using Non-invaSIve mONitoring in Non-intubated Patients With Acute Hypoxemic Respiratory Failure or Post-extubation Failure: the PREVISION Study","PREVISION","Inclusion Criteria:\n\n* Age of ≥ 18 years\n* Using NIV or HFNC anywhere in the hospital\n\nExclusion Criteria:\n\n* Chronic CO2 retention\n* Neuromuscular disorder\n* Requiring home NIV (CPAP or BIPAP)\n* Tracheostomy\n* Contraindication to EIT placement: pacemaker\u002Fdefibrillator implantation, burns at the area of EIT placement",{"count":50,"type":20},80,"3 Months","The goal of this observational study is to assess the potential non-invasive tools (e.g. regional ventilation, respiratory muscle response, lung mechanic's parameters) to identify the risk of failure when using high flow nasal cannula (HFNC) or non-invasive ventilation (NIV).\n\nThe main question, it aims to answer is:\n\nDoes abnormal regional ventilation could predict HFNC or NIV failure?",[27,54,55,56],"Hypoxemic Respiratory Failure","Weaning Failure","Respiratory",[58,59,60,61,62,63,64],"Electrical impedance tomography","High flow nasal cannula","Non-invasive ventilation","Diaphragm","Weaning failure","Post-extubation","Hypoxemic respiratory failure","2025-05-15",{"date":67,"type":32},"2025-05-20",{"date":69,"type":32},"2025-01-27",{"date":71,"type":20},"2025-06",{"name":73,"class":39},"Unity Health Toronto",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":82,"conditions":83,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":94,"locationsCount":40},"100399707","lung-barometric-measurements-in-normal-and-in-respiratory-distressed-lungs-100399707","NCT04484727","\"Lung Barometric Measurements in Normal And in Respiratory Distressed Lungs\"","LUNAR","Inclusion Criteria:\n\n* Patients above18 years\n* ASA 1-3\n* Planned\u002Facute ventilator treatment in ICU or OR\n\nExclusion Criteria:\n\n* Patients under 18 years\n* ASA 4 and above\n* severe COPD\u002Femphysema\u002Fheart failure\n* PEEP\\>16 and\u002For FiO2 \\>80%\n* elevated intracranial pressure\n* defect coagulation\n* non-treated known or suspected pneumothorax",{"count":19,"type":20},"Little is known about how lung mechanics are affected during the very early phase after starting mechanical ventilation. Since the conventional method of measuring esophageal pressure is complicated, hard to interpret and expensive, there are no studies on lung mechanics on intensive care patients directly after intubation, during the first hours of ventilator treatment and forward until the ventilator treatment is withdrawn. Published studies have collected data using the standard methods from day 1 to 3 of ventilator treatment for respiratory system mechanics, i.e. the combined mechanics of lung and chest wall. Consequently, information on lung mechanical properties during the first critical hours of ventilator treatment is missing and individualization of ventilator care done on the basis of respiratory system mechanics, which are not representative of lung mechanics on an individual patient basis. We have developed a PEEP-step method based on a change of PEEP up and down in one or two steps, where the change in end-expiratory lung volume ΔEELV) is determined and lung compliance calculated as ΔEELV divided by ΔPEEP (CL = ΔEELV\u002FΔPEEP). This simple non-invasive method for separating lung and chest wall mechanics provides an opportunity to enhance the knowledge of lung compliance and the transpulmonary pressure. After the two-PEEP-step procedure, the PEEP level where transpulmonary driving pressure is lowest can be calculated for any chosen tidal volume.\n\nThe aim of the present study in the ICU is to survey lung mechanics from start of mechanical ventilation until extubation and to determine PEEP level with lowest (least injurious) transpulmonary driving pressure during ventilator treatment. The aim of the study during anesthesia in the OR, is to survey lung mechanics in lung healthy and identify patients with lung conditions before anesthesia, which may have an increased risk of postoperative complications.",[84,27,85,86,87],"Ventilator-Induced Lung Injury","Ventilator Lung","Ventilation Therapy; Complications","Ventilator Associated Pneumonia","2025-03-13",{"date":90,"type":32},"2025-03-17",{"date":92,"type":32},"2022-05-01",{"date":36,"type":20},{"name":95,"class":39},"Göteborg University",{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":100,"acronym":101,"eligibilityCriteria":102,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":103,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":105,"conditions":106,"keywords":4,"overallStatus":109,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":4},"100564670","non-invasive-monitoring-of-mixed-venous-oxygen-saturation-using-the-capnodynamic-method-in-adults-100564670","NCT06632197","Non-invasive Monitoring of Mixed Venous Oxygen Saturation Using the Capnodynamic Method in Adults","CAPNO-SVO2","Inclusion Criteria:\n\n* Age \\> 18 years\n* Not participating in any other interventional study at the time of the study.\n* Patients under controlled mechanical ventilation in passive conditions.\n* Situations where the responsible physician deems that, for the benefit of clinical management and therapeutic decision-making, the patient would benefit from the placement of a pulmonary artery catheter (Swan-Ganz) and\u002For monitoring of central or mixed venous saturation.\n* Obtaining informed consent.\n\nExclusion Criteria:\n\n* Failure to obtain informed consent.\n* No need for invasive mechanical ventilation.",{"count":104,"type":20},25,"The objective of this study is to compare the accuracy and correlation of the capnodynamic method for measuring mixed venous oxygen saturation (SvO2) with the standard reference method (pulmonary artery catheter), with the potential for the capnodynamic method to replace the traditional method in selected cases.",[27,107,108],"Cardiac Failure","Mechanical Ventilation Pressure High","NOT_YET_RECRUITING","2024-10-08",{"date":112,"type":32},"2024-10-10",{"date":114,"type":20},"2024-12",{"date":116,"type":20},"2025-08",{"name":118,"class":39},"Fundación de Investigación Biomédica - Hospital Universitario de La Princesa"]