[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ventral-hernia-repair\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ventral-hernia-repair":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,40],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":4},"100622541","orion-study-mesh-position-and-risk-during-subsequent-minimally-invasive-abdominal-surgery-100622541",false,"NCT07384962","ORION Study: Mesh Position and Risk During Subsequent Minimally Invasive Abdominal Surgery","Prospective Evaluation of the Impact of Prior Ventral Hernia Repair on Subsequent Reoperations and Neurological Sequelae, Comparing Intra-peritoneal vs. Extra-peritoneal Mesh Placement: the ORION Study","ORION","Inclusion Criteria\n\n* Adults aged 18 years or older.\n* Patients who previously underwent minimally invasive ventral hernia repair (primary, incisional, or recurrent) with intraperitoneal or extraperitoneal mesh placement.\n* Patients scheduled to undergo elective or emergency minimally invasive abdominal surgery for any indication (including, but not limited to, hernia recurrence, bowel obstruction, cholecystectomy, colorectal, or gynecologic procedures).\n* Patients in whom an initial minimally invasive approach is attempted, even if conversion to open surgery occurs after exploratory access or adhesiolysis.\n* Ability to provide written informed consent, according to local regulations.\n\nExclusion Criteria\n\n* Patients undergoing primary open abdominal surgery without an initial minimally invasive approach.\n* Patients with a history of open ventral hernia repair as the index hernia procedure.\n* Patients without available information on prior mesh position.\n* Patients who decline or are unable to provide informed consent.","ALL","18 Years",{"count":20,"type":21},790,"ESTIMATED","OBSERVATIONAL","Ventral hernia repair is one of the most commonly performed abdominal surgical procedures worldwide, increasingly carried out using minimally invasive techniques. In this setting, mesh reinforcement is standard practice, but the optimal anatomical plane for mesh placement remains debated. Intraperitoneal and extraperitoneal mesh positions may have different long-term consequences, particularly when patients undergo subsequent abdominal surgery. However, prospective data evaluating the impact of prior mesh position on reoperative risk and postoperative outcomes are limited.\n\nThe ORION study is a prospective, multicentre, observational cohort study designed to evaluate the impact of prior minimally invasive ventral hernia repair with intraperitoneal versus extraperitoneal mesh placement on subsequent minimally invasive abdominal surgery. The primary objective is to compare the incidence of intraoperative visceral injury during adhesiolysis between the two mesh positions. Secondary objectives include the assessment of adhesion burden and severity, duration and extent of adhesiolysis, conversion to open surgery, and adhesion-related postoperative complications.\n\nIn a predefined subgroup of patients undergoing surgery for ventral hernia recurrence, the study also evaluates short-term postoperative outcomes, including chronic post-surgical pain, neuropathic pain features, sensory disturbances, and analgesic use.\n\nBy prospectively collecting standardized intraoperative and postoperative data across multiple centres, the ORION study aims to provide real-world evidence on the long-term surgical and functional implications of mesh positioning in minimally invasive ventral hernia repair.",[25],"Ventral Hernia Repair",[27],"ventral hernia","NOT_YET_RECRUITING","2026-06-11",{"date":31,"type":32},"2026-06-12","ACTUAL",{"date":34,"type":21},"2026-06-30",{"date":36,"type":21},"2027-01-31",{"name":38,"class":39},"Istituto Auxologico Italiano","OTHER",{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":50,"phases":51,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":77},"100635163","comparative-evaluation-of-preoperative-preparation-methods-in-patients-with-large-incisional-hernias-100635163","NCT07549113","Comparative Evaluation of Preoperative Preparation Methods in Patients With Large Incisional Hernias","Comparative Evaluation of Different Preoperative Optimization Strategies in Patients With Large, Complex, and Giant Incisional Hernias","AWR-PREP","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Patients with ventral incisional hernia requiring elective surgical repair\n* Large and\u002For complex hernia defects requiring preoperative preparation\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Age under 18 years\n* Emergency surgery\n* Pregnancy\n* Contraindications to botulinum toxin A injection or progressive pneumoperitoneum\n* Severe uncontrolled comorbidities precluding surgery\n* Inability or refusal to provide informed consent",{"count":49,"type":21},120,"INTERVENTIONAL",[52],"NA","Patients with large, complex, or giant incisional hernias often require advanced preoperative optimization to facilitate safe abdominal wall reconstruction and reduce postoperative complications. Several strategies are currently used in clinical practice, including botulinum toxin A injection, progressive preoperative pneumoperitoneum, and their combination. However, the optimal differentiated approach based on hernia characteristics and abdominal wall tissue deficiency remains unclear.\n\nThis study aims to compare the effectiveness and safety of different preoperative preparation strategies in patients with large postoperative ventral hernias and loss of abdominal wall domain. Outcomes of patients receiving botulinum toxin A, progressive preoperative pneumoperitoneum, combined preparation, or no specific preparation will be analyzed.\n\nThe study will evaluate operative feasibility, ability to achieve fascial closure, postoperative complications, recurrence, and overall treatment outcomes.",[55,25],"Incisional Hernia Repair",[57,58,59,60,61,62,63,64,65],"Giant incisional hernia","Complex abdominal wall reconstruction","Botulinum toxin A","Progressive pneumoperitoneum","Preoperative optimization","Component separation","Hernia repair","Loss of domain","Ventral hernia surgery","RECRUITING","2026-04-16",{"date":69,"type":32},"2026-04-23",{"date":71,"type":32},"2024-04-01",{"date":73,"type":21},"2028-05-01",{"name":75,"class":76},"State Budget Public Health Institution Scientific Research Institute - Ochapovsky Regional Clinical Hospital","OTHER_GOV",1]