[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ventral-hernia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ventral-hernia":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,51,81,109,139,168,192,213,235,255,289,326,346,366],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100613507","image-guided-herniorrhaphy-study-100613507",false,"NCT07267494","Image-Guided Herniorrhaphy Study","Image-guided Herniorrhaphy Safety and Efficacy Pilot","Inclusion Criteria:\n\n* English-speaking adult with reducible hernia(s) or diastasis smaller than approximately 8 cm seeking treatment for their hernia but not able or willing to undergo traditional surgery (open, laparoscopic, or robotic)\n* Patient must be willing to undergo a novel 30- to 60-minute image-guided needle-based procedure\n\nExclusion Criteria:\n\n* Children, prisoners, and pregnant women (possibly requiring a pregnancy test on the day of the procedure)\n* Patients with a known reaction to local anesthetic or sedation medications or the suture material to be used\n* Patients with irreducible hernias\n* Patients with herniation not visible by ultrasound or CT\n* Patients that do not fit the diameter of a CT gantry or the weight limit of the procedural CT table\n* Patients without insurance or not willing to pay out-of-pocket for the study procedure","ALL","18 Years",{"count":19,"type":20},30,"ESTIMATED","INTERVENTIONAL",[23],"NA","This pilot clinical study will evaluate the safety and effectiveness of a new image-guided, needle-based approach for repairing abdominal or groin hernias in adults who are unable or unwilling to undergo traditional open or laparoscopic surgery. The technique uses ultrasound and, when needed, CT imaging to guide a hollow needle preloaded with barbed suture through the skin to close the hernia defect without large incisions or general anesthesia. Each participant will undergo one image-guided procedure and will be followed for eight months to assess complications and changes in hernia-related quality of life. Approximately thirty participants will be enrolled. The study aims to determine whether this minimally invasive approach is safe, feasible, and capable of improving hernia symptoms enough to justify a larger clinical trial",[26,27,28,29,30,31],"Hernia","Hernia Abdominal Wall","Ventral Hernia","Inguinal Hernia","Hiatal Hernia","Diastasis Recti",[33,34,35,36,37],"Image-guided herniorrhaphy","hernia","pilot study","quality of life","safety and feasability","NOT_YET_RECRUITING","2026-06-12",{"date":41,"type":42},"2026-06-16","ACTUAL",{"date":44,"type":20},"2026-12-01",{"date":46,"type":20},"2029-05-01",{"name":48,"class":49},"University of California, Davis","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":21,"phases":61,"briefSummary":63,"conditions":64,"keywords":65,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":80},"100610377","phase-2-study-of-agn-151607-dp-to-assess-adverse-events-and-change-in-disease-activity-in-adult-participants-undergoing-open-abdominal-ventral-hernia-repair-100610377","NCT07226791","Study of AGN-151607-DP to Assess Adverse Events and Change in Disease Activity in Adult Participants Undergoing Open Abdominal Ventral Hernia Repair","A Phase 2 Double-Blind, Placebo-Controlled, Adaptive, Dose-Escalation Study to Evaluate the Safety and Efficacy of AGN-151607-DP (USAN: gemibotulinumtoxinA) for the Achievement of Primary Fascial Closure Without the Use of Component Separation Technique, in Subjects Undergoing Open Abdominal Ventral Hernia Repair","Inclusion Criteria:\n\n\\- Midline ventral hernia requiring open surgical repair.\n\nExclusion Criteria:\n\n* Medical condition that may put the participant at increased risk with exposure to AGN-151607-DP, including diagnosed muscular dystrophy (e.g., Duchenne's muscular dystrophy), myasthenia gravis, Eaton-Lambert syndrome, amyotrophic lateral sclerosis, mitochondrial disease, or any other significant disease which might interfere with neuromuscular function.\n* History of abdominal or hernia repair surgery requiring hospitalization within 6 months prior to screening.","80 Years",{"count":60,"type":20},200,[62],"PHASE2","A ventral hernia happens when the muscles in the front of your belly become weak and let organs push through, causing a bulge. If it gets worse, intestines can slip into the bulge, leading to serious pain and health problems. This study aims to asses if AGN-151607-DP is safe and effective for closing the belly wall after open ventral hernia surgery, without needing a complex procedure. Adverse Events and change in disease activity will be assessed.\n\nAGN-151607-DP is an investigational drug being developed to treat ventral hernia. Participants will be randomly placed in treatment groups to receive either AGN151607-DP or matching placebo. Approximately 200 adult participants with midline ventral hernia needing open surgical repair will be enrolled in approximately 30 sites in the United States.\n\nParticipants will receive intramuscular injections of AGN-161607-DP or matching placebo on Day 1. Duration of the study is approximately 25 months.\n\nThere may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular weekly visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.",[28],[28,66,67,68],"AGN-151607-DP","Primary fascial closure","Open Abdominal Ventral Hernia Repair","RECRUITING","2026-06-09",{"date":72,"type":42},"2026-06-11",{"date":74,"type":42},"2026-02-04",{"date":76,"type":20},"2030-05",{"name":78,"class":79},"AbbVie","INDUSTRY",11,{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":89,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":90,"targetDuration":4,"studyType":21,"phases":91,"briefSummary":92,"conditions":93,"keywords":94,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":108},"100475596","robotic-versus-open-ventral-hernia-repair-100475596","NCT05472987","Robotic Versus Open Ventral Hernia Repair","Robotic Versus Open Ventral Hernia Repair: A Randomized Controlled Trial","ROVHR","Inclusion Criteria:\n\n* 18 years and older\n* 7 cm to 15 cm wide hernia midline defects\n* BMI less than or equal to 45\n* Patient deemed both an open and robotic candidate by operating surgeon\n\nExclusion Criteria:\n\n* 17 years old or younger\n* prisoners\n* pregnant patients\n* Emergent patients\n* BMI greater than 45\n* Hernia defects less than 7 cm or greater than 15 cm in width",true,{"count":60,"type":20},[23],"This is a randomized trial comparing open retromuscular ventral hernia repair to robotic retromuscular ventral hernia repair.",[28],[95,26,96,97,98],"Robotic","Ventral hernia","Open hernia","Mesh","2025-10-02",{"date":101,"type":42},"2025-10-07",{"date":103,"type":42},"2022-07-25",{"date":105,"type":20},"2027-08-01",{"name":107,"class":49},"Lucas Beffa",4,{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":4,"eligibilityCriteria":115,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":116,"enrollmentInfo":117,"targetDuration":4,"studyType":21,"phases":119,"briefSummary":120,"conditions":121,"keywords":125,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":50},"100605477","comparison-of-two-plane-blocks-used-in-open-ventral-hernia-repair-operations-100605477","NCT07163026","Comparison of Two Plane Blocks Used in Open Ventral Hernia Repair Operations","Comparison of Analgesic Efficacy of Erector Spinae Plane Block and External Oblique-Intercostal Plane Block in Patients Undergoing Open Ventral Hernia Repair","Inclusion Criteria:\n\n* Patients scheduled for open ventral hernia repair under general anesthesia\n* Patients with ASA scores (American Society of Anesthesiologists) 1 and 2\n* Patients with a body mass index between 18.5 and 34.9\n\nExclusion Criteria:\n\n* Patients scheduled for open ventral hernia repair under spinal or epidural anesthesia\n* Patients who have previously undergone spine surgery.\n* Patients with known local anesthetic allergy\n* Pregnant women\n* Mentally uncooperative patients\n* Patients with a history of chronic analgesic use","65 Years",{"count":118,"type":20},50,[23],"The aim of this study is to compare the postoperative analgesic efficacy of bilateral erector spinae plane block and bilateral external oblique-intercostal plane block in patients undergoing open ventral hernia repair.",[28,122,123,124],"Postoperative Pain","Postoperative Nausea","Postoperative Vomiting",[126,127,128],"erector spinae plane block","external oblique intercostal plane block","bupivacain","2025-09-14",{"date":131,"type":42},"2025-09-16",{"date":133,"type":20},"2025-09-30",{"date":135,"type":20},"2025-12-15",{"name":137,"class":138},"Ankara Ataturk Sanatorium Training and Research Hospital","OTHER_GOV",{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":145,"eligibilityCriteria":146,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":147,"enrollmentInfo":148,"targetDuration":4,"studyType":21,"phases":150,"briefSummary":151,"conditions":152,"keywords":155,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":50},"100604098","the-impact-study-personalized-physical-therapy-for-better-recovery-and-a-stronger-core-after-hernia-surgery-100604098","NCT07145099","The IMPACT Study: Personalized Physical Therapy for Better Recovery and a Stronger Core After Hernia Surgery","The IMPACT Study: A Randomized Controlled Trial of Individualized Management Post Ventral Hernia Repair (VHR) Utilizing Abdominal Core Therapy for Enhanced Recovery and Health Outcomes","IMPACT","Inclusion Criteria:\n\n* Participants must be aged 18-75.\n* Diagnosed clinically or via objective testing by a surgeon with a ventral transverse hernia \\>4 cm and \\\u003C10 cm.\n* Scheduled for elective surgical correction of a non-recurrent, primary or incisional ventral hernia.\n* Independent functional status.\n\nExclusion Criteria:\n\n* Individuals currently receiving or who have received PT within the last 30 days.\n* Individuals currently using an assistive device for ambulation.\n* Individuals diagnosed with a neurologic disorder will be excluded.\n* History of or plan for Botox injection or muscle release related to the hernia.\n* Pregnancy","75 Years",{"count":149,"type":20},100,[23],"The goal of this clinical trial is to evaluate the efficacy, safety, and cost-effectiveness of a tailored physical therapy (PT) intervention targeting Abdominal Core Health components in patients recovering from ventral hernia repair. The study focuses on patients aged 18-75 diagnosed with a ventral transverse hernia between 4 cm and 10 cm, scheduled for elective Ventral Hernia Repair (VHR).\n\nThe main questions it aims to answer are:\n\n* Will tailored PT significantly improve abdominal core strength, biomechanical stability, and functional mobility compared to usual care at 3-months post-surgery?\n* Will tailored PT lead to higher patient-reported quality of life and satisfaction scores, with a lower incidence of post-operative complications such as bowel obstruction and pelvic floor dysfunction over a 1-year follow-up?\n* Will tailored PT result in decreased healthcare utilization, leading to overall cost savings or neutrality compared to usual care over the first year after VHR?\n\nResearchers will compare the tailored physical therapy group to a usual care group to see if the tailored intervention leads to significant improvements in clinical efficacy, patient outcomes, and cost-effectiveness.\n\nParticipants will:\n\n* Be randomly assigned to either the Usual Care Group or the PT Group.\n* If in the Usual Care Group, receive standard post-operative instructions for 12 weeks, including guidance on binder use, safe lifting, and gradual return to activities.\n* If in the PT Group, receive foundational post-operative instructions for the first 2 weeks (similar to usual care). Undergo 6 structured and individualized PT sessions over 10 weeks if in the PT Group, with progression based on Oswestry Disability Index (ODI) and Pelvic Floor Distress Inventory-20 (PFDI-20) scores, including Symptom Modulation, Movement Control, Functional Optimization, or Impairment-Based interventions.\n\nParticipants undergo data collection at 2 weeks, 12 weeks, and 1 year post-operation, including imaging, functional mobility tests, pain scales, patient-reported outcomes, physical measurements, and tracking of complications and healthcare utilization. Participate in semi-structured interviews after the 12-week assessment to provide qualitative insights into their experiences and perceived barriers\u002Ffacilitators.",[28,153,154],"Ventral Incisional Hernia","Post Operative Pain",[156,157,158],"Physical Therapy","Rehabilitation","Economic Impact","2025-09-02",{"date":161,"type":42},"2025-09-10",{"date":163,"type":20},"2026-01-01",{"date":165,"type":20},"2028-01-01",{"name":167,"class":49},"Thomas Jefferson University",{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":174,"eligibilityCriteria":175,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":176,"targetDuration":4,"studyType":21,"phases":178,"briefSummary":179,"conditions":180,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":4},"100544086","open-versus-robotic-retromuscular-repair-in-medium-to-large-ventral-hernias-100544086","NCT06364306","oPen Versus RobotIc retrOmuscular Repair in Medium to Large Ventral Hernias","oPen Versus RobotIc retrOmuscular Repair in Medium to Large Ventral Hernias - the PRIOR Multicentre Randomized Controlled Trial","PRIOR","Inclusion Criteria:\n\n* Patient age \\>18 years\n* Informed consent obtained\n* Transverse diameter of ventral hernia \\>4cm - 15cm\n* Eligible to open and minimally-invasive surgery according to preoperative anaesthetic assessment\n\nExclusion Criteria:\n\n* precedent hernia treatment with mesh placement in the retromuscular space\n* precedent anterior or posterior component separation or transversus abdominis release (TAR)\n* active wound infection\n* current cancer diagnosis\n* presence of ileostomy, colostomy or ileal conduit\n* liver disease defined by the presence of ascites\n* end-stage renal disease requiring dialysis\n* need of an emergency surgery\n* pregnancy\n\nCriteria for participating surgeons Each participating surgeon has performed 20 or more OVHR and RVHR.",{"count":177,"type":20},140,[23],"This study investigates on the effect of two different operative techniques to treat large abdominal wall defects.\n\nThe goal of this clinical trial is to learn if the minimally-invasive, robotically-assisted ventral hernia repair (RVHR) leads to a better outcome than the open ventral hernia repair (OVHR).\n\nThe main questions it aims to answer are:\n\nlength of stay after the operation rate of complications rate of recurrence and reoperations quality of life.\n\nParticipants will:\n\nEither be operated using the RVHR or OVHR will be followed up either in person or via email \u002F phone call at day 7, day 30, 6 months, 1, 3 and 5 years after the surgery to asses the above-stated main and some more outcomes.",[28,181,182],"Incisional Hernia","Abdominal Wall Defect","2025-04-15",{"date":185,"type":42},"2025-04-18",{"date":187,"type":20},"2025-10-01",{"date":189,"type":20},"2031-12-31",{"name":191,"class":49},"University Hospital, Basel, Switzerland",{"id":193,"slug":194,"hasResults":11,"nctId":195,"briefTitle":196,"officialTitle":197,"acronym":198,"eligibilityCriteria":199,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":200,"targetDuration":4,"studyType":21,"phases":202,"briefSummary":203,"conditions":204,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":206,"startDateStruct":208,"completionDateStruct":210,"leadSponsor":212,"locationsCount":50},"100544317","extraperitoneal-plasty-vs-intraperitoneal-onlay-mesh-in-ventral-hernia-repair-100544317","NCT06367309","ExtrAperitoneaL Plasty vs Intraperitoneal oNlay mEsh in Ventral Hernia Repair","ExtrAperitoneaL Plasty vs Intraperitoneal oNlay mEsh in Ventral Hernia Repair - the Randomized Controlled ALPINE Trial","ALPINE","Inclusion Criteria:\n\n* Patient age \\>18 years\n* Informed consent obtained\n* Primary or incisional ventral hernia\n* Epigastric, umbilical or infraumbilical ventral hernias with transversal diameter \\>1cm and \\\u003C\u002F= 4cm, +\u002F- rectus diastasis which doesn't demand specific treatment\n* If multiple hernias: cumulative transversal diameter \\\u003C\u002F= 4cm\n* Considered eligible for minimally-invasive approach\n\nExclusion Criteria:\n\n* Subxyphoidal or suprapubic hernias\n* precedent hernia treatment with mesh placement in the retromuscular space\n* liver disease defined by the presence of ascites\n* end-stage renal disease requiring dialysis\n* need of an emergency surgery\n* pregnancy\n* need of rectus diastasis treatment intraoperatively\n\nCriteria for participating surgeons\n\n\\- Each participating surgeon has performed 20 or more laparoscopic IPOM procedures and 20 or more eTEP procedures.",{"count":201,"type":20},138,[23],"This study investigates on the effect of two different operative techniques to treat abdominal wall hernias.\n\nThe goal of this clinical trial is to learn if the eTEP (Extended totally extraperitoneal repair) technique leads to a better outcome than the IPOM (Intraperitoneal onlay mesh) technique.\n\nThe main questions it aims to answer are:\n\n* pain after the operation\n* rate of complications\n* rate of recurrence and reoperations\n* quality of life.\n\nParticipants will:\n\nEither be operated using the eTEP or the IPOM technique. Be followed up either in person or via email \u002F phone call at day 1, day 7, day 14, 6 weeks, 6 months, 1, 3 and 5 years after the surgery to asses the above-stated main and some more outcomes.",[28,182],"2025-04-08",{"date":207,"type":42},"2025-04-11",{"date":209,"type":42},"2024-07-01",{"date":211,"type":20},"2030-12-31",{"name":191,"class":49},{"id":214,"slug":215,"hasResults":11,"nctId":216,"briefTitle":217,"officialTitle":218,"acronym":219,"eligibilityCriteria":220,"healthyVolunteers":89,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":221,"targetDuration":4,"studyType":21,"phases":222,"briefSummary":223,"conditions":224,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":226,"startDateStruct":228,"completionDateStruct":230,"leadSponsor":232,"locationsCount":234},"100551275","anovo-surgical-system-in-ventral-hernia-100551275","NCT06457971","Anovo Surgical System in Ventral Hernia","Clinical Assessment Protocol: Anovo Surgical System in Ventral Hernia","CLEVER","Inclusion Criteria:\n\n* Subject is at least 18 years old.\n* Subjects able to provide written informed consent.\n* Subject deemed eligible candidate by surgeon and will comply with the study procedures.\n* Subjects with ventral hernia.\n* Subjects with ASA grade I to III.\n* Subject must sign and date informed consent prior to treatment.\n* Subject can undergo general anesthesia per anesthesiologist assessment.\n\nExclusion Criteria:\n\n* Women who are pregnant or breast-feeding or who wish to become pregnant during the period of the clinical investigation.\n* Subject has medical condition, which in the judgement of the investigator makes the subject a poor candidate for the investigational procedure.\n* Participation in another clinical trial that is in the active phase.\n* Subject unwilling or inability to follow procedures outlined in the protocol.\n* Subjects who are not suitable for robotic surgery, the Subject will be excluded from the study and the will be considered a screen failure and the surgeon will proceed with a standard multiport laparoscopic Hernia repair.\n* Subjects who present any adverse event before use the Anovo Surgical System (\"Anovo\") that can affect evaluation of safety and performance of Investigational Device.",{"count":118,"type":20},[23],"The study is aimed to clinically assess the AnovoTM Surgical System in ventral hernia procedures. Extensive preclinical testing of the system's integrity and safety has been performed to assure adequate safety for this trial.",[28],"2024-11-19",{"date":227,"type":42},"2024-11-21",{"date":229,"type":42},"2024-01-14",{"date":231,"type":20},"2025-12",{"name":233,"class":79},"Momentis Surgical",2,{"id":236,"slug":237,"hasResults":11,"nctId":238,"briefTitle":239,"officialTitle":240,"acronym":4,"eligibilityCriteria":241,"healthyVolunteers":89,"sex":16,"minAge":17,"maxAge":242,"enrollmentInfo":243,"targetDuration":4,"studyType":21,"phases":244,"briefSummary":245,"conditions":246,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":247,"lastUpdatePostDateStruct":248,"startDateStruct":250,"completionDateStruct":252,"leadSponsor":253,"locationsCount":4},"100565519","sublay-versus-intraperitoneal-onlay-mesh-repair-in-large-ventral-hernias-100565519","NCT06643234","Sublay Versus Intraperitoneal Onlay Mesh Repair in Large Ventral Hernias","Sublay Versus Intraperitoneal Onlay Mesh Repair in Large Ventral Hernias. A New Technique","Inclusion Criteria:\n\n* Age (18-70) years, both sexes.\n* Fitness for surgery.\n* Patients with uncomplicated ventral hernia.\n* Large anterior abdominal wall defect.\n\nExclusion Criteria:\n\n* Patients don't fit for general anesthesia due to sever co-morbidity.\n* Patients with complicated ventral hernia.\n* Patient refusal of surgical intervention.\n* History of bleeding disorders.\n* Pregnancy in female patients","70 Years",{"count":118,"type":20},[23],"The aims of this study is to compare the efficacy of modified sublay hernioplasty versus intraperitoneal onlay mesh repair for large ventral hernias.\n\nSpecifically, this study will assess the primary outcome of recurrence rate one year post surgery and evaluate secondary outcomes, including intraoperative complications, infection rates, pain levels, and post operative hospital stay durations.",[28],"2024-10-24",{"date":249,"type":42},"2024-10-26",{"date":251,"type":20},"2024-11-01",{"date":44,"type":20},{"name":254,"class":49},"Ahmed Kahlawy Mahrous Mohamed",{"id":256,"slug":257,"hasResults":11,"nctId":258,"briefTitle":259,"officialTitle":260,"acronym":261,"eligibilityCriteria":262,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":263,"targetDuration":4,"studyType":21,"phases":265,"briefSummary":266,"conditions":267,"keywords":273,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":279,"lastUpdatePostDateStruct":280,"startDateStruct":282,"completionDateStruct":284,"leadSponsor":286,"locationsCount":288},"100563076","strong-for-surgery--strong-for-life---intensive-prehabilitation-for-risk-reduction-in-ventral-hernia-repair-100563076","NCT06611462","STRONG for Surgery & Strong for Life - Intensive Prehabilitation for Risk Reduction in Ventral Hernia Repair","Effect of Tailored, Intensive Prehabilitation for Risky Lifestyles Before Ventral Hernia Repair on Postoperative Outcomes, Health, and Costs - a Randomised Controlled Trial (STRONG-Hernia)","STRONG-Hernia","Inclusion Criteria:\n\n* Participants ≥18 years scheduled for ventral hernia repair (defect smaller than 8cm)\n* Enough time for at least 4 weeks of prehabilitation\n* Screened positive for at least 1 risky SNAP factor\n* Signed informed consent\n\nExclusion Criteria:\n\n* Ventral hernia repairs with defect larger than 8 cm\n* Pregnancy\u002Fbreastfeeding\n* Allergy\u002Fother contradiction to pharmaceutical and\u002For nutritional support\n* Contradiction to exercise\n* Previous complicated alcohol withdrawal symptoms (delirium or seizures)\n* Not able to participate in intervention due to psychiatric ilness",{"count":264,"type":20},400,[23],"The five risky lifestyles Smoking, Nutrition (obesity and malnutrition), risky Alcohol intake, and Physical inactivity (SNAP) are common in surgical patients and associated with worse postoperative outcomes. Mono-factor interventions targeting and improving these risky lifestyles have been shown to reduce the risk at surgery, but there is a lack of systematic assessment of all five lifestyles of the patient before surgery and related optimization.\n\nThis study aims to evaluate the effect of intensive combined lifestyle interventions (the STRONG programme) compared with treatment as usual in patients undergoing ventral hernia repair on postoperative complications, health, and costs on short and longer term.\n\nThe hypothesis is that the STRONG programme will halve the complication rates within 30 days.",[28,268,269,270,271,272],"Surgery","Risk Reduction","Lifestyle","Postoperative Complications","Prehabilitation",[28,268,269,271,272,274,275,276,277,278],"Smoking","Alcohol drinking","Obesity","Malnutrition","Physical Inactivity","2024-09-20",{"date":281,"type":42},"2024-09-25",{"date":283,"type":42},"2024-03-04",{"date":285,"type":20},"2028-03-01",{"name":287,"class":49},"Bispebjerg Hospital",3,{"id":290,"slug":291,"hasResults":11,"nctId":292,"briefTitle":293,"officialTitle":294,"acronym":4,"eligibilityCriteria":295,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":296,"enrollmentInfo":297,"targetDuration":4,"studyType":299,"phases":4,"briefSummary":300,"conditions":301,"keywords":307,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":317,"lastUpdatePostDateStruct":318,"startDateStruct":320,"completionDateStruct":322,"leadSponsor":324,"locationsCount":50},"100509958","factors-influencing-the-results-of-treatment-in-patients-with-hernias-of-various-localizations-100509958","NCT05920200","Factors Influencing the Results of Treatment in Patients With Hernias of Various Localizations","Factors Affecting the Results of Treatment of Patients With Hernias of Various Localization: Evaluation of Treatment Results Using an Automated Hernia Register","Inclusion Criteria:\n\n* All mesh and non-mesh repairs that have been registered in the KHR from January 9, 2020, until December 31, 2023.\n\nExclusion Criteria:\n\n* Patients not having a 11-digit state-assigned Personal insurance policy number.\n* Parastomal hernia;\n* infected hernias;","90 Years",{"count":298,"type":20},4000,"OBSERVATIONAL","The study attempts to quantify the relative risks for acute postoperative pain, complications rate, chronic postoperative pain (CPIP) and recurrence rate after different methods of repair of groin, umbilical and incisional hernia depending on surgical technique, mesh type and fixation suture material.\n\nFor this purpose the investigators will analyze data from the Kalinigrad Hernia Registry (KHR).",[29,302,303,28,304,305,306],"Femoral Hernia","Umbilical Hernia","Chronic Pain","Acute Post Operative Pain","Recrrence Rate",[34,308,309,310,311,312,313,314,315,316],"register","inguinal hernia","femoral hernia","umbilical hernia","ventral hernia","CPIP","postoperative complications","chronic post-operative pain","recurrence rate","2024-07-22",{"date":319,"type":42},"2024-07-23",{"date":321,"type":42},"2020-01-09",{"date":323,"type":20},"2025-12-31",{"name":325,"class":49},"Immanuel Kant Baltic Federal University",{"id":327,"slug":328,"hasResults":11,"nctId":329,"briefTitle":330,"officialTitle":331,"acronym":4,"eligibilityCriteria":332,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":147,"enrollmentInfo":333,"targetDuration":4,"studyType":21,"phases":334,"briefSummary":335,"conditions":336,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":337,"lastUpdatePostDateStruct":338,"startDateStruct":340,"completionDateStruct":342,"leadSponsor":344,"locationsCount":4},"100543178","evaluation-of-posterior-component-separation-technique-in-the-management-of-complex-ventral-hernia-100543178","NCT06352489","Evaluation of Posterior Component Separation Technique in the Management of Complex Ventral Hernia.","Posterior Component Separation in the Management of the Complex Ventral Hernia","Inclusion Criteria:\n\n* patients with complex ventral hernia with contraindication to the conventional surgical therapy.\n\nExclusion Criteria:\n\n1. patients with contraindication to long standing anesthesia.\n2. patients with emergency hernia situation.\n3. pregnant patients.",{"count":19,"type":20},[23],"* Assess short term outcome of posterior component separation technique(PCS) including the regain of the physiological function of the abdominal wall.\n* Detect most common post operative complications related to AWR techniques in a 6 months duration after operation.",[28],"2024-04-02",{"date":339,"type":42},"2024-04-08",{"date":341,"type":20},"2024-05-01",{"date":343,"type":20},"2026-06",{"name":345,"class":49},"Assiut University",{"id":347,"slug":348,"hasResults":11,"nctId":349,"briefTitle":350,"officialTitle":351,"acronym":4,"eligibilityCriteria":352,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":353,"targetDuration":4,"studyType":21,"phases":355,"briefSummary":356,"conditions":357,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":358,"lastUpdatePostDateStruct":359,"startDateStruct":361,"completionDateStruct":363,"leadSponsor":365,"locationsCount":50},"100535706","minimally-invasive-techniques-in-ventral-hernioplasty-100535706","NCT06255314","Minimally Invasive Techniques in Ventral Hernioplasty","Evaluation of Minimally Invasive Ventral Hernioplasty With Extraperitoneal Mesh Placement","Inclusion Criteria:\n\n* • Able to give informed consent for inclusion in the study\n\n  * Age of the patient : above 18 years\n  * Any type of ventral hernia including umbilical,paraumbilical,epigastric,spigelian and incisional hernias\n\nExclusion Criteria:\n\n* • Patients with inguinal hernia.\n\n  * Strangulated or obstructed hernia.\n  * Previous mesh hernia repair.\n  * Loss of abdominal domain.\n  * Infected or contaminated field.\n  * Defect size more than 10cm.",{"count":354,"type":20},45,[23],"1. Review the surgical outcome of different techniques using extraperitoneal ventral hernia repair regarding postoperative pain. wound infection ,hospital stay , recurrence ,mesh migration and mesh induced visceral complications.\n2. Reviewing advantages and drawbacks of each surgical technique regarding feasibility ,cost effectiveness and technical difficulties",[28],"2024-02-02",{"date":360,"type":42},"2024-02-13",{"date":362,"type":20},"2024-02",{"date":364,"type":20},"2026-10",{"name":345,"class":49},{"id":367,"slug":368,"hasResults":11,"nctId":369,"briefTitle":370,"officialTitle":371,"acronym":372,"eligibilityCriteria":373,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":374,"enrollmentInfo":375,"targetDuration":4,"studyType":21,"phases":377,"briefSummary":379,"conditions":380,"keywords":381,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":385,"lastUpdatePostDateStruct":386,"startDateStruct":388,"completionDateStruct":390,"leadSponsor":392,"locationsCount":50},"100476772","phase-3-bariatric-surgery-with-mesh-repair-of-ventral-hernia-a-randomized-controlled-trial-100476772","NCT05488288","Bariatric SUrgery With Mesh REpair of Ventral Hernia: a Randomized Controlled Trial","Bariatric Surgery With Mesh Repair of Ventral Hernia: a Randomized Controlled Trial","BeSURE","Inclusion Criteria:\n\n* Patients between 18 and 60 years.\n* Body Mass Index (BMI) ≥ 40 kg\u002Fm² or ≥ 35 kg\u002Fm² associated with at least one comorbidity that can improve after BS.\n* Body Mass Index (BMI) \\\u003C 50 kg\u002Fm².\n* Primary or first recurrent incisional midline VH, umbilical or epigastric, width between 1 cm and 4 cm, on abdominopelvic CT-scan without contrast injection.\n* Decision for primary sleeve gastrectomy or by-pass after multidisciplinary discussion.\n* Request for BS approved by health insurance authorities.\n* Written informed consent from patient.\n\nExclusion Criteria:\n\n* Previous VH repair with mesh.\n* Other types of abdominal hernia (lateral, subxiphoidal, infraumbilical, suprapubic, parastomal, non-midline port-site, and groin hernia).\n* Decision of performing BS by laparotomy.\n* Reoperation for BS (excepted previous adjustable gastric banding).\n* Ongoing abdominal skin infection.\n* Emergency surgery.\n* ASA (American Society of Anesthesiologists) score\\>3.\n* Ongoing pregnancy or breast-feeding.\n* Patient not covered by social insurance.\n* Patient under legal guardianship.\n* Patient already included in a clinical trial on hernia recurrence.","60 Years",{"count":376,"type":20},354,[378],"PHASE3","The primary objective of the study is to demonstrate that hernia recurrence (VH) repair with non absorbable mesh concomitant to Bariatric Surgery (BS) decreases the risk of VH, with or without surgical repair, during the first two years after BS when compared to VH suture repair without mesh.\n\nAs secondary objectives, the study aims to assess the impact of concomitant VH repair with non absorbable mesh versus suture repair in morbidly obese BS candidates on the following measures: - hernia recurrence at 1 year after randomization; - reoperation for hernia recurrence at 2 years after randomization; - strangulated hernia, surgical infection and mesh bulging at one year after randomization; - postoperative morbidity and mortality at 90 days after randomization; - benefit-risk ratio; - chronic pain at three months, six months, one year and two years after randomization; - quality of life during the two years after randomization; - incremental cost utility ratio; - short- and mid-term weight loss. To study if the efficacy of mesh versus suture VH repair differs according to the type and size of VH and to the surgical technique.",[28],[28,382,276,383,384],"Bariatric surgery","Mesh repair","Suture","2023-08-30",{"date":387,"type":42},"2023-08-31",{"date":389,"type":42},"2023-07-24",{"date":391,"type":20},"2030-01",{"name":393,"class":49},"Assistance Publique - Hôpitaux de Paris"]