[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ventricular-septal-defect\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ventricular-septal-defect":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,73],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100623177","bypass-clear-priming-vsd-cardiopulmonary-bypass-circuit-reduce-bypass-associated-inflammation-100623177",false,"NCT07393243","Bypass Clear Priming VSD Cardiopulmonary Bypass Circuit Reduce Bypass Associated Inflammation?","Does Clear Priming of the Cardiopulmonary Bypass Circuit Reduce Bypass Associated Inflammation in Ventricular Septal Defect Patients?","Inclusion Criteria:\n\n* Weight between 5-10kg\n* Age 1-18 months\n* Requiring cardiopulmonary bypass as part of clinically indicated surgery\n* Surgery performed by Dr. Bohuta or Dr. Greene\n\nExclusion Criteria:\n\n* Hemoglobin\u002Fhematocrit too low for clear CPB prime (post-dilution Hct \\\u003C24%)\n* Pre-operative ECMO support\n* Active infection\n* Not clinically appropriate for clear prime (instability, arrhythmias, desaturation, etc.)\n* Genetic syndrome\n* Pork allergy or family requests pork avoidance","ALL","1 Month","18 Months",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this trial is to study if priming the pump used during cardiac surgery with non-blood fluids instead of donated blood products reduces the inflammation that occurs after heart surgery. The study will focused on pediatric participants who require open heart surgery to repair certain types holes in the heart.\n\nTypically for pediatric patients, the cardiopulmonary bypass pump is \"primed\" (filled) with donated blood products. This project is going to test if the exposure to these blood products causes inflammation. Patients experience significant inflammation (swelling) after undergoing cardiopulmonary bypass. This inflammation can interfere and slow down the patient's recovery from cardiac surgery. With this project, the investigator are studying if filling the bypass pump with non-blood products reduces the bypass-associated inflammation.\n\nThe investigators are also studying if using non-blood fluids to fill the bypass pump reduces bypass associated side effects.\n\nThe investigators are also trying to understand how the inflammation starts. The investigators also want to study genetic material called DNA that is collected from a person's blood. Instructions for the body are contained in parts of DNA called genes. Genes determine things like hair and eye color. The investigator hope by studying genes the investigator can learn more about the inflammation that occurs after heart surgery, but the investigators might use participant's genetic information to study other diseases or conditions other the inflammation that occurs after heart surgery.\n\nThe investigators will be studying the recovery of 60 participants between 1 month to 18 months of age who require open heart surgery to repair ventricular septal defects (VSDs), a congenital heart defect where there a hole between the lower chambers of the heart.\n\nParticipants will:\n\nAllow for information about how the participants recover from surgery to be collected.\n\nAllow blood samples during and after surgery to be collected to understand how the markers of inflammation change between the two groups (blood versus non-blood priming).",[27],"Ventricular Septal Defect",[29,30,31,32],"cardiac surgery","cardiopulmonary bypass","inflammation","blood product","NOT_YET_RECRUITING","2026-02-05",{"date":36,"type":37},"2026-02-06","ACTUAL",{"date":39,"type":21},"2026-02-25",{"date":41,"type":21},"2030-12",{"name":43,"class":44},"Seattle Children's Hospital","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":45},"100568063","mechanical-complications-of-acute-myocardial-infarction-a-multicenter-prospective-study-100568063","NCT06676345","Mechanical Complications of Acute Myocardial Infarction: a Multicenter Prospective Study","Mechanical Complications of Acute Myocardial Infarction: a Multicenter Prospective Observational Study","CAUTION 2","Inclusion Criteria:\n\n* all the patients diagnosed with post-infarction mechanical complications, independently from the treatment assigned\n\nExclusion Criteria:\n\n* patients with cardiac rupture not acute myocardial infarction related","18 Years",{"count":56,"type":21},800,"OBSERVATIONAL","In 2019, the international study titled \"CAUTION Study - 1\" (MeChanical complicAtions of acUte myocardial infarcTion: an InternatiOnal multiceNter cohort study), a retrospective multicenter study, was launched and registered on ClinicalTrials.gov (Identifier: NCT03848429). This study highlighted the outcomes of surgical treatment of post-infarction mechanical complications in patients operated between 2000 and 2019. Several scientific publications have resulted from this registry, which involved 27 international centers and recruited about 800 patients. However, retrospective studies are inherently limited by factors such as selection bias and a high number of missing data, affecting data interpretation and consistency of results. Moreover, most registries report only data about surgical patients or, in rare situations, about patients treated percutaneously. To overcome these limitations, a prospective study has been designed to collect more precise and focused data and achieve results that better reflect the current clinical practice, including all the patients diagnosed with post-infarction mechanical complications, independently from the treatment assigned.\n\n\"CAUTION Study - 2\" is, therefore, a prospective, multicenter cohort study with the primary aim of analyzing the outcomes of surgical, percutaneous and conservative treatment of post-infarction mechanical complications in the contemporary era.",[27,60,61,62],"Papillary Muscle Rupture","Cardiac Rupture","Pseudoaneurysm","RECRUITING","2025-05-07",{"date":66,"type":37},"2025-05-11",{"date":68,"type":37},"2025-01-01",{"date":70,"type":21},"2032-12-31",{"name":72,"class":44},"Maastricht University Medical Center",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":16,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":84,"conditions":85,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":45},"100553929","clinical-evaluation-of-ventricular-septal-defect-vsd-in-children-at-sohag-univesity-hospital-100553929","NCT06492473","Clinical Evaluation Of Ventricular Septal Defect (VSD) In Children at Sohag Univesity Hospital","Clinical Evaluation Of Ventricular Septal Defect (VSD) in Children at Sohag University Hospital","Inclusion Criteria:\n\n* all children from date of birth to age of 16 years old including both genders diagnosed to have isolated VSD or apart from another cardiac anomalies\n\nExclusion Criteria:\n\n\\-","1 Day","16 Years",{"count":83,"type":21},100,"ventricular septal defect(VSD) are one of the most common significant CHD and account for up to 40% of all cardiac abnormalities.VSD is commonly isolated defect as well as intrinsic component of several complex cardiac malformations including tetrology of fallot ,double- outlet right ventricle(RV),transposition of great vessles,aortic coartication or interruption ,and truncus arteriosus",[27],"2024-07-08",{"date":88,"type":37},"2024-07-09",{"date":90,"type":37},"2024-06-24",{"date":92,"type":21},"2025-06-24",{"name":94,"class":44},"Sohag University"]