[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"vestibular-dysfunction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:vestibular-dysfunction":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100640814","spatial-orientation-navigation-and-neuropsychologic-function-in-patients-with-vestibular-implant-100640814",false,"NCT07627087","Spatial Orientation, Navigation, and Neuropsychologic Function in Patients With Vestibular Implant","Vestibular Implant Tested in Patients With Peripheral Vestibular Damage: Effects on Spatial Orientation, Navigation, and Neuropsychologic Function","1. Patients receiving vestibular implants at UNIGE:\n\n   Their inclusion criteria are defined as follows:\n   * Deaf, scheduled for CI surgery\n   * Minimum of five year history of documented absence of bilateral auditory and vestibular function, based on review of their audiograms and vestibular tests.\n   * Vestibular testing consistent with BVL\n   * No neurologic disease. note: these patients are recruited and implanted by the group at the University of Geneva Hospital (UNIGE) as part of their ongoing research. The study team are not involved in any way with the decision to surgically implant patients with cochlear or vestibular implants, nor are the researchers involved in any way with pre- or post-operative clinical care. The researchers only involvement is to perform the cognitive tests before, during, and after relatively short periods of stimulation using the vestibular implant (VI)\n2. Vestibular patients tested at MEE: vestibular testing consistent with unilateral or bilateral vestibular damage.\n\nBoth aspects of the study share the same exclusion criteria:\n\nExclusion Criteria:\n\n* No known neurologic or otologic disease other than the vestibular and auditory deficits noted above.\n* Pregnancy. Pregnant women and women up to 4 months postpartum will be excluded because of the known effects and unknown potential effects of pregnancy on sensory function.\n* Body weight \\>250 lbs (due to motion device safety limits)\n* The chronic use of vestibular suppressant medication (benzodiazepine, antihistamine, anticholinergic)\n* Inability to stand or walk unassisted.\n* Blindness.\n* Unstable medical condition.\n* Orthopedic or musculoskeletal injuries\u002Fconditions that affect gait or balance.\n* Ongoing neck or spinal pain\u002Finjuries or recent history of neck or spinal surgery\n* Amputation, musculoskeletal deformity, or significant leg-length discrepancy\n* A history of severe head trauma.\n* Any major psychiatric disorder (e.g., psychosis, schizophrenia, panic disorder), not including anxiety or depression.\n* Severe heart or pulmonary conditions\n* Active cancer for which chemo-\u002Fradiation therapy is being received.","ALL","18 Years","80 Years",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24],"NA","The vestibular system, located in the inner ear, provides information to the brain information about how head acceleration and orientation relative to gravity. Damage to the vestibular system is usually permanent and can contribute to a lower quality of life. The goal of this research is to to examine how vestibular implants (VI) may improve performance of cognitive tasks in patients with severe vestibular damage. These higher-level cognitive behaviors include (1) orientation relative to gravity, (2) navigation, and (3) neuropsychologic function. VI patients will be tested in these three cognitive domains across study sessions: pre-stimulation (VI implanted but stimulation OFF), following chronic stimulation (12 days, VI-ON), and then again 1 month later with the VI turned off. There will be both \"true\" stimulation experiments during which the VI will provide motion-modulated stimulation and also \"placebo\" stimulation (no motion cues, tonic stimulus). The order of these experiments will be randomized and separated by 3 months. Researchers will compare VI data in the three cognitive domains (spatial orientation, navigation, \\& neuropsychologic function) with control data from non-implanted bilateral vestibular loss (BVL) and unilateral vestibular loss (UVL) patients and normal subjects.",[27,28,29],"Vestibular Dysfunction","Bilateral Vestibular Loss","Vestibular Implant",[31,32,33,34,35,36],"bilateral vestibular loss","vestibular implant","neuropsychologic function","cognitive function","spatial orientation","navigation","RECRUITING","2026-05-30",{"date":40,"type":41},"2026-06-04","ACTUAL",{"date":43,"type":41},"2026-01-22",{"date":45,"type":21},"2029-07-31",{"name":47,"class":48},"Massachusetts Eye and Ear Infirmary","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":16,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":62,"conditions":63,"keywords":66,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":75,"leadSponsor":77,"locationsCount":49},"100585968","impact-of-vestibular-function-on-deaf-infants-activities-of-daily-living-100585968","NCT06909266","Impact of Vestibular Function on Deaf Infants' Activities of Daily Living","IVANS","Inclusion Criteria:\n\nGroup 1: Deaf children with confirmed vestibular impairment. Group 2: Deaf children without vestibular impairment. Group 3: Hearing children without vestibular impairment (control group).\n\nExclusion Criteria:\n\nPresence of neuromotor or orthopedic disorders. Presence of pervasive developmental disorders that could interfere with daily activity assessments.\"","1 Day","2 Years",{"count":60,"type":21},105,"OBSERVATIONAL","This non-interventional study aims to assess the impact of vestibular impairments on the daily life activities of deaf children aged 0 to 2 years old. Three groups of participants will be included: deaf children with vestibular impairment, deaf children without vestibular impairment, and hearing children without vestibular dysfunction (control group).\n\nChildren's daily activities will be evaluated through the OT Hope 0-5 years tool, a parent-administered questionnaire designed to measure competencies in different areas: personal care, play, and social interactions. This study also includes qualitative interviews with parents to further explore how vestibular impairments affect children's daily routines.\n\nIt is hypothesized that:\n\n* Deaf children with vestibular impairments will show lower scores in daily life activities compared to the other two groups.\n* Deaf children without vestibular impairments will demonstrate scores closer to those of hearing children but may show some differences due to their hearing status.\n\nThe research is conducted at the Robert Debré Hospital, in Paris, and aims to enroll 105 children over a three-year period. The data collected will provide insights into the specific needs of children with vestibular impairments and lay the groundwork for targeted early interventions.",[27,64,65],"Hearing Loss","Motor Development",[67,68,69],"Deafness","vestibular disorder","occupational therapy","NOT_YET_RECRUITING","2025-03-27",{"date":73,"type":41},"2025-04-03",{"date":71,"type":21},{"date":76,"type":21},"2028-04-01",{"name":78,"class":48},"Assistance Publique - Hôpitaux de Paris"]