[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"viral-lower-respiratory-tract-infection-lrti\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:viral-lower-respiratory-tract-infection-lrti":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":5},"100625055","gut-microbiome-and-immune-response-in-severe-rsv-infection-in-vietnamese-infants-100625055",false,"NCT07417657","Gut Microbiome and Immune Response in Severe RSV Infection in Vietnamese Infants","Impact of the Gut Microbiome on Immune Response and Disease Severity in Acute Respiratory Syncytial Virus (RSV) Infection in Vietnamese Children: A Prospective Observational Study","GUT-LUNG RSV","Inclusion Criteria:\n\nAge 1 to 24 months RT-PCR positive for RSV from respiratory specimen Symptoms consistent with acute lower respiratory tract infection Parent\u002Flegal guardian provides informed consent\n\nExclusion Criteria:\n\nPrematurity \\\u003C32 weeks gestation or birthweight \\\u003C1500 g Chronic conditions (e.g., congenital heart disease, chronic lung disease, chronic liver\u002Fkidney disease) Primary or acquired immunodeficiency Severe malnutrition (weight-for-age Z-score \\\u003C -3 SD) Antibiotic use within 2 weeks before admission Probiotic use within 4 weeks before admission Co-infection with other pathogens (viral\u002Fbacterial) Stool sample not obtained within 24 hours of admission","ALL","1 Month","24 Months",{"count":21,"type":22},250,"ESTIMATED","OBSERVATIONAL","Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infection in young children, and a substantial proportion of severe cases occur in previously healthy infants. The gut-lung axis suggests that gut microbiome composition may modulate respiratory immune responses. This prospective observational study in Vietnam will compare gut microbiome profiles and systemic immune cytokine responses between infants with severe RSV infection and those with mild RSV infection, aiming to identify microbiome-immune signatures associated with disease severity.",[26,27,28],"Respiratory Syncytial Virus Infection","Bronchiolitis","Viral Lower Respiratory Tract Infection (LRTI)",[30,31,32,33,34,35,36,27,37],"RSV","gut microbiome","16S rRNA","Gut-lung axis","Vietnam","infants","Biomarkers","Lower respiratory tract infection","NOT_YET_RECRUITING","2026-02-11",{"date":41,"type":42},"2026-02-18","ACTUAL",{"date":44,"type":22},"2026-04-01",{"date":46,"type":22},"2029-12-31",{"name":48,"class":49},"Phuc Huu Phan","OTHER"]