[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"viral-respiratory-tract-infections\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:viral-respiratory-tract-infections":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,56],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":55},"100624563","premabiom-metatranscriptomics-of-the-respiratory-microbiome-to-predict-the-occurrence-of-bronchopulmonary-dysplasia-in-preterm-infants-100624563",false,"NCT07411261","PremaBiom: Metatranscriptomics of the Respiratory Microbiome to Predict the Occurrence of Bronchopulmonary Dysplasia in Preterm Infants","PremaBiom","Inclusion Criteria:\n\n* Preterm infants with gestational age at birth lower than 32 gestational weeks and 6 days.\n* Hospital stay in one of the participant neonatal care units\n* Infants covered by the social security system of at least one of their parents\n* Whose parents have been informed about the study and agree to sign the informed consent form\n\nExclusion Criteria:\n\n* Palliative care only\n* Lack of parental consent\n* Parents who are minors or under legal protection (guardianship, conservatorship, judicial protection)\n* Parents who do not speak French","ALL","72 Hours",{"count":19,"type":20},270,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this clinical trial is to understand the impact of respiratory microbiome maturation in respiratory health of preterm infants under 32 gestational weeks. The main questions it aims to answer are:\n\n* What is the role of microbiome maturation in respiratory health (development of bronchopulmonary dysplasia, childhood asthma and viral respiratory infections) of preterm infants ?\n* Which environmental or health factors are involved in the maturation of the respiratory microbiome ?\n\nParticipants will undergo follow-up from birth until 3 years of corrected age including nasal swabs, stool samples, and for some of them blood and milk sample.",[26,27,28,29,30],"Bronchopulmonary Dysplasia","Preterm Infant Development","Asthma Childhood","Bronchiolitis","Viral Respiratory Tract Infections",[32,33,34,35,36,37,38,39,40,41,42],"respiratory microbiome","bronchopulmonary dysplasia","Prematurity","asthma","bronchiolitis","inflammation","inate immunity","respiratory tract infections","dysbiosis","personalized medicine","metatranscriptomics","NOT_YET_RECRUITING","2026-02-11",{"date":46,"type":47},"2026-02-13","ACTUAL",{"date":49,"type":20},"2026-03",{"date":51,"type":20},"2031-03",{"name":53,"class":54},"University Hospital, Caen","OTHER",6,{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":11,"sex":16,"minAge":64,"maxAge":4,"enrollmentInfo":65,"targetDuration":67,"studyType":68,"phases":4,"briefSummary":69,"conditions":70,"keywords":75,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":91},"100614369","the-fever-clinic-acute-respiratory-cohort-100614369","NCT07278700","The Fever Clinic Acute Respiratory Cohort","The Fever Clinic Acute Respiratory Cohort (FACTS): A Prospective Real-World Cohort Study of Patients Presenting to Fever Clinics: Clinical Features, Laboratory and Radiographic Findings, and Long-Term Outcomes of Acute Respiratory Infections","FACTS","Inclusion Criteria:\n\n* Age ≥ 18 years (based on official identification document).\n* Presence of fever at the time of visit or within 24 hours prior to the visit, defined as a documented temperature of ≥37.3°C axillary\u002Ftympanic, ≥37.8°C orally, or ≥38.0°C rectally.\n* The primary cause of fever, as determined by the attending physician, is a respiratory tract infection.\n* Blood draw is required as part of standard clinical care.\n* Ability to comprehend the study's purpose, procedures, and potential risks, and willingness to provide written informed consent.\n\nExclusion Criteria:\n\n* Inability to provide independent informed consent due to impaired consciousness or other reasons.\n* Inability to comply with the study procedures.\n* Medical contraindications to blood sampling, such as severe coagulopathy (e.g., INR \\> 3.0, platelet count \\\u003C 50 × 10⁹\u002FL).\n* Diagnosed with a terminal illness (e.g., advanced malignancy, severe multiple organ failure) and a life expectancy of less than 3 months.","18 Years",{"count":66,"type":20},1000,"30 Days","OBSERVATIONAL","This prospective cohort study aims to characterize the natural progression and outcomes of acute respiratory infections among patients presenting to fever clinics. At enrollment, patients' clinical symptoms, laboratory findings, and chest imaging data will be collected. Longitudinal follow-up will be conducted to evaluate disease progression, complications, and long-term outcomes.\n\nAs an observational study, no interventions are involved; all patients receive routine clinical management as directed by their attending physicians. This real-world study design enables the assessment of the natural course of acute respiratory infections and the identification of factors associated with clinical outcomes.",[71,72,73,30,74],"Acute Respiratory Infections","Febrile Illnesses","Community-acquired Pneumonia","Influenza-like Illness",[76,77,78,79,80],"Respiratory Tract Infections","Fever","Community-Acquired Pneumonia","Anti-Bacterial Agents","Disease Progression","RECRUITING","2025-12-11",{"date":84,"type":47},"2025-12-12",{"date":86,"type":47},"2025-10-10",{"date":88,"type":20},"2028-10",{"name":90,"class":54},"Fudan University",1]