[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"visual-field-defect\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:visual-field-defect":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,55,90,125,146],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":36,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100642991","home-based-vision-rehabilitation-guided-by-brain-imaging-100642991",false,"NCT07635329","Home-based Vision Rehabilitation Guided by Brain Imaging","Behavioral Rehabilitation Through Image-Guided Home-based Training","BRIGHT","Inclusion Criteria:\n\n1. At least 18 years of age.\n2. Capable of providing informed consent and complying with study procedures.\n3. Unilateral or bilateral focal brain damage causing visual field loss.\n4. At least three months post-stroke or traumatic brain injury, or a stable brain tumor within the past year.\n5. Eligible for MRI based on standard safety screening.\n\nExclusion Criteria:\n\n1. Severe neurological or psychiatric conditions unrelated to the focal lesion that may interfere with study participation or data interpretation.\n2. Current or recent (within the past 6 months) drug or alcohol abuse or addiction as defined by DSM-5.\n3. Ocular disease or disorder.","ALL","18 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"NA","The BRIGHT (Behavioral Rehabilitation Through Image-Guided Home-based Training) study aims to evaluate the effectiveness of image-guided, home-based perceptual training at improving visual performance in individuals with visual field loss.\n\nUsing a prospective, crossover design, BRIGHT combines visual behavioral testing, neuroimaging, and a home-based intervention. It aims to 1) identify neural pathways that support training-induced visual plasticity; and 2) compare the efficacy of different types of visual training delivered in a home-based setting.",[27,28,29,30,31,32,33,34,35],"Visual Field Defect","Stroke","Hemianopia Homonymous","Quadrantanopia","Cortical Blindness","Visual Field Defect, Peripheral","Visual Field Loss","Traumatic Brain Injury","Brain Tumor",[37,38,39,40,41],"neuroplasticity","stroke","vision","TBI","brain tumor","RECRUITING","2026-06-03",{"date":45,"type":46},"2026-06-09","ACTUAL",{"date":48,"type":21},"2026-07-01",{"date":50,"type":21},"2030-03-31",{"name":52,"class":53},"Georgetown University","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":62,"targetDuration":4,"studyType":22,"phases":64,"briefSummary":65,"conditions":66,"keywords":71,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":54},"100583352","visual-restoration-using-focused-ultrasound-stimulation-and-immersive-virtual-reality-after-stroke-100583352","NCT06875206","Visual Restoration Using Focused Ultrasound Stimulation and Immersive Virtual Reality After Stroke","LIFU-IVR","Inclusion Criteria:\n\n* ≥ 18 years old of any gender and race\n* Clinical ischemic stroke or hemorrhagic (confirmed by CT or MRI) that occurred \\>= 6-24 months ago\n* Partial or complete homonymous hemianopsia on clinical exam\n\nExclusion Criteria:\n\n* Documented history of severe dementia with or without medication before stroke that affect subject's ability to participate in and be compliant to study protocol\n* Significant upper motor deficits and the subject cannot do IVR sessions at the baseline\n* History of seizures\n* Inability to get a new MRI\n* Presence of any ultrasonic stimulation risk factors: an electrically, magnetically, or mechanically activated metal or nonmetal implant including cardiac pacemaker, intracerebral vascular clips, or any other electrically sensitive support system; non-fixed metal in any part of the body; pregnancy (the effect of ultrasonic stimulation on the fetus is unknown); preexisting scalp lesion or wound or bone defect or hemicraniectomy.\n* Patients will be excluded if they have a previous diagnosis of hemianopsia, a new diagnosis of central retinal ischemic injury, or visual blindness or a history of any other ocular disease.\n* Concerns about the inability to complete study visits\u002Fprocedures by the PI.",{"count":63,"type":21},28,[24],"This research will explore if brain stimulation combined with virtual reality therapy improves visual impairment. The stimulation technique is called low-intensity focused ultrasound stimulation (LIFUS). The treatment uses ultrasound to stimulate vision specific parts of the brain. Before this therapy, the participants will get structural brain imaging. Functional brain imaging will be performed before and after the study's completion to measure brain activity response to therapy.\n\nThe purpose of this research study is to evaluate patients who have had a stroke between 6 and 24 months ago with a visual field impairment. The duration of active participation in the study is 1.5 months.",[28,27,67,68,30,69,70],"Visual Field Defect Following Cerebrovascular Accident","Hemianopia","Occipital Lobe Infarct","Visual Fields Hemianopsia",[72,38,73,74,75,76,77,78,79],"virtual reality","visual deficit","chronic stroke","ultrasound stimulation","neuromodulation","stroke recovery","visual field defect","funcational imaging","NOT_YET_RECRUITING","2026-05-19",{"date":83,"type":46},"2026-05-22",{"date":85,"type":21},"2026-12-01",{"date":87,"type":21},"2027-04",{"name":89,"class":53},"Duke University",{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":4,"eligibilityCriteria":96,"healthyVolunteers":11,"sex":17,"minAge":97,"maxAge":98,"enrollmentInfo":99,"targetDuration":4,"studyType":101,"phases":4,"briefSummary":102,"conditions":103,"keywords":107,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":54},"100625829","retinopathy-of-prematurity---visual-function-and-retinal-structure-100625829","NCT07427719","Retinopathy of Prematurity - Visual Function and Retinal Structure","Children Treated for Retinopathy of Prematurity - Study of Visual Function and Retinal Structure","Inclusion criteria:\n\n* Patients treated for ROP with either laser or injection of A-VEGF.\n* Patients previously diagnosed with ROP but not treated for the condition.\n\nExclusion criteria:\n\n* Age below six years at date of examination.\n* A developmental level not compatible with performing the study examinations.\n* Patients born or treated outside Norway\n* Known ocular or systemic disease that can give structural or functional changes in the retina.","6 Years","20 Years",{"count":100,"type":21},140,"OBSERVATIONAL","Children born prematurely may develop a characteristic retinal disease named retinopathy of prematurity (ROP). This disease could lead to retinal detachment and blindness. ROP was traditionally treated with laser, but injection with a medication (A-VEGF) has become more common.\n\nIn this study, the researchers will explore whether treatment of ROP affects visual function and retinal development. To explore this, the study group will examine children with ROP (but not treated) with children treated with either laser or injection. The researchers will compare the children's visual functions (e.g. visual acuity and visual field) and their retinas (e.g. central and peripheral retina).",[104,105,106,27],"Retinopathy of Prematurity (ROP)","Prematurity Complications","Cerebral Visual Impairment",[108,109,110,111,112,113,114,115],"Retinopathy of Prematurity","Treatment","Laser","anti-vascular endothelial growth factor","Visual field defect","Cerebral visual impairment","Refractive errors","Prematurity","2026-02-16",{"date":118,"type":46},"2026-02-23",{"date":120,"type":21},"2026-04-01",{"date":122,"type":21},"2029-06-01",{"name":124,"class":53},"Oslo University Hospital",{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":131,"eligibilityCriteria":132,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":133,"targetDuration":4,"studyType":22,"phases":135,"briefSummary":136,"conditions":137,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":54},"100601043","visual-plasticity-following-brain-lesions-100601043","NCT07105358","Visual Plasticity Following Brain Lesions","Vision Improvement Through Behavioral Rehabilitation And Neuroplasticity Training","VIBRANT","A. Stroke, brain tumor, or traumatic brain injury patients\n\nInclusion Criteria:\n\n1. At least 18 years of age.\n2. Capable of providing informed consent and complying with study procedures.\n3. Unilateral or bilateral focal brain damage causing loss of vision.\n4. At least three months post-stroke or traumatic brain injury, or a stable brain tumor within the past year.\n\nExclusion Criteria:\n\n1. Severe CNS diseases or disorders unrelated to the focal lesion, which could interfere with study results.\n2. Severe mental health challenges that could interfere with study results, or current or recent (within the past 6 months) drug or alcohol abuse or addiction as defined by DSM-5.\n3. Vision loss resulting from ocular disease or disorder.\n\nB. Healthy volunteers (age-matched controls):\n\nInclusion Criteria:\n\n1. At least 18 years of age.\n2. Capable of providing informed consent and complying with study procedures.\n\nExclusion Criteria:\n\n1. Any CNS diseases or psychiatric disorders (e.g., epilepsy, schizophrenia) that would interfere with study results.\n2. Previous head injury.\n3. Present or past (within past 6 months) drug or alcohol abuse or addiction based on DSM-5.",{"count":134,"type":21},30,[24],"The VIBRANT (Vision Improvement through Behavioral Rehabilitation And Neuroplasticity Training) study is a prospective, double-blind, crossover design (within-subject) in participants with homonymous hemianopia-a type of visual field loss resulting from damage to the post-chiasmatic visual pathways. It aims to investigate whether transcranial random noise stimulation (tRNS) combined with perceptual learning-based training has potential for improving visual impairments.",[27,28,68,30,31,35,34,32],"2025-07-29",{"date":140,"type":46},"2025-08-05",{"date":142,"type":46},"2025-07-17",{"date":144,"type":21},"2028-06-30",{"name":52,"class":53},{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":152,"eligibilityCriteria":153,"healthyVolunteers":11,"sex":17,"minAge":154,"maxAge":4,"enrollmentInfo":155,"targetDuration":4,"studyType":22,"phases":156,"briefSummary":157,"conditions":158,"keywords":4,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":166,"lastUpdatePostDateStruct":167,"startDateStruct":169,"completionDateStruct":171,"leadSponsor":173,"locationsCount":175},"100493300","effectiveness-of-av-stimulation-in-immersive-vr-to-improve-visual-perception-and-driving-performance-100493300","NCT05703360","Effectiveness of AV-stimulation in Immersive VR to Improve Visual Perception and Driving Performance","Effectiveness of Audiovisual Stimulation in Immersive Virtual Reality to Improve Visual Perception and Driving Performance: a Pilot Study","Re:DriVR","Inclusion Criteria:\n\n* Male and female \\> 25 years old.\n* Visual field defects due to TBI or stroke\n* BCVA ≥ 20\u002F50.\n* Previously held a valid driving license and were active drivers.\n* Ability to follow the visual and auditory stimuli and training instructions.\n* Online auditory test positive (-5dBHL to 60dBHL range) at 125 Hz (for research purposes only)\n* Home Wi-Fi access.\n\nExclusion Criteria:\n\n* Both eyes with media opacity that impairs visual field testing.\n* Inability to perform during testing and training.\n* Cognitive\u002Fmotor condition incompatible with driving simulator and\u002For VR.\n* Recreational or medicinal consumption of psychoactive drugs.\n* 3 consecutive VRISE scores \\\u003C 25 at inclusion.\n* History of vertigo or dizziness.\n* Visual neglect.\n* Prior\u002Fcurrent vision rehabilitation interventions.\n* Photosensitive epilepsy.","25 Years",{"count":134,"type":21},[24],"The goal of this clinical trial is to evaluate the effectiveness of an immersive virtual-reality (IVR) based stimulation program, in improving visual perception for people who have lost their driver's license due to perceptual or cognitive impairments.\n\nThe main questions it aims to answer are:\n\n1. Can the 6-week IVR stimulation program help improve driving performance?\n2. Will participants experience improvement in visual detection and perception after training?\n\nStudy Design Summary:\n\n* Participants will be randomized into a waitlist group or intervention-first group\n* The VR-based intervention will consist of training every 2 days for six weeks\n* Waitlist group will wait 6 weeks before starting intervention at study midpoint (week 7)\n* Intervention-first group will begin with intervention (week 1-6) and then stop intervention at study midpoint\n* Participants will complete tests related to driving performance, visual attention, and visual fields at the start of study, midpoint, and end of study\n\nResearchers will analyze data for changes from baseline in outcome measures.",[28,159,160,161,162,27,163,164,165],"Visual Impairment","Low Vision","Virtual Reality","Visual Spatial Processing","Visual Processing Speed","Cognitive Impairment","Driving Impaired","2024-12-16",{"date":168,"type":46},"2024-12-19",{"date":170,"type":21},"2025-02-01",{"date":172,"type":21},"2025-12-01",{"name":174,"class":53},"University Health Network, Toronto",2]