[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"vocal-cord-dysfunction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:vocal-cord-dysfunction":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,74],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100492667","clinical-feasibility--validation-of-the-virtual-reality-glenxrose-speech-language-therapies-100492667",false,"NCT05695131","Clinical Feasibility & Validation of the Virtual Reality GlenxRose Speech-Language Therapies","Clinical Implementation, Feasibility, & Validation of the Virtual Reality Delivered GlenxRose Speech-Language Therapies to Improve Patient Adherence and Treatment Outcomes","Inclusion Criteria:\n\n* Adults receiving speech-language therapy at the Glenrose Rehabilitation Hospital (Edmonton, AB, Canada; Alberta Health Services)\n* Presence of a speech disorder\n* Proficiency in English\n* Able to provide signed informed consent to participate in the study\n\nExclusion Criteria:\n\n* Severe cognitive impairments and\u002For behavioural impairments\n* Communication disorders that impact comprehension of verbal commands and understanding of scale used in the study\n* Previous history of neurological or psychiatric disorder\n* Substance use disorders","ALL","18 Years",{"count":19,"type":20},30,"ESTIMATED","INTERVENTIONAL",[23],"NA","Factors related to successful rehabilitation are often directly related to adherence; for instance, dosage, frequency, and intensity can burden the patient regarding time and motivational factors. Furthermore, surrounding salience, patients may lose interest or find an intervention boring after a few sessions. It is well documented that nonadherence not only impacts rehabilitation for the patient but can also further prolong treatment, and increase hospital and clinician costs, in addition to a higher prevalence of future comorbidities. Therefore, strategies that improve patient adherence can significantly help optimize patient care and treatment outcomes.\n\nOne avenue to increase patient adherence is through the gamification of rehabilitation therapies using virtual reality (VR). Gamification of rehabilitation therapy can make mass practice required in rehabilitation therapies seemingly fun and more personally engaging for the patient. Additionally, the immersive experience achieved through VR can further promote salience and be customizable to individual patient requirements. As VR systems are now highly portable and relatively simple to utilize, they can provide an excellent opportunity to continue rehabilitation practice on the home front. Overall, the VR gamification of rehabilitation may increase adherence by shifting patients' perspectives of therapy as tedious, boring, or a hassle, to a fun and engaging game that ultimately helps their recovery processes.\n\nThe GlenXRose VR-delivered speech-language therapies (Cognitive Projections Lab, University of Alberta) have been developed and piloted in collaboration with the Glenrose Rehabilitation Hospital with the overall goal of increasing patient adherence, treatment outcomes, and satisfaction with vocal therapy. The proposed studies are to investigate the feasibility of implementing this technology in routine clinical care (specific to voice disorders), obtaining clinician feedback, examining associated financial costs, and continuing to examine the effect of the GlenXRose VR speech-language therapies on patient adherence and clinical outcomes, compared to traditional clinical care.",[26,27],"Vocal Cord Dysfunction","Speech Disorders",[29,30,31,32,33],"Vocal","Speech","Speech-Language Pathology","Virtual Reality","VR","RECRUITING","2026-05-07",{"date":37,"type":38},"2026-05-12","ACTUAL",{"date":40,"type":38},"2023-09-20",{"date":42,"type":20},"2026-06-30",{"name":44,"class":45},"University of Alberta","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":16,"minAge":55,"maxAge":17,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":46},"100547342","detection-of-vocal-fold-motion-impairment-on-noninvasive-positive-pressure-100547342","NCT06406725","Detection of Vocal Fold Motion Impairment on Noninvasive Positive Pressure","Point-of-Care Ultrasound to Detect Vocal Fold Motion Impairment on Pediatric Patients on Noninvasive Positive Pressure Ventilation","Inclusion Criteria:\n\n* Age 0 to 18 years\n* Scheduled to receive a fiberoptic nasolaryngoscopy with the otolaryngology team to assess for vocal fold motion impairment\n* Status post great vessel, esophageal, or tracheal surgery that could disrupt the recurrent laryngeal nerve\n\nExclusion Criteria:\n\n* Tracheostomy in place\n* Age \\>18 years\n* History of vocal cord paralysis\u002Fparesis\n* Patients who cannot have their neck placed in a neutral or slightly extended position due to injury or ligament laxity",true,"1 Day",{"count":57,"type":20},50,"OBSERVATIONAL","The goal of this prospective, observational study is to evaluate for the presence of vocal fold motion impairment (VFMI) in the children admitted to the pediatric intensive care unit on noninvasive positive pressure ventilation (NIV PPV). Participants will have two ultrasounds of their vocal folds performed, once while on NIV PPV and once after weaned off of the NIV PPV. This results of these scans will be reviewed against one another and against the gold standard, fiberoptic nasolaryngoscopy (FNL). The main question this study aims to answer is: Can POCUS be used to reliably detect VFMI while pediatric patients on supported with NIV PPV?",[26,61,62,63,64],"Vocal Cord Paralysis","Vocal Cord Paresis","Recurrent Laryngeal Nerve Palsy","Recurrent Laryngeal Nerve Injuries","2026-04-30",{"date":67,"type":38},"2026-05-06",{"date":69,"type":38},"2024-03-30",{"date":71,"type":20},"2028-05-30",{"name":73,"class":45},"Nemours Children's Clinic",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":54,"sex":16,"minAge":17,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":21,"phases":84,"briefSummary":86,"conditions":87,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":46},"100625276","early-phase-1-respiratory-and-real-time-dynamics-in-exercise-induced-paradoxical-vocal-fold-motion-100625276","NCT07420530","Respiratory and Real-time Dynamics in Exercise-Induced Paradoxical Vocal Fold Motion","EILO","Inclusion Criteria for Exercise-Induced Laryngeal Obstruction (EILO):\n\n* Physically active \\>2.5 hours per week\n* Patients with EILO, as diagnosed by routine clinical examination by physician and\u002For speech language pathologist\n* Age range of 18-26 years\n* Greater difficulty breathing inside compared to out and difficulty breathing which is exacerbated at peak exercise and stops 1-5 minutes after exercise\n* Score of 7 or higher on the Dyspnea Index, which is a validated instrument to capture participant self-report of upper airway dyspnea symptoms.\n* Classified as low risk, based on the modified Physical Activity Readiness Questionnaire (PAR-Q) questionnaire, body mass index, and non-smoking status\n* Negative history of voice disorders, self-report of cognitive difficulties, asthma or other lung disease, cardiac disease, serious orthopedic injuries, current uncontrolled hypertension, illicit drug use, seizure\u002Fepilepsy, claustrophobia, use of beta blockers.\n* No metallic, mechanical or magnetic implants such as cardiac devices, cochlear, or other non-removable ear implants, any prosthesis, stents, deep brain stimulator, etc.\n\nInclusion Criteria for Controls\n\n* Physically active \\>2.5 hours per week\n* Age range of 18-26 years\n* Classified as low risk, based on the modified PAR-Q questionnaire, body mass index, and non-smoking status\n* Negative history of voice disorders, self-report of cognitive difficulties, asthma or other lung disease, cardiac disease, serious orthopedic injuries, current uncontrolled hypertension, illicit drug use, seizure\u002Fepilepsy, claustrophobia, use of beta blockers.\n* No metallic, mechanical or magnetic implants such as cardiac devices, cochlear, or other non-removable ear implants, any prosthesis, stents, deep brain stimulator, etc.\n\nExclusion Criteria for EILO:\n\n* Individuals older than 26 years and younger than 18 years of age.\n* Women who are pregnant or could possibly be pregnant.\n* BMI \\> 25 kg\u002Fm2\n* A 'yes' answer to any of the 14 questions on the PAR-Q pre-participation questionnaire\n* Current smoker\n* Positive history of voice disorders, self-report of cognitive difficulties, asthma or other lung disease, cardiac disease, serious orthopedic injuries, current uncontrolled hypertension, illicit drug use, seizure\u002Fepilepsy, claustrophobia, use of beta blockers.\n* Presence of metallic, mechanical or magnetic implants such as cardiac devices, cochlear, or other non-removable ear implants, any prosthesis, stents, deep brain stimulator, etc.\n* Do not report the following: Greater difficulty breathing inside compared to out and difficulty breathing which is exacerbated at peak exercise and stops 1-5 minutes after exercise\n\nExclusion Criteria for Controls\n\n* Individuals older than 26 years and younger than 18 years of age.\n* Women who are pregnant or could possibly be pregnant.\n* BMI \\> 25 kg\u002Fm2\n* A 'yes' answer to any of the 14 questions on the PAR-Q pre-participation questionnaire\n* Current smoker\n* Positive history of voice disorders, self-report of cognitive difficulties, asthma or other lung disease, cardiac disease, serious orthopedic injuries, current uncontrolled hypertension, illicit drug use, seizure\u002Fepilepsy, claustrophobia, use of beta blockers.\n* Presence of metallic, mechanical or magnetic implants such as cardiac devices, cochlear, or other non-removable ear implants, any prosthesis, stents, deep brain stimulator, etc.\n* Significant acute or chronic medical, neurologic, or illness in the patient that, in the judgment of the Principal Investigator, could compromise subject safety, limit the ability to complete the study, and\u002For compromise the objectives of the study","26 Years",{"count":83,"type":20},120,[85],"EARLY_PHASE1","The overall objectives of the proposed research are to:\n\n1. Evaluate the diagnostic validity of a novel mechano-acoustic signatures of task-characteristic activity during symptomatic and asymptomatic breathing in Exercise-Induced Laryngeal Obstruction (EILO) patients with the use of a novel miniature, soft wearable skin-mounted device,\n2. Identify the mechanism\u002Fs of paradoxical respiratory control in EILO by quantifying the relationship between pulmonary mechanics, partial pressure of carbon dioxide (PCO2) maintenance, and vocal fold aperture prior to and during symptomatic and asymptomatic exercise ventilation, and\n3. Identify unique biophysiological factors contributing to EILO among exercisers with and without EILO. Findings will be highly novel and clinically significant for early identification and management of EILO.\n\nFor the study there are three separate visits:\n\n1. Free running with the device on the neck\n2. Exercise treadmill study\n3. Undergoing MRI (Magnetic Resonance Imaging) of the vocal tract.",[88,89,26],"Exercise-Induced Vocal Cord Dysfunction","Paradoxical Vocal Fold Motion","2026-02-26",{"date":92,"type":38},"2026-03-02",{"date":94,"type":20},"2026-04-20",{"date":96,"type":20},"2032-01-20",{"name":98,"class":45},"Indiana University"]