[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"voice-disorders\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:voice-disorders":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,54,82,102,130,161],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100525814","brain-and-voice-signatures-in-teachers-100525814",false,"NCT06126627","Brain and Voice Signatures in Teachers","Neurobiological and Psychobiological Signatures of Vocal Effort in Early Career Teachers","BRAVO1","Inclusion Criteria:\n\nTeachers (max. 10 years full-time) or student teachers in good health between 21 and 39 years with symptoms of vocal fatigue.\n\nControl participants in good health between 21 and 39 years without symptoms of vocal fatigue.\n\nExclusion Criteria:\n\n* Lefthandedness\n* Smoking (past 5 years)\n* Known changes of the vocal folds (e.g., vocal fold nodules), vocal fold paralysis, surgeries on the larynx or thryoid or current organic or neurological changes of the vocal folds or vocal function per videoendoscopy and -stroboscopy of the larynx\n* History of voice therapy\n* Hoarseness\n* Respiratory illness, allergies (respiratory, silver), reflux or asthma at time of participation\n* Hearing disorder or hearing aids\n* Psychological, neurological or endocrinological disorders\n* Psychotropic or steorid medications\n* Body mass index \\> 30\n* Indications against MRI such as metail parts in or on the body (e.g., permanent dental prostheses or braces, screws, prostheses, piercings or large tattoos\n* Nearsightedness \\> -5 diopters, if only glasses are worn\n* Claustrophobia\n* Pregnancy",true,"FEMALE","21 Years","39 Years",{"count":22,"type":23},100,"ESTIMATED","INTERVENTIONAL",[26],"NA","Primary muscle tension dysphonia voice disorder with symptoms of vocal strain and vocal fatigue is common and can have a significant negative impact on quality of Life. Yet, primary muscle tension dysphonia's causes are unknown precluding precise diagnostic classification. Stress and personality are thought to play a role and thus, the project aims to determine the practical and clinical effect of stress on the control of voice and speech in the brain. Participants are female early career teachers and student teachers with symptoms of vocal fatigue, as well as control participants without vocal fatigue, who perform speech tasks on two different occasions. Neural (imaging of brain), psychobiological (saliva, personality), and voice and speech (muscle activity of voice muscles on the neck with surface sensors, audio recordings) data will compare reactivity patterns of teachers who are stressresponders with those who are nonresponders as well as control participants. The central hypothesis is that voice box stress responders have heightened emotion-motor activations involving the emotional voice production pathway, which correlate with changes in voice muscle activity in the anterior neck. The results will provide fundamentally missing data in our understanding of the role of stress in vocal complaints and will yield new insights about the neural underpinnings of primary muscle tension dysphonia. The study findings will have a significant impact on how clinicians identify so-called laryngoresponders to help them prevent voice disorders.",[29,30],"Voice Disorders","Voice Fatigue",[32,33,34,35,36,37,38,39,40],"voice disorders","vocal fatigue","occupational voice disorders","stress reactivity","vocal control","laryngeal motor cortex","teachers","speech motor control","voice motor control","RECRUITING","2025-08-20",{"date":44,"type":45},"2025-08-27","ACTUAL",{"date":47,"type":45},"2023-08-01",{"date":49,"type":23},"2026-07-31",{"name":51,"class":52},"University Hospital, Bonn","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":4,"studyType":24,"phases":65,"briefSummary":67,"conditions":68,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":81},"100513829","early-phase-1-project-4-ambulatory-biofeedback-and-voice-therapy-for-patients-with-vocal-hyperfunction-100513829","NCT05970562","Project 4: Ambulatory Biofeedback and Voice Therapy for Patients With Vocal Hyperfunction","Preliminary Studies to Test the Effects of Ambulatory Biofeedback in Small Groups of Patients With Vocal Hyperfunction: Study 3","Inclusion criteria for PVH:\n\n* Diagnosis of vocal fold nodules and polyps.\n* Secondary diagnosis of laryngopharyngeal reflux (LPR) or gastro-esophageal reflux disease (GERD)\n* Secondary diagnoses commonly associated with phonotrauma like erythema, edema, varies, ectasia, laryngitis, secondary\u002Freactive muscle tension dysphonia (MTD), hemorrhage, etc.\n\nExclusion criteria for PVH:\n\n* Any secondary diagnosis not directly related to phonotrauma, like cyst, sulk, cancer, bamboo nodule, known or suspected paralysis, etc.\n\nInclusion criteria for NPVH:\n\n* Diagnosis of primary MTD.\n* Allowable secondary diagnoses are LPR and GERD.\n\nExclusion criteria for NPVH:\n\n* Any secondary diagnosis related to pathological structure (e.g., nodules, polyps, edema, cancer), neurology (e.g., paralysis, Parkinson's Disease), or respiration (e.g., chronic cough, paradoxical vocal fold motion).","ALL","18 Years","65 Years",{"count":22,"type":23},[66],"EARLY_PHASE1","Vocal hyperfunction (VH) is the most commonly treated class of voice disorders by speech-language pathologists and voice therapy is the primary curative treatment. Patients and clinicians report that generalizing improved voicing into daily life is the most significant barrier to successful therapy. We will test if extending biofeedback into the patient's daily life using ambulatory voice monitoring will significantly improve generalization during therapy and if individual patient factors, like how easily they can modify their voice and engagement during therapy, moderate the effects of the biofeedback.",[29,69,70,71],"Vocal Fold Polyp","Vocal Nodules in Adults","Muscle Tension Dysphonia","2025-05-07",{"date":74,"type":45},"2025-05-11",{"date":76,"type":45},"2024-03-01",{"date":78,"type":23},"2029-04-01",{"name":80,"class":52},"Massachusetts General Hospital",2,{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":17,"sex":61,"minAge":62,"maxAge":4,"enrollmentInfo":88,"targetDuration":4,"studyType":24,"phases":90,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":53},"100456237","improving-efficacy-of-voice-therapy-concepts-via-telepractice-and-mobile-app-technology-100456237","NCT05220982","Improving Efficacy of Voice Therapy Concepts Via Telepractice and Mobile App Technology","Inclusion Criteria:\n\n* Vocally healthy student in a bachelor of education program with student teaching planned for spring\n* Professional teacher who is currently working as a teacher with voice complaints, but has not sought help for the complaints\n* Owner of either an android or iOS smartphone or tablet.\n\nExclusion Criteria:\n\n* Not a student teacher\n* Not a professional teacher.\n* Does not own a smartphone.",{"count":89,"type":23},32,[26],"Due to the COVID-19 pandemic, telepractice has grown rapidly. To date, synchronous telepractice (i.e., in real-time videoconferencing) has been the focus of most research with asynchronous telepractice (i.e. information stored and accessed later) being used minimally only to record synchronous encounters. Descriptions of voice therapy concepts are minimally available in the literature with no standard reporting framework and no clinical efficacy or effectiveness data. Thus, the proposed study will address these barriers. First, an asynchronous method will be developed that will impact both in-person and telepractice services by offering repeated learning opportunities in the client's environment. The method includes ecological momentary intervention (EMI) through a daily voice therapy practice app, server, and web portal that is flexible in its programming to meet the needs of the client, offers performance feedback, and charts results over time. Second, voice therapy concepts will be tested improving our knowledge about such concepts that facilitate successful client-centered outcomes for both prevention and treatment of voice problems. The participants in the study will be teachers who have a high prevalence of voice problems, impact the healthcare system when treatment is needed, and negatively affect students' learning abilities in the classroom when communicating with a voice problem. Third, the Rehabilitation Treatment Specification System (RTSS) framework will be used to describe the voice therapy concepts. The concepts include: training multiple voices to meet all the clients' vocal needs, defining voice qualities by the anatomy and physiology of the voice production system, generalizing voice targets into hierarchical speech tasks, and using \"new\" vs \"other\u002Fold\" voice to help the client become their own clinician. Vocally healthy student teachers and professional teachers with voice complaints will be randomized into one of four voice therapy conditions delivered via telepractice. Both groups of teachers are needed to assess the concepts for prevention and treatment. Condition 2, which fully represents the proposed voice therapy concepts, will be superior to the other three conditions, which do not fully represent the concepts, by demonstrating a greater decrease in client-reported primary outcome measures of the Voice Handicap Index-10 and factor 1 and 2 of the Vocal Fatigue Index. Secondary outcomes of acoustic measures, Borg Category Ratio-10 scales for vocal and mental effort, and voice therapy satisfaction surveys will also be investigated. The results will be useful at a practical level by advancing asynchronous telepractice and by improving efficacy of voice therapy concepts. In addition, the results will lay the groundwork for future studies involving development of EMI platforms in other areas of speech-language pathology and testing additional voice therapy concepts that facilitate successful client-centered outcomes.",[29],"2024-08-27",{"date":95,"type":45},"2024-08-28",{"date":97,"type":45},"2022-08-31",{"date":99,"type":23},"2025-08-31",{"name":101,"class":52},"West Chester University of Pennsylvania",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":61,"minAge":62,"maxAge":4,"enrollmentInfo":109,"targetDuration":4,"studyType":24,"phases":111,"briefSummary":112,"conditions":113,"keywords":115,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":53},"100556368","rct-face-to-face-group-voice-therapy-vs-telepractice-group-voice-therapy-for-muscle-tension-dysphonia-100556368","NCT06524193","RCT Face-to-face Group Voice Therapy vs Telepractice Group Voice Therapy for Muscle Tension Dysphonia","Comparing Face-to-face Group Voice Therapy to Telepractice Group Voice Therapy for Muscle Tension Dysphonia: A Non-inferiority Randomized Controlled Trial","Inclusion Criteria:\n\n* Above or equal to 18 years of age;\n* Diagnosis of primary MTD or secondary MTD where voice therapy is the primary mode of treatment, such as vocal fold nodules;\n* Chinese-speaking subjects only.\n\nExclusion Criteria:\n\n* Dysphonia of neurogenic or psychogenic origin;\n* Secondary muscle tension dysphonia in which voice therapy is not the primary treatment modality, such as vocal polyp, vocal cyst, granuloma, papilloma;\n* Low computer literacy or without social or family support for telepractice;\n* Patients who are not capable of making own consent;\n* Patients who are receiving other modalities of treatment which is not part of this current study, such as traditional Chinese medicine.",{"count":110,"type":23},168,[26],"The goal of this clinical trial is to compare face-to-face group voice therapy to telepractice group voice therapy for muscle tension dysphonia (MTD). The main questions it aims to answer are:\n\n* The effectiveness of telepractice voice therapy for MTD using a randomized controlled trial study design.\n* The effectiveness of telepractice group voice therapy using a randomized controlled trial study design.\n\nParticipants will receive telepractice group voice therapy or face-to-face group voice therapy. Researchers will compare telepractice group voice therapy to face-to-face group voice therapy for patients with MTD to see if it has the same effectiveness.",[29,71,114],"Aphonia",[29,71,116,117,118,119,120],"Group Therapy","Telepractice","Service Delivery Model of Voice Therapy","Voice Therapy","Randomised controlled trail","2024-07-26",{"date":123,"type":45},"2024-07-29",{"date":125,"type":45},"2024-06-25",{"date":127,"type":23},"2026-07",{"name":129,"class":52},"Chinese University of Hong Kong",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":61,"minAge":138,"maxAge":139,"enrollmentInfo":140,"targetDuration":4,"studyType":24,"phases":142,"briefSummary":143,"conditions":144,"keywords":147,"overallStatus":152,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":4},"100552464","investigating-muscle-trainings-respiratory-outcomes-and-voice-enhancement-in-parkinsons-disease-100552464","NCT06473428","Investigating Muscle Training's Respiratory Outcomes and Voice Enhancement in Parkinson's Disease","The Association of Pulmonary Function, Diaphragm Thickness and Excursion, and Phonatory Measures in Parkinson's Disease","IMPROVE-PD","Inclusion Criteria:\n\n* Patients with Parkinson's disease (Hoehn \\& Yahr stage I-III),\n* Patients aged 30-85\n* Patients with stable medical condition, regular medication adherence, and ability to follow instructions.\n\nExclusion Criteria:\n\n* Patients with cognitive impairment\n* Patients with respiratory or other neurological diseases\n* Patients with smoking history\n* Patients with respiratory complications\n* Patients with recent chest\u002Fabdominal surgery\n* Patients with clinical instability\n* Patients who are unable to perform pulmonary function tests correctly","30 Years","85 Years",{"count":141,"type":23},45,[26],"This study aims to investigate the effects of different types of respiratory muscle training on lung function, diaphragm movement, and voice quality in patients with Parkinson's disease (PD). PD often leads to breathing difficulties and voice abnormalities due to weakened respiratory muscles and reduced diaphragm mobility. The study will involve 45 participants with PD, randomly assigned to three groups: one group will perform inspiratory muscle training, the second group will perform both inspiratory and expiratory muscle training, and the third group will receive placebo-controlled expiratory muscle training. The hypothesis is that targeted respiratory muscle training will significantly improve pulmonary function, diaphragm excursion, and phonatory measures compared to the placebo group. The findings aim to develop effective rehabilitation strategies to enhance the quality of life and communication abilities in individuals with PD.",[145,146,29],"Parkinson Disease","Pulmonary Disease",[148,149,150,151],"Parkinson's disease","Pulmonary function","Respiratory muscle training","Diaphragm","NOT_YET_RECRUITING","2024-06-18",{"date":125,"type":45},{"date":156,"type":23},"2024-07-01",{"date":158,"type":23},"2027-06-30",{"name":160,"class":52},"National Taiwan University Hospital",{"id":162,"slug":163,"hasResults":11,"nctId":164,"briefTitle":165,"officialTitle":165,"acronym":4,"eligibilityCriteria":166,"healthyVolunteers":17,"sex":61,"minAge":167,"maxAge":168,"enrollmentInfo":169,"targetDuration":4,"studyType":170,"phases":4,"briefSummary":171,"conditions":172,"keywords":173,"overallStatus":152,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":4},"100466000","multimodal-analysis-of-structural-voice-disorders-based-on-speech-and-stroboscopic-laryngoscope-video-100466000","NCT05348031","Multimodal Analysis of Structural Voice Disorders Based on Speech and Stroboscopic Laryngoscope Video","Inclusion Criteria:\n\nLaryngeal cancer, laryngeal precancerous lesions, benign laryngeal lesions with voice disorders, healthy people without throat diseases\n\nExclusion Criteria:\n\n1. A history of laryngeal surgery\n2. Patients with voice disorders caused by various causes except laryngeal cancer, laryngeal precancerous lesions, and benign laryngeal lesions\n3. The audio quality is not clear, the stroboscopic laryngoscope does not clearly display the anatomical area related to the glottis, and it is underexposed and blocked;","20 Years","80 Years",{"count":53,"type":23},"OBSERVATIONAL","This study intends to collect clinical data such as strobary laryngoscope images and vowel audio data of patients with structural voice disorders and healthy individuals, and to establish a multimodal voice disorder diagnosis system model by using deep learning algorithms. Multi-classification of diseases that cause voice disorders can be applied to patients with voice disorders but undiagnosed in clinical practice, thereby assisting clinicians in diagnosing diseases and reducing misdiagnosis and missed diagnosis. In addition, some patients with voice disorders can be managed remotely through the audio diagnosis model, and better follow-up and treatment suggestions can be given to them. Remote voice therapy can alleviate the current situation of the shortage of speech therapists in remote areas of our country, and increase the number of patients who need voice therapy. opportunity. Remote voice therapy is more cost-effective, more flexible in time, and more cost-effective.",[29],[174,175,176,177,178],"deep learning","multimodality","structural voice disorders","stroboscopic laryngoscope video","Speech","2022-04-22",{"date":181,"type":45},"2022-04-27",{"date":183,"type":23},"2022-05-06",{"date":185,"type":23},"2027-02-20",{"name":187,"class":52},"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University"]