[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"volunteer\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:volunteer":33},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":34,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100610787","phase-1-a-study-to-evaluate-the-safety-of-increasing-doses-of-df5112-in-healthy-adults-100610787",false,"NCT07232121","A Study to Evaluate the Safety of Increasing Doses of DF5112 in Healthy Adults","A Phase 1 Double-Blind, Randomized, Placebo-Controlled, Single Ascending Dose Study to Evaluate Safety, Tolerability, Pharmacokinetics, Immunogenicity and Pharmacodynamics of DF5112 in Healthy Adult Participants","DF5112","Key Inclusion Criteria:\n\n* Male or female participants aged 18 to 55 years (inclusive) at the time of informed consent.\n* Body mass index (BMI) between ≥ 18.0 and ≤ 32.0 kg\u002Fm2 and body weight ≥ 45 kg.\n* At the discretion of the Principal Investigator (PI) or designee, in good general health, with no significant medical history, and have no clinically significant abnormalities on physical examination at Screening and\u002For before the first administration of IP.\n* Clinical laboratory values within normal range as specified by the testing laboratory, unless deemed not clinically significant by the PI or designee.\n\nKey Exclusion Criteria:\n\n* History or presence of cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrinological, hematological, or neurological disorders that, in the opinion of the PI or designee, are capable of significantly altering the absorption, metabolism, or elimination of drugs; constituting a risk when taking the study intervention; or interfering with the interpretation of data.\n* History of lymphoproliferative disease or any known malignancy or history of malignancy of any organ system treated or untreated within the past 5 years, regardless of whether there is evidence of local recurrence or metastases (except for squamous and basal cell carcinoma of the skin or actinic keratoses that have been treated with no evidence of recurrence in the past 12 weeks; carcinoma in situ of the cervix or non-invasive malignant colon polyps that have been removed).\n* History of or evidence of recurrent or chronic bacterial or fungal infections including those of the skin, vagina, oral cavity, etc., or systemic fungal infection.\n* History of unexplained, recurrent infection, or infection requiring treatment with systemic antibiotics within 90 days prior to dosing on Day 1.\n* Active oral infection.\n* Acute illness (e.g. common cold) within 2 weeks prior to Screening, or seasonal influenza or COVID within 4 weeks prior to Screening.\n* History of latent or active tuberculosis that has not been adequately treated, at the discretion of the PI or designee.\n* Positive or inconclusive hepatitis B or hepatitis C based antibody tests at Screening.\n* Positive human immunodeficiency virus (HIV) antibody test at Screening.\n* History of severe allergy, hypersensitivity reaction, or anaphylaxis to drugs or human proteins or components of the study drug formulation used in this study.\n* Any vaccination within 1 month of Day 1 and planned within 1 month post Day 1. Any live or attenuated vaccine within 1 month prior to Day 1 and planned within 3 months post Day 1.",true,"ALL","18 Years","55 Years",{"count":22,"type":23},48,"ESTIMATED","INTERVENTIONAL",[26],"PHASE1","This is a double-blind, randomized, placebo-controlled, single ascending dose (SAD) study to evaluate safety, tolerability, pharmacokinetics (PK), immunogenicity and pharmacodynamics (PD) of DF5112 in healthy adult participants. A total of 48 participants are planned to be randomized into 6 cohorts. Additional cohorts at intermediate dose levels may be evaluated. Each cohort will include 8 healthy participants randomized to receive DF5112 or placebo through intravenous (IV) or subcutaneous (SC) administration. Following dose administration participants will be confined at the clinical research unit for observation for approximately 1 week and then will return for subsequent pre-identified follow up visits through Day 29.",[29,30,31,32,33],"Healthy Participants","Healthy Adult Females","Healthy Adult Male","Healthy","Volunteer",[35,36],"Healthy Volunteer","Healthy Participant","RECRUITING","2026-03-26",{"date":40,"type":41},"2026-04-01","ACTUAL",{"date":43,"type":41},"2026-01-12",{"date":45,"type":23},"2026-12",{"name":47,"class":48},"Dragonfly Therapeutics","INDUSTRY",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":24,"phases":60,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":49},"100620206","effect-of-transcutaneous-electrical-stimulation-on-peripheral-blood-flow-100620206","NCT07354607","Effect of Transcutaneous Electrical Stimulation on Peripheral Blood Flow","Effect of Transcutaneous Electrical Stimulation on Peripheral Blood Flow - a Pilot Study","VASC-STIM","Inclusion Criteria:\n\n* Subject aged 18 years or older\n* Having freely given written consent, after being informed of the purpose of the study, its conduct and its risks.\n* Affiliated with a social security scheme\n\nExclusion Criteria:\n\n* Persons with pacemakers or any other implantable electrical devices,\n* Pregnant women\n* Suffering from dermatological conditions or muscle\u002Fskin lesions on the arms and forearms.\n* Participant unable to give free and informed consent.\n* Participant unable to comply with the specific procedures of the study.\n* Participant deprived of liberty or benefiting from legal protection measures.",{"count":59,"type":23},36,[61],"NA","The goal of this clinical trial is to learn if transcutaneous electrical nerve stimulation can affect blood flow in healthy volunteers. The main question it aims to answer is:\n\nDetermine the stimulation parameters (frequency in the range 5- 100Hz and proximal or distal placement) inducing the most significant hyperaemic response in volunteers.\n\nParticipants will attend to one visit ( 1h30) , 6 protocol of stimulation will be tested on his arm . If his agree, an optionnal measure will be made during another visit. During this optionnal visit, two modalities of intensity adjustment will be tested in regard of the result of the first part of the study.",[33,64],"Adult",[66,67],"transcutaneous electrical nerve stimulation","blood flow","2026-03-09",{"date":70,"type":41},"2026-03-10",{"date":72,"type":41},"2026-02-04",{"date":74,"type":23},"2026-08-01",{"name":76,"class":77},"Centre Hospitalier Metropole Savoie","OTHER"]