[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"weakness-muscle\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:weakness-muscle":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,42,70,97,120,153],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100054284","early-phase-1-metformin-and-aclr-muscle-recovery-100054284",false,"NCT07699367","Metformin and ACLR Muscle Recovery","Metformin and Muscle Recovery Following ACL Surgery","Inclusion Criteria:\n\n1. Age between 40y and older\n2. BMI: \\\u003C30 kg\u002Fm2\n3. Full thickness ACL tear\n4. Less than 6 months between ACL injury and scheduled ACLR\n\nExclusion Criteria:\n\n1. Prior ACL tear in limb scheduled for reconstruction or current bilateral ACL tear\n2. Total knee dislocation\n3. Anticipated quadriceps ACLR grafts\n4. Current infection near the lower limb\n5. Inability to attend physical therapy sessions\n6. Post-operative loading restrictions\n7. History of cardiovascular disease (e.g., CHF, CAD, MI, CVA)\n8. History of endocrine or metabolic disease such as hypo\u002Fhyperthyroidism and diabetes (Treated hypo\u002Fhyperthyroid for at least 6 months will be permitted)\n9. History of stroke with motor disability\n10. History of respiratory disease (acute upper respiratory infection, history of chronic lung disease)\n11. Self-reported pregnancy\n12. Bleeding disorder\n13. Implanted electronic devices (e.g., pacemakers, electronic infusion pumps, stimulators)\n14. Cancer or history of successfully treated cancer (less than 1 year) other than basal cell carcinoma\n15. Chronic systemic corticosteroid use (≥ 2 weeks) within 4 weeks of enrollment and for study duration (intra-articular\u002Ftopical\u002Finhaled therapeutic or physiologic doses of corticosteroids will be permitted)\n16. Androgens or growth hormone within 6 months of enrollment and for study duration (topical physiologic androgen replacement will be permitted)\n17. Currently taking estrogen products (topical estrogen products will be permitted)\n18. Taking anticoagulant medication (warfarin\u002FCoumadin, heparin) that may complicate the muscle biopsy\n19. Any staff members who report directly to the principal investigators","ALL","40 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"EARLY_PHASE1","The purpose of this research study is to determine if Metformin taken after anterior cruciate ligament reconstruction (ACLR) surgery can decrease muscle fibrosis, cellular senescence and improve leg strength. ACL injury and surgery increase muscle collagen content and inflammation which slows the recovery of muscle and function and ultimately impacts the quality of life. Individuals enrolled in the study will be randomized to receive metformin (or placebo) for 4 months after surgery. The investigators will measure muscle strength and inflammatory markers in muscle biopsy samples after the intervention period. Investigators will also follow up with participants 8 months later to determine the lasting effects of the intervention.",[26,27,28],"Atrophy","Inflammation","Weakness, Muscle","NOT_YET_RECRUITING","2026-07-09",{"date":32,"type":33},"2026-07-13","ACTUAL",{"date":35,"type":20},"2026-11-01",{"date":37,"type":20},"2032-10-01",{"name":39,"class":40},"University of Utah","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":21,"phases":52,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":69},"100495034","assisted-ambulation-to-improve-health-outcomes-for-older-medical-inpatients-100495034","NCT05725928","Assisted Ambulation to Improve Health Outcomes for Older Medical Inpatients","Randomized Trial of Assisted Ambulation to Improve Health Outcomes for Older Medical Inpatients","Inclusion Criteria:\n\nParticipants must meet all of the inclusion criteria listed below to participate in this study:\n\n1. ≥65 years of age\n2. Admitted to a medical service\n3. Complete history and physical examination on file\n4. 6-Clicks score of 16-23\n5. Insurance with Traditional Medicare or Medicare Advantage\n\nExclusion Criteria:\n\nAny patient meeting any of the exclusion criteria listed below at baseline will be excluded from study participation:\n\n1. Significant language barrier that requires a translator (other than Spanish at Baystate site only)\n2. Discharge planned for that day or the following day\n3. Observation status\n4. Surgical procedure planned\n5. Patients diagnosed with unstable angina or other medical conditions precluding participation in exercise\u002Fambulation\n6. Permanent residence in a skilled nursing facility\n7. Comfort care measures only\n8. \\>48 hours since admission\n9. Active infection with COVID-19\n10. Other active infection requiring contact or droplet precautions\n11. Order for bedrest","65 Years",{"count":51,"type":20},3000,[53],"NA","The investigator proposes to conduct a randomized trial of supervised ambulation delivered by mobility technician (MT) up to three times daily, including weekends, to hospitalized medical patients. The aims of the study are to compare the short and intermediate-term outcomes of patients randomized to the intervention versus those patients randomized to receive usual care, to identify patients who are most likely to benefit from the intervention and to assess whether the intervention increases or decreases overall costs of an episode of care, including the cost of the MTs, the index hospitalization and the first 30 days post enrollment.",[56,57,58,28],"Mobility Limitation","Frailty","Hospital Acquired Condition","RECRUITING","2026-06-05",{"date":62,"type":33},"2026-06-08",{"date":64,"type":33},"2023-05-15",{"date":66,"type":20},"2026-12-01",{"name":68,"class":40},"The Cleveland Clinic",5,{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":16,"minAge":78,"maxAge":4,"enrollmentInfo":79,"targetDuration":4,"studyType":21,"phases":81,"briefSummary":82,"conditions":83,"keywords":84,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":41},"100550004","blood-flow-restriction-training-for-people-with-disabilities-100550004","NCT06441422","Blood Flow Restriction Training for People With Disabilities","Effectiveness of Low Load Resistance Training With Blood Flow Restriction in Individuals With Disabilities","Inclusion Criteria:\n\n* Male or female\n* Age \\> or = 18\n* English speaking\n* Able to understand and perform upper extremity exercises\n\nExclusion Criteria:\n\n* Pregnant\n* Body mass index \\>40 kg·m-2\n* Uncontrolled hypertension (\\>150\u002F90 mmHg)\n* Presence of neuromuscular junction and other muscle diseases\n* Myocardial infarction in the past 6 months\n* Unstable cardiovascular disease\n* History of an upper limb deep vein thrombosis\n* History of autonomic dysreflexia\n* Upper extremity fracture within the last 6 months",true,"18 Years",{"count":80,"type":20},24,[53],"A large portion of the American population live with disabilities. People with disabilities can find it difficult to perform standard exercise routines. Regular exercise is necessary to be healthy, especially as people age. Lack of exercise can lead to secondary health concerns, like loss of muscle mass, diabetes, heart attack or stroke, to name a few. For exercise to be most beneficial, a certain degree of intensity must be achieved. Low load blood flow restriction training may be able to mimic the intensity of beneficial exercise without actually exercising hard. It may be a good option for people with disabilities who find it difficult to exercise.",[28],[85,86,87],"Disability","Blood flow restriction","Low load blood flow restriction training","2026-04-29",{"date":90,"type":33},"2026-05-01",{"date":92,"type":33},"2024-12-12",{"date":94,"type":20},"2027-12-31",{"name":96,"class":40},"Medical College of Wisconsin",{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":103,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":21,"phases":108,"briefSummary":109,"conditions":110,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":118,"locationsCount":41},"100506704","precision-medicine-and-physical-function-100506704","NCT05877846","Precision Medicine and Physical Function","A Precision Nutrition Approach to Enhancing Physical Function in Older Adults: A Pilot, Feasibility Study","HMB","Inclusion Criteria:\n\n* English-speaking older adults aged 65 to 85 years (of all genders and sexes, race or ethnicity)\n* A University of North Carolina at Chapel Hill (UNC) Geriatrics Medicine clinic patient;\n* Chronic medical conditions -these are based on the 21 Medicare multiple chronic conditions (e.g., alcohol abuse, arthritis (osteoarthritis, rheumatoid), asthma, atrial fibrillation, autism spectrum disorders, cancer (breast, colorectal, lung, prostate), chronic kidney disease, chronic obstructive pulmonary disease, depression, diabetes, drug\u002Fsubstance abuse, heart failure, hepatitis, HIV\u002FAIDS, hyperlipidemia, hypertension, ischemic heart disease, osteoporosis, schizophrenia\u002Fother psychotic disorders, stroke);\n\nExclusion Criteria:\n\n* Age \\\u003C65 years and \\>85 years old\n* A medical diagnosis of dementia\n* Those without a negative subjective weakness screener (\\\u003C1)\n* Individuals with life-threatening or untreated psychiatric diagnosis that would interfere with study participation and require significant modification to meet their needs such as untreated major depressive disorder, substance abuse, suicidal ideation or untreated severe mental illness (schizophrenia, bipolar disorder)\n* Life-threatening illness including those receiving palliative care or hospice services\n* Individuals unwilling\u002Funable to provide consent\n* Inability to complete the protocol procedures\n* Elective surgery in the next four months\n* Medications - antiobesity (weight loss agents) medications that lead to weight loss\n* Hospitalization for heart failure in past 6 months, advanced non-skin cancer (Stage III or IV) on treatment; Advanced liver failure; Chronic renal insufficiency on hemodialysis; advanced Chronic obstructive pulmonary disease (COPD) that would prevent engagement\n\n  \\*\\*\\*Vitamin D \\>80 ng\u002FdL:\n* At baseline, the investigators will check Vit D levels - recognize that processing is highly dependent on the McLendon lab and may take up to 7+ days to come back.\n* Concurrently, the investigators will consider continuing consent, enrollment, study procedures.\n* Provide at Visit 2 the beta-hydroxymethyl butyrate\u002FVitamin D supplement\n* Once the results have been received and reviewed - if the levels exceed 80 ng\u002FdL, then the participant will be informed.\n* At that point, the investigators will either exclude the participant or, if available, see whether the company is willing to provide formulations of just beta-hydroxymethyl butyrate (HMB)and provide this to the participant\n* These guidelines account for the fact that Vit D is not recommended by American Geriatrics Society to check routinely, and that levels \\\u003C80 (or even 120 ng\u002FmL) rarely lead to toxicity.","85 Years",{"count":107,"type":20},25,[53],"The investigators aim to conduct a 12-week, single-arm, pre\u002Fpost-intervention of b-hydroxy-methylbutyrate in persons aged 65 to 85 years to assess feasibility and acceptability of the intervention and study procedures, secondary outcomes of physical function and changes in multi-omics patterns, and exploratory outcomes that will allow the team to describe physical function phenotype. The investigators' primary outcomes are the: feasibility of the study procedures (including safety), feasibility of the intervention delivery, and acceptability of study procedures and measures. Secondary outcomes include: Objective and subjective physical function measures that predict disability including the 30-second sit-to-stand, knee strength, isokinetic strength, grip strength, gait speed, 400-m walk test, Pittsburgh Fatiguability, PROMIS global health-10, social support, anthropometry, National Institutes of Health (NIH) Cognitive toolbox, Automated Self-Administered 24-hour Dietary Assessment (ASA-24), Community Healthy Activities Model Programs (CHAMPS), Ultrasound Imaging, Magnetic Resonance Imaging (MRI), Changes in untargeted metabolomic profile data based on qualitative or semiquantitative analysis of the most probable detectable metabolites in laboratory samples , Discover potential metabolites that explain changes in physical function using a discovery science, precision medicine approach (discovery science approach that is exploratory)",[57,28,111],"Multiple Chronic Conditions","2026-02-12",{"date":114,"type":33},"2026-02-17",{"date":116,"type":33},"2023-11-01",{"date":66,"type":20},{"name":119,"class":40},"University of North Carolina, Chapel Hill",{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":124,"acronym":125,"eligibilityCriteria":126,"healthyVolunteers":11,"sex":16,"minAge":78,"maxAge":4,"enrollmentInfo":127,"targetDuration":4,"studyType":21,"phases":129,"briefSummary":130,"conditions":131,"keywords":137,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":41},"100557504","adherence-to-long-term-exoskeleton-rehabilitation-to-treat-lower-limb-weakness-and--or-deficiencies-in-adult-population-100557504","NCT06538974","Adherence to Long-term Exoskeleton Rehabilitation to Treat Lower Limb Weakness and \u002F or Deficiencies in Adult Population","ALERT","Inclusion Criteria:\n\n* Patient suffering from lower limb weaknesses and \u002F or deficiencies regardless of the cause\n* Adult patient ≥18 years old\n* Patient able to read and write in French and who have signed an informed consent form\n* Patient affiliated to a social security system.\n\nExclusion Criteria:\n\n* Individual with severe spasticity of adductor muscles, hamstring, quadriceps and triceps surae. Severe spasticity is defined by a score of 4 on the modified Ashworth scale\n* Pregnant woman\n* Individual with history of osteoporotic fracture and \u002F or pathology or treatment causing secondary osteoporosis\n* Pressure Ulcer of Grade I or higher according to the NPUAP International Pressure Ulcer Classification System- EPUAP, in areas of contact with the Atalante X system\n* Severe aphasia limiting ability to express needs or to fulfil questionnaires, at the discretion of the physician.\n* Patient with a cardiac or respiratory contraindication to physical exertion, at discretion of the physician\n* Patient unable to deliver his\u002Fher consent\n* Patient under legal protection\n* Patient participating at the same time in another study\n* Patients with morphological contraindications to the use of the Atalante X exoskeleton (as per user's manual) with exceptions as follows: knee flessum of 20° authorized if sensibility is present; equinus of the ankle of 20° allowed regardless of presence or absence of sensibility, hip flessum of 20° allowed regardless of presence or absence of sensibility.",{"count":128,"type":20},100,[53],"In 2019, approximately 2.4 billion people worldwide required rehabilitation for various health pathologies, a 63% increase since 1990. It has been suggested that current rehabilitation frameworks (inpatient, outpatient, and community-based) are insufficient to meet local population needs due to issues like long waiting times, lack of facilities, prioritization, funding, and accessibility.Patients with lower limb weaknesses, resulting from various conditions (for example stroke, traumatic brain injury, spinal cord injury and others) require long-term management and motivation for engagement, which are crucial for functional outcomes. This highlights the need for sustainable gait and balance rehabilitation.\n\nNew technologies like exoskeletons have shown promising results in short-term inpatient programs, improving gait, balance, and quality of life, however, long-term follow-up data are still needed.\n\nThe present clinical investigation is a national, prospective, open-label interventional trial, proposing a 12-month outpatient rehabilitation program with the Atalante X exoskeleton to treat lower limb weakness and\u002For impairments in 100 participants. The rehabilitation program consists of at least one exoskeleton rehabilitation session per week. At the end of the first-year experimental phase, participants can continue for an additional year in the voluntary phase. The program aims to explore the potential long-term effects of supervised robotic rehabilitation on motor, cognitive, bowel, bladder functions, quality of life, and well-being. Assessments are conducted at baseline, after 4 and 12 months of exoskeleton rehabilitation, and at 16 and 24 months for participants in the voluntary phase.",[132,133,134,135,28,136],"Motor Disorders","Gait Disorders, Neurologic","Neurodegenerative Diseases","Spinal Cord Injuries","Cerebrovascular Accident",[138,139,140,141,142],"Hands-free Exoskeleton","Atalante X","Gait","Balance","Rehabilitation","2024-07-31",{"date":145,"type":33},"2024-08-06",{"date":147,"type":33},"2023-02-16",{"date":149,"type":20},"2027-07-02",{"name":151,"class":152},"Wandercraft","INDUSTRY",{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":157,"acronym":158,"eligibilityCriteria":159,"healthyVolunteers":77,"sex":16,"minAge":49,"maxAge":4,"enrollmentInfo":160,"targetDuration":4,"studyType":21,"phases":162,"briefSummary":163,"conditions":164,"keywords":170,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":41},"100501881","yoomi-effect-of-gamified-physical-therapy-exercise-software-on-inpatient-mobility-100501881","NCT05815017","YOOMI: Effect of Gamified Physical Therapy Exercise Software on Inpatient Mobility","YOOMI","Inclusion Criteria:\n\n* \\>= 65 years of age\n* English-fluency in reading and speaking\n* Capacity to consent\n* Enrolled in HELP program\n* Attending physician confirms there are no medical contraindications to in-bed exercises\n\nExclusion Criteria:\n\n* Unstable Psychiatric Illness\n* Unstable\u002FCritically Ill Patients requiring ICU-level of care\n* Surgical tube present (e.g. JP drains)\n* Surgery during the hospitalization\n* Bed Rest Activity Order",{"count":161,"type":20},80,[53],"Patients admitted to the hospital often develop functional impairments due to being in bed most of the day. Each day of bedrest leads to significant muscle loss. As a result, many patients become dependent on others or require rehabilitation at a facility to improve mobility and function prior to returning home. Staff in the hospital is limited and often unable to mobilize patients every day while hospitalized. The investigators are testing a new experimental gamified physical therapy exercise software to see if it can be a fun, enjoyable way to help mobilize patients without the assistance of staff. The primary aim of this pilot\u002Fproof of concept study is to determine whether gamified physical therapy software can help inpatients exercise within the safety of their own beds and preserve pre-hospitalization function.",[28,165,166,167,58,168,169],"Delirium in Old Age","Muscle Atrophy or Weakness","Muscle Loss","Physical Disability","Physical Inactivity",[171,172,173,174,175,176],"Artificial Intelligence (AI)","Physical Therapy","Hospitalization related muscle atrophy","Hospitalization associated decline","Inpatient rehabilitation","AI driven physical therapy","2024-03-06",{"date":179,"type":33},"2024-03-08",{"date":181,"type":33},"2023-11-29",{"date":183,"type":20},"2024-12",{"name":185,"class":40},"Rutgers, The State University of New Jersey"]