[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"weaning-failure-of-mechanical-ventilation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:weaning-failure-of-mechanical-ventilation":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,50,79,100,121,136],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100587044","ultrasound-evaluation-of-cardiac-function-during-spontaneous-breathing-trials-100587044",false,"NCT06923267","Ultrasound Evaluation of Cardiac Function During Spontaneous Breathing Trials","Ultrasound Evaluation of Cardiac Function During Three Spontaneous Breathing Trials in Intensive Care Unit : A Prospective Interventional Study","ATARI","Inclusion Criteria:\n\n* Intubated patient undergoing invasive mechanical ventilation for at least 24 hours and scheduled for a spontaneous breathing trial\n* Richmond Agitation Sedation Scale (RASS) between -1 and +1\n* Patient at high risk of re-intubation with at least one of the following criteria:\n\n  * Underlying cardiac disease (left ventricular dysfunction with left ventricular ejection fraction ≤ 45%, documented ischemic heart disease, chronic atrial fibrillation, known history of cardiogenic pulmonary edema)\n  * Underlying respiratory disease (COPD, Emphysema, bronchial dilatation, asthma, obesity\u002Fhypoventilation syndrome, restrictive lung disease)\n\nExclusion Criteria:\n\n* Neuromuscular pathology (myasthenia type) preceding hospitalization\n* Pregnant or breast-feeding women\n* Patient already included in the study\n* Protected person (under guardianship or curatorship)\n* Person under court protection\n* Person not affiliated to a social security scheme","ALL","18 Years",{"count":20,"type":21},24,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to evaluate the evolution of a cardiac ultrasound index (E\u002FE') during 3 spontaneous breathing trials in Intensive Care Unit (ICU) adults (over 18 years) patients at risk for weaning failure. The main objective is to find out which spontaneous breathing trial is the least demanding in terms of heart work.\n\nInvestigators will compare 3 consecutive spontaneous breathing trials in a random order to see if one is superior to the others.\n\nParticipants will not have to perform any specific procedure apart from breathing without respiratory support during the spontaneous breathing trial. During these trials, the investigator will perform cardiac ultrasound measurements.",[27,28,29,30,31],"Weaning Invasive Mechanical Ventilation","Weaning-induced Pulmonary Edema","Weaning Failure of Mechanical Ventilation","Spontaneous Breathing Test","Intensive Care Units (ICUs)",[33,34,35,36],"Humidified high flow","Cardiac ultrasound","Spontaneous breathing trial","T-Piece","RECRUITING","2026-05-21",{"date":40,"type":41},"2026-05-22","ACTUAL",{"date":43,"type":41},"2025-04-30",{"date":45,"type":21},"2027-05",{"name":47,"class":48},"Centre Hospitalier Régional d'Orléans","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":65,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":49},"100636871","combined-predictive-value-of-rsbi-and-cally-index-in-predicting-weaning-success-in-icu-patients-100636871","NCT07571317","Combined Predictive Value of RSBI and CALLY Index in Predicting Weaning Success in ICU Patients","Combined Predictive Value of Rapid Shallow Breathing Index (RSBI) and CRP-Albumin-Lymphocyte (CALLY) Indices in Predicting the Success of Weaning From Mechanical Ventilation in Intensive Care Patients: A Prospective Observational Study","Inclusion Criteria:\n\n* Patients aged 18 years and older\n* Patients who have received invasive mechanical ventilation for at least 24 hours in the general intensive care unit.\n\nPatients who meet standard clinical weaning criteria (e.g., hemodynamic stability with minimal or no vasopressor support, adequate cough reflex, absence of excessive airway secretions).\n\nPatients deemed ready for a Spontaneous Breathing Trial by the attending physician.\n\nExclusion Criteria:\n\n* Patients under the age of 18.\n* Patients with a known or detected pregnancy.\n* Patients with a diagnosis of malignancy.\n* Patients with neuromuscular diseases that could impair respiratory effort or muscle strength assessments (e.g., Myasthenia Gravis, Amyotrophic Lateral Sclerosis, Guillain-Barré syndrome).",{"count":58,"type":21},105,"OBSERVATIONAL","The primary objective of this prospective observational study is to evaluate the effectiveness of combining the Rapid Shallow Breathing Index (RSBI) and CRP-Albumin-Lymphocyte (CALLY) index to predict weaning success in adult patients within the intensive care unit. While weaning from mechanical ventilation is a critical clinical step, existing physiological metrics like RSBI do not fully capture a patient's inflammatory or nutritional status. This research introduces the CALLY index calculated as the ratio of the patient's immuno-nutritional reserve (Albumin and Lymphocytes) to systemic inflammation (CRP) as a complementary metabolic marker. By tracking approximately 105 participants at Basaksehir Cam and Sakura City Hospital, the study monitors weaning success over both a 48 hour and a 7 day period to identify both immediate and late phase extubation failures. The ultimate goal is to provide a more holistic prediction model that potentially reduces re-intubation rates and improves clinical outcomes by accurately identifying the optimal time for ventilator removal.",[62,63,64,29],"Critical Illness","Respiratory Insufficiency","Ventilator Weaning",[66,67,68,69],"mechanical ventilation","ventilator weaning","Systemic Inflammation","CRP-Albumin-Lymphocyte Ratio","2026-05-06",{"date":72,"type":41},"2026-05-11",{"date":74,"type":21},"2026-05-04",{"date":76,"type":21},"2026-07-31",{"name":78,"class":48},"Istanbul University - Cerrahpasa",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":86,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":22,"phases":89,"briefSummary":90,"conditions":91,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":98,"locationsCount":49},"100336215","speckle-tracking-echocardiography-for-the-prediction-of-weaning-failure-100336215","NCT03657524","Speckle Tracking Echocardiography for the Prediction of Weaning Failure","Combined Thoracic Ultrasound Using Speckle Tracking for the Prediction of Weaning Failure : a Prospective Multicenter Study","Inclusion Criteria:\n\n\\- Patients hospitalized in intensive care unit under mechanical fulfilling the criteria of ventilation weaning trial.\n\nExclusion Criteria:\n\n* Less than 18 years old.\n* Pregnancy\n* Non sinusal cardiac rhythm\n* Neuro Myopathy\n* Tracheotomy\n* Lack of echogenicity to perform at least a four chamber apical view",true,{"count":88,"type":21},110,[24],"Deciding the optimal timing for extubation in patients who are mechanically ventilated can be challenging, and traditional weaning predictor tools are not accurate. Recent studies suggest that isolated sonographic assessment of the respiratory and cardiac function (ie diastolic function and filling pressure), in mechanically ventilated patients may assist in identifying patients at risk of weaning failure. Recently, the association of conventional echocardiography and lung ultrasound showed promising results for the prediction of post extubation distress. Speckle Tracking is an emerging tool in intensive care medicine that has never been investiguated for the prediction of weaning failure. It could early detects diastolic dysfunction and and elevated filling pressure. Of more, speckle tracking is known to be less operator dependant. The main objective of our study is to evaluate the diagnosis accuracy of speckle tracking echocardiography performed during a weaning trial to predict weaning failure. The secondary objectives are to assess the diagnosis accuracy of combined heart and lung ultrasound to predict weaning failure.",[29],"2026-02-10",{"date":94,"type":41},"2026-02-12",{"date":96,"type":41},"2019-05-20",{"date":38,"type":21},{"name":99,"class":48},"Assistance Publique Hopitaux De Marseille",{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":107,"targetDuration":109,"studyType":59,"phases":4,"briefSummary":110,"conditions":111,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":49},"100598779","evaluation-of-left-ventricular-function-to-predict-weaning-success-in-the-intensive-care-unit-100598779","NCT07075926","Evaluation of Left Ventricular Function to Predict Weaning Success in the Intensive Care Unit","Evaluation of Left Ventricular Function to Predict Weaning Success in the Intensive Care Unit: A Prospective Observational Study","Inclusion Criteria:\n\n* Currently receiving mechanical ventilation in the ICU\n* Planned extubation after meeting standard weaning criteria\n* Hemodynamically stable at the time of echocardiographic evaluation\n* Written informed consent obtained from the patient or legally authorized representative\n\nExclusion Criteria:\n\n* Surgery within the previous 24 hours\n* Presence of significant valvular heart disease or known cardiomyopathy\n* Inadequate acoustic window for transthoracic echocardiography\n* Ongoing use of extracorporeal support (e.g., ECMO)\n* Patients with Do-Not-Resuscitate (DNR) orders or expected to die within 24 hours\n* Re-intubation planned prophylactically regardless of clinical status\n* Pregnant patients",{"count":108,"type":21},50,"1 Day","The goal of this prospective observational study is to evaluate whether left ventricular function parameters assessed via transthoracic echocardiography (TTE) can predict weaning success from mechanical ventilation in adult intensive care unit (ICU) patients. The main questions it aims to answer are:\n\nCan the Left Ventricular Outflow Tract Velocity Time Integral (LVOT VTI) predict successful extubation?\n\nWhat is the prognostic value of other echocardiographic measures such as Mitral Annular Plane Systolic Excursion (MAPSE), E\u002Fe' ratio, E\u002FA ratio, Mitral Deceleration Time (MDT), and Myocardial Performance Index (Tei index) in forecasting weaning outcomes?\n\nParticipants will:\n\nBe adults receiving mechanical ventilation and scheduled for weaning\n\nUndergo transthoracic echocardiography (TTE) within 2 hours after meeting weaning criteria\n\nHave the following parameters measured: LVOT VTI, MAPSE, E\u002Fe', E\u002FA, MDT, and Tei index\n\nBe monitored for 24 hours post-extubation to determine if they remain off ventilatory support, including reintubation, non-invasive ventilation, or high-flow oxygen therapy\n\nThis study aims to provide a comprehensive understanding of how systolic, diastolic, and global cardiac functions influence extubation success, potentially improving ICU decision-making and reducing complications, length of stay, and healthcare costs.",[29],"2025-09-02",{"date":114,"type":41},"2025-09-09",{"date":116,"type":41},"2025-07-31",{"date":118,"type":21},"2026-07-16",{"name":120,"class":48},"Kanuni Sultan Suleyman Training and Research Hospital",{"id":122,"slug":123,"hasResults":11,"nctId":124,"briefTitle":125,"officialTitle":126,"acronym":4,"eligibilityCriteria":127,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":128,"targetDuration":109,"studyType":59,"phases":4,"briefSummary":130,"conditions":131,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":132,"startDateStruct":133,"completionDateStruct":134,"leadSponsor":135,"locationsCount":49},"100598629","evaluation-of-right-ventricular-function-to-predict-weaning-success-in-the-intensive-care-unit-100598629","NCT07073976","Evaluation of Right Ventricular Function to Predict Weaning Success in the Intensive Care Unit","Evaluation of Right Ventricular Function to Predict Weaning Success in the Intensive Care Unit: A Prospective Observational Study","Inclusion Criteria:\n\n* Receiving invasive mechanical ventilation in the ICU\n* Planned extubation (weaning) according to standard clinical criteria\n* Hemodynamically stable at the time of transthoracic echocardiography (TTE)\n* Ability to undergo echocardiographic assessment within 2 hours prior to extubation\n* Informed consent obtained from patient or legal representative\n\nExclusion Criteria:\n\n* Known severe tricuspid valve disease or congenital heart disease\n* Moderate to severe pericardial effusion or cardiac tamponade\n* Inadequate acoustic window for transthoracic echocardiography\n* Patients requiring urgent or unplanned extubation\n* Use of extracorporeal life support (e.g., ECMO) at the time of assessment\n* Known pulmonary embolism or acute cor pulmonale\n* Pregnancy",{"count":129,"type":21},60,"The goal of this prospective observational study is to evaluate whether right ventricular (RV) function parameters assessed via transthoracic echocardiography (TTE) can predict weaning success in adult intensive care unit (ICU) patients who are mechanically ventilated. The main questions it aims to answer are:\n\nCan the TAPSE (Tricuspid Annular Plane Systolic Excursion) value predict successful extubation?\n\nDo other right heart parameters (tricuspid S', RV-FAC, right atrial area, pulmonary valve acceleration time) provide additional prognostic value for weaning outcomes?\n\nParticipants will:\n\nBe adult ICU patients planned for weaning from mechanical ventilation.\n\nUndergo transthoracic echocardiography within 2 hours after meeting clinical weaning criteria.\n\nHave the following echocardiographic parameters measured: TAPSE, tricuspid S', RV-FAC, right atrial area, and pulmonary valve acceleration time.\n\nBe monitored for 24 hours after extubation to assess weaning success (defined as no need for reintubation, non-invasive ventilation, or high-flow oxygen support).",[29],{"date":114,"type":41},{"date":116,"type":41},{"date":118,"type":21},{"name":120,"class":48},{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":142,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":144,"enrollmentInfo":145,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":147,"conditions":148,"keywords":152,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":49},"100568634","ventilatory-settings-and-monitoring-variables-associated-with-weaning-failure-in-critically-ill-patients-100568634","NCT06683781","Ventilatory Settings and Monitoring Variables Associated With Weaning Failure in Critically Ill Patients","Ventilatory Settings and Monitoring Variables Associated With Weaning Failure in Critically Ill Patients: A Retrospective Study","WEAN-FAIL","Inclusion Criteria:\n\n* Over 18 years\n* MV for at least 48 hours, regardless of the cause of onset\n* Undergone at least one extubation, regardless of the outcome\n* At least one spontaneous breathing trial (SBT) during their ICU stay, regardless of the outcome\n\nExclusion Criteria:\n\n* MV records containing incorrect or inconsistent data\n* did not have adequate or continuous monitoring during the weaning process","100 Years",{"count":146,"type":21},1077,"Mechanical ventilation (MV) is essential in managing acute respiratory failure. Its duration is a crucial aspect since both, unnecessary prolongation and premature withdrawal have deleterious effects on patient outcomes in the ICU. The process of weaning refers to the set of procedures and evaluations carried out to discontinue MV. Regardless of the definition used, within the population undergoing weaning, there is a group of patients who successfully pass the daily screening but fail the spontaneous breathing trial (SBT) or the separate attempt (SA). In Argentina, this figure is 39.5%, and 31.4% in patients with COVID-19. On the other hand, another group of patients successfully passes the SA, is extubated, but fails in post-extubation. This failure rate varies in the literature, ranging from approximately 10 to 20%. In our country, this figure is 16% in the general population and rises to 29.7% in COVID-19 patients. Additionally, this population is divided into those who cannot tolerate ventilation without an artificial airway due to upper airway patency issues (such as laryngeal edema), i.e., \"airway failure,\" and those who experience acute respiratory failure. In 2023, the WEAN SAFE study reported novel findings regarding variables associated with weaning failure. In multivariable analysis, it was found that the MV settings and monitoring variables at the time of the first SBT - respiratory rate, positive end-expiratory pressure (PEEP), dynamic airway pressure difference (peak pressure (Ppeak) minus PEEP) on the day of the SA - were associated with weaning failure. In this context, the investigators will conduct a retrospective cohort study, whose primary objective will be to assess which MV settings and monitoring variables are associated with weaning failure.\n\n\\*\\*Primary Objective\\*\\* To determine if there are any MV settings or monitoring variables that are associated with extubation failure.\n\n\\*\\*Secondary Objective\\*\\* To determine if there are any MV settings or monitoring variables that are associated with failure in the first SBT.",[149,150,29,151],"Mechanical Ventilation","Weaning Failure","Intensive Care Unit ICU",[153,66],"weaning failure","2025-03-12",{"date":156,"type":41},"2025-03-17",{"date":158,"type":41},"2024-12-01",{"date":160,"type":21},"2026-08-01",{"name":162,"class":48},"Hospital Italiano de Buenos Aires"]