[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"weaning-failure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:weaning-failure":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,16,0,[8,51,78,106,135,165,192,213,237,270,295,315,336,357,380,402],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100413048","improving-our-understanding-of-respiratory-muscle-training-to-facilitate-weaning-from-mechanical-ventilation-in-the-icu-100413048",false,"NCT04658498","Improving Our Understanding of Respiratory Muscle Training to Facilitate Weaning From Mechanical Ventilation in the ICU","TrainToWean","Inclusion Criteria:\n\n* Difficult and prolonged weaning patients\n* Adequate oxygenation\n* Febrile temperature \\\u003C 38ºC\n* Hemodynamic stability\n* Stable blood pressure\n* No or minimal vasopressors\n* No myocardial ischemia\n* Adequate hemoglobin and mentation\n* Resolution of disease acute phase\n* Able to follow simple verbal commands related to IMT\n* Mechanically ventilated via a tracheostomy or endotracheal tube\n\nExclusion Criteria:\n\n* Pre-existing neuromuscular disease\n* Agitation\n* Hemodynamically instable (arrhythmia, decompensated heart failure, coronary insufficiency)\n* Hemoptysis\n* Diaphoresis\n* Spinal cord injury above T8\n* Use of any type of home MV support prior to hospitalization\n* Skeletal pathology that impairs chest wall movements\n* Poor general prognosis or fatal outcome","ALL","18 Years",{"count":19,"type":20},90,"ESTIMATED","INTERVENTIONAL",[23],"NA","Mechanical ventilation is a life-saving treatment frequently applied in intensive care unit (ICU). Nonetheless, by putting at rest the respiratory muscles, it can lead to respiratory muscle weakness and atrophy, which are accompanied by prolonged duration of mechanical ventilation, difficult weaning and increased ICU mortality. Despite a strong theoretical rationale and some evidence supporting the use of inspiratory muscle training (IMT) to address respiratory muscle weakness and atrophy, the optimal approach to IMT remains largely uncertain. In fact, mechanistic studies evaluating physiological adaptations that occur in respiratory muscles of mechanically ventilated patients in response to different training regimens have not been conducted so far.\n\nThe aim of this study is to comprehensively investigate changes in respiratory muscle function in response to three different conditions that patients will be exposed to during their period of weaning from mechanical ventilation.",[26],"Weaning Failure",[28,29,30,31,32,33,34,35,36,37],"ICU acquired muscle weakness","IMT","Weaning outcomes","Maximal inspiratory pressure","Diaphragm EMG","Surface EMG","Diaphragm ultrasounds","Microbiopsies","Difficult to wean patients","Respiratory muscles","RECRUITING","2026-03-16",{"date":41,"type":42},"2026-03-18","ACTUAL",{"date":44,"type":42},"2023-02-01",{"date":46,"type":20},"2026-10",{"name":48,"class":49},"KU Leuven","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":4},"100618883","characterization-of-weaning-practices-in-icus-of-global-south-countries-100618883","NCT07337408","Characterization of Weaning Practices in ICUs of Global South Countries","Characterization of Weaning Practices in ICUs of Global South Countries: A Prospective Observational Study","Inclusion Criteria:\n\n* Age \\> 18 years.\n* Receiving care at an intensive care unit.\n* Endotracheal intubation.\n* Mechanical ventilation for 12 hours or more.\n* First separation attempt, as defined in the WIND Classification - \"Separation attempt from mechanical ventilation: an spontaneous breathing trial with or without extubation, or an extubation directly performed without identified spontaneous breathing trial (whatever the type: planned or unplanned extubation)\" - planned to occur in the next 6 hours or that occurred less than 2 hours ago.\n\nExclusion Criteria:\n\n* Patients with prior extubation failure.\n* Patients with prior spontaneous breathing trial failure.\n* Patients unable to obey commands.\n* Neuromuscular disease or cervical spinal cord injury.\n* Tracheostomy.\n* Do-not-resuscitate order or contraindication for reintubation.\n* Lack of informed consent.\n* Terminal extubation.\n* Previously included in the study.",{"count":59,"type":20},900,"OBSERVATIONAL","This is a prospective observational study to be conducted in intensive care units of Global South countries. Patients on mechanical ventilation for more than 12 hours who have initiated the weaning process and for whom the attending team plans extubation within the next 6 hours will be included. Data will be collected for each patient during the first 7 days after extubation, with follow-up until hospital discharge or death. We plan to conduct the study in intensive care units from Global South countries (low- and middle-income countries predominantly located in the Southern Hemisphere, though some in the Northern Hemisphere are also considered).",[63,26,64],"Weaning From Mechanical Ventilation","Weaning From Mechanical Ventilation, Extubation",[66,26,67],"Weaning from mechanical ventilation","Weaning from mechanical ventilation, extubation","NOT_YET_RECRUITING","2026-02-11",{"date":71,"type":42},"2026-02-12",{"date":73,"type":20},"2026-02",{"date":75,"type":20},"2027-04",{"name":77,"class":49},"Hospital do Coracao",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":21,"phases":87,"briefSummary":88,"conditions":89,"keywords":94,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":4},"100619381","quantification-of-systemic-congestion-by-ultrasound-as-a-predictor-of-weaning-failure-from-mechanical-ventilation-100619381","NCT07343882","Quantification of Systemic Congestion by Ultrasound As a Predictor of Weaning Failure From Mechanical Ventilation","SCOUT","Inclusion Criteria:\n\n* Patients aged \\> 18 years.\n* Admitted to an Intensive Care Unit (ICU).\n* Requiring invasive mechanical ventilation for more than 48 hours.\n* Meeting the center's standard criteria to begin weaning and undergo an SBT.\n\nExclusion Criteria:\n\n* Inadequate ultrasound window for assessment.\n* Presence of \"do not reintubate\" orders.\n* Patients with a tracheostomy.\n* Presence of atrial fibrillation.\n* Diagnosed liver cirrhosis (portal hypertension).\n* Absence of qualified personnel to perform the ultrasound at the time of the SBT.\n* Denial of informed consent.",{"count":86,"type":20},350,[23],"Mechanical ventilation is an essential, life-saving therapy in the ICU, allowing critically ill patients to rest and recover. Transitioning patients back to spontaneous breathing-known as weaning-is clinically challenging. The first attempt, the Spontaneous Breathing Trial (SBT), fails in 10-30% of cases. Identifying the mechanisms behind failure is crucial, as unsuccessful weaning prolongs ICU stay and increases the risk of reintubation, which worsens prognosis. The SCOUT study aims to improve prediction and management of weaning failure.\n\nThe main objective of the study is to evaluate whether a specific ultrasound-based method, the Venous Excess Ultrasound Score (VExUS), can predict failure of weaning from mechanical ventilation. A key pathophysiological factor is systemic venous congestion. When a patient initiates an SBT, the increased respiratory effort shifts venous return and may precipitate cardiovascular decompensation with pulmonary fluid accumulation, termed weaning-induced pulmonary edema (WIPO). Notably, this may occur even in patients without known cardiac disease.\n\nDetecting clinically relevant congestion before SBT is difficult. Fluid balance and body weight are imprecise, physical examination lacks sensitivity, and biomarkers such as NT-proBNP have limited predictive capacity. VExUS offers a promising, non-invasive approach by directly assessing venous flow patterns in major veins (inferior vena cava, hepatic, portal, and renal veins), providing an estimation of systemic venous pressure and congestion. The central hypothesis is that elevated VExUS grades prior to SBT will identify patients at high risk of failure, enabling proactive optimization and potentially improving outcomes.\n\nSCOUT is designed as a prospective, multicenter, observational study. Standard clinical management of mechanical ventilation and weaning remains unchanged. After informed consent, baseline data will be obtained immediately before SBT, including vital signs, ventilator parameters, blood sampling, and three non-invasive ultrasound assessments: cardiac, pulmonary, and VExUS. During the 30-120-minute SBT, the patient breathes with reduced ventilatory support while their clinical tolerance is evaluated. At the end of the SBT, selected measurements are repeated. Weaning failure is defined as: early termination of SBT due to intolerance, need for invasive or non-invasive ventilation within 48 h after extubation, or death within 48 h. Data are anonymized and stored securely (REDCap) in compliance with Spanish and EU data protection regulations.\n\nThe study is low-risk and provides no direct individual benefit, but may benefit future ICU patients by improving weaning strategies and prognostication.",[26,90,91,92,93],"Pulmonary Edema - Acute","Mechanical Ventilation","POCUS","VExUS",[95,96],"Weaning induced pulmonary edema","Venous Excess Ultrasound grading system","2026-01-16",{"date":99,"type":42},"2026-01-21",{"date":101,"type":20},"2026-04-01",{"date":103,"type":20},"2027-06-01",{"name":105,"class":49},"Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":113,"targetDuration":4,"studyType":21,"phases":115,"briefSummary":116,"conditions":117,"keywords":120,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":134},"100620921","evaluation-of-heepsync-a-novel-algorithm-for-transcutaneous-electrical-stimulation-of-respiratory-muscles-in-mechanically-ventilated-patients-100620921","NCT07363902","Evaluation of heepSync, a Novel Algorithm for Transcutaneous Electrical Stimulation of Respiratory Muscles in Mechanically Ventilated Patients.","Clinical Safety and Feasibility Study for Non-CE Marked Medical Device: Evaluation of heepSync, a Novel Algorithm for Transcutaneous Electrical Stimulation of Respiratory Muscles in Mechanically Ventilated Patients.","Inclusion Criteria:\n\nPatient population 1\n\n* Adult patients with acute hypoxemic respiratory failure who have been under controlled mechanical ventilation for at least 24 hours prior to enrollment.\n* Clinically stable: oxygen saturation \\> 90% with a fractional inspired oxygen ≤ 0.50, eternal PEEP ≤ 10 cm H2O, temperature ranging from 35.5 to 38.5 ºC, no intravenous administration of vasoactive agents.\n\nPatient population 2\n\n* Adult patients with acute hypoxemic respiratory failure who have been under pressure support mechanical ventilation for at least 24 hours prior to enrollment.\n* Clinically stable: oxygen saturation \\> 90% with a fractional inspired oxygen ≤ 0.50, eternal PEEP ≤ 10 cm H2O, temperature ranging from 35.5 to 38.5 ºC, no intravenous administration of vasoactive agents.\n\nExclusion Criteria:\n\n* Patients treated with neuromuscular blocking agents\n* Patients with neuromuscular disease\n* Patients with a pacemaker or past history of arrhythmia\n* Patients with physical obstacles that prevent thoracic or abdominal electrostimulation (e.g., abdominal trauma, recent abdominal surgery, polytrauma, broken or irritated skin)\n* BMI \\> 40 kg\u002Fm2\n* Hemodynamically unstable (noradrenaline \\>0.1 microgram\u002Fkg\u002Fmin)\n* Pregnancy\n* Patients under the age of 18\n* The formalized ethical decision to withhold or withdraw life support\n* Patient under guardianship\n* Patients deprived of liberties\n* Patients already enrolled in the present study, in a previous episode of acute respiratory failure.\n* The patient who does not consent.",{"count":114,"type":20},20,[23],"Up to 76% of ICU patients on mechanical ventilation develop significant respiratory muscle atrophy within the first 24 hours, contributing to prolonged ventilation, increased morbidity, and higher healthcare costs. To date, there is no practical, non-invasive technology that offers synchronized, personalized electrostimulation for both inspiratory and expiratory muscles during mechanical ventilation.\n\nHeecap is a medical product designed to provide transcutaneous electrical stimulation of the respiratory muscles (TERM) that are involved in inspiration and expiration, detecting those in which it is clinically relevant and safe to provide such stimulation in assisted respiration.\n\nThe following study aims to evaluate the safety and preliminary performance of the stimulation algorithm in mechanically ventilated patients in the ICU. This evaluation will specifically focus on the algorithm's ability to synchronize stimulation with the patient's breathing patterns, and on evaluating the safety and feasibility of the TERM in activating respiratory muscles.",[118,119,26],"Ventilator-induced Diaphragm Dysfunction","VIDD",[121,122,123],"Transcutaneous Electrical Stimulation","Mechanical ventilation","respiratory muscles","2026-01-15",{"date":126,"type":42},"2026-01-23",{"date":128,"type":42},"2024-12-01",{"date":130,"type":20},"2026-05",{"name":132,"class":133},"Tesai Care SL","INDUSTRY",3,{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":141,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":143,"targetDuration":4,"studyType":21,"phases":145,"briefSummary":147,"conditions":148,"keywords":149,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":164},"100601031","phase-4-shorter-weaning-from-invasive-ventilation-with-levosimendan-100601031","NCT07105202","Shorter Weaning From Invasive Ventilation With Levosimendan","Shorter Weaning From Invasive Ventilation With Levosimendan: a Randomized, Double-blind, Multicentre Study in Critically Ill Patients","WEANLESS","Inclusion Criteria:\n\n* Invasively ventilated \\> 48 hours.\n* Failed at least one spontaneous breathing trial (SBT).\n* Age above 18 years.\n* Female patients with age \\\u003C 60 must have a negative pregnancy test (blood or urine) prior to participation.\n\nExclusion Criteria:\n\n* Pre-existing neuromuscular disease (congenital or acquired)\n* Endotracheally intubated primarily for neurological reason (e.g., traumatic brain injury, intracranial haemorrhage, epilepsy, intracranial infection), or developed severe intracranial haemorrhage\u002Finfarction during ICU stay.\n* Contra-indications for levosimendan: severe renal failure (creatinine clearance \\\u003C30mL\u002Fmin) unless managed with appropriate continuous kidney replacement therapy (such as CRRT), severe liver failure (Child-Pugh class C), history of torsade des pointes; known significant mechanical obstructions affecting ventricular filling\u002F outflow or both; prolonged QTc interval (QTc \\> 470ms); breast feeding; known hypersensitivity to levosimendan.\n* Treatment with intermittent haemodialysis.\n* Treatment limitation decision in place: do not reintubate\n* Previous treatment with levosimendan within 30 days.\n* Currently in another interventional trial that might interact with study drug or primary outcome.",{"count":144,"type":20},250,[146],"PHASE4","Prolonged weaning from mechanical ventilation is a common and serious challenge in the ICU, associated with increased morbidity, mortality, and length of stay. Diaphragm dysfunction plays a key role in weaning failure, and current strategies to support respiratory muscle function are limited. Levosimendan is a calcium sensitizer that enhances cardiac and skeletal muscle contractility, including the diaphragm, without increasing oxygen demand.\n\nThe investigators hypothesize that treatment with Levosimendan in difficult-to-wean ICU patients will improve diaphragm function and thereby shorten the duration of mechanical ventilation compared to placebo.",[91,26],[150,151,152,153,154],"mechanical ventilation","weaning","critically ill patients","levosimendan","diaphragm","2026-01-08",{"date":157,"type":42},"2026-01-09",{"date":159,"type":42},"2025-09-17",{"date":161,"type":20},"2028-08-01",{"name":163,"class":49},"Radboud University Medical Center",8,{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":171,"eligibilityCriteria":172,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":173,"targetDuration":175,"studyType":60,"phases":4,"briefSummary":176,"conditions":177,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":50},"100601367","surface-electrical-myography-oxygen-consumption-effort-and-weaning-in-the-mechanically-ventilated-patient-in-the-intensive-care-unit-100601367","NCT07109570","Surface Electrical Myography, Oxygen Consumption, Effort, and Weaning in the Mechanically Ventilated Patient in the Intensive Care Unit","Surface Electrical Myography, Oxygen Consumption (VO2), Effort, and Weaning in the Mechanically Ventilated Patient in the Intensive Care Unit (ICU): SERA-Effort Study","SERA-Effort","Inclusion Criteria:\n\n* 18 years of age or older\n* Esophageal catheter in situ (standard of care)\n* Eligible for an SBT in the near future according to the LUMC SBT protocol currently valid\n\nExclusion Criteria:\n\n* Severe cardiac failure NYHA class IV without mechanical support (LVAD or Impella)\n* COPD Gold IV\n* Pregnancy\n* Patients with ECMO",{"count":174,"type":20},60,"2 Days","The goal of this observational study is to measure effort using esophageal pressure measurements, oxygen consumption and diaphragm activity in mechanically ventilated Intensive Care Unit patients during a Spontaneous Breathing Trial. The main question aims to answer whether the sEMG signal derived from the SERA device, effort parameters and oxygen consumption have an association with weaning failure.\n\nParticipants will be measured while performing a spontaneous breathing trial.",[178,179,26,91,180,181,182],"Critical Illness","Intensive Care Units (ICUs)","Spontaneous Breathing Trial","Diaphragm Electrical Activity","Oxygen Consumption","2025-11-20",{"date":185,"type":42},"2025-11-26",{"date":187,"type":42},"2025-07-08",{"date":189,"type":20},"2029-06",{"name":191,"class":49},"Leiden University Medical Center",{"id":193,"slug":194,"hasResults":11,"nctId":195,"briefTitle":196,"officialTitle":197,"acronym":4,"eligibilityCriteria":198,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":199,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":201,"conditions":202,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":50},"100574083","effect-of-hypophosphatemia-on-neuro-excursion-efficiency-during-mechanical-ventilator-weaning-100574083","NCT06754670","Effect of Hypophosphatemia on Neuro-excursion Efficiency During Mechanical Ventilator Weaning","Hypophosphatemia in Wean","Inclusion criteria:\n\nage ≥18 years old; Acute respiratory failure, tracheal intubation patients; Invasive ventilator use time ≥48 hours; Clinically determined remission of primary disease, has switched to auxiliary ventilation mode and plans to go offline in the near future.\n\nExclusion criteria:\n\npatients with severe neuromuscular disease; Patients with central system diseases; Patients using muscle relaxants for more than 48 hours; Patients who have been or are about to be discontinued from life support; Patients with contraindications for gastric tube insertion after esophagogastric fundus varices, digestive tract perforation, and upper digestive tract surgery; Pregnant patients; Ultrasonic window is poor.",{"count":200,"type":20},70,"Hypophosphatemia is a common phenomenon in the ICU, and several retrospective studies have shown that hypophosphatemia is associated with prolonged mechanical ventilation in ICU patients. However, the specific mechanism and causal relationship are not clear. Previous studies have shown that phosphate infusion improves the contraction of the diaphragm induced by exogenous electrical stimulation, but the effect of hypophosphatemia and phosphate supplementation on the pathophysiology in decannulated patients on mechanical ventilation has not been confirmed. The study group hypothesized that hypophosphatemia affects neural conduction function and muscle contraction by affecting ATP synthesis. Correcting hypophosphatemia may improve respiratory muscle strength and potentially improve diaphragmatic neural conduction, ultimately improving the patient's neuromuscular conversion efficiency and facilitating discharge.\n\n1. The attending physician evaluates the patient's ventilator condition daily and meets the disconnection criteria (spontaneous breathing, RSBI \\\u003C 105 (min\\*ml)-1, stable hemodynamics: norepinephrine or epinephrine ≤ 0.1μg\u002Fkg\u002Fmin, PEEP ≤ 8cmH2O, FiO2 ≤ 50%, no increase in ventilator support conditions in the past 24 hours, PS 10cmH2O, MAAS score 2-4, pH ≥ 7.30, discontinuation of all sedative medications). After signing an informed consent form, a diaphragm electromyography (EEG) catheter is placed. (The diaphragm EEG catheter is a gastric tube with diaphragm electromyography monitoring function, with the same placement process and risks as a regular gastric tube. There is a small probability of complications such as nasal mucosal damage.)\n2. Start CPAP disconnection: Adjust the ventilator PS 10 → 0 cmH2O, and keep the other conditions unchanged. Collect ventilator parameters, diaphragm electromyography (EAdi) parameters, and diaphragm ultrasound parameters at 0, 1, 3, 5, 10, 20, and 30 minutes after the trial begins, and collect the maximum EAdi and diaphragm ultrasound during quiet state.\n3. Simultaneously monitor blood inorganic phosphorus, and divide the patients into two groups: the low phosphorus group (\\\u003C0.8mmol\u002FL) and the control group (0.8-1.4 mmol\u002FL). Low phosphorus patients receive intravenous phosphate supplementation according to the clinical phosphate supplementation protocol at our center \\[1-5\\]: patients with blood phosphorus \\\u003C 0.4mmol\u002FL receive 40mmol of glycerol phosphate sodium intravenously via infusion or injection over 4-6 hours; patients with blood phosphorus 0.4-0.8mmol\u002FL receive 30mmol of glycerol phosphate sodium intravenously via infusion or injection; Normal phosphorus patients do not require any special treatment.\n4. 24h after the first CPAP offline, patients in both groups repeated the CPAP offline process, collected related parameters, and measured blood inorganic phosphorus.",[91,26,203],"Hypophosphatemia","2025-05-27",{"date":206,"type":42},"2025-05-31",{"date":208,"type":42},"2024-10-01",{"date":210,"type":20},"2025-08-01",{"name":212,"class":49},"Peking Union Medical College",{"id":214,"slug":215,"hasResults":11,"nctId":216,"briefTitle":217,"officialTitle":217,"acronym":4,"eligibilityCriteria":218,"healthyVolunteers":11,"sex":16,"minAge":219,"maxAge":4,"enrollmentInfo":220,"targetDuration":222,"studyType":60,"phases":4,"briefSummary":223,"conditions":224,"keywords":225,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":228,"lastUpdatePostDateStruct":229,"startDateStruct":231,"completionDateStruct":233,"leadSponsor":235,"locationsCount":50},"100593225","role-of-regional-lung-compliance-and-dynamic-transpulmonary-driving-pressure-in-the-liberation-difficulty-in-tracheostomized-patients-receiving-prolonged-mechanical-ventilation-100593225","NCT07003672","Role of Regional Lung Compliance and Dynamic Transpulmonary Driving Pressure in the Liberation Difficulty in Tracheostomized Patients Receiving Prolonged Mechanical Ventilation","Inclusion Criteria:\n\n* Post-tracheostomy patients who are transferred to the subacute respiratory care ward of National Taiwan University Hospital must use respirators for at least 14 days;\n* Be at least 20 years old;\n* The oxygen concentration required when using the respirator does not exceed 50%\n\nExclusion Criteria:\n\n* The vital signs are unstable or require continuous use of vasopressors;\n* Pregnancy;\n* Chronic obstructive pulmonary disease or asthma;\n* Those who have contraindications to the placement of esophageal pressure balloons, such as abnormal blood coagulation, esophageal varices, and those who have undergone esophageal or gastric surgery in the past six months;\n* Those who have contraindications to the use of electrical impedance tomography, such as heart rhythm regulators.","20 Years",{"count":221,"type":20},120,"16 Weeks","This project focuses on the analysis of the correlation between transpulmonary driving pressure and uneven lung ventilation and regional lung compliance in patients using prolonged mechanical ventilation (PMV), in order to understand the clinical occurrence of failure of the final spontaneous breathing test and inability to breathe. Respiratory physiology impairments in patients successfully discharged from respirators.",[26],[226,227],"prolonged mechanical ventilation，PMV","chronic critical illness，CCI","2025-05-26",{"date":230,"type":42},"2025-06-04",{"date":232,"type":42},"2025-01-16",{"date":234,"type":20},"2028-06-30",{"name":236,"class":49},"National Taiwan University Hospital",{"id":238,"slug":239,"hasResults":11,"nctId":240,"briefTitle":241,"officialTitle":242,"acronym":243,"eligibilityCriteria":244,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":245,"targetDuration":247,"studyType":60,"phases":4,"briefSummary":248,"conditions":249,"keywords":253,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":261,"lastUpdatePostDateStruct":262,"startDateStruct":264,"completionDateStruct":266,"leadSponsor":268,"locationsCount":50},"100571147","predicting-failure-of-non-invasive-ventilatory-support-using-non-invasive-monitoring-in-non-intubated-patients-with-acute-hypoxemic-respiratory-failure-or-post-extubation-failure-the-prevision-study-100571147","NCT06716463","PREdicting Failure of Non-inVasIve Ventilatory Support Using Non-invaSIve mONitoring in Non-intubated Patients With Acute Hypoxemic Respiratory Failure or Post-extubation Failure. The PREVISION Study","PREdicting Failure of Non-inVasIve Ventilatory Support Using Non-invaSIve mONitoring in Non-intubated Patients With Acute Hypoxemic Respiratory Failure or Post-extubation Failure: the PREVISION Study","PREVISION","Inclusion Criteria:\n\n* Age of ≥ 18 years\n* Using NIV or HFNC anywhere in the hospital\n\nExclusion Criteria:\n\n* Chronic CO2 retention\n* Neuromuscular disorder\n* Requiring home NIV (CPAP or BIPAP)\n* Tracheostomy\n* Contraindication to EIT placement: pacemaker\u002Fdefibrillator implantation, burns at the area of EIT placement",{"count":246,"type":20},80,"3 Months","The goal of this observational study is to assess the potential non-invasive tools (e.g. regional ventilation, respiratory muscle response, lung mechanic's parameters) to identify the risk of failure when using high flow nasal cannula (HFNC) or non-invasive ventilation (NIV).\n\nThe main question, it aims to answer is:\n\nDoes abnormal regional ventilation could predict HFNC or NIV failure?",[250,251,26,252],"Ventilatory Failure","Hypoxemic Respiratory Failure","Respiratory",[254,255,256,257,258,259,260],"Electrical impedance tomography","High flow nasal cannula","Non-invasive ventilation","Diaphragm","Weaning failure","Post-extubation","Hypoxemic respiratory failure","2025-05-15",{"date":263,"type":42},"2025-05-20",{"date":265,"type":42},"2025-01-27",{"date":267,"type":20},"2025-06",{"name":269,"class":49},"Unity Health Toronto",{"id":271,"slug":272,"hasResults":11,"nctId":273,"briefTitle":274,"officialTitle":275,"acronym":276,"eligibilityCriteria":277,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":278,"enrollmentInfo":279,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":281,"conditions":282,"keywords":285,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":287,"lastUpdatePostDateStruct":288,"startDateStruct":290,"completionDateStruct":291,"leadSponsor":293,"locationsCount":50},"100568634","ventilatory-settings-and-monitoring-variables-associated-with-weaning-failure-in-critically-ill-patients-100568634","NCT06683781","Ventilatory Settings and Monitoring Variables Associated With Weaning Failure in Critically Ill Patients","Ventilatory Settings and Monitoring Variables Associated With Weaning Failure in Critically Ill Patients: A Retrospective Study","WEAN-FAIL","Inclusion Criteria:\n\n* Over 18 years\n* MV for at least 48 hours, regardless of the cause of onset\n* Undergone at least one extubation, regardless of the outcome\n* At least one spontaneous breathing trial (SBT) during their ICU stay, regardless of the outcome\n\nExclusion Criteria:\n\n* MV records containing incorrect or inconsistent data\n* did not have adequate or continuous monitoring during the weaning process","100 Years",{"count":280,"type":20},1077,"Mechanical ventilation (MV) is essential in managing acute respiratory failure. Its duration is a crucial aspect since both, unnecessary prolongation and premature withdrawal have deleterious effects on patient outcomes in the ICU. The process of weaning refers to the set of procedures and evaluations carried out to discontinue MV. Regardless of the definition used, within the population undergoing weaning, there is a group of patients who successfully pass the daily screening but fail the spontaneous breathing trial (SBT) or the separate attempt (SA). In Argentina, this figure is 39.5%, and 31.4% in patients with COVID-19. On the other hand, another group of patients successfully passes the SA, is extubated, but fails in post-extubation. This failure rate varies in the literature, ranging from approximately 10 to 20%. In our country, this figure is 16% in the general population and rises to 29.7% in COVID-19 patients. Additionally, this population is divided into those who cannot tolerate ventilation without an artificial airway due to upper airway patency issues (such as laryngeal edema), i.e., \"airway failure,\" and those who experience acute respiratory failure. In 2023, the WEAN SAFE study reported novel findings regarding variables associated with weaning failure. In multivariable analysis, it was found that the MV settings and monitoring variables at the time of the first SBT - respiratory rate, positive end-expiratory pressure (PEEP), dynamic airway pressure difference (peak pressure (Ppeak) minus PEEP) on the day of the SA - were associated with weaning failure. In this context, the investigators will conduct a retrospective cohort study, whose primary objective will be to assess which MV settings and monitoring variables are associated with weaning failure.\n\n\\*\\*Primary Objective\\*\\* To determine if there are any MV settings or monitoring variables that are associated with extubation failure.\n\n\\*\\*Secondary Objective\\*\\* To determine if there are any MV settings or monitoring variables that are associated with failure in the first SBT.",[91,26,283,284],"Weaning Failure of Mechanical Ventilation","Intensive Care Unit ICU",[286,150],"weaning failure","2025-03-12",{"date":289,"type":42},"2025-03-17",{"date":128,"type":42},{"date":292,"type":20},"2026-08-01",{"name":294,"class":49},"Hospital Italiano de Buenos Aires",{"id":296,"slug":297,"hasResults":11,"nctId":298,"briefTitle":299,"officialTitle":299,"acronym":300,"eligibilityCriteria":301,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":302,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":303,"conditions":304,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":306,"lastUpdatePostDateStruct":307,"startDateStruct":309,"completionDateStruct":311,"leadSponsor":313,"locationsCount":50},"100515349","estimation-of-the-diaphragm-electrical-activity-and-intercostal-thickening-fraction-during-different-pattern-of-mechanical-ventilation-psv-versus-nava-100515349","NCT05990348","Estimation of the Diaphragm Electrical Activity and Intercostal Thickening Fraction During Different Pattern of Mechanical Ventilation: PSV Versus NAVA","InterThick","Inclusion Criteria:\n\n* patients who have failed at least one weaning attempt\n* mechanical ventilation for at least 24 hours\n\nExclusion Criteria:\n\n* Pregnancy\n* Obesity (Body Mass Index \\> 35 kg\u002Fm2)\n* Contraindication to the insert of a nasogastric tube\n* Neuromuscular diseases",{"count":114,"type":20},"the introduction of new MV modalities has shown promising results in reducing the incidence of weaning failure, mainly due to a more physiologic approach which allows respiratory muscle preservation. Among them, the Neurally Adjust Ventilatory Assist (NAVA) seemed to be associated with lower incidence of weaning failure and subsequent duration of mechanical ventilation, compared to standard modalities like the Pressure Support Ventilation (PSV) . Moreover, NAVA allows the evaluation of the diaphragm electrical activity (EAdi), an index of diaphragmatic neural respiratory drive. However, no study has compared TFic values during PSV and NAVA modalities in patients with difficult weaning from MV admitted in ICU.",[305,26],"Respiratory Failure","2024-10-17",{"date":308,"type":42},"2024-10-18",{"date":310,"type":42},"2022-07-01",{"date":312,"type":20},"2025-09-30",{"name":314,"class":49},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS",{"id":316,"slug":317,"hasResults":11,"nctId":318,"briefTitle":319,"officialTitle":320,"acronym":4,"eligibilityCriteria":321,"healthyVolunteers":322,"sex":16,"minAge":17,"maxAge":323,"enrollmentInfo":324,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":325,"conditions":326,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":327,"lastUpdatePostDateStruct":328,"startDateStruct":330,"completionDateStruct":332,"leadSponsor":334,"locationsCount":50},"100564323","predictive-value-of-airway-occlusion-pressure-maximal-inspiratory-pressure-and-their-ratio-for-successful-extubation-in-patients-with-traumatic-brain-injury-100564323","NCT06627686","Predictive Value of Airway Occlusion Pressure, Maximal Inspiratory Pressure and Their Ratio for Successful Extubation in Patients With Traumatic Brain Injury","Predictive Value of Airway Occlusion Pressure, Maximal Inspiratory Pressure and Their Ratio for Successful Extubation in Patients With Traumatic Brain Injury Observational Study","Traumatic brain injury (closed type) patients who will be admitted to ICU and intubated and MV more than 24 hours will be included in this study.\n\nAge from 18 to 65 years (male or female).\n\nFulfillment of Criteria of readiness for weaning off MV :\n\nResolution of the cause of respiratory insufficiency and MV. Stable hemodynamic profile",true,"65 Years",{"count":174,"type":20},"The aim of this study will be to measure the predictive power of the respiratory muscle determinants including The maximal inspiratory pressure, and central drive determinant including Airway occlusion pressure and ratio between them in weaning outcome of traumatic brain injury patients undergoing invasive mechanical ventilation.",[26],"2024-10-03",{"date":329,"type":42},"2024-10-04",{"date":331,"type":42},"2023-09-01",{"date":333,"type":20},"2024-10-05",{"name":335,"class":49},"Benha University",{"id":337,"slug":338,"hasResults":11,"nctId":339,"briefTitle":340,"officialTitle":341,"acronym":342,"eligibilityCriteria":343,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":344,"targetDuration":175,"studyType":60,"phases":4,"briefSummary":345,"conditions":346,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":348,"lastUpdatePostDateStruct":349,"startDateStruct":351,"completionDateStruct":353,"leadSponsor":355,"locationsCount":356},"100546168","oxygen-consumption-vo2-effort-and-weaning-in-the-mechanically-ventilated-patient-in-the-intensive-care-unit-icu-100546168","NCT06391424","Oxygen Consumption (VO2), Effort, and Weaning in the Mechanically Ventilated Patient in the Intensive Care Unit (ICU)","Oxygen Consumption (VO2), Effort, and Weaning in the Mechanically Ventilated Patient in the Intensive Care Unit (ICU): EXTUBATE Study","EXTUBATE","Inclusion Criteria:\n\n* Age above 18 years\n* \\> 24 hours mechanically ventilated\n* Eligible for a spontaneous breathing trial according to the clinical team\n* Regular SBT (\"Regulier SBT\") according to the Leiden University Medical Center (LUMC) protocol\n* Hemodynamically stable\n* Esophageal Catheter in situ\n\nExclusion Criteria:\n\n* Severe chronic obstructive pulmonary disease (COPD) (Gold class IV) if it results in a non regular SBT according to the LUMC protocol.\n* Heart failure (LVEF \\\u003C30%) if it results in a non regular SBT according to the LUMC protocol\n* Known pregnancy",{"count":174,"type":20},"In patients who are mechanically ventilated for more than 72 hours weaning failure is a common issue. The Spontaneous breathing trial (SBT) is often done to assess if the patient can be extubated with a high chance of success. However, re-intubation rates are between 15 - 20 % after a successful SBT. The rapid shallow breathing index (RSBI) is an important parameter used in an SBT. Because the high incidence of extubation failure (re-intubation within 48 hours) a search for a better parameter than the RSBI is warranted. Using the measured end-tidal oxygen (etO2) of mechanically ventilated patients it is possible to calculate the VO2, which is a measure of patient effort. The VO2 is a parameter with the potential to predict weaning success or failure, together with other parameters of patient effort like the work of breathing (WOB), pressure time product (PTP) and esophageal pressure swings, reflecting muscle strength of the diaphragm. Therefore, the investigators want to investigate if these parameters are associated with an SBT success or failure.",[178,347,182,26,91,180],"Intensive Care Unit","2024-09-02",{"date":350,"type":42},"2024-09-19",{"date":352,"type":42},"2024-01-01",{"date":354,"type":20},"2026-01",{"name":191,"class":49},2,{"id":358,"slug":359,"hasResults":11,"nctId":360,"briefTitle":361,"officialTitle":362,"acronym":4,"eligibilityCriteria":363,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":364,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":365,"conditions":366,"keywords":368,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":371,"lastUpdatePostDateStruct":372,"startDateStruct":374,"completionDateStruct":376,"leadSponsor":378,"locationsCount":50},"100551756","extremes-of-respiratory-effort-in-weaning-failure-from-mechanical-ventilation-a-prospective-observational-study-100551756","NCT06464224","Extremes of Respiratory Effort in Weaning Failure From Mechanical Ventilation: a Prospective Observational Study","Are the Extremes of Respiratory Efforts During Assisted Ventilation Associated With Weaning Failure in Critical Ill Patients: a Prospective Observational Study","Inclusion Criteria:\n\n* Patients over 18 years old, admitted to the Glória D'or hospital, undergoing orotracheal intubation and invasive mechanical ventilation, in their first 7 years on spontaneous ventilation, who accept to participate in the study by signing the free and informed consent form (or by their legal responsible).\n\nExclusion Criteria:\n\n* • Neuromuscular disease;\n\n  * Phrenic nerve injury;\n  * MV for less than 24 hours;\n  * Previously tracheostomized patient;\n  * Age under 18;\n  * Use of neuromuscular blocker \\> 72h;\n  * COPD;\n  * Patients with pulmonary fibrosis;\n  * Pregnancy;\n  * Patient under palliative care;\n  * COVID-19 pneumonia;\n  * Patients reintubated after extubation in this hospitalization for less than 3 weeks.",{"count":50,"type":20},"The presence of high levels of respiratory effort in patients under mechanical ventilation may worsen the adjacent lung injury even after adapting protective ventilation. Primary outcome: To evaluate the failure rate of weaning from IMV and its relationship with the lower and upper extremes of respiratory effort and the upper extreme of dynamic pulmonary stress during the first 7 days of spontaneous ventilation. Analyze the influence of these extremes based on the thresholds of Pocc, P0.1 and their derivatives Pmus, Ptp, din and MP: in relation to days off MV (in the 28-day interval); Total weaning time; Rate and time for tracheostomy; Length of stay in the ICU and hospital; In-hospital mortality rate. CAAE: 78185823.4.0000.5249. Prospective multicenter observational study, carried out in the ICUs of Glória D'or and Niteroi D'or hospitals, from January 2024 to July 2026, in patients over 18 years old, undergoing orotracheal intubation and IMV, in their first 7 days on spontaneous ventilation. Hypothesis: Extremes of respiratory effort and dynamic pulmonary stress would be associated with a higher rate of weaning from IMV, as well as longer time on IMV and subsequent longer hospital stay.",[367,26],"Mechanical Ventilation Pressure High",[369,370],"respiratory drive","respiratory effort","2024-07-19",{"date":373,"type":42},"2024-07-23",{"date":375,"type":42},"2024-04-01",{"date":377,"type":20},"2026-07",{"name":379,"class":49},"Universidade Federal do Rio de Janeiro",{"id":381,"slug":382,"hasResults":11,"nctId":383,"briefTitle":384,"officialTitle":385,"acronym":4,"eligibilityCriteria":386,"healthyVolunteers":322,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":387,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":389,"conditions":390,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":394,"lastUpdatePostDateStruct":395,"startDateStruct":397,"completionDateStruct":398,"leadSponsor":400,"locationsCount":50},"100548693","exploration-of-mechanisms-for-weaning-failure-100548693","NCT06424314","Exploration of Mechanisms for Weaning Failure","Changes in Respiratory Mechanics in Patients With Failed Ventilator Withdrawal","Inclusion Criteria:\n\n* Invasive mechanical ventilation for at least 48 hours\n\nExclusion Criteria:\n\n* neuromuscular disease；Postoperative patients or patients with traumatic brain injury",{"count":388,"type":20},30,"This study is a prospective physiologic study. The primary study population will be adult invasive tracheal intubated patients with COPD, and investigators will collect relevant demographic data, vital signs, and baseline physiologic parameters of the patients prior to the spontaneous breathing test（SBT).\n\nThe participants will be divided into a successful withdrawal group and a failed withdrawal group according to the SBT outcome, and the changes in the above parameters during SBT will be compared between the two groups .",[26,391,392,393],"Central Respiratory Depression","Diaphragm Injury","Phrenic Nerve Disorder","2024-07-08",{"date":396,"type":42},"2024-07-09",{"date":396,"type":42},{"date":399,"type":20},"2025-12-01",{"name":401,"class":49},"The First Affiliated Hospital of Guangzhou Medical University",{"id":403,"slug":404,"hasResults":11,"nctId":405,"briefTitle":406,"officialTitle":406,"acronym":407,"eligibilityCriteria":408,"healthyVolunteers":11,"sex":16,"minAge":409,"maxAge":410,"enrollmentInfo":411,"targetDuration":4,"studyType":21,"phases":413,"briefSummary":415,"conditions":416,"keywords":417,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":421,"lastUpdatePostDateStruct":422,"startDateStruct":424,"completionDateStruct":426,"leadSponsor":428,"locationsCount":4},"100530294","phase-3-preventing-celiac-disease-by-weaning-with-mediterranean-diet-100530294","NCT06184906","Preventing Celiac Disease by Weaning With Mediterranean Diet","PEMED","Inclusion Criteria:\n\n* \\- Healthy newborns with a birth weight greater than 2000 grams.\n* Residence in Municipality 8, Piscinola-Scampia.\n\nExclusion Criteria:\n\n* \\- Newborns suffering from severe prematurity.\n* Newborns with congenital malformations.\n* Newborns afflicted by severe diseases.","1 Month","10 Months",{"count":412,"type":20},3200,[414],"PHASE3","Background: The introduction of solid foods in alignment with the Mediterranean Diet (MD) post-exclusive milk feeding has been demonstrated to cultivate a lasting affinity for healthy eating during infancy and childhood. Despite this, access to healthy diets remains a challenge for numerous children, particularly in underserved areas. The clinical trial under discussion is set in Scampia, a municipality in Naples, Italy, known for its dense population and socio-economic challenges. This trial, utilizing the Family Pediatrician (FP) system, aims to promote MD nutrition among children in Scampia to potentially prevent or reduce chronic childhood diseases.\n\nStudy Design: In this pragmatic trial, FPs are utilized as the unit for randomization to administer the intervention. The intervention group will be introduced to an intensified MD-based diet from weaning, incorporating adult-type MD foods, while the control group will follow standard regional dietary guidelines. Dietary adherence and health outcomes are to be periodically monitored, and genetic and microbiome analyses will be conducted using collected saliva and stool samples. Incorporating a Bayesian group sequential design, this trial is structured to conduct interim analyses for efficacy, aligning with local healthcare systems for optimal resource allocation.\n\nConclusion: The study is poised to be methodologically innovative and socially impactful, utilizing existing healthcare frameworks to enhance childhood nutrition in challenging environments. Outcomes from this trial are expected to provide valuable insights into the effects of MD-based nutrition on child health and potentially serve as a model for promoting healthier diets in urban suburbs globally.",[26],[418,419,420],"Infant Weaning","Mediterranean Diet","Celiac Disease","2024-05-07",{"date":423,"type":42},"2024-05-08",{"date":425,"type":20},"2024-06-15",{"date":427,"type":20},"2030-12-31",{"name":429,"class":49},"University of Naples"]