[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"weaning-from-mechanical-ventilation-extubation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:weaning-from-mechanical-ventilation-extubation":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":27,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":4},"100618883","characterization-of-weaning-practices-in-icus-of-global-south-countries-100618883",false,"NCT07337408","Characterization of Weaning Practices in ICUs of Global South Countries","Characterization of Weaning Practices in ICUs of Global South Countries: A Prospective Observational Study","Inclusion Criteria:\n\n* Age \\> 18 years.\n* Receiving care at an intensive care unit.\n* Endotracheal intubation.\n* Mechanical ventilation for 12 hours or more.\n* First separation attempt, as defined in the WIND Classification - \"Separation attempt from mechanical ventilation: an spontaneous breathing trial with or without extubation, or an extubation directly performed without identified spontaneous breathing trial (whatever the type: planned or unplanned extubation)\" - planned to occur in the next 6 hours or that occurred less than 2 hours ago.\n\nExclusion Criteria:\n\n* Patients with prior extubation failure.\n* Patients with prior spontaneous breathing trial failure.\n* Patients unable to obey commands.\n* Neuromuscular disease or cervical spinal cord injury.\n* Tracheostomy.\n* Do-not-resuscitate order or contraindication for reintubation.\n* Lack of informed consent.\n* Terminal extubation.\n* Previously included in the study.","ALL","18 Years",{"count":19,"type":20},900,"ESTIMATED","OBSERVATIONAL","This is a prospective observational study to be conducted in intensive care units of Global South countries. Patients on mechanical ventilation for more than 12 hours who have initiated the weaning process and for whom the attending team plans extubation within the next 6 hours will be included. Data will be collected for each patient during the first 7 days after extubation, with follow-up until hospital discharge or death. We plan to conduct the study in intensive care units from Global South countries (low- and middle-income countries predominantly located in the Southern Hemisphere, though some in the Northern Hemisphere are also considered).",[24,25,26],"Weaning From Mechanical Ventilation","Weaning Failure","Weaning From Mechanical Ventilation, Extubation",[28,25,29],"Weaning from mechanical ventilation","Weaning from mechanical ventilation, extubation","NOT_YET_RECRUITING","2026-02-11",{"date":33,"type":34},"2026-02-12","ACTUAL",{"date":36,"type":20},"2026-02",{"date":38,"type":20},"2027-04",{"name":40,"class":41},"Hospital do Coracao","OTHER",{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":57,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":70},"100594453","direct-extubation-versus-extubation-after-a-spontaneous-breathing-trial-in-patients-at-low-risk-of-extubation-failure-100594453","NCT07019636","Direct Extubation Versus Extubation After a Spontaneous Breathing Trial in Patients at Low Risk of Extubation Failure","T-REX","Inclusion Criteria:\n\n* Age older than 18 years and \\\u003C 65 years old\n* Nasal or oral intubation longer than 24 hours and less than 4 days\n* Satisfaction to each following weaning readiness criteria:\n\n  1. Respiratory rate \\\u003C 35 cycles per minute\n  2. SpO2 \\>90% with FiO2\\\u003C40% and PEEP\\\u003C8 cmH2O\n  3. RASS score between -2 and +2 with low level or no sedatives\n  4. No need or low doses of vasopressors\n  5. Adequate cough\n* Inform consent by patient or legal representative or the close relative or emergency inclusion procedure.\n\nExclusion Criteria:\n\n* Risk factor for extubation failure as defined by any of the following criteria:\n\n  * Chronic cardiac disease (left ejection fraction below 45%, documented history of cardiogenic pulmonary edema, permanent atrial fibrillation).\n  * Chronic respiratory disease (severe COPD, documented restricted lung disease or obesity-hypoventilation syndrome)\n  * Body mass index \\> 30 kg\u002Fm2\n  * Airway patency problems, including high risk of developing laryngeal edema, inability to deal with respiratory secretions, brain injury, documented swallowing disorders\n* Tracheostomy\n* Underlying chronic neuromuscular disease\n* Do not resuscitate orders\n* Pregnant or lacting woman\n* Patient under guardianship\n* Patient without healthcare insurance\n* Refusal to participate and sign the written consent\n* Patients with traumatic brain injury\n* Post surgery patients\n* Patients included in another interventional trial that may have an impact on the evaluation criteria of the present study\n* Patient under AME","65 Years",{"count":51,"type":20},314,"INTERVENTIONAL",[54],"NA","This randomized controlled open label trial aims at comparing a weaning strategy including a spontaneous breathing trial as a prerequisite for extubation to a weaning strategy without a spontaneous breathing trial (direct extubation) in patients with readiness to be weaned criteria and considered at low risk of extubation failure. The main endpoint will be the proportion of patients successfully extubated within the 24 hours after randomization as compared to extubation after a successful spontaneous breathing trial (SBT).",[26],[58,59,60],"Weaning","Mechanical ventilation","Extubation","2025-06-16",{"date":63,"type":34},"2025-06-19",{"date":65,"type":20},"2025-09-15",{"date":67,"type":20},"2027-10-15",{"name":69,"class":41},"Assistance Publique - Hôpitaux de Paris",1]