[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"weaning-from-mechanical-ventilation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:weaning-from-mechanical-ventilation":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,45,71,100,133,158,181,212],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100634181","effect-of-adding-pnf-to-imt-on-weaning-off-mv-100634181",false,"NCT07536347","Effect of Adding PNF to IMT on Weaning Off MV","Effect of Adding Proprioceptive Neuromuscular Facilitation to Inspiratory Muscle Training on Weaning Off Mechanical Ventilation","PNF\u002FIMT\u002FMV","Inclusion Criteria:\n\n* Adults of both sexes\n* patients older than 18 years\n* Conscious and cooperative\n* Hemodynamic stability without significant vasopressor support.\n* No continuous sedation.\n* Mechanically ventilated due to type 1 or type 2 respiratory failure (RF) for at least 24 hours.\n* Mechanically ventilated in assisted ventilation mode\n* Are able to participate in training actively, weanable as regard shallow breathing index.\n* presence of weaning criteria as defined in the European Consensus Conference in 2007, including sedation reduction, spontaneous breathing cycles, Partial pressure of oxygen (PaO2)\u002F fraction of inspired oxygen (FiO2) ≥ 150, absence of inotropes or vasopressors at high doses or increasing doses (\\\u003C 1 mg\u002Fh), oxy-hemoglobin saturation (SaO2) \\> 90% with FiO2≤ 50%, positive end expiratory pressure (PEEP) ≤ 8 cmH2O, temperature between 36 and 39 °C.\n\nExclusion Criteria:\n\n* Hemodynamic or respiratory instability\n* Condition that can compromise weaning, such as heart failure.\n* Condition that can prevent adequate performance of inspiratory muscle training, such as neuropathy or myopathy.\n* Thoracic or abdominal surgery precluding the use of PNF exercises\n* Rib fractures\n* Current pregnancy\n* Cardiac arrest with a guarded neurological prognosis\n* Deep coma","ALL","18 Years",{"count":20,"type":21},93,"ESTIMATED","INTERVENTIONAL",[24],"NA","the goal of this clinical trial is to find out the effect of adding proprioceptive neuromuscular facilitation to inspiratory muscle training on weaning off mechanical ventilation. the main question it aims to answer is is there a significant difference in the effect of inspiratory muscle training combined with PNF on the duration of weaning in the mechanically ventilated ICU patients.\n\nresearchers will compare effect of (Inspiratory muscle training combined with PNF) to (Inspiratory muscle training) and control group.\n\nparticipants will be mechanically ventilated both sexes patients will be recruited in this study from intensive care unit, their ages older than 18 years. The selected patients will be mechanically ventilated due to respiratory failure and will randomly assigned into three equal groups.",[27],"Weaning From Mechanical Ventilation",[29,30,31,32],"proprioceptive neuromuscular facilitation","weaning","Inspiratory muscle training","diaphragmatic excretion","NOT_YET_RECRUITING","2026-04-11",{"date":36,"type":37},"2026-04-17","ACTUAL",{"date":39,"type":21},"2026-04-25",{"date":41,"type":21},"2026-12-01",{"name":43,"class":44},"Beni-Suef University","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":4},"100618883","characterization-of-weaning-practices-in-icus-of-global-south-countries-100618883","NCT07337408","Characterization of Weaning Practices in ICUs of Global South Countries","Characterization of Weaning Practices in ICUs of Global South Countries: A Prospective Observational Study","Inclusion Criteria:\n\n* Age \\> 18 years.\n* Receiving care at an intensive care unit.\n* Endotracheal intubation.\n* Mechanical ventilation for 12 hours or more.\n* First separation attempt, as defined in the WIND Classification - \"Separation attempt from mechanical ventilation: an spontaneous breathing trial with or without extubation, or an extubation directly performed without identified spontaneous breathing trial (whatever the type: planned or unplanned extubation)\" - planned to occur in the next 6 hours or that occurred less than 2 hours ago.\n\nExclusion Criteria:\n\n* Patients with prior extubation failure.\n* Patients with prior spontaneous breathing trial failure.\n* Patients unable to obey commands.\n* Neuromuscular disease or cervical spinal cord injury.\n* Tracheostomy.\n* Do-not-resuscitate order or contraindication for reintubation.\n* Lack of informed consent.\n* Terminal extubation.\n* Previously included in the study.",{"count":53,"type":21},900,"OBSERVATIONAL","This is a prospective observational study to be conducted in intensive care units of Global South countries. Patients on mechanical ventilation for more than 12 hours who have initiated the weaning process and for whom the attending team plans extubation within the next 6 hours will be included. Data will be collected for each patient during the first 7 days after extubation, with follow-up until hospital discharge or death. We plan to conduct the study in intensive care units from Global South countries (low- and middle-income countries predominantly located in the Southern Hemisphere, though some in the Northern Hemisphere are also considered).",[27,57,58],"Weaning Failure","Weaning From Mechanical Ventilation, Extubation",[60,57,61],"Weaning from mechanical ventilation","Weaning from mechanical ventilation, extubation","2026-02-11",{"date":64,"type":37},"2026-02-12",{"date":66,"type":21},"2026-02",{"date":68,"type":21},"2027-04",{"name":70,"class":44},"Hospital do Coracao",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":82,"conditions":83,"keywords":84,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":99},"100603221","high-flow-nasal-cannula-versus-high-velocity-nasal-insufflation-for-weaning-100603221","NCT07133698","High Flow Nasal Cannula Versus High Velocity Nasal Insufflation for Weaning","High Flow Nasal Cannula vs. High Velocity Nasal Insufflation for Weaning From Mechanical Ventilation in Respiratory ICU","Inclusion Criteria:\n\n* Adults (≥18 years) intubated for \\>24 hours due to acute respiratory failure, identified as high-risk for extubation failure AND fulfilling standard readiness-to-wean criteria (e.g., resolution of cause of intubation, adequate gas exchange \\[P\u002FF ≥150\\], hemodynamic stability, spontaneous breathing trial \\[SBT\\] success)\n\nExclusion Criteria:\n\n* Patients with central nervous system disorders unrelated to hypercapnic encephalopathy or hypoxemia.\n* Patients with post arrest encephalopathy.\n* Patient with previous tracheotomy.\n* Patients who received noninvasive ventilation without subsequent intubation.\n* Patients with end organ failure.","80 Years",{"count":80,"type":21},90,[24],"In intensive care units (ICUs), approximately 10% to 15%of patients ready to be separated from a ventilator experience extubation failure leading to reintubation. In patients considered at high risk, these rates can even exceed 20%. Because reintubation is associated with particularly high mortality a strategy of oxygenation aimed at avoiding reintubation deserves consideration. Although noninvasive ventilation may prevent postextubation respiratory failure in patients at high risk only 2 small-scale randomized clinical trials (RCTs) have shown decreased reintubation rates compared with standard oxygen. The most recent international clinical practice guidelines recommend the use of noninvasive ventilation to prevent post extubation respiratory failure in patients at high risk of extubation failure (7). However, up until now, no large-scale RCT has demonstrated a significant reduction of reintubation rates with noninvasive ventilation compared with standard oxygen. Thereby, most patients are treated with standard oxygen in clinical practice and only10% of them receive noninvasive ventilation after extubation in the ICU.\n\nHigh-flow nasal cannula (HFNC) oxygen therapy is a new type of respiratory support system which can supply high flow mixed gases through special nasal prongs at a sufficient temperature and humidity for patient comfort. Many studies have confirmed that the comfort and tolerance of HFNC is significantly higher than that of NIV. As an alternative to NIV, HFNC has been shown to be as efficacious as NIV in preventing post-extubation respiratory failure or re-intubation in patients with hypoxemic respiratory failure.\n\nHigh-velocity nasal insufflation, a form of high-flow nasal cannula, focuses on optimum efficiency of the dead-space purge to augment ventilation (removal of carbon dioxide from the dead space between breaths), in addition to providing other effects of high-flow nasal cannula. This is accomplished by use of small-bore nasal cannulae (typically 2.7-mm internal diameter for adult patients) to produce high velocity flow that is approximately 360% greater than that of the larger bore cannulae used in previous studies. According to flow analyses8 and clinical experience, high velocity nasal insufflation typically requires a flow of 25 to 35 L\u002Fmin in adults to accomplish a complete purge of the extrathoracic anatomic reservoir between breaths.",[27],[85,86,87,88],"Weaning","HFNC","HVNI","Noninvasive ventilation","RECRUITING","2025-08-20",{"date":92,"type":37},"2025-08-21",{"date":94,"type":37},"2024-02-01",{"date":96,"type":21},"2025-10-01",{"name":98,"class":44},"Assiut University",1,{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":107,"targetDuration":109,"studyType":54,"phases":4,"briefSummary":110,"conditions":111,"keywords":117,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":4},"100602202","comparison-of-diaphragm-ultrasound-and-rsbi-for-predicting-weaning-success-in-mechanically-ventilated-icu-patients-100602202","NCT07120438","Comparison of Diaphragm Ultrasound and RSBI for Predicting Weaning Success in Mechanically Ventilated ICU Patients","Comparison Between Diaphragmatic Ultrasound and Rapid Shallow Breathing Index (RSBI) in Predicting Weaning Success in Patients on Mechanical Ventilation for More Than 48 Hours in the ICU of Dr. Sardjito Hospital, Yogyakarta","Inclusion Criteria:\n\n1. Patients who have been on mechanical ventilation for more than 48 hours\n2. Adult patients aged ≥18 years\n3. Patients who meet the criteria for hemodynamic stability for weaning\n4. Patients or their families have provided written informed consent\n5. Patients with FiO₂ \\\u003C 50%, PEEP level \\\u003C 5 cm H₂O, respiratory rate \\\u003C 30 breaths per minute, PaO₂\u002FFiO₂ \\> 200, and GCS \\> 13\n6. Patients who have successfully completed the Spontaneous Awakening Trial (SAT) and Spontaneous Breathing Trial (SBT)\n\nExclusion Criteria:\n\n1. Patients with neuromuscular disorders, anatomical abnormalities of the diaphragm, or diaphragmatic palsy\n2. Patients with a history of severe thoracic trauma affecting diaphragm function on one or both sides\n3. Pregnancy",{"count":108,"type":21},55,"2 Days","The goal of this observational study is to evaluate the predictive value of diaphragmatic ultrasound compared to the Rapid Shallow Breathing Index (RSBI) in determining weaning success among mechanically ventilated patients in the ICU for more than 48 hours.\n\nThe main question it aims to answer is:\n\nWhich is more effective in predicting weaning success: diaphragmatic ultrasound (including Diaphragmatic Excursion \\[DE\\] and Diaphragm Thickening Fraction \\[DTF\\]) or RSBI, in patients ventilated \\>48 hours in the ICU of Dr. Sardjito General Hospital, Yogyakarta?\n\nParticipants will be adult ICU patients who are undergoing weaning from mechanical ventilation after more than 48 hours. Before extubation, each participant will undergo diaphragmatic ultrasound assessment to measure DE and DTF, along with RSBI measurement. The predictive accuracy of these parameters will be evaluated by comparing them with the actual weaning outcomes.\n\nSecondary objectives include:\n\n1. Assessing whether diaphragmatic ultrasound is associated with a higher weaning success rate than RSBI.\n2. Evaluating the correlation between DE values and successful weaning.\n3. Determining the optimal cutoff values of DE and DTF as predictors of weaning failure.\n4. Analyzing the incidence of weaning failure in patients who do not meet optimal diaphragm function criteria.\n5. Identifying DE and DTF thresholds that may help reduce the risk of reintubation.",[112,113,114,27,115,116],"Ventilator Weaning","Mechanical Ventilation","Respiratory Insufficiency Requiring Mechanical Ventilation","Weaning From Mechanical Ventilation in Care Unit","Intensive Care Unit Patients",[118,119,120,121,122,123,57],"Diaphragmatic Ultrasound","Rapid Shallow Breathing Index","Diaphragm Thickening Fraction","Diaphragm Excursion","Weaning Prediction","ICU","2025-08-06",{"date":126,"type":37},"2025-08-13",{"date":128,"type":21},"2025-08",{"date":130,"type":21},"2026-03",{"name":132,"class":44},"Gadjah Mada University",{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":4,"eligibilityCriteria":139,"healthyVolunteers":11,"sex":17,"minAge":140,"maxAge":141,"enrollmentInfo":142,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":144,"conditions":145,"keywords":147,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":154,"leadSponsor":156,"locationsCount":99},"100594688","doxapram-administration-on-diaphragmatic-excursion-in-mechanically-ventilated-patients-with-chronic-obstructive-pulmonary-disease-undergoing-spontaneous-breathing-trial-100594688","NCT07022704","Doxapram Administration on Diaphragmatic Excursion in Mechanically Ventilated Patients With Chronic Obstructive Pulmonary Disease Undergoing Spontaneous Breathing Trial","The Influence of Doxapram Administration on Diaphragmatic Excursion in Mechanically Ventilated Patients With Chronic Obstructive Pulmonary Disease Undergoing Spontaneous Breathing Trial: a Prospective Observational Study","Inclusion Criteria:\n\n* Patients with moderate to severe chronic obstructive pulmonary disease undergoing spontaneous breathing trial\n\nExclusion Criteria:\n\n* Refusal Allergy to doxapram neuromuscular disorders inability to evaluate the diaphragm","20 Years","65 Years",{"count":143,"type":21},35,"Researchers aim to evaluate the impact of doxapram administration on diaphragmatic excursion in chronic obstructive pulmonary disease (COPD) patients undergoing spontaneous breathing trial",[146,113,27],"COPD",[146,148,149],"Doxapram","Diaphragmatic excursion","2025-06-22",{"date":152,"type":37},"2025-06-26",{"date":150,"type":21},{"date":155,"type":21},"2025-11-01",{"name":157,"class":44},"Cairo University",{"id":159,"slug":160,"hasResults":11,"nctId":161,"briefTitle":162,"officialTitle":163,"acronym":4,"eligibilityCriteria":164,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":165,"targetDuration":166,"studyType":54,"phases":4,"briefSummary":167,"conditions":168,"keywords":169,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":99},"100551822","diaphragmatic-thickening-fraction-as-a-predictor-of-successful-weaning-100551822","NCT06465082","Diaphragmatic Thickening Fraction as a Predictor of Successful Weaning","Role of Diaphragmatic Thickening Fraction as a Predictor of Successful Weaning From Mechanical Ventilation","Inclusion Criteria:\n\n* Adult patients \\>18 years old, who are in need for mechanical ventilation as: Life threatening hypoxia, Respiratory rate \\> 30 breath\u002Fmin, Disturbed conscious level.\n\nExclusion Criteria:\n\n* Age \\\u003C18 years.\n* Pregnancy\n* Surgical incisions likely to interfere with ultrasound examination.\n* Hepato-splenomegaly, Ascites\n* Neuromuscular disease as Myasthenia gravis, kypho-scoliosis\n* Diaphragmatic Paralysis (paralyzed diaphragm exhibiting abnormal paradoxical movement, i.e., moving in a cranial direction during inspiration",{"count":108,"type":21},"6 Months","The aim of this study is to assess the validity of the diaphragmatic thickening Fraction measured by ultrasound as a predictor for successful weaning from mechanical ventilation.",[27],[170,171],"mechanical ventilation.","diaphragmatic thickening Fraction","2025-05-27",{"date":174,"type":37},"2025-05-29",{"date":176,"type":37},"2024-09-05",{"date":178,"type":21},"2025-12-15",{"name":180,"class":44},"Mansoura University Hospital",{"id":182,"slug":183,"hasResults":11,"nctId":184,"briefTitle":185,"officialTitle":185,"acronym":186,"eligibilityCriteria":187,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":188,"targetDuration":4,"studyType":22,"phases":190,"briefSummary":191,"conditions":192,"keywords":196,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":204,"startDateStruct":206,"completionDateStruct":208,"leadSponsor":210,"locationsCount":99},"100575796","physiological-effect-high-flow-tracheal-oxygen-on-viscosity-of-airway-mucus-and-respiratory-effort-in-patients-weaning-from-invasive-mechanical-ventilation-100575796","NCT06776939","Physiological Effect High-flow Tracheal Oxygen on Viscosity of Airway Mucus and Respiratory Effort in Patients Weaning from Invasive Mechanical Ventilation","PIONEER","Inclusion:\n\n* Age ≥18 years\n* Weaning from mechanical ventilation with tracheostomy\n\nExclusion Criteria:\n\n* Longstanding tracheostomy, defined as tracheostomy being present prior to current hospital admission\n* Tracheostomy primarily indicated for chronic upper airway obstruction or to secure airway patency due to persistent stupor\u002Fcoma\n* Chronic positive pressure respiratory support at home (excluding night-time continuous positive airway pressure for sleep apnea)\n* Mucociliary disease in medical history (e.g. cystic fibrosis, pulmonary ciliary dyskinesia)\n* Neuromuscular disease in medical history (excluding ICU-acquired weakness)\n* Contra-indication placement oesophageal balloon for measurement of PES, such as:\n\n  * Fractures in mandibular, orbital or ethmoid bone or skull base\n  * Esophageal varices or surgery in medical history\n  * Severe bleeding disorders\n* Hemoptysis in 72 hours prior to the first disconnection session. Clinically relevant hemoptysis is defined as hemoptysis requiring tracheal\u002Fendobronchial or radiologic intervention, or administration of pro-coagulating drugs such as tranexamic acid.",{"count":189,"type":21},20,[24],"Rationale: Tracheostomized patients weaning from mechanical ventilation are at risk for dryness of airway mucosa and sputum accumulation during disconnection from mechanical ventilation. High-flow tracheal oxygen (HFTO) is being used as supportive therapy during disconnection sessions in tracheostomized patients weaning from invasive mechanical ventilation (IMV) to limit dryness while maintaining oxygenation. We recently summarized the studies comparing physiological effects HFTO as compared to other interfaces, collectively referred to as conventional oxygen therapy (COT), in a systematic review and identified areas of lacking knowledge: effect on sputum viscoelasticity, respiratory effort early in the weaning process and dyspnea sensation. We hypothesize that HFTO, compared to COT, decreases viscoelasticity of the sputum and provides respiratory support during weaning. This may improve weaning by facilitating clearance of airway mucus, preventing respiratory failure, and providing comfort by decreasing dyspnea.\n\nObjective: To determine the physiological effect of HFTO compared to COT on sputum viscoelasticity, respiratory effort and dyspnoea.\n\nStudy design: Pilot study with randomized crossover design, single-center. Study population: Twenty adult patients weaning from mechanical ventilation with tracheostomy.\n\nIntervention (if applicable): Crossover with COT and HFTO during two days in the weaning phase.\n\nMain study parameters\u002Fendpoints: Primary endpoint: sputum viscoelasticity measured by rheology during long disconnection sessions in the final phase of weaning. Secondary endpoints: respiratory effect measured by swings in esophageal pressure (PES) and prevalence and severity of dyspnoea sensation by visual analogue scale (VAS).\n\nNature and extent of the burden and risks associated with participation, benefit and group relatedness: The study compares two therapeutic modalities both used in clinical care without side-effects or complications. Study procedures and measurements consist of standard clinical procedures that are performed daily in clinical setting with negligible risk of deterioration for the patient. During weaning with HFTO sputum clearance might be more easy for the patient and respiratory effort might decrease, both are assumed to be beneficial for the weaning process of the patient.",[193,194,195],"Weaning from Mechanical Ventilation","Tracheostomy Weaning","Respiratory Failure",[197,198,199,200,201,202],"weaning from mechanical ventilation","tracheostomy","high flow oxygen","airway mucus","respiratory effort","dyspnea","2025-01-10",{"date":205,"type":37},"2025-01-15",{"date":207,"type":37},"2025-01-06",{"date":209,"type":21},"2026-07-01",{"name":211,"class":44},"Henrik Endeman",{"id":213,"slug":214,"hasResults":11,"nctId":215,"briefTitle":216,"officialTitle":217,"acronym":4,"eligibilityCriteria":218,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":219,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":221,"conditions":222,"keywords":223,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":227,"lastUpdatePostDateStruct":228,"startDateStruct":230,"completionDateStruct":232,"leadSponsor":234,"locationsCount":4},"100571749","ultrasound-assessment-of-the-thickening-fraction-of-the-respiratory-muscles-for-predicting-weaning-outcomes-100571749","NCT06724302","Ultrasound Assessment of the Thickening Fraction of the Respiratory Muscles for Predicting Weaning Outcomes","The Accuracy of Ultrasound Assessment of the Thickening Fraction of the Diaphragm, Parasternal Intercostal, and Abdominal Expiratory Muscles for Predicting Weaning Outcomes in Mechanically Ventilated Patients","Inclusion Criteria:\n\n* Patients will be enrolled if they are ≥18 years old, on invasive mechanical ventilation (MV) for more than 48 h and are eligible for first spontaneous breathing trial (SBT) after fulfilling all the following criteria:\n\n  1. Resolution or improvement of the disease leading to MV.\n  2. Adequate oxygenation, indicated by arterial oxygen partial pressure to inspired oxygen fraction (PaO2\u002FFiO2) ≥ 200 mmHg, both with positive end-expiratory pressure (PEEP) ≤ 5 cmH2O and rapid shallow breathing index\\\u003C 105.\n  3. Adequate pulmonary function, indicated by a RR\\\u003C30 breaths\u002Fmin with VT ≥5 mL\u002Fkg ideal body weight (IBW) and no significant respiratory acidosis with normal serum electrolytes.\n  4. Stable hemodynamics status, without or with minimal vasopressors\n  5. Conscious and cooperative patient\n  6. Absence of excessive tracheobronchial secretion (\\\u003C3 times suction in the past 8 hours).\n  7. Effective cough reflex .Exclusion Criteria:\n\n  \u003C!-- -->\n\n  1. Pregnancy.\n  2. Presence of tracheostomy, pleural effusion, pneumothorax, pneumomediastinum, or hemothorax.\n  3. Presence of rib fractures.\n  4. Pre-existing cervical spinal injury, history or final diagnosis of neuromuscular disorders, and diaphragmatic paralysis or disorders\n  5. Use of neuromuscular blocking agents within 48 hours.\n  6. A distorted abdominal wall anatomy, or damage to the abdominal wall.\n  7. Patients with localized fluid collections in the abdomen, hernias, abdominal wall hematomas, inguinal masses, femoral hernias, abdominal surgeries.\n  8. BMI≥ 40\n  9. Patients with previously failed SBT",{"count":220,"type":21},80,"The accuracy of ultrasound assessment of the thickening fraction of the diaphragm, parasternal intercostal, and abdominal expiratory muscles for predicting weaning outcomes in mechanically ventilated patients. A prospective observational study",[27],[224,225,226],"diaghragm","Parasternal intercostal","Abdominal expiratory","2024-12-06",{"date":229,"type":37},"2024-12-09",{"date":231,"type":21},"2025-01",{"date":233,"type":21},"2026-12",{"name":235,"class":44},"Tanta University"]