[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"weaning-induced-pulmonary-edema\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:weaning-induced-pulmonary-edema":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100644254","hemodynamic-impact-of-the-spontaneous-ventilation-test-in-patients-at-risk-of-weaning-pulmonary-oedema-100644254",false,"NCT07666880","Hemodynamic Impact of the Spontaneous Ventilation Test in Patients at Risk of Weaning Pulmonary Oedema","WAPITI 2","Inclusion Criteria:\n\n* Adult patient (\\> 18 years) on invasive mechanical ventilation in the ICU for more than 48 hours\n* In the ventilator weaning phase with a first SBT planned\n* At risk of WIPE: age over 65 years and\u002For any type of heart disease and\u002For chronic respiratory failure and\u002For obesity\n\nExclusion Criteria:\n\n* Patient who has already participated in the study\n* No transthoracic echocardiographic images suitable for analysis\n* Non-sinus rhythm (including pacemaker)\n* Tracheostomy\n* Chronic neuromuscular or neurodegenerative disease\n* Persons deprived of liberty or under legal protection\n* Pregnant or breastfeeding woman","ALL","18 Years",{"count":19,"type":20},88,"ESTIMATED","INTERVENTIONAL",[23],"NA","Weaning-induced pulmonary edema (WIPE) from the ventilator is a frequent cause of extubation failure or delay, which prolongs the duration of invasive mechanical ventilation and the associated morbidity and mortality. WIPE is a very frequent cause of extubation failure in at-risk patients. A spontaneous breathing trial (SBT) is performed before extubating a patient, either by disconnecting the patient from the ventilator (T-piece SBT) or by setting the ventilator to spontaneous breathing mode with pressure support at 7 cm H2O and zero positive end-expiratory pressure (PS-ZEEP SBT). There is currently no recommendation regarding which SBT modality should be used, particularly in patients at risk of WIPE. The hemodynamic changes induced by the SBT can lead to WIPE, which typically develops within minutes of the SBT onset.\n\nThe hypothesis being tested is that, by altering intrathoracic pressure during the patient's inspiration (negative pressure), the T-piece SBT leads to a greater increase in left ventricular filling pressures compared to the PS-ZEEP SBT.",[26],"Weaning-induced Pulmonary Edema",[28],"Weaning-induced pulmonary edema","NOT_YET_RECRUITING","2026-06-18",{"date":32,"type":33},"2026-06-24","ACTUAL",{"date":35,"type":20},"2026-08-01",{"date":37,"type":20},"2029-08-07",{"name":39,"class":40},"University Hospital, Limoges","OTHER",4,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":21,"phases":52,"briefSummary":53,"conditions":54,"keywords":59,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100587044","ultrasound-evaluation-of-cardiac-function-during-spontaneous-breathing-trials-100587044","NCT06923267","Ultrasound Evaluation of Cardiac Function During Spontaneous Breathing Trials","Ultrasound Evaluation of Cardiac Function During Three Spontaneous Breathing Trials in Intensive Care Unit : A Prospective Interventional Study","ATARI","Inclusion Criteria:\n\n* Intubated patient undergoing invasive mechanical ventilation for at least 24 hours and scheduled for a spontaneous breathing trial\n* Richmond Agitation Sedation Scale (RASS) between -1 and +1\n* Patient at high risk of re-intubation with at least one of the following criteria:\n\n  * Underlying cardiac disease (left ventricular dysfunction with left ventricular ejection fraction ≤ 45%, documented ischemic heart disease, chronic atrial fibrillation, known history of cardiogenic pulmonary edema)\n  * Underlying respiratory disease (COPD, Emphysema, bronchial dilatation, asthma, obesity\u002Fhypoventilation syndrome, restrictive lung disease)\n\nExclusion Criteria:\n\n* Neuromuscular pathology (myasthenia type) preceding hospitalization\n* Pregnant or breast-feeding women\n* Patient already included in the study\n* Protected person (under guardianship or curatorship)\n* Person under court protection\n* Person not affiliated to a social security scheme",{"count":51,"type":20},24,[23],"The goal of this clinical trial is to evaluate the evolution of a cardiac ultrasound index (E\u002FE') during 3 spontaneous breathing trials in Intensive Care Unit (ICU) adults (over 18 years) patients at risk for weaning failure. The main objective is to find out which spontaneous breathing trial is the least demanding in terms of heart work.\n\nInvestigators will compare 3 consecutive spontaneous breathing trials in a random order to see if one is superior to the others.\n\nParticipants will not have to perform any specific procedure apart from breathing without respiratory support during the spontaneous breathing trial. During these trials, the investigator will perform cardiac ultrasound measurements.",[55,26,56,57,58],"Weaning Invasive Mechanical Ventilation","Weaning Failure of Mechanical Ventilation","Spontaneous Breathing Test","Intensive Care Units (ICUs)",[60,61,62,63],"Humidified high flow","Cardiac ultrasound","Spontaneous breathing trial","T-Piece","RECRUITING","2026-05-21",{"date":67,"type":33},"2026-05-22",{"date":69,"type":33},"2025-04-30",{"date":71,"type":20},"2027-05",{"name":73,"class":40},"Centre Hospitalier Régional d'Orléans",1]