[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"weaning-invasive-mechanical-ventilation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:weaning-invasive-mechanical-ventilation":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,50,89,113,141],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100587044","ultrasound-evaluation-of-cardiac-function-during-spontaneous-breathing-trials-100587044",false,"NCT06923267","Ultrasound Evaluation of Cardiac Function During Spontaneous Breathing Trials","Ultrasound Evaluation of Cardiac Function During Three Spontaneous Breathing Trials in Intensive Care Unit : A Prospective Interventional Study","ATARI","Inclusion Criteria:\n\n* Intubated patient undergoing invasive mechanical ventilation for at least 24 hours and scheduled for a spontaneous breathing trial\n* Richmond Agitation Sedation Scale (RASS) between -1 and +1\n* Patient at high risk of re-intubation with at least one of the following criteria:\n\n  * Underlying cardiac disease (left ventricular dysfunction with left ventricular ejection fraction ≤ 45%, documented ischemic heart disease, chronic atrial fibrillation, known history of cardiogenic pulmonary edema)\n  * Underlying respiratory disease (COPD, Emphysema, bronchial dilatation, asthma, obesity\u002Fhypoventilation syndrome, restrictive lung disease)\n\nExclusion Criteria:\n\n* Neuromuscular pathology (myasthenia type) preceding hospitalization\n* Pregnant or breast-feeding women\n* Patient already included in the study\n* Protected person (under guardianship or curatorship)\n* Person under court protection\n* Person not affiliated to a social security scheme","ALL","18 Years",{"count":20,"type":21},24,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to evaluate the evolution of a cardiac ultrasound index (E\u002FE') during 3 spontaneous breathing trials in Intensive Care Unit (ICU) adults (over 18 years) patients at risk for weaning failure. The main objective is to find out which spontaneous breathing trial is the least demanding in terms of heart work.\n\nInvestigators will compare 3 consecutive spontaneous breathing trials in a random order to see if one is superior to the others.\n\nParticipants will not have to perform any specific procedure apart from breathing without respiratory support during the spontaneous breathing trial. During these trials, the investigator will perform cardiac ultrasound measurements.",[27,28,29,30,31],"Weaning Invasive Mechanical Ventilation","Weaning-induced Pulmonary Edema","Weaning Failure of Mechanical Ventilation","Spontaneous Breathing Test","Intensive Care Units (ICUs)",[33,34,35,36],"Humidified high flow","Cardiac ultrasound","Spontaneous breathing trial","T-Piece","RECRUITING","2026-05-21",{"date":40,"type":41},"2026-05-22","ACTUAL",{"date":43,"type":41},"2025-04-30",{"date":45,"type":21},"2027-05",{"name":47,"class":48},"Centre Hospitalier Régional d'Orléans","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":58,"enrollmentInfo":59,"targetDuration":61,"studyType":62,"phases":4,"briefSummary":63,"conditions":64,"keywords":72,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":88},"100600524","a-new-tool-for-extubation-readiness-in-mechanically-ventilated-patients-readiness-for-extubation-score-100600524","NCT07098611","A New Tool for Extubation Readiness in Mechanically Ventilated Patients: Readiness for EXtubation Score","A New Tool for Extubation Readiness in Mechanically Ventilated Patients: Readiness for EXtubation Score (REXs STUDY)","REXs","Inclusion Criteria:\n\n\\- Patients who are in the weaning process from mechanical ventilation after being connected to invasive mechanical ventilation in the intensive care unit.\n\nExclusion Criteria:\n\n* Patients without legal guardian consent.\n* Tracheostomized patients.\n* Patients enrolled in other studies.\n* Individuals with diaphragmatic pacers.\n* Pregnant patients.","89 Years",{"count":60,"type":21},470,"6 Weeks","OBSERVATIONAL","Liberation from mechanical ventilation involves three steps: weaning, readiness assessment, and extubation. Readiness is determined using clinical criteria such as improvement of the underlying condition, hemodynamic stability, and adequate respiratory effort. Successful extubation is defined as not requiring invasive support within 48 hours. Due to the complexity of ICU patients, various clinical parameters and multi-component scores have been developed to predict extubation success. This study aims to develop and evaluate a multi-component score, the Readiness for EXtubation score (REXs), to predict extubation readiness in ICU patients under invasive mechanical ventilation.",[65,66,67,68,69,70,71,27],"Ventilator Weaning","Respiration, Artificial","Respiratory Failure","Extubation Readiness","Extubation Failure","Extubation Succeeded","Intensive Care Patients Invasively Ventilated",[73,74,75,76,77,78],"mechanical ventilation","extubation","weaning","readiness","prediction","score","2026-04-29",{"date":81,"type":41},"2026-05-05",{"date":83,"type":41},"2025-06-15",{"date":85,"type":21},"2026-12-30",{"name":87,"class":48},"Medipol University",7,{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":93,"acronym":4,"eligibilityCriteria":94,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":95,"enrollmentInfo":96,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":98,"conditions":99,"keywords":100,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":49},"100627944","multidimensional-correlation-analysis-of-heart-rate-variability-and-weaning-assessment-parameters-in-critically-mechanically-ventilated-patients-100627944","NCT07455214","Multidimensional Correlation Analysis of Heart Rate Variability and Weaning Assessment Parameters in Critically Mechanically Ventilated Patients","Inclusion Criteria:\n\n* Age between 18 and 85 years.\n* Received mechanical ventilation for more than 24 hours and clinically assessed as ready for a Spontaneous Breathing Trial (SBT).\n* Stable ECG signal quality before extubation, meeting the basic requirements for HRV analysis.\n* Obtained informed consent from the patient or their legal representative, and agreed to participate in this study and cooperate with the 72-hour follow-up after extubation.\n\nExclusion Criteria:\n\n* Individuals with permanent pacemakers, defibrillators, or other devices that affect monitoring data.\n* Individuals on continuous deep sedation (RAS ≤ -4) and unable to regain consciousness in the short term.\n* Individuals with severe arrhythmias or unstable cardiovascular conditions that prevent reliable HRV analysis.\n* Individuals with cognitive impairment or mental illness that prevents them from cooperating with the research process, or individuals deemed unsuitable for participation in this study by their clinicians.","85 Years",{"count":97,"type":21},100,"Background： Conventional weaning assessments are widely used but often affected by factors such as poor patient cooperation, neuromuscular issues, or unstable consciousness, leading to uncertainty in extubation timing. Studies have shown that HRV differs significantly between successful and failed extubation cases. However, most research features small sample sizes, focuses on single HRV indicators, and lacks integration with traditional assessments, limiting HRV's clinical application.\n\nEffect： The study aims to develop a predictive model combining HRV and traditional weaning indicators to provide a more objective and sensitive physiological reference for ventilator weaning decisions in critical care settings.",[27],[101,102,103],"Heart rate variability","BEATINFO ECG Sensor","Weaning assessment parameters","2026-04-06",{"date":106,"type":41},"2026-04-09",{"date":108,"type":41},"2025-12-09",{"date":110,"type":21},"2026-08-31",{"name":112,"class":48},"Fu Jen Catholic University Hospital",{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":119,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":121,"targetDuration":4,"studyType":22,"phases":123,"briefSummary":124,"conditions":125,"keywords":130,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":49},"100602946","endotracheal-suctionning-during-positive-pressure-extubation-in-icu-100602946","NCT07130123","Endotracheal Suctionning During Positive Pressure Extubation in ICU","Removal of the Intubation Tube Under Positive Pressure With or Without Endotracheal Suctioning During Extubation in Intensive Care: a Prospective Randomised Controlled Trial","INTENTION","Inclusion Criteria:\n\n* Adult patient\n* Intubated for more than 48 hours\n* Patient for whom extubation is prescribed by the patient's physician\n\nExclusion Criteria:\n\n* Headboard restriction\\>30°.\n* Decision to limit active treatment in advance of reintubation\n* Protected person (under guardianship or curatorship)\n* Person under court protection\n* Persons deprived of liberty\n* Persons not affiliated to a social security scheme\n* Pregnant or breast-feeding woman\n* No co-inclusion with a study whose period of interest is follow-up within 3 hours of extubation.",{"count":122,"type":21},120,[24],"The aim of this clinical trial is to evaluate endotracheal suctioning during positive pressure extubation in mechanically ventilated adult patients (over 18 years old) in the intensive care unit (ICU). The main question it aims to answer is whether the intervention improves the respiratory oxygenation index (ROX) three hours after extubation compared to no endotracheal suction during positive pressure extubation.\n\nParticipants will only need to be extubated by the nursing team in the ICU. Follow-up will consist of evaluating respiratory rate, pulse oximetry and inspired oxygen fraction for three hours following extubation.",[126,27,127,128,129],"Mechanical Ventilation With Oral Intubation","Oxygen Saturation Measurement","Rox Index","Extubation",[131,74,132],"rox index","Suctionning","2025-12-12",{"date":135,"type":41},"2025-12-19",{"date":137,"type":41},"2025-10-03",{"date":139,"type":21},"2027-10",{"name":47,"class":48},{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":145,"acronym":4,"eligibilityCriteria":146,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":147,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":149,"conditions":150,"keywords":153,"overallStatus":155,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":49},"100601339","cardio-circulatory-and-respiratory-monitoring-for-prediction-of-outcome-in-mechanically-ventilated-chronic-obstructive-pulmonary-disease-patients-100601339","NCT07109206","Cardio-circulatory and Respiratory Monitoring for Prediction of Outcome in Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients","Inclusion Criteria:\n\n* All COPD patients who are mechanically ventilated for more than 48 h due to acute exacerbation and fulfilling weaning criteria will be included in the study.\n\nExclusion Criteria:\n\n1. Patients younger than 18 years old.\n2. Patients with pneumothorax, pleural, or pericardial effusion.\n3. Patients with injuries, burns, or wounds which precludes the proper application of the device electrodes.",{"count":148,"type":21},104,"Chronic Obstructive Pulmonary Disease (COPD) remains a leading cause of morbidity and mortality worldwide, often necessitating invasive mechanical ventilation (MV) during acute exacerbations. Weaning these patients from MV is a critical juncture in their care, as prolonged ventilation is associated with increased complications, including ventilator-associated pneumonia, diaphragmatic dysfunction, and higher healthcare costs. Traditional weaning indices, such as the Rapid Shallow Breathing Index (RSBI), Maximum Inspiratory Pressure (MIP), and the Integrative Weaning Index (IWI), New Integrative Weaning Index (NIWI) have been employed to predict weaning outcomes. However, their predictive accuracy in COPD patients is variable, often due to the heterogeneous nature of the disease and the presence of comorbidities. Recent advancements have introduced non-invasive hemodynamic monitoring tools, such as the ICON® (Electrical Cardiometry), which measures parameters like cardiac output, stroke volume, and thoracic fluid content. These parameters may offer additional insights into a patient's readiness for weaning by providing real-time data on cardiovascular and fluid status, which are crucial in the weaning process. There is a scarcity of data comparing the predictive value of ICON parameters with traditional weaning indices in COPD patients. Understanding whether ICON-derived metrics can enhance weaning predictions and lead to more individualized and effective weaning strategies, reducing the duration of MV and improving patient outcomes.",[151,152,27],"COPD (Chronic Obstructive Pulmonary Disease)","Cardiometry",[154],"Intensive-care, COPD, ICON, Weaning","NOT_YET_RECRUITING","2025-07-31",{"date":158,"type":41},"2025-08-07",{"date":160,"type":21},"2025-08-30",{"date":162,"type":21},"2028-07-20",{"name":164,"class":48},"Assiut University"]