[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"weaning-mechanical-ventilation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:weaning-mechanical-ventilation":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,45,71,87,114],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100632808","hypnosis-during-mechanical-ventilation-weaning-100632808",false,"NCT07518498","Hypnosis During Mechanical Ventilation Weaning","Hypnosis During Mechanical Ventilation Weaning : Feasibility and Physiological Impact","HYPREA","Inclusion Criteria:\n\n* Patients aged 18 and older\n* Patients hospitalized in the intensive care unit and requiring invasive mechanical ventilation for at least 48 hours\n* Presence of the prerequisite criteria for ventilator weaning: effective cough, minimal bronchial congestion, patient awake and not agitated, hemodynamic stability (heart rate less than 140 beats per minute, systolic blood pressure between 90 and 160 mmHg without vasopressors), pressure support ventilation, FiO2 \\\u003C 40% and PEEP ≤ 8 cmH2O, PaO2\u002FFiO2 \\> 150, pH \\> 7.35, respiratory rate \\\u003C 35 per minute\n* Patients enrolled in a social security program or eligible for such a program\n* Patients who has received complete information about the clinical research protocol and has signed an informed consent form\n* Patients who has undergone a preliminary clinical examination appropriate for the clinical research\n\nExclusion Criteria:\n\n* Contraindication to hypnosis (particularly severe psychotic disorders)\n* Non-French-speaking individuals\n* Deaf or hard-of-hearing individuals\n* State of agitation or acute delirium\n* Individuals who have already undergone a spontaneous ventilation test or an attempt at orotracheal extubation during their hospitalization\n* Individuals receiving a new anxiolytic or sedative treatment within 2 hours prior to the weaning test\n* Individuals with a tracheostomy\n* Women of childbearing age who do not have access to effective contraception\n* Individuals covered by Articles L. 1121-5, L. 1121-7, and L. 1121-8 of the Public Health Code (pregnant women, women in labor, or breastfeeding women, minors not emancipated, adult subject to a legal protection measure, adult unable to give consent)\n* Person deprived of liberty by a judicial or administrative decision, or a person receiving psychiatric care pursuant to Articles L. 3212-1 and L. 3213-1","ALL","18 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","Hypnosis is defined as an altered state of consciousness characterized by an increased susceptibility to suggestion. It is a technique commonly used in the medical field, primarily for the management of pain and anxiety.\n\nThe literature demonstrates that better pain management is correlated with a shorter length of stay in the ICU and a shorter duration of mechanical ventilation.\n\nIn patients hospitalized in the ICU requiring invasive mechanical ventilation, the emotional component plays a significant role in dyspnea, which can become an obstacle to weaning from ventilation. The analgesic and anxiolytic treatments used carry numerous side effects and contraindications, limiting their use in ICU patients. Furthermore, pulmonary edema is a common cause of failure to wean from invasive mechanical ventilation. By reducing the occurrence of hypertension and tachycardia, hypnosis could be used as a therapeutic strategy to limit its incidence. Thus, hypnosis could be a valuable therapeutic tool for improving tolerance and the success of ventilator weaning.\n\nAlthough hypnosis is already commonly used in intensive care units, its use is still limited by a lack of evidence for more specific indications. It is in this context that this study was conducted, to assess the feasibility of conducting a hypnosis session during weaning from invasive mechanical ventilation in the intensive care unit.",[27,28,29],"Hypnosis","Weaning Mechanical Ventilation","Hypnosis During Weaning From Invasive Mechanical Ventilation",[27,28,31],"Intensive care unit","NOT_YET_RECRUITING","2026-04-07",{"date":35,"type":36},"2026-04-08","ACTUAL",{"date":38,"type":21},"2026-07-01",{"date":40,"type":21},"2027-07-01",{"name":42,"class":43},"Central Hospital, Nancy, France","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":4},"100617887","one-hour-positive-pressure-ventilation-after-a-pressure-support-spontaneous-breathing-trial-100617887","NCT07324460","One-Hour Positive Pressure Ventilation After a Pressure Support Spontaneous Breathing Trial","One-Hour Positive Pressure Ventilation After a Pressure Support Spontaneous Breathing Trial: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients aged \\> 18 years.\n* Admitted to the intensive care unit (surgical or medical).\n* With endotracheal intubation.\n* Mechanical ventilation for more than 72 hours.\n* Who underwent successful spontaneous breathing trial (according to the study protocol) and is considered able to be extubated.\n\nExclusion Criteria:\n\n* Patients unable to obey commands.\n* With non-planned extubation.\n* Neuromuscular disease and cervical spinal cord injury.\n* Tracheostomy.\n* Contraindication for cardiopulmonary resuscitation or reintubation.\n* Terminal extubation.\n* Lack of informed consent.\n* Previously included in the trial.",{"count":53,"type":21},4000,[24],"This is a randomized, open, multicenter, pragmatic, adaptive clinical trial with intention-to-treat analysis. The study will compare two weaning strategies from mechanical ventilation in critically ill patients admitted to intensive care units, with more than 72 hours of mechanical ventilation and with a successful spontaneous breathing trial on pressure support. Immediately after a successful spontaneous breathing trial, eligible patients will be randomized into 2 groups that will be treated according to one of the following interventions:1) One-hour positive pressure ventilation: as soon as the success of the spontaneous breathing trial is confirmed, the patient is submitted to mechanical ventilation for 1 hour using the previous ventilatory parameters and, afterwards, extubated.2) Immediate extubation: the patient is extubated immediately after the success of the spontaneous breathing trial.",[57,28,58],"Airway Extubation","Extubation Failure",[60,28,61],"Airway extubation","Extubation failure","2026-02-11",{"date":64,"type":36},"2026-02-12",{"date":66,"type":21},"2026-02",{"date":68,"type":21},"2030-02",{"name":70,"class":43},"Hospital do Coracao",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":78,"targetDuration":4,"studyType":22,"phases":79,"briefSummary":80,"conditions":81,"keywords":82,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":83,"startDateStruct":84,"completionDateStruct":85,"leadSponsor":86,"locationsCount":4},"100617881","one-hour-positive-pressure-ventilation-after-a-t-piece-spontaneous-breathing-trial-100617881","NCT07324382","One-Hour Positive Pressure Ventilation After a T-Piece Spontaneous Breathing Trial","One-Hour Positive Pressure Ventilation After a T-Piece Spontaneous Breathing Trial: A Randomized Clinical Trial","GS-Wean Tpiece",{"count":53,"type":21},[24],"This is a randomized, open, multicenter, pragmatic, adaptive clinical trial with intention-to-treat analysis. The study will compare two weaning strategies from mechanical ventilation in critically ill patients admitted to intensive care units, with more than 72 hours of mechanical ventilation and with a successful spontaneous breathing trial on T-piece. Immediately after a successful spontaneous breathing trial, eligible patients will be randomized into 2 groups that will be treated according to one of the following interventions:\n\n1. One-hour positive pressure ventilation: as soon as the success of the spontaneous breathing trial is confirmed, the patient is submitted to mechanical ventilation for 1 hour using the previous ventilatory parameters and, afterwards, extubated.\n2. Immediate extubation: the patient is extubated immediately after the success of the spontaneous breathing trial.",[57,58,28],[60,61,28],{"date":64,"type":36},{"date":66,"type":21},{"date":68,"type":21},{"name":70,"class":43},{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":93,"eligibilityCriteria":94,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":95,"targetDuration":4,"studyType":97,"phases":4,"briefSummary":98,"conditions":99,"keywords":100,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":113},"100621595","external-validation-of-vvi-100621595","NCT07372664","External Validation of VVI","External Validation of the Volume-Velocity Index for Weaning Prediction: a Multicenter Observational Study","E-VVI","Inclusion Criteria:\n\n* Mechanically ventilated patients for more than 48h\n* First Spontaneous breathing trial\n* Deemed as ready to undergo weaning by the treating physician, according to published readiness criteria (DOI: 10.1183\u002F09031936.00010206)\n\nExclusion Criteria:\n\n* pregnant patients\n* preexisting diaphragmatic disease or injury\n* tracheostomy",{"count":96,"type":21},100,"OBSERVATIONAL","Failure of liberation from mechanical ventilation increases days spent being mechanically ventilated, the length of stay and the morbidity of patients. Thus it is crucial that those patients who are ready to be liberated are accurately detected. In this study the investigators want to externally validate an index (the volume-velocity index, VVI) which in a preliminary study was found to predict with high accuracy the outcome of ventilator liberation.\n\nIn this study, in patients who are deemed ready to undergo weaning by their treating physician the investigators will measure the excursion of the diaphragm, the principal respiratory muscle, the inspiratory time and the tidal volume and the volume breathed by the patient at each respiration in three phases:\n\n1. during pressure support ventilation with 5\u002F5,\n2. during pressure support ventilation with 8\u002F0,\n3. during t-tube or pressure support ventilation with 0\u002F0. All of these phases are ventilatory modalities widely used during weaning from mechanical ventilation.\n\nThe investigators will evaluate whether VVI can predict accurately the weaning outcome.",[28],[101,102,103],"weaning","mechanical ventilation","ultrasound","RECRUITING","2026-02-08",{"date":62,"type":36},{"date":108,"type":36},"2025-12-28",{"date":110,"type":21},"2026-09",{"name":112,"class":43},"University of Thessaly",3,{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":17,"minAge":121,"maxAge":122,"enrollmentInfo":123,"targetDuration":4,"studyType":22,"phases":125,"briefSummary":126,"conditions":127,"keywords":129,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":44},"100598073","weaning-from-mechanical-ventilation-after-pediatric-cardiac-surgery-100598073","NCT07066748","Weaning From Mechanical Ventilation After Pediatric Cardiac Surgery","Weaning From Mechanical Ventilation After Pediatric Cardiac Surgery. A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Age 2-10years.\n2. Both sex.\n3. after fulfilling weaning criteria\n4. being pain free (observational pain\u002Fdiscomfort scale \\\u003C 4). the weaning criteria; which include: low mandatory ventilator rate \\[6-8\\] or less; fraction of inspired oxygen (FIO2) ≤ 40; level of positive end expiratory pressure (PEEP) \\[3-5 cmH2O\\] guided by pressure\u002Fvolume loop; reversal of the cause of postoperative mechanical ventilation; oxygenation index (OI) (mean air way pressure × FIO2\u002FPaO2) \\\u003C 5; dynamic compliance (Cdyn) \\> 1 ml\u002F cmH2O\u002Fkg\n\nExclusion Criteria:\n\n1. Duration of mechanical ventilation is more than 48 hours\n2. Patients on high inotropic support (unstable hemodynamics)\n3. Patients with disturbed conscious level\n4. Patients with palliative cardiac shunting procedures (e.g., BT shunt, Glenn shunt).","2 Years","10 Years",{"count":124,"type":21},34,[24],"Weaning from mechanical ventilation post congenital cardiac surgery is often challenging. It is well known that not all patients can be early extubated, although most are suitable for early postoperative weaning and extubating despite complex operative procedures. With advances in anaesthesia management, cardiopulmonary bypass (CPB), and surgical techniques, the trend of 'fast tracking', and early extubating of pediatrics postcardiac surgery seems to be feasible. Unnecessary prolonged mechanical ventilation increases the complication risks as airway trauma, ventilator associated pneumonia, and increased hospital stay",[28,128],"Pediatric Cardiac Surgery",[130,131],"automatic tube compensation","congenital cardiac anomalies","2025-07-14",{"date":134,"type":36},"2025-07-15",{"date":136,"type":21},"2025-08",{"date":138,"type":21},"2025-12",{"name":140,"class":43},"Alexandria University"]