[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"weaning\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:weaning":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,50,78,102],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100516838","diaphragmatic-speckle-tracking-during-spontaneous-breathing-trial-100516838",false,"NCT06009731","Diaphragmatic Speckle Tracking During Spontaneous Breathing Trial","DIAPHRAGMATIC SPECKLE TRACKING DURING SPONTANEOUS BREATHING TRIAL","DIAST","Inclusion Criteria:\n\n* Consecutive adult patients (≥18 years old) undergoing mechanical ventilation for at least 24h (regardless of the reason of intubation)\n* patients fulfilling criteria for an SBT\n* patients will have to be able to trigger ventilator breaths with a reasonable level of assistance,\n* patients with lack of severe impairment in gas exchange,\n* patients that not require significant hemodynamic support.\n* Patients will be recruited by the study coordinator following completion of informed consent from the patient or legally authorized substitute decision maker.\n\nExclusion Criteria:\n\n* Use of pressure support during the SBT.\n* Severe hemodynamic instability (\\>30% increase in vasopressors in the last 6 hours or norepinephrine \\> 0.5 µg\u002Fkg\u002Fmin).\n* Severe or very severe chronic obstructive pulmonary disease (COPD) according to the GOLD criteria (stage III: FEV1 30-50% predicted; stage IV: FEV1 \\\u003C 30% predicted).\n* Known or suspected severe or progressive neuromuscular disorder likely to result in prolonged or chronic ventilator dependence\n* Clinical judgement of the attending physician.","ALL","18 Years",{"count":20,"type":21},60,"ESTIMATED","OBSERVATIONAL","Currently, measurement of transdiaphragmatic pressure (Pdi) using oesophageal and gastric balloons is the gold standard for the assessment of diaphragmatic effort. This technique is relatively invasive and its interpretation may be complex. The diaphragmatic longitudinal strain (LSdi) and strain rate (LSRdi) might provide additional information in the assessment of diaphragmatic effort and movement during SBT, allowing early detection of diaphragmatic dysfunction. Patients will be monitored during a 30-120 minutes SBT consisting of no assistance on the ventilator using CPAP with a pressure level of 0 cmH2O. Parameters to evaluate diaphragm function will include diaphragmatic strain (LSdi and LSRdi), diaphragmatic thickening fraction (TFdi), and airway occlusion pressure (ΔP0.1 and ΔPocc). These parameters will be measured immediately before ('baseline') the SBT, as well as 2 minutes ('early' assessment), 15 ('intermediate' assessment) and 30 minutes ('late' assessment) after the beginning of the SBT.",[25,26,27,28,29,30],"Weaning","Spontaneous Breathing Trial","Mechanical Ventilation","Speckle Tracking","Strains","Diaphragm",[32,33,34,35,29,36],"weaning","spontaneous breathing trial","mechanical ventilation","speckle tracking","diaphragm","RECRUITING","2026-05-12",{"date":40,"type":41},"2026-05-15","ACTUAL",{"date":43,"type":41},"2023-06-12",{"date":45,"type":21},"2027-07",{"name":47,"class":48},"Centre Hospitalier Universitaire, Amiens","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":49},"100559220","optimal-timing-for-spontaneous-breathing-trials-100559220","NCT06561295","Optimal Timing for Spontaneous Breathing Trials","Impact of Spontaneous Breathing Trial Timing on Outcomes in Mechanically Ventilated Adult Patients","Inclusion Criteria:\n\n* Adults aged 21 years or older.\n* Patients who have been on mechanical ventilation for more than 48 hours.\n* Patients who have completed at least one SBT.\n\nExclusion Criteria:\n\n* Patients intubated at other hospitals.\n* Patients intubated for surgical or interventional procedures.\n* Patients receiving venovenous extracorporeal membrane oxygenation (VV-ECMO).\n* Patients with a tracheostomy.","21 Years",{"count":59,"type":21},348,"INTERVENTIONAL",[62],"NA","This study aims to explore how the timing of Spontaneous Breathing Trials (SBTs) affects recovery in adult patients who are on mechanical ventilation in the ICU. SBTs are tests used to determine if a patient is ready to breathe on their own without the help of a ventilator. The study will compare two different timing strategies for these trials: one group of patients will have the test early in the morning, while the other group will have it later in the morning. By observing the outcomes, such as how long patients need to stay on the ventilator, the study hopes to find the best time to perform these trials to help patients recover more quickly and safely.",[65,25],"Respiration, Artificial",[67,25,68],"Spontaneous breathing trial","Mechanical ventilation duration","2025-09-26",{"date":71,"type":41},"2025-09-30",{"date":73,"type":41},"2024-09-17",{"date":75,"type":21},"2026-12-30",{"name":77,"class":48},"Rush University Medical Center",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":60,"phases":86,"briefSummary":87,"conditions":88,"keywords":4,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":4},"100597674","objective-evaluation-of-cough-effort-in-tracheotomized-patients-lost-study-100597674","NCT07061561","Objective Evaluation of Cough Effort in Tracheotomized Patients (LOST Study)","Inclusion Criteria:\n\n* Adult patients (18 years or older)\n* Hospitalized in post-intensive care rehabilitation unit (SRPR) or intensive care unit (ICU)\n* Tracheotomized during the weaning process\n* Medical prescription for physiotherapy assessment\n* Medical prescription for speech therapy assessment\n\nExclusion Criteria:\n\n* Patients who have undergone total laryngectomy\n* Patients with severe swallowing disorders\n* Patients with cognitive impairments incompatible with understanding instructions\n* Patients under medical decision to stop active treatments\n* Patients who refuse to participate or refuse to sign informed consent\n* Patients under guardianship or curatorship\n* Patients not affiliated with a social security scheme",{"count":85,"type":21},34,[62],"This study aims to evaluate how well tracheotomized patients can cough before and after their tracheostomy tube is removed. Cough strength is measured using two different tools-Peak Flow and Lorio. Researchers want to find out if the cough measurement taken before removing the tube can help predict how effective the patient's cough will be afterward. The study will also explore factors that might influence cough strength and compare the usefulness of the two tools. Additionally, it will assess how patients feel about using these devices and the role of diaphragm ultrasound in predicting cough effectiveness.",[89,90,25,91,30],"Tracheostomy","Cough","Respiratory Function Tests","NOT_YET_RECRUITING","2025-07-02",{"date":95,"type":41},"2025-07-11",{"date":97,"type":21},"2025-07-15",{"date":99,"type":21},"2026-11-15",{"name":101,"class":48},"Centre Hospitalier de Saint-Denis",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":106,"acronym":107,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":109,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":111,"conditions":112,"keywords":113,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":5},"100580634","survey-of-different-modes-of-weaning-in-pediatric-population-100580634","NCT06839846","Survey of Different Modes of Weaning in Pediatric Population","DIVPED","Inclusion Criteria:\n\nParents group:\n\n* Overage parents with children between the ages of 4 and 18 months\n* Need to have an electronic tool that allows direct access to the link connected to an internet network\n* Understanding of the Italian language\n* Obtaining informed consent from the parent completing the questionnaire\n\nPediatricians group:\n\n* Activities of Free Choice Pediatrician in Italy.\n* Need to have an electronic tool that allows direct access to the link connected to an Internet network\n* Obtaining informed consent\n\nExclusion Criteria:\n\nParents group:\n\n\\- Parents of children with chronic neurological diseases, dysphagia, chronic diseases involving specific diet, intestinal diseases resulting in malabsorption;\n\nPediatricians group:\n\n\\- None",{"count":110,"type":21},500,"Infant weaning refers to the transition from a diet based on the exclusive intake of milk (mother's milk or formula) to a diversified diet that is complete with all the nutrients necessary for proper infant development. For this purpose, a diet supplementary to milk, which is gradually reduced, is undertaken in order to gradually acquire the dietary pattern followed by the family.\n\nThere are different types of weaning, which vary according to traditions, ethnicity and scientific currents. These include traditional weaning and on-demand self-weaning. The former consists of weaning with specific infant foods (example: freeze-dried, homogenized, vegetable broth, creams..) offered at set doses, quantities, and times. On the other hand, 'autodivezzamento on demand is a mode of weaning entrusted to the child's request, leaving the child to choose quantities and types of food, even prepared at home, during family meals. The aim of our study is to establish the prevalence of different modes of weaning and the perception of advantages and disadvantages related to them by parents and Free Choice Pediatricians by means of two different dedicated questionnaires. The study also aims to assess possible risks resulting from the transition to complementary feeding, for example, errors in feeding or inhalation of foreign bodies.",[25],[32],"2025-02-17",{"date":116,"type":41},"2025-02-21",{"date":118,"type":41},"2022-04-01",{"date":120,"type":21},"2025-06-30",{"name":122,"class":48},"IRCCS Azienda Ospedaliero-Universitaria di Bologna"]