[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"well-being-psychological\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:well-being-psychological":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,45,0,25,[9,43,81,114,146,170,200,227,255,281,301,330,352,375,400,431,453,476,502,525,551,585,612,645,678],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100620644","phase-1-consciousness-and-psilocybin-effects-on-well-being-the-copewell-study-100620644",false,"NCT07360301","Consciousness and Psilocybin Effects on Well-Being: The CoPEWell Study","Inclusion Criteria:\n\n* Age 18 to 45 years (inclusive) at screening, of any identified gender and racial\u002Fethnic group\n* Physically healthy; does not meet criteria for an exclusionary medical condition\n* No exclusionary sleep condition\n* English-speaking (able to provide consent and complete questionnaires)\n* Sub-optimal self-reported wellbeing\n\nExclusion Criteria:\n\n* Exclusionary DSM-5 psychiatric diagnosis and\u002For active suicidal ideation\n* Exclusionary medical conditions or sleep conditions\n* Clinically significant safety lab abnormalities (i.e., Complete Blood Count with Differential, Comprehensive Metabolic Panel, and urinalysis)\n* Clinically significant electrocardiogram (ECG)\n* Use of psychotropic or CNS-altering medications within 3 months of screening\n* Hypertension or tachycardia",true,"ALL","18 Years","45 Years",{"count":21,"type":22},120,"ESTIMATED","INTERVENTIONAL",[25],"PHASE1","This study is exploring how psilocybin (a psychedelic drug) may improve mood and wellbeing. Many people report feeling better after taking psilocybin, but it is not clear why. The CoPEWell study will test whether these improvements come from the psychedelic experience itself (the \"trip\") or from direct effects on the brain. To study this, up to 120 participants will be enrolled to receive psilocybin either while awake or asleep and can expect to be on study for up to 4 months.",[28,29],"Well-Being, Psychological","Psychedelic Experiences","NOT_YET_RECRUITING","2026-06-30",{"date":33,"type":34},"2026-07-02","ACTUAL",{"date":36,"type":22},"2026-09",{"date":38,"type":22},"2028-02",{"name":40,"class":41},"University of Wisconsin, Madison","OTHER",1,{"id":44,"slug":45,"hasResults":12,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":16,"sex":17,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":55,"briefSummary":57,"conditions":58,"keywords":62,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":80},"100643387","reducing-school-dropout-and-enhancing-pupils-sense-of-belonging-and-participation-through-co-created-music-based-activities-100643387","NCT07632391","Reducing School Dropout and Enhancing Pupils' Sense of Belonging and Participation Through Co-created Music-based Activities","Reducing School Dropout and Enhancing Pupils' Sense of Belonging and Participation Through Co-created Music-based Activities: The RESONATE Cluster-randomised Crossover Trial","RESONATE","Inclusion Criteria:\n\n* Pupils from the area Bergen, Norway.\n* High school pupils.\n* Sufficient Scandinavian language skills.\n* Between age 15-25.\n\nExclusion Criteria:\n\n* Does not speak a Scandinavian language sufficiently.\n* Planning to change school during the school year.\n* Uncorrected hearing impairment.","15 Years","25 Years",{"count":54,"type":22},200,[56],"NA","RESONATE is a cluster-randomised crossover trial focusing on reducing school dropout rates and fostering belonging through co-created music-based activites, by combining music therapy (MT), psychology, and social sciences.\n\nAbout 200 participants will be recruited in the area of Bergen, Norway. They will be randomized into the following intervention arms: group music activity followed by usual school schedule or usual school schedule followed by group music activity.",[59,28,60,61],"Preventative Health","Salutogenesis","Mastery",[63,64,65,66,67,68,69,70],"Music therapy","Mental health","Adolescent","Music-based intervention","High school","Young adult","School dropout","Positive youth development","2026-06-02",{"date":73,"type":34},"2026-06-08",{"date":75,"type":22},"2026-08-15",{"date":77,"type":22},"2027-12-23",{"name":79,"class":41},"NORCE Norwegian Research Centre AS",16,{"id":82,"slug":83,"hasResults":12,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":16,"sex":17,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":23,"phases":93,"briefSummary":94,"conditions":95,"keywords":99,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":113},"100611437","randomized-controlled-trial-of-a-family-focused-intervention-for-caregivers-and-young-adolescents-phase-3-of-flourish-100611437","NCT07240571","Randomized Controlled Trial of a Family-focused Intervention for Caregivers and Young Adolescents (Phase 3 of FLOURISH)","Family-Focused Adolescent & Lifelong Health Promotion: Prevention of Adolescent Mental Health Problems in Eastern Europe","FLOURISH","Inclusion Criteria:\n\n* For Caregivers:\n\nMust be 18 years or older at baseline assessment\n\nMust be the primary caregiver of an adolescent aged 10-14 who has resided in the same household for at least four nights a week in the past month\n\nMust be able to speak at least one of the local languages in which the program will be offered (e.g., Macedonian, Romanian, Russian, Ukrainian or Albanian)\n\nMust agree to participate in the program and provide informed consent for both themselves and their adolescent\n\nFor Adolescents:\n\nMust be aged 10-14 at the baseline assessment\n\nMust provide assent to participate in the study\n\nMust have caregiver consent to participate.\n\nExclusion Criteria:\n\n* No formal exclusion criteria have been established for the FLOURISH project. However, during the study introduction, the research team will guide participants through a consent form that asks whether they are currently experiencing acute distress or a mental or physical health condition that could interfere with participation. The decision to participate will be made by the individual. If a potential participant indicates they are unable to take part due to acute health issues, the research team will provide appropriate referrals to other services.","10 Years","14 Years",{"count":92,"type":22},1280,[56],"The aim of this study is to conduct a multi-country randomized waitlist controlled trial to evaluate the effectiveness, cost-effectiveness, and scalability of the optimized Parenting for Lifelong Health (PLH) for Parents and Teens program in Moldova and North Macedonia. In Phase 2 of the FLOURISH project, a factorial trial tested multiple intervention components and identified the optimized intervention package. In Phase 3, this trial will assess the implementation, outcomes, and economic impact of the optimized PLH program delivered to adolescents aged 10-14 and their caregivers. ALTERNATIVA will deliver the program in North Macedonia and the Health for Youth Association in the Republic of Moldova.",[96,97,98,28],"Adolescent - Emotional Problem","Parent Child Relationship","Family Functioning",[100,101,102,64,103],"Multiphase Optimization Strategy (MOST)","Family-based intervention","Adolescents","Randomized trial","RECRUITING","2026-05-28",{"date":71,"type":34},{"date":108,"type":34},"2025-10-24",{"date":110,"type":22},"2026-11-30",{"name":112,"class":41},"University of Klagenfurt",2,{"id":115,"slug":116,"hasResults":12,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":120,"eligibilityCriteria":121,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":122,"enrollmentInfo":123,"targetDuration":4,"studyType":23,"phases":125,"briefSummary":126,"conditions":127,"keywords":130,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":42},"100589867","developing-resilience-in-transgender-and-nonbinary-individuals---exploring-the-impact-of-social-challenges-in-the-metaverse-100589867","NCT06959992","Developing Resilience in Transgender and Nonbinary Individuals - Exploring the Impact of Social Challenges in the Metaverse","Evaluating the Efficacy of Virtual Support Groups Fostering Resilience for Gender Diverse People: a Randomized Clinical Trial in the Metaverse","RESILIDENT","Inclusion Criteria:\n\n* Transgender and nonbinary individuals with a stable gender-identity or questioning\n\nExclusion Criteria:\n\n* Presence of acute psychiatric instability (e.g., acute psychotic symptomatology or acute suicide risk)\n* Not being part of the transgender population\n* Younger than 18","35 Years",{"count":124,"type":22},123,[56],"The goal of this clinical trial is to test the effectiveness of conducting a support group in the Metaverse designed to develop and\u002For improve resilience in gender diverse people. By exploring the impact of different social challenges in a virtual environment, the main question it aims to answer is whether this approach on conducting support group sessions with gender diverse people will strengthen their resilience and associated abilities (self-compassion) compared to a control group and a waitlist.",[128,28,129],"Resilience,Psychological","Self-Compassion",[131,132,133,134,135,136,137],"Metaverse","Gender minorities","Support groups","Resilience","Well-being","Randomized clinical trial","Self-compassion","2026-05-24",{"date":105,"type":34},{"date":141,"type":34},"2025-09-01",{"date":143,"type":22},"2026-12",{"name":145,"class":41},"University of Bucharest",{"id":147,"slug":148,"hasResults":12,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":4,"eligibilityCriteria":152,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":153,"targetDuration":4,"studyType":23,"phases":155,"briefSummary":156,"conditions":157,"keywords":158,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":42},"100618461","mental-health-app-and-impact-on-wellbeing-100618461","NCT07331922","Mental Health App and Impact on Wellbeing","Landing Place: Impact of the Landing Place Mental Health App on Mental Health and Well-being","Inclusion Criteria:\n\n* Penn State Behrend students\n* Over the age of 18\n* Must have an iPhone\n\nExclusion Criteria:\n\n* People outside of Penn State\n* Minors\n* People currently in therapy",{"count":154,"type":22},160,[56],"The goal of this clinical trial is to learn if intervention with Landing Place mental health app can support wellness in college students. The main questions it aims to answer are:\n\nCan the app increased well-being in college students? Will the app have increased use and usability by the college students? Researchers will compare two groups of participants to see if the app intervention will increase wellbeing and app usability rates.\n\nParticipants will randomly assigned into group 1 and 2. Group 1 will not use the app at all. Group 2 will use the app almost every day for 4 weeks.",[28],[159,160,135],"Digital Mental Health","College Students","2026-05-04",{"date":163,"type":34},"2026-05-06",{"date":165,"type":22},"2026-08",{"date":167,"type":22},"2027-05",{"name":169,"class":41},"Penn State University",{"id":171,"slug":172,"hasResults":12,"nctId":173,"briefTitle":174,"officialTitle":175,"acronym":176,"eligibilityCriteria":177,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":52,"enrollmentInfo":178,"targetDuration":4,"studyType":23,"phases":179,"briefSummary":180,"conditions":181,"keywords":185,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":42},"100560122","daoist-zhanzhuang-and-human-flourishing-100560122","NCT06573034","Daoist Zhanzhuang and Human Flourishing","Standing Like a Tree: Effects and Mechanisms of Daoist Zhanzhuang on Human Flourishing","Z-Flo","Inclusion Criteria:\n\n1. young adults aged between 18 and 25 years old when they enroll;\n2. be willing and available (e.g., intend to remain in Charlotte or the surrounding area or willing to travel to UNCC campus for in person visits) to participate to 12 month study;\n3. able to stand for 30 minutes;\n4. scoring above 18 on the Perceived Stress Scale (moderate stress); and\n5. able to read, speak and understand English.\n\nExclusion Criteria:\n\n1. experience of qigong-related practice in the past 5 years;\n2. reporting regular medication use that directly modulates immune system functioning (e.g., steroids, cytokine inhibitors, high levels of non-steroidal anti-inflammatory medication, chemotherapy, etc.) or sedates the nervous system (e.g., benzodiazepines, anti-epileptics, tranquilizers, etc.) or alters heart rate (e.g., beta blockers, calcium channel blocker, stimulants, etc.);\n3. self-reported illicit drug use in the past 3 months or substance dependence over the past month (e.g., alcohol binge drinking 2+ days\u002Fweek, using tobacco or nicotine products 5+ days\u002Fweek, cannabis and related products 2+ days\u002Fweek, etc.);\n4. physical impairment that does not allow them to stand for 30 mins (e.g., severe obesity, need wheel-chair or equipment to assist with walking, recent injury that limits standing, etc.), and\n5. severe mental health conditions that could prevent regular practice (e.g., hospitalized in the past 12 months for mental health condition).",{"count":21,"type":22},[56],"This project investigates the impact of Daoist Zhanzhuang (sometimes spelled as Chan Chuang) on human flourishing, and explores the physiological, psychological, and spiritual mechanisms. This study will be a two-arm randomized controlled trial, with mixed-methods and repeated-measures assessment of outcome variables. The two arms will include an active control condition (i.e., sham wall squat) and the Daoist Zhanzhuang condition. Outcome variables will include physiological measures of heart rate variability and inflammatory biomarkers, psychological scales of human flourishing variables, phenomenological interviews of mystical experiences, and daily ecological momentary assessment of human flourishing and mysticism. Randomly assigned into two conditions, 120 participants will complete a three-week intensive practice phase with 9 in-person sessions, followed by a nine-week self-guided practice phase with 4 in-person check-in sessions, and 3 follow-up practice and assessment sessions. Complete assessment (physiological measures, psychological scales, and phenomenological interviews) will be administered at five time points: T1 at about two weeks before the intervention, T2 at the end of the three-week intensive practice, T3 at the end of the 3-month intervention, T4 at the 6-month follow-up, and T5 at the 12-month follow-up. In addition, daily ecological momentary assessment of flourishing variables and practice-induced experiences will be administered daily after the practice for the entire 3-month intervention period.",[182,183,184,28],"Stress, Physiological","Stress, Psychological","Inflammatory Response",[186,187,188,189,190],"Human Flourishing","Daoist Zhanzhuang (Chan Chuang)","Heart Rate Variability","Immune Function","Mysticism","2026-04-27",{"date":193,"type":34},"2026-05-01",{"date":195,"type":34},"2024-08-29",{"date":197,"type":22},"2027-07",{"name":199,"class":41},"University of North Carolina, Charlotte",{"id":201,"slug":202,"hasResults":12,"nctId":203,"briefTitle":204,"officialTitle":205,"acronym":4,"eligibilityCriteria":206,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":207,"enrollmentInfo":208,"targetDuration":4,"studyType":23,"phases":210,"briefSummary":211,"conditions":212,"keywords":216,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":218,"lastUpdatePostDateStruct":219,"startDateStruct":221,"completionDateStruct":223,"leadSponsor":225,"locationsCount":42},"100587993","healing-hearts-of-hospitalized-patients-100587993","NCT06935604","Healing Hearts of Hospitalized Patients","Healing Hearts of Hospitalized Patients With Virtual Reality: A Pragmatic, Crossover Trial","Inclusion Criteria:\n\n* Adults aged 18 years and above\n* Able to provide informed consent\n* Able to follow verbal instructions\n* Adequate motor skills for upper extremities to operate VR equipment\n* Clinically stable\n* English speaking\n* Willing to participate in mindfulness activities\n\nExclusion Criteria:\n\n* Severe cognitive impairment\n* Clinically unstable\n* Facial trauma prohibiting headset use\n* Physical limitations in facial, neck, upper extremities that hinder use of VR equipment\n* History of seizures or other neurological conditions\n* Severe motion sickness\n* Active nausea\n* Severe visual impairment\n* Severe cognitive impairment","99 Years",{"count":209,"type":22},42,[56],"The study aims to evaluate the impact of a bedside-delivered virtual reality (VR) mindfulness experience on well-being and psychosocial outcomes among hospitalized adult patients compared to standard of care (SOC; no added mindfulness intervention).",[28,213,214,215],"Anxiety","Affect","Relaxation",[217],"Virtual Reality","2026-04-21",{"date":220,"type":34},"2026-04-24",{"date":222,"type":22},"2026-06-01",{"date":224,"type":22},"2027-05-31",{"name":226,"class":41},"Stanford University",{"id":228,"slug":229,"hasResults":12,"nctId":230,"briefTitle":231,"officialTitle":232,"acronym":233,"eligibilityCriteria":234,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":235,"enrollmentInfo":236,"targetDuration":4,"studyType":23,"phases":238,"briefSummary":239,"conditions":240,"keywords":242,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":246,"lastUpdatePostDateStruct":247,"startDateStruct":249,"completionDateStruct":251,"leadSponsor":253,"locationsCount":42},"100582750","reducing-psychological-distress-to-optimize-recovery-of-elderly-icu-survivors-and-caregivers-restore-icu-100582750","NCT06867367","REducing pSychological diSTress To Optimize Recovery of Elderly ICU Survivors and Caregivers (RESTORE-ICU)","REducing pSychological diSTress To Optimize Recovery of Elderly ICU Survivors and Caregivers (RESTORE-ICU): A Pilot Feasibility Study","RESTORE-ICU","Patient Inclusion\u002FExclusion Criteria\n\nInclusion Criteria:\n\n1. Provide signed and dated informed consent and understand the nature of the study sufficiently to allow completion of all study assessments.\n2. Elderly ICU survivors aged over 60 years who have experienced long ICU stays of more than five days.\n3. Caregivers who either live in the same household as the survivor or visit more than three times a week.\n\nExclusion Criteria:\n\nCo-enrollment in other interventional studies will not be allowed.\n\n1. Age \\>=85 years (Justification: Assessment instruments not validated in this age group and patients in extremes of age may have limited proficiency to engage in proposed meditative practices)\n2. Non-English speaking\u002FLow-English proficiency (Justification: assessment instruments are not validated in a sufficient range of languages, and the research team lacks polylingual capabilities or the financial resources to hire interpreters for the duration of all proposed assessments.)\n3. Non-US resident\n4. Recent or current meditation, yoga, breathwork or associated MBI intervention practice (\\> 2 times per week). (Justification: as the primary outcome is to evaluate the feasibility and adherence of patients to a multicomponent MBI, recent or current practice of the individual or combined components would directly influence the endpoint).\n5. Individuals discharged to a non-home location, such as a rehabilitation center, nursing home, or long-term acute care facility.\n6. Individuals with limited internet access, which would prevent access to online guided meditation\n7. Prisoners.\n8. Individuals who refuse to participate in the study.\n9. Not on vasopressor or inotropic support at the time of enrollment.\n10. Not on non-invasive ventilation, high-flow nasal cannula (HFNC), or mechanically ventilated.\n11. Not on continuous renal replacement therapy (CRRT).\n12. Failure to pass Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) screening (\\>3.6; Justification: Cognitive decline would limit the ability to engage with and complete the study interventions and assessments).\n13. Scores ≥ 5 on either the anxiety or depression subscales suggesting severe symptom levels.\n14. Known diagnosis of moderate or severe dementia.\n15. Neurological injury.\n16. Residing in a medical institution before admission.\n17. Patient on hospice at or before the time of enrollment.\n18. Mechanical ventilation at baseline or solely for airway protection.\n19. Patient not expected to go home (e.g., transfer to a facility).\n20. Patient not expected to survive two months or expected to transition to hospice.\n21. Patient died in hospital before enrollment.\n22. Attending physician declined enrollment.\n23. Patient discharged before being approached for consent.\n24. Either the patient or caregiver in the dyad declined participation (based on IQCODE or consent).\n\nCaregiver Inclusion\u002FExclusion Criteria\n\nInclusion Criteria:\n\n1. Provide signed and dated informed consent and understand the nature of the study sufficiently to allow completion of all study assessments.\n2. Caregivers who either live in the same household as the survivor or visit more than three times a week.\n3. Age ≥18 years old.\n\nExclusion Criteria:\n\n1. Non-English speaking\u002FLow-English proficiency (Justification: assessment instruments are not validated in a sufficient range of languages, and the research team lacks polylingual capabilities or the financial resources to hire interpreters for the duration of all proposed assessments.)\n2. Non-US resident\n3. Recent or current meditation, yoga, breathwork or associated MBI intervention practice (\\> 2 times per week). (Justification: as the primary outcome is to evaluate the feasibility and adherence of patients to a multicomponent MBI, recent or current practice of the individual or combined components would directly influence the endpoint).\n4. Individuals with limited internet access, which would prevent access to online guided meditation\n5. Prisoners.\n6. Individuals who refuse to participate in the study.\n7. Diagnosed with severe psychiatric disorders, such as schizophrenia, bipolar disorder, or ongoing substance abuse, that could interfere with participation.\n8. Individuals actively receiving treatment for recent trauma\n9. Scores ≥ 5 on either the anxiety or depression subscales suggesting severe symptom levels.\n10. severe or acute medical illness","85 Years",{"count":237,"type":22},14,[56],"This research study aims to explore whether a set of simple breathing techniques and guided meditations can improve the psychological well-being and recovery of ICU survivors and their caregivers.\n\nICU survivors and their caregivers often experience high levels of stress, anxiety, and depression after discharge. This study investigates whether practicing Isha Kriya, a guided meditation, and Nadi Shuddhi, a breathing technique, can support their mental health and relationship quality. These practices are delivered through a mobile app or in a group setting.\n\nParticipants enroll as a caregiver-patient dyad and will engage in these techniques throughout the study. In addition to the practices, brain activity will be recorded using a safe, non-invasive EEG device. The EEG, a lightweight cap with small sensors, measures brainwaves to assess potential changes in brain function and connection. EEG recordings will take place in the hospital during two sessions, each lasting approximately 40 minutes.\n\nParticipants will also complete short surveys at five time points throughout the study, assessing mood, stress, and relationship quality. Baseline demographic information will be collected, and at the conclusion of the study, a brief interview will be conducted to gather feedback on the experience.\n\nThe study spans approximately seven weeks, with the overall goal of determining whether these breathing and meditation practices can provide accessible and scalable mental health support for ICU survivors and their caregivers.",[241,28],"Relationship, Family",[243,244,245],"mental health","relationship quality","ICU recovery","2026-04-16",{"date":248,"type":34},"2026-04-20",{"date":250,"type":22},"2026-05",{"date":252,"type":22},"2027-12",{"name":254,"class":41},"Beth Israel Deaconess Medical Center",{"id":256,"slug":257,"hasResults":12,"nctId":258,"briefTitle":259,"officialTitle":260,"acronym":4,"eligibilityCriteria":261,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":262,"targetDuration":4,"studyType":23,"phases":264,"briefSummary":265,"conditions":266,"keywords":269,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":276,"completionDateStruct":277,"leadSponsor":279,"locationsCount":4},"100634797","a-mindfulness-based-stress-reduction-training-program-model-100634797","NCT07544355","A Mindfulness-Based Stress Reduction Training Program Model","A Mindfulness-Based Stress Reduction Training Program Model for Empowering Nursing Students","Inclusion Criteria:\n\n* Volunteering to participate in the study,\n* Being a nursing student,\n* Having completed the pre-test,\n* Not having a stress score within the normal range,\n* Not having received any prior training on this subject,\n* Not having a severe psychiatric illness (psychosis, schizophrenia, etc.) diagnosed by a physician and requiring medication.\n\nExclusion Criteria:\n\n* Not volunteering to participate in the study,\n* Not being a nursing student,\n* Not completing the pre-test,\n* Having a stress score within the normal range in the pre-test results,\n* Not having received any prior training on this subject,\n* Having a psychiatric illness (psychosis, schizophrenia, etc.) diagnosed by a physician and requiring medication.",{"count":263,"type":22},93,[56],"Mindfulness-based practices are used to regulate mood, alleviate or completely eliminate symptoms that cause stress and depression, and positively influence well-being. The Mindfulness-Based Stress Reduction Program is a mindfulness approach applied to individuals with physical and psychological complaints and aims to reduce stress levels (Kral et al., 2022).\n\nThe Mindfulness-Based Stress Reduction Program is a widely used meditation practice that includes individual or group practices aimed at creating awareness in individuals, such as breath awareness meditation, body scan, walking meditation, and yoga, taught by a practitioner. Each of the practices involves focusing attention on the experience of the present moment (Kral et al., 2022). However, it aims for individuals under stress to respond consciously to situations instead of automatically reacting (Gotink et al., 2016). Unlike traditional meditation, the Mindfulness-Based Stress Reduction Program is based on focused attention, the individual's clear observation of themselves and events, and breath meditation. The aim is for individuals to recognize their automatic responses to events and to transform their existing responses without judgment (Gotink et al., 2016).\n\nThe main objective of this study is to determine the effect of a mindfulness-based stress reduction training program on emotion regulation and stress levels of nursing students, thereby enabling them to gain competence in this area.",[267,213,268,28],"Depression","Stress",[270,271,272],"Mindfulness","Nursing Students","Mindful Awareness","2026-04-15",{"date":275,"type":34},"2026-04-22",{"date":248,"type":22},{"date":278,"type":22},"2027-01-30",{"name":280,"class":41},"Istanbul Medeniyet University",{"id":282,"slug":283,"hasResults":12,"nctId":284,"briefTitle":285,"officialTitle":285,"acronym":4,"eligibilityCriteria":286,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":287,"targetDuration":4,"studyType":23,"phases":289,"briefSummary":290,"conditions":291,"keywords":4,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":294,"startDateStruct":295,"completionDateStruct":297,"leadSponsor":299,"locationsCount":42},"100499585","ending-the-hiv-epidemic-an-all-facility-intervention-for-patient-and-healthcare-staff-well-being-100499585","NCT05785169","Ending the HIV Epidemic: An All-facility Intervention for Patient and Healthcare Staff Well-being","Inclusion Criteria:\n\n* Selected Ryan White Clinics. Selection based on the following:\n\nFirst, clinic leaders will complete a 15-min Site Characteristics Survey, assessing suitability for participation and clinic comparability. Staff and leadership at Ryan White clinics will next complete an anonymous 15-minute Eligibility Survey.\n\nWithin each clinic, both clinic staff and patients will be invited to participate.\n\nExclusion Criteria:\n\n* Non-Ryan White Clinics\n* Clinics not located in the geographical area of interest\n* Clinics that are not interested in participating",{"count":288,"type":22},1000,[56],"The scope of this study is to engage Ryan White HIV\u002FAIDS Program (RWHAP) funded organizations in the South\u002FEast US to co-develop context-responsive programs utilizing evidence-informed interventions to reduce stigma against living with HIV (PLH) who have difficulties accessing and remaining engaged in life-saving treatment. Five RWHAP clinics will be selected for this trial. Clinic members will participate in interactive trainings to raise awareness of and reduce stigma, from the clinic policy level to individual attitudes. Clinic members and select patients will complete self-administered surveys every 6 months over 24 months.",[292,293,28],"Stigma","HIV",{"date":248,"type":34},{"date":296,"type":34},"2025-01-27",{"date":298,"type":22},"2028-04",{"name":300,"class":41},"Columbia University",{"id":302,"slug":303,"hasResults":12,"nctId":304,"briefTitle":305,"officialTitle":305,"acronym":4,"eligibilityCriteria":306,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":307,"targetDuration":4,"studyType":23,"phases":309,"briefSummary":310,"conditions":311,"keywords":314,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":321,"lastUpdatePostDateStruct":322,"startDateStruct":324,"completionDateStruct":326,"leadSponsor":328,"locationsCount":42},"100633068","moving-kindergartens-feasibility-study-100633068","NCT07521878","Moving Kindergartens Feasibility Study","Inclusion Criteria:\n\n* Pedagogical staff\u002Fleaders in included kindergartens\n\nExclusion Criteria:\n\n* None",{"count":308,"type":22},100,[56],"Objective of the study: The primary aim of this study is to evaluate the feasibility of a proposed intervention designed to support the daily movement practices and fostering joy of movement in Danish kindergartens, as well as the implementation strategies intended to facilitate adoption. Additionally, the feasibility of the planned measurement and procedures for a future effectiveness study will be examined.\n\nMethods: The study uses a mixed-methods design to examine the feasibility of the intervention and the future evaluation design. The planned duration of the intervention period is 10 weeks. The intervention consists of multiple integrated components co-designed with pedagogical staff, leaders, experts in kindergarten movement culture, and a team of researchers, to collectively support the daily movement practice in kindergartens. Alongside the intervention components, tailored strategies are developed to facilitate adoption and implementation. The intervention elements are categorized into four main types: 1) Formal establishment of the project; 2) Components of physical activity integrated in existing structures in the kindergarten; 3) Organizational and staff training; 4) Inspirational materials, tools and exemplary plans.\n\nThe use of a co-design approach in close collaboration between kindergartens, experts, and a team of researchers will ensure contextual relevance and shared ownership. This approach is expected to enhance acceptability, feasibility, and sustainability of the intervention. The mixed-methods evaluation design, use of theoretical implementation frameworks, and tailored strategies further strengthen the study. The findings from this feasibility study will inform the refinement of the final intervention and guide the planning of a forthcoming effectiveness study.",[312,28,313],"Physical Activity","Motor Skills",[315,316,317,318,319,320],"pre-school children","kindergarten","feasibility","acceptability","sustainability","kindergarten staff","2026-04-07",{"date":323,"type":34},"2026-04-13",{"date":325,"type":34},"2026-03-02",{"date":327,"type":22},"2026-07",{"name":329,"class":41},"University College Copenhagen",{"id":331,"slug":332,"hasResults":12,"nctId":333,"briefTitle":334,"officialTitle":335,"acronym":4,"eligibilityCriteria":336,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":337,"targetDuration":4,"studyType":23,"phases":339,"briefSummary":340,"conditions":341,"keywords":4,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":343,"lastUpdatePostDateStruct":344,"startDateStruct":346,"completionDateStruct":348,"leadSponsor":350,"locationsCount":42},"100560807","chinese-poem-writing-for-improving-mental-wellbeing-100560807","NCT06581952","Chinese Poem Writing for Improving Mental Wellbeing","Chinese Poem Writing for Improving Mental Wellbeing of Adult Volunteers Serving for People Recovering From Mental Illness","Inclusion Criteria:\n\n* Volunteers serving for people recovering from mental illness or other community residents\n* Aged 18 years old and above\n* Able to understand Cantonese and read Chinese\n\nExclusion Criteria:\n\n* Physically or mentally unable to communicate\n* Unwilling to participate or give consent\n* Being involved in other similar activities or research",{"count":338,"type":22},30,[56],"This research proposal aims to explore the impact of poem writing on the well-being of adult volunteers serving patients recovering from mental illness in Hong Kong. The research design was a single-arm intervention study with 30 participants. The intervention consists of two sessions of poem writing, each lasting for 3 hours, led by experienced Chinese teachers or drama directors. The themes of the poems will focus on accomplishment, joy, and gratitude. The primary outcomes are mental well-being and happiness, measured using the Short Warwick-Edinburgh Mental Well-being Scale and a single-item happiness scale. Feasibility outcomes include recruitment rate, retention rate, and acceptability of the interventions. Secondary outcomes include depressive symptoms, anxiety, interest in poem writing, perceived benefits after the activity, and the number of successfully written poems. The proposal also includes plans for in-depth interviews with participants to gather qualitative data. The results will be analyzed descriptively and narratively, with no efficacy statistical tests due to the nature of this feasibility study. The proposal highlights the potential of poem writing as a therapeutic tool for volunteers serving patients recovering from mental illness, enhancing their overall well-being.",[28,342],"Happiness","2026-03-11",{"date":345,"type":34},"2026-03-13",{"date":347,"type":34},"2024-06-13",{"date":349,"type":22},"2027-03-31",{"name":351,"class":41},"Hong Kong Metropolitan University",{"id":353,"slug":354,"hasResults":12,"nctId":355,"briefTitle":356,"officialTitle":357,"acronym":4,"eligibilityCriteria":358,"healthyVolunteers":16,"sex":17,"minAge":359,"maxAge":4,"enrollmentInfo":360,"targetDuration":4,"studyType":23,"phases":361,"briefSummary":362,"conditions":363,"keywords":4,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":366,"lastUpdatePostDateStruct":367,"startDateStruct":369,"completionDateStruct":371,"leadSponsor":373,"locationsCount":113},"100551674","the-impact-of-the-family-room-app-on-caregivers-100551674","NCT06463158","The Impact of the Family Room App on Caregivers","A Phase I Clinical Trial Evaluating the Impact of the Family Room App on Caregiver Well-being, Satisfaction, and Engagement in the Intensive Care Unit","Inclusion Criteria:\n\n* 19 years of age or older\n* Present at participant's bedside during the intensive care unit (ICU) admission\n* Participant's legally authorized representative (LAR) or designated caregiver to make medical decisions on their behalf\n\nExclusion Criteria:\n\n• Not legally authorized representative (LAR) or designated caregiver to make medical decisions on their behalf","19 Years",{"count":308,"type":22},[56],"Engaging families in patient care during serious illness can enhance care quality, reduce social isolation, boost satisfaction, and lower healthcare costs. However, active involvement of family caregivers remains limited because there are no evidence-based tools to guide clinicians on how to include them effectively. This study will test and refine previously developed point-of-care application, Family Room, and determine its effectiveness by comparison with a control group. A series of surveys will be used to evaluate caregiver well-being, engagement and satisfaction.",[28,364,365],"Engagement","Satisfaction, Consumer","2026-02-19",{"date":368,"type":34},"2026-02-23",{"date":370,"type":34},"2024-07-01",{"date":372,"type":22},"2027-02",{"name":374,"class":41},"University of Nebraska",{"id":376,"slug":377,"hasResults":12,"nctId":378,"briefTitle":379,"officialTitle":379,"acronym":4,"eligibilityCriteria":380,"healthyVolunteers":16,"sex":381,"minAge":18,"maxAge":4,"enrollmentInfo":382,"targetDuration":4,"studyType":23,"phases":384,"briefSummary":385,"conditions":386,"keywords":4,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":391,"lastUpdatePostDateStruct":392,"startDateStruct":394,"completionDateStruct":396,"leadSponsor":398,"locationsCount":113},"100609964","the-pregnant-pregnant-resident-empowerment-guidance-and-advocacy-in-training-coaching-project-100609964","NCT07221422","The PREGNANT (Pregnant Resident Empowerment, GuidaNce, and Advocacy iN Training) Coaching Project","Inclusion Criteria:\n\n1. Age 18 or older\n2. English fluency and literacy\n3. Resident or fellow level MD or DO trainee\n4. Pregnant or up to 3 months post-partum\n\nExclusion Criteria:\n\n1. Unable to provide consent.\n2. Unable to complete electronic surveys and video calls.","FEMALE",{"count":383,"type":22},48,[56],"This is a mixed-methods study designed to develop and evaluate an innovative coaching program for physician trainee mothers. Approximately 48 participants will be recruited from informational flyers posted in resident work areas and distributed by program directors and GME. Interested participants will email study staff. Participants will be randomized to the control or intervention arm. Intervention participants will meet monthly with a novice physician coach of their choice (one-on-one) and a certified physician coach (with an assigned group of 6 peers through video-conferencing).\n\nParticipants in both arms of the study will respond to surveys at three points: enrollment (baseline), 4 months, and 7 months. At each point, they will spend approximately 10 minutes filling the survey. The survey will query demographics, burnout, professional fulfillment, imposter phenomenon, self-valuation, self-efficacy, resilience, quality of life, and impact of work on professional relationships. The coaching intervention will last 4 months, and the 7 month survey will be used only to assess long-term effects of the intervention. At the conclusion of the study (7 months after enrollment), participants will be interviewed over video communication (secure Partners or Harvard Zoom) for approximately 30 minutes.",[387,28,388,389,390],"Burnout, Professional","Imposter Phenomenon","Self Efficacy","Quality of Life","2026-02-06",{"date":393,"type":34},"2026-02-10",{"date":395,"type":34},"2025-11-04",{"date":397,"type":22},"2026-12-01",{"name":399,"class":41},"Massachusetts General Hospital",{"id":401,"slug":402,"hasResults":12,"nctId":403,"briefTitle":404,"officialTitle":405,"acronym":406,"eligibilityCriteria":407,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":408,"enrollmentInfo":409,"targetDuration":4,"studyType":23,"phases":411,"briefSummary":412,"conditions":413,"keywords":416,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":423,"lastUpdatePostDateStruct":424,"startDateStruct":425,"completionDateStruct":427,"leadSponsor":429,"locationsCount":42},"100622694","heart-rate-variability-biofeedback-in-security-forces-100622694","NCT07386951","Heart Rate Variability Biofeedback in Security Forces","Heart Rate Variability Biofeedback in Distress Regulation and Burnout Prevention Among Security Forces","GNR-HRVB","Inclusion Criteria:\n\n1. Operational military personnel of the Guarda Nacional Republicana (GNR) performing security, patrol, criminal investigation, or road safety duties\n2. Any military rank or professional category within operational roles\n3. Age between 18 and 55 years, inclusive\n4. Both males and females\n5. Capable of providing informed consent in Portuguese language\n\nExclusion Criteria:\n\n1. Extended sick leave or medical absence\n2. Currently involved in serious disciplinary proceedings\n3. Use, modification, or initiation of psychotropic medication (including antidepressants, anti-anxiety medications, antipsychotics, mood stabilizers) within the past 6 months","55 Years",{"count":410,"type":22},50,[56],"This exploratory study evaluates the effectiveness of a 12-session Heart Rate Variability Biofeedback (HRV-BFB) protocol in reducing distress and burnout while promoting psychological well-being among Portuguese National Republican Guard (GNR) professionals. Exposed to high occupational stress from unpredictable risks, shift work, and limited resources, these individuals face elevated vulnerability to chronic stress outcomes. The intervention leverages real-time HRV feedback to enhance autonomic regulation, breathing techniques, and emotional self-regulation.",[414,28,415],"Psychological Distress","Burnout",[417,418,415,419,420,421,422],"Heart rate variability biofeedback","HRV biofeedback","Stress management","Psychological distress","Mental health promotion","Workplace well-being","2026-02-04",{"date":391,"type":34},{"date":426,"type":34},"2026-01-28",{"date":428,"type":22},"2026-08-01",{"name":430,"class":41},"Egas Moniz - Cooperativa de Ensino Superior, CRL",{"id":432,"slug":433,"hasResults":12,"nctId":434,"briefTitle":435,"officialTitle":436,"acronym":4,"eligibilityCriteria":437,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":438,"enrollmentInfo":439,"targetDuration":4,"studyType":23,"phases":440,"briefSummary":441,"conditions":442,"keywords":4,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":445,"lastUpdatePostDateStruct":446,"startDateStruct":448,"completionDateStruct":450,"leadSponsor":451,"locationsCount":42},"100613779","the-use-of-cannabidiol-suppositories-for-sexual-pain-100613779","NCT07271030","The Use of Cannabidiol Suppositories for Sexual Pain","The Use of Cannabidiol Suppositories for Sexual Pain: A Randomised Controlled Study","Inclusion Criteria:\n\n* Has previously used cannabidiol in any capacity and has not experienced any allergic reaction\n* Is experiencing sexual pain\n* There will be an absence of co occurring difficulties\n* Has attempted sexual intercourse in the last month\n* Age 18 years or older\n* Read and write English\n* Patient Health Questionnaire 9 screening score range between 0-9 mild\n* General Anxiety Disorder 7 screening score range between 0-9 mild\n* There are no restrictions on sex, gender, sexuality, or disability\n\nExclusion Criteria:\n\nHas experienced an allergic reaction to cannabidiol in any capacity\n\n* Has not attempted sexual intercourse in the last month\n* Has co occurring difficulties\n* Aged below 18 years old\n* Are not experiencing sexual pain\n* Patient Health Questionnaire 9 screening score range between moderate to severe - 10-27\n* General Anxiety Disorder 7 screening score range between 10- 21.","100 Years",{"count":410,"type":22},[56],"Research aim: To determine how cannabidiol suppositories might reduce sexual pain during intimacy. Outcomes are also hoped to increase sexual functioning, well-being, and quality of life.\n\nResearch intention: If cannabidiol suppository intervention reduces sexual pain and increases general well-being, then this research would be repeated on a larger scale, targeting psychosexual services.\n\nA brief overview of the intervention:\n\nQuantitatively, randomisation of cannabidiol suppositories will be into dose-specific groups. The intervention will be delivered over a period of one month, with follow-up scheduled at 12 weeks. Qualitatively, participants were asked approximately eight open-ended feedback questions throughout the study.",[28,390,443,444],"Sexual Behavior","Sexual Pain Disorder","2026-01-23",{"date":447,"type":34},"2026-01-26",{"date":449,"type":34},"2026-01-16",{"date":165,"type":22},{"name":452,"class":41},"London Metropolitan University",{"id":454,"slug":455,"hasResults":12,"nctId":456,"briefTitle":457,"officialTitle":458,"acronym":4,"eligibilityCriteria":459,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":460,"enrollmentInfo":461,"targetDuration":4,"studyType":23,"phases":463,"briefSummary":464,"conditions":465,"keywords":4,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":467,"lastUpdatePostDateStruct":468,"startDateStruct":470,"completionDateStruct":472,"leadSponsor":474,"locationsCount":42},"100510259","a-study-of-latin-dance-for-post--lung-transplant-100510259","NCT05924113","A Study of Latin Dance for Post- Lung Transplant","Efficacy of Latin Dance for Promoting Wellbeing in Post Lung Transplant Recipients as Measured by Several Functional Measures, in the Outpatient Setting","Inclusion Criteria:\n\n\\- Ambulatory with or without assisting devices (not on supplemental oxygen is not exclusionary), who have completed outpatient cardiopulmonary rehab and good pain control.\n\nExclusion Criteria:\n\n\\- Tracheostomy, Hemodialysis, gastro-jejunal tubes, nasogastric tubes, wound vacs, chest tube, high levels of oxygen supplementation (mask vs nasal canula), recent falls.","80 Years",{"count":462,"type":22},52,[56],"The purpose of this research study is to see if participating in Latin dance for 12 sessions can improve wellbeing in several areas including balance, fear of movement, anxiety, depression and spirometry.",[466,28],"Lung Transplant","2026-01-03",{"date":469,"type":34},"2026-01-06",{"date":471,"type":34},"2023-06-12",{"date":473,"type":22},"2030-12-31",{"name":475,"class":41},"Mayo Clinic",{"id":477,"slug":478,"hasResults":12,"nctId":479,"briefTitle":480,"officialTitle":481,"acronym":4,"eligibilityCriteria":482,"healthyVolunteers":16,"sex":381,"minAge":18,"maxAge":4,"enrollmentInfo":483,"targetDuration":4,"studyType":23,"phases":485,"briefSummary":486,"conditions":487,"keywords":489,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":493,"lastUpdatePostDateStruct":494,"startDateStruct":496,"completionDateStruct":498,"leadSponsor":500,"locationsCount":42},"100583320","rct-for-latina-mental-health-using-web-based-apps-100583320","NCT06874790","RCT for Latina Mental Health Using Web-Based Apps","Randomized Controlled Trial of a Choice-driven, Interactive, Storytelling Web-based App to Investigate Mental Health Treatment Initiation Among Symptomatic Latinas","Inclusion Criteria:\n\n* Latina (women who are from or have family ties to Latin America)\n* Currently resides in LA or Orange County\n* Age 18 and older\n* Able to speak, read, and write in English or Spanish\n* Score 10 or higher on GAD-7 and\u002For PHQ-8\n* Access to the internet via smartphone, tablet, or computer\n* Not currently receiving mental health therapy or pharmacotherapy\n* Has not accessed mental health services during the previous 6 months\n\nExclusion Criteria:\n\n* Not Latina or Hispanic\n* Under age 18",{"count":484,"type":22},700,[56],"This study compares a choice-driven, interactive, evidence-informed storytelling web-based app intervention with links to resources and treatment (Tx) recommendations (made by a character via her blog) and Tx locator, to a web-based app with links to publicly available informational internet videos, MH resources, and a treatment locator for at least moderately anxious\u002Fdepressed untreated English and Spanish speaking Latinas to determine if a story-based, character-driven approach is more effective for catalyzing mental health treatment initiation.",[488,213,267,28],"Mental Health",[490,491,492],"Latina","Women","Therapy","2025-12-18",{"date":495,"type":34},"2025-12-22",{"date":497,"type":34},"2025-07-09",{"date":499,"type":22},"2028-11-30",{"name":501,"class":41},"University of California, Los Angeles",{"id":503,"slug":504,"hasResults":12,"nctId":505,"briefTitle":506,"officialTitle":506,"acronym":4,"eligibilityCriteria":507,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":508,"targetDuration":4,"studyType":23,"phases":510,"briefSummary":511,"conditions":512,"keywords":513,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":517,"lastUpdatePostDateStruct":518,"startDateStruct":520,"completionDateStruct":522,"leadSponsor":524,"locationsCount":42},"100596888","the-advancing-dynamic-and-personalized-training-study-100596888","NCT07051330","The Advancing Dynamic And Personalized Training Study","Inclusion Criteria:\n\n* Elevated symptoms of depression (PHQ-9 greater than or equal to 5)\n* proficiency in English\n* access to a smartphone and internet\n* ability to receive text messages\n\nExclusion Criteria:\n\n* Prior experience with meditation\n* Prior use of the Healthy Minds Program app\n* History of psychosis or mania\n* Plans to travel in the next six weeks\n* Suicidal ideation or thoughts of self-harm indicated by PHQ-9 item 9 and BDI item 9\n* Failure to select the correct code word mentioned in the welcome video\n* Not a US citizen\n* Non-permanent resident\n* Self-identification as artificial intelligence (AI)\n* Has a hearing impairment",{"count":509,"type":22},1500,[56],"This study aims to enhance the Healthy Minds Program (HMP) app by developing and testing a personalized, data-driven approach to optimize long-term well-being. 1100 participants will be enrolled and on study for up to 4 months (4 week intervention plus 3 month follow-up).",[28],[514,515,516],"personalized well-being","HMP app","Healthy Minds Program","2025-12-01",{"date":519,"type":34},"2025-12-08",{"date":521,"type":34},"2025-07-20",{"date":523,"type":22},"2027-06",{"name":40,"class":41},{"id":526,"slug":527,"hasResults":12,"nctId":528,"briefTitle":529,"officialTitle":530,"acronym":4,"eligibilityCriteria":531,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":532,"enrollmentInfo":533,"targetDuration":4,"studyType":23,"phases":535,"briefSummary":536,"conditions":537,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":542,"lastUpdatePostDateStruct":543,"startDateStruct":545,"completionDateStruct":547,"leadSponsor":549,"locationsCount":4},"100609695","neurofeedback-and-well-being-among-people-with-co-occurring-obsessive-compulsive-disorder-and-post-traumatic-stress-symptoms-100609695","NCT07217925","Neurofeedback and Well-Being Among People With Co-Occurring Obsessive Compulsive Disorder and Post-traumatic Stress Symptoms","Exploring the Influence of Neurofeedback on the Well-Being of People With Symptoms of Obsessive Compulsive Disorder and Post-traumatic Stress Symptoms","Inclusion Criteria:\n\n1. being a client placed on the clinic waitlist to receive exposure-response prevention for OCD symptoms at the Anxiety and OCD Treatment Center of Ann Arbor, in Ann Arbor, MI.\n2. having self-reported symptoms of OCD;\n3. having post-traumatic stress symptoms as indicated by a score of 3 or higher on the Primary Care PTSD Screen for DSM-5 (PC-PTSD-5) screening measure;\n4. being age 18+.\n5. being a citizen of the United States of America -\n\nExclusion Criteria:\n\n1. a lifetime history of significant untreated mental illness (not currently treated schizophrenia, schizoaffective disorder, bipolar disorder, or substance use disorder) or neurological or pervasive developmental disorder;\n2. a documented history of epilepsy;\n3. lifetime history of any head injury with loss of consciousness;\n4. current exposure domestic or intimate partner violence or otherwise state that their current living conditions are unsafe;\n5. current experiences of psychosis or suicidality within the last six months;\n6. currently taking, or in the past month has taken benzodiazepines, narcotic drugs, or cannabis;\n7. currently pregnant\n8. engagement in self-harming behaviors in the last 3 months that required medical attention;\n9. lack of competence to understand or consent to the study procedures;\n10. lack of fluency in written and spoken English. -","90 Years",{"count":534,"type":22},20,[56],"The proposed study will collect novel data evaluating the feasibility of a neurofeedback training program delivered to prospective clients with a history of clinically concerning trauma-related mental health symptoms who are on a wait list to receive obsessive compulsive disorder-specific psychotherapy at an outpatient mental health clinic. This study will evaluate the influence of neurofeedback training on participant's overall sense of well-being, and additionally, whether any enhanced well-being is subsequently associated with positive changes in symptoms of obsessive compulsive disorder, post-traumatic stress, dissociation and other trauma-related mental health symptoms, emotional regulation, etc.",[28,538,539,540,541],"Mood Disturbance","Emotional Regulation","Dissociation","Post Traumatic Stress Symptoms","2025-11-10",{"date":544,"type":34},"2025-11-12",{"date":546,"type":22},"2025-11",{"date":548,"type":22},"2029-01",{"name":550,"class":41},"Wayne State University",{"id":552,"slug":553,"hasResults":12,"nctId":554,"briefTitle":555,"officialTitle":555,"acronym":4,"eligibilityCriteria":556,"healthyVolunteers":16,"sex":17,"minAge":557,"maxAge":4,"enrollmentInfo":558,"targetDuration":4,"studyType":23,"phases":560,"briefSummary":561,"conditions":562,"keywords":564,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":576,"lastUpdatePostDateStruct":577,"startDateStruct":579,"completionDateStruct":581,"leadSponsor":583,"locationsCount":42},"100604679","physiological-hormonal-and-dna-based-mechanisms-of-psychosocial-stress-and-therapeutic-effect-100604679","NCT07152652","Physiological, Hormonal, and DNA-based Mechanisms of Psychosocial Stress and Therapeutic Effect","Inclusion Criteria:\n\n* Adult (age 18 and above)\n* Student in the University of Helsinki, Finland\n* Able to speak\u002Fread Finnish, Swedish, or English\n\nExclusion Criteria:\n\n* None","18 Months",{"count":559,"type":22},148,[56],"The goal of this trial is to learn if the Groups 4 Health (G4H) intervention is effective in supporting student well-being at the University of Helsinki. It will also learn about the factors that may influence the efficacy of the intervention (such as facilitators characteristics, stress physiology and changes in gene expression). The main questions it aims to answer are:\n\n1. Is the G4H intervention effective and cost-effective in supporting student well-being?\n2. To what extent participants' physiological, hormonal, or molecular characteristics mediate the therapeutic effect of the G4H\n3. To what extent participants' genotype moderates the effect of the G4H\n4. To what extent facilitators' characteristics mediate or moderate the effect of the G4H\n\nData is collected from both the intervention participants and the facilitators.\n\nThe G4H facilitators will:\n\n* Facilitate the G4H intervention.\n* Fill in questionnaires and provide physiological and molecular measurements before, during, and after the G4H intervention.\n\nThe G4H participants will:\n\n* Participate in the G4H intervention.\n* Fill in questionnaires and provide physiological, hormonal and molecular measurements before, during, and after the G4H intervention.",[28,563],"Loneliness",[565,566,488,563,567,213,267,568,569,570,571,572,573,574,575],"University Students","Group Intervention","Social Isolation","Social Anxiety","Social Cohesion","Groups 4 Health","Stress system functioning","Genetics","Epigenetics","Experience Sampling Method","Stress physiology","2025-09-23",{"date":578,"type":34},"2025-09-29",{"date":580,"type":34},"2025-09-12",{"date":582,"type":22},"2028-12",{"name":584,"class":41},"University of Helsinki",{"id":586,"slug":587,"hasResults":12,"nctId":588,"briefTitle":589,"officialTitle":589,"acronym":590,"eligibilityCriteria":591,"healthyVolunteers":12,"sex":17,"minAge":592,"maxAge":593,"enrollmentInfo":594,"targetDuration":4,"studyType":596,"phases":4,"briefSummary":597,"conditions":598,"keywords":4,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":604,"lastUpdatePostDateStruct":605,"startDateStruct":607,"completionDateStruct":609,"leadSponsor":610,"locationsCount":42},"100540139","multidimensional-evaluation-of-patients-affected-by-obstructive-apnea-syndrome-osas-before-and-after-ventilotherapy-100540139","NCT06312956","Multidimensional Evaluation of Patients' Affected by Obstructive Apnea Syndrome (OSAS) Before and After Ventilotherapy","MULTI-OSAS","Inclusion Criteria:\n\n* OSAS diagnosis (AHI \\> 5)\n* handedness: right\n\nExclusion Criteria:\n\n* previous ventilotherapy\n* neurological and\u002For neurodegenerative conditions\n* Personality disorders, autism spectrum disorders, schizophrenia, psychosis\n* sleep disorders comorbidities (eg., narcolepsy)","20 Years","60 Years",{"count":595,"type":22},65,"OBSERVATIONAL","This observational study aims to evaluate multiple dimensions of health in patients with Obstructive Sleep Apnea Syndrome (OSAS), before and after three weeks of ventilotherapy.\n\nSpecifically, the study aims to identify pre- vs post-treatment differences in the following domains:\n\n* cognitive performance\n* blood expression of biomarkers related to neurodegeneration\n* psychosocial wellbeing\n\nThus, patients will complete the following evaluations before (T0) and after (T1) ventilotherapy:\n\n* neuropsychological standard assessment\n* blood sampling\n* psychosocial self-reported questionnaires",[599,600,28,601,602,603],"Obstructive Sleep Apnea","Sleep Disorder","Cognitive Impairment","Cognitive Change","Neurologic Signs","2025-09-02",{"date":606,"type":34},"2025-09-09",{"date":608,"type":34},"2024-02-29",{"date":143,"type":22},{"name":611,"class":41},"Istituto Auxologico Italiano",{"id":613,"slug":614,"hasResults":12,"nctId":615,"briefTitle":616,"officialTitle":617,"acronym":4,"eligibilityCriteria":618,"healthyVolunteers":16,"sex":381,"minAge":359,"maxAge":122,"enrollmentInfo":619,"targetDuration":4,"studyType":23,"phases":620,"briefSummary":621,"conditions":622,"keywords":626,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":636,"lastUpdatePostDateStruct":637,"startDateStruct":639,"completionDateStruct":641,"leadSponsor":643,"locationsCount":42},"100601564","non-diet-nutrition-education-and-its-effects-on-eating-behavior-body-image-and-well-being-in-adult-women-100601564","NCT07112131","Non-Diet Nutrition Education and Its Effects on Eating Behavior, Body Image, and Well-Being in Adult Women","The Effect of Non-Diet Nutrition Education on Eating Behavior, Body Image, and Well-Being in Adult Women: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Female,\n* Aged between 19-35 years,\n* Body Mass Index (BMI) between 18.5-24.9,\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding,\n* Diagnosed eating disorder or other psychiatric condition,\n* Currently enrolled in a weight loss program,\n* Following a restrictive diet due to medical conditions.",{"count":462,"type":22},[56],"The goal of this clinical trial is to evaluate whether a non-diet nutrition education program can improve eating behaviors, body image, and well-being in normal-BMI women aged 19-35 years. The main questions it aims to answer are:\n\n* Does participation in an 8-week non-diet nutrition education program improve eating behavior, body image, and well-being over time in the intervention group compared to the control group?\n* Is there a significant difference between the intervention and control groups in eating behavior, body image, and well-being after the intervention?\n\nResearchers will compare an intervention group receiving an 8-week non-diet nutrition education with a control group receiving no intervention, to see if the program leads to improvements in psychological and behavioral outcomes without focusing on weight loss.\n\nParticipants will:\n\n* Complete pre- and post-intervention assessments, including validated questionnaires on eating behavior (DEBQ, FCQ, IES-2), body image (BAS, Stunkard Figure Rating Scale), and psychological well-being (WHO-5, Rosenberg Self-Esteem Scale), as well as a 3-day food diary.\n* Be randomly assigned to either the intervention group (8-week online non-diet nutrition education sessions) or the control group (no intervention).\n* Engage in 8 weekly, 60-minute sessions focused on intuitive eating, body acceptance, and health-promoting nutrition.",[623,624,28,625],"Eating Behaviors","Body Image","Young Adult Females",[627,628,629,630,631,632,633,634,635],"Non-diet approach","Intuitive eating","Body acceptance","Body image","Eating behavior","Psychological well-being","Young adult women","Nutrition education","Randomized controlled trial","2025-08-01",{"date":638,"type":34},"2025-08-08",{"date":640,"type":34},"2025-07-21",{"date":642,"type":22},"2025-10",{"name":644,"class":41},"Tuğba TÜRKCAN",{"id":646,"slug":647,"hasResults":12,"nctId":648,"briefTitle":649,"officialTitle":650,"acronym":651,"eligibilityCriteria":652,"healthyVolunteers":16,"sex":17,"minAge":653,"maxAge":4,"enrollmentInfo":654,"targetDuration":4,"studyType":23,"phases":655,"briefSummary":656,"conditions":657,"keywords":660,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":669,"lastUpdatePostDateStruct":670,"startDateStruct":672,"completionDateStruct":674,"leadSponsor":676,"locationsCount":42},"100598503","promoting-mental-and-cognitive-health-in-old-age-through-scalable-evidence-based-interventions-100598503","NCT07072338","Promoting Mental and Cognitive Health in Old Age Through Scalable Evidence-based Interventions","PROMISE: Promoting Mental and Cognitive Health in Old Age Through Scalable Evidence-Based Interventions - Study Protocol for a Randomized Controlled Trial","PROMISE","Inclusion Criteria:\n\n* Aged 65 years or older.\n* Ability to speak and read the official language of their place of residence (French or German).\n* Ability to use and access a digital device for a digital training platform provided for the training.\n\nExclusion Criteria:\n\n* Aged below 65.\n* Inability to use and lack of access to a digital device required for using the digital training platform.","65 Years",{"count":288,"type":22},[56],"Mental and cognitive health are key determinants of healthy and successful aging. These two domains are closely intertwined: while chronic stress can impair cognitive functioning, cognitive decline may in turn heighten stress and reduce overall well-being in older adults. This project aims to evaluate the effectiveness and scalability of a multidomain intervention to support mental and cognitive health in older adults. A single-blind, randomized, controlled 2×2 factorial trial will be conducted with a large sample of community-dwelling adults aged 65 years and older in the German- and French-speaking regions of Switzerland. Participants will be randomly assigned to one of four intervention arms: (1) WHO Self-Help Plus stress management training (SH+), (2) multidomain cognitive training focused on lifestyle and behavior change (COG), (3) a combined SH+ and COG intervention (SH+\u002FCOG), or (4) an active control group (CG) involving podcast listening and discussion. All interventions will include in-person group sessions, while the SH+, COG, and SH+\u002FCOG arms additionally offer a digital platform for self-guided home training. Primary outcomes (mental and cognitive health), secondary outcomes and moderators (cognitive functioning, stigma, self-efficacy, self-concept, loneliness, digital literacy, cognitive reserve, sociodemographic variables) will be assessed at baseline, post-intervention (10 weeks), and at 2- and 6-month follow-ups through a self-administered ambulatory assessment.",[28,658,659],"Cognition","Ageing",[661,243,662,663,664,665,666,667,668],"well-being","cognitive health","healthy aging","cognitive function","stress-management training","Acceptance and commitment therapy","cognitive training","lifrstyle intervention","2025-07-15",{"date":671,"type":34},"2025-07-18",{"date":673,"type":22},"2026-01-01",{"date":675,"type":22},"2028-06-30",{"name":677,"class":41},"University of Geneva, Switzerland",{"id":679,"slug":680,"hasResults":12,"nctId":681,"briefTitle":682,"officialTitle":682,"acronym":4,"eligibilityCriteria":683,"healthyVolunteers":16,"sex":381,"minAge":18,"maxAge":408,"enrollmentInfo":684,"targetDuration":4,"studyType":596,"phases":4,"briefSummary":685,"conditions":686,"keywords":687,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":691,"lastUpdatePostDateStruct":692,"startDateStruct":693,"completionDateStruct":694,"leadSponsor":695,"locationsCount":42},"100516303","evaluation-of-patient-reported-outcomes-measurement-information-system-promis-29-v21-for-postpartum-women-100516303","NCT06002763","Evaluation of Patient-Reported Outcomes Measurement Information System (PROMIS)-29 v2.1 for Postpartum Women","Inclusion Criteria:\n\n* 18 years old and over\n* singleton births\n* 37 or more weeks gestational age\n* multiparous or nulliparous patients\n* spontaneous vaginal delivery or scheduled cesarean delivery with labor analgesia or neuraxial anesthesia\n* give informed written consent\n\nExclusion Criteria:\n\n* refusal to take part\n* are unable to give or have withdrawn consent\n* patients unable to communicate fluently in English\n* patients who are less than 18 years old\n* patients who had fetal demise or severely morbid fetal conditions such as intubation, cooling, expected surgical correction of congenital anomaly during hospitalization (although NICU admissions will be included)\n* patients who were admitted in ICU\n* patients who had failed neuraxial analgesia such as replaced epidurals or failed spinal requiring conversion to general anesthesia\n* patients who had general anesthesia for cesarean delivery as defined by \"GETA\", including sedatives and deep sedation if not intubated\n* patients who had intrapartum cesarean or had assisted\u002Foperative (i.e. vacuum, forceps) vaginal delivery.",{"count":54,"type":22},"There is no widely used, statistically validated assessment for physical and mental health for the short- to medium-term in a postpartum population. PROMIS-29 has been validated for the assessment of these factors in a generic population, but has not been specifically evaluated for use with postpartum women.\n\nThis study is a longitudinal, single center observational cohort study designed to evaluate the reliability of the Patient-Reported Outcomes Measurement Information System (PROMIS)-29 v2.1 survey in a postpartum population. PROMIS-29 is a survey designed to screen for pain, impairments in mood, physical function, and activities of daily living. While this survey has shown utility in other populations, it has yet to be assessed in an obstetric population. The investigators plan to recruit patients who are recently postpartum from vaginal or cesarean delivery to complete virtual surveys at defined time points (0, 2, 6, and 12 weeks after delivery). The investigators will subject survey data to statistical measures of validity and reliability comparing with contemporaneously collected surveys of established metrics for quality of life (WHOQoLBREF) and general (global) state of health (numerical rating score 1-100).\n\nThe hypothesis is that the PROMIS-29 v2.1 questionnaire is a statistically valid and reliable means of assessing physical and mental health in a postpartum population.",[28],[688,689,690],"cesarean delivery","vaginal delivery","postpartum recovery","2025-07-10",{"date":669,"type":34},{"date":497,"type":34},{"date":327,"type":22},{"name":696,"class":41},"Samuel Lunenfeld Research Institute, Mount Sinai Hospital"]