[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"wheeze\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:wheeze":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100247201","pediatric-arm-of-dzl-all-age-asthma-cohort-100247201",false,"NCT02496468","Pediatric Arm of DZL All Age Asthma Cohort","The All Age Asthma Cohort (ALLIANCE) of the German Center for Lung Research (DZL), Pediatric Arm","ALLIANCE","Inclusion Criteria:\n\n* informed consent by parents (and by children if age \\> 8 years)\n* age 6 months to 18 years\n* term delivery (≥ 37 weeks)\n* active\u002Fpassive understanding of German\n* age 6 months - \\\u003C 6 years: preschool wheeze (more than two episodes of wheeze during 12 months prior to inclusion)\n* age at least 6 years: doctor diagnosed asthma (according to current guidelines)\n\nExclusion Criteria:\n\n* known inborn or perinatal pulmonary disease\n* airway malformation\n* oxygen therapy after birth with a duration of more than 24 hours\n* ventilator support or mechanical ventilation after birth\n* diagnoses of cystic fibrosis; primary ciliary dyskinesia\n* heart failure diagnosed after birth affecting pulmonary circulation\n* major respiratory diseases such as e.g. interstitial lung disease\n* any current non-atopic comorbidity\n* fever of at least 38.5°C during the last two weeks prior to the planned first visit",true,"ALL","6 Months","18 Years",{"count":22,"type":23},1500,"ESTIMATED","OBSERVATIONAL","Despite its common occurrence, still little is known about pathomechanisms determining different wheeze and asthma trajectories and phenotypes in children, and those beginning in adulthood. Therefore, deciphering underlying determinants for different childhood and adult asthma phenotypes is urgently needed to develop personalized treatment approaches targeting distinct underlying mechanisms. Thereby, secondary prevention early in the disease process can also be achieved. The decoding of such mechanisms and their translation to the individual patient is the aim of the Disease Area Asthma Allergy of the 'German Centre for Lung Research' (DZL).",[27,28,29,30],"Asthma","Wheeze","Hypersensitivity","Endophenotype",[32,33,34,35,36,37,38],"childhood asthma","preschool wheeze","adult asthma","transition","phenotype","endotype","trajectory","RECRUITING","2024-08-27",{"date":42,"type":43},"2024-08-28","ACTUAL",{"date":45,"type":4},"2013-01",{"date":47,"type":23},"2027-12",{"name":49,"class":50},"LMU Klinikum","OTHER",5]