[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"whipple-procedure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:whipple-procedure":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100638458","map--versus-cardiac-index-guided-hemodynamic-management-in-whipple-surgery-100638458",false,"NCT07603336","MAP- Versus Cardiac Index-Guided Hemodynamic Management in Whipple Surgery","Comparison of the Effects of Mean Arterial Pressure-Based and Cardiac Index-Based Intraoperative Hemodynamic Management on Postoperative Renal Function in Patients Undergoing Pancreaticoduodenectomy: A Prospective Randomized Study","Inclusion Criteria:\n\n* Patients aged 18 to 80 years\n* Patients with American Society of Anesthesiologists physical status II-III\n* Patients with estimated glomerular filtration rate ≥60 mL\u002Fmin\u002F1.73 m²\n* Patients scheduled for pancreaticoduodenectomy \u002F Whipple procedure\n* Patients who provide written informed consent\n\nExclusion Criteria:\n\n* Patients younger than 18 years or older than 80 years\n* Patients with estimated glomerular filtration rate \\\u003C60 mL\u002Fmin\u002F1.73 m²\n* Patients with American Society of Anesthesiologists physical status other than II-III\n* Patients who refuse to participate in the study\n* Patients who withdraw consent at any stage of the study","ALL","18 Years","80 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","This prospective randomized study aims to compare the effects of two intraoperative hemodynamic management strategies on early postoperative renal function in patients undergoing pancreaticoduodenectomy. Patients will be allocated to either mean arterial pressure-guided hemodynamic management or cardiac index-guided hemodynamic management during surgery.\n\nPancreaticoduodenectomy is a major abdominal surgical procedure associated with prolonged operative duration, considerable fluid shifts, blood loss, and hemodynamic instability. These factors may contribute to impaired renal perfusion and postoperative renal dysfunction. Although mean arterial pressure is commonly used to guide intraoperative hemodynamic management, blood pressure alone may not fully reflect systemic blood flow or tissue perfusion. Cardiac index-guided management may provide a more direct assessment of global circulatory adequacy.\n\nThe primary outcome of the study is the change in serum creatinine level from the preoperative baseline value to the postoperative 72nd hour. Secondary outcomes include intraoperative hemodynamic variables, fluid and vasopressor requirements, urine output, postoperative renal function parameters, length of intensive care unit and hospital stay, and 30-day mortality.",[27,28],"Whipple Procedure","Intraoperative Hemodynamic Management",[30,31,32,33],"Whipple procedure","Cardiac index","Mean arterial pressure","Hemodynamic management","RECRUITING","2026-05-27",{"date":37,"type":38},"2026-05-28","ACTUAL",{"date":35,"type":38},{"date":41,"type":21},"2027-12-28",{"name":43,"class":44},"Ankara Etlik City Hospital","OTHER_GOV",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":74},"100617428","antiseptic-coated-sutures-and-pancreatic-fistula-risk-after-pancreatoduodenectomy-100617428","NCT07318493","Antiseptic-Coated Sutures and Pancreatic Fistula Risk After Pancreatoduodenectomy","Does Antiseptic Coated Suture Reduce Pancreatic Fistula Rate After Pancreatoduodenectomy: A Randomized Controlled Trial","Triclosan","Inclusion Criteria:\n\n* Subjects must be undergoing a scheduled pancreatoduodenectomy.\n* Age ≥18 years.\n* Subjects must have the ability to understand and the willingness to sign a written informed consent document\n\nExclusion Criteria:\n\n* Patients \\\u003C 18 years old\n* Patients who are pregnant\n* Patients with history of previous pancreatic surgery\n* Patients who are unable to provide informed consent",{"count":55,"type":21},436,[24],"The purpose of this study is to determine if the use of antiseptic-coated sutures is better than the use of the standard sutures in preventing postoperative fistulas within 90 days after pancreatoduodenectomy.",[59,27],"Pancreatoduodenectomy",[61,62,63],"pancreatoduodenectomy","whipple procedure","sutures","2026-01-19",{"date":66,"type":38},"2026-01-21",{"date":68,"type":38},"2026-01-13",{"date":70,"type":21},"2031-02",{"name":72,"class":73},"The Cleveland Clinic","OTHER",3]