[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"white-matter-lesions\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:white-matter-lesions":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100498919","diagnostic-value-of-evog-100498919",false,"NCT05776511","Diagnostic Value of eVOG","Diagnostic Value of Digital Video Oculography in Patients With White Matter Lesions","DIVEyes","Patients Inclusion Criteria:\n\n* Patients referred to our tertiary center for a diagnostic workup of white matter hypersignals\n* Absence of oculomotor disorders on conventional clinical examination\n* Age \\> 18 years\n\ncontrols Inclusion criteria:\n\n* The controls can be recruited from the accompanying persons of the patients selected for the study, from the staff of the CHU of Nice or from the entourage of the investigating team;\n* Absence of known oculomotor disorders by the control\n* Age \\> 18 years\n\nExclusion Criteria:\n\n* Presence of a neurological, ophthalmological or general pathology that may interfere with the performance of digital video oculography",true,"ALL","18 Years",{"count":21,"type":22},150,"ESTIMATED","INTERVENTIONAL",[25],"NA","Eye movement is a complex neurological function controlled by many structures located in the central nervous system. The eyeball is mobile within the orbit and its movements are carried out using 6 muscles innervated by 3 oculomotor nerves allowing to perform reflex or voluntary eye movements in all elementary directions.\n\nSo-called internuclear structures allow the two eyeballs to perform combined movements. The attack of these structures during an acute or chronic neurological disease will most often cause oculomotor paralysis in one or more directions of gaze which will be perceived by the patient as double vision.\n\nSo-called supranuclear structures make it possible to generate different types of eye movements: saccades, which are extremely rapid eye movements of very short duration, eye pursuit, which is a slow movement whose purpose is to follow a moving visual target and finally, certain neural circuits are intended to stabilize the gaze.\n\nMany neurological diseases can be accompanied by oculomotor abnormalities affecting saccades or ocular pursuit. These include neurodegenerative diseases characterized by diffuse neurological damage.\n\nInvolvement of gaze stabilization structures is also frequently found in certain neurological diseases affecting the posterior fossa.\n\nThe clinical examination of oculomotricity focuses mainly on the analysis of ocular mobility in the different directions of space by asking the subject to fix an object (for example a pen) or the index of the examiner in moving in different directions in space. During a classic clinical examination, it is then possible to detect anomalies such as oculomotor paralysis or nystagmus, it is however very difficult to assess the speed or the precision of the saccades, as well as the quality of the pursuit ocular.\n\nAs a result, the development of techniques to accurately record eye movements has emerged as a need in order to help in the diagnosis of certain visual disorders and certain neurodegenerative diseases.\n\nVideo oculography (VOG) is a technique for precisely recording and analyzing the movements of the eyeballs.\n\nThe use of VOG in neurology has long been dominated by helping to diagnose certain neurodegenerative diseases and in particular certain atypical Parkinson's syndromes. The value of VOG has also been demonstrated in certain pathologies characterized by atrophy of the brainstem or cerebellum, of hereditary or acquired origin. Some studies have also assessed its contribution to the diagnosis and management of certain dementias and certain psychiatric diseases such as schizophrenia. More recently, the interest of VOG has also emerged in the management of patients with a demyelinating disease of the multiple sclerosis spectrum.\n\nThe VOG has a number of limitations to its large-scale use, first of all, it is an examination requiring specific, relatively expensive equipment. On the other hand, the examination requires know-how, both for the passing of the tests but also for the processing and analysis of the data.\n\nThe eVOG (mobile VideoOculoGraphy) application has been developed to record oculomotor movements during different paradigms: horizontal saccades, vertical saccades, antisaccades, horizontal pursuit, vertical pursuit thanks to a tablet fixed on a support allowing keep in a stable and fixed position.\n\nThe eVOG app was compared to a conventional VOG platform in a first study. The objective was to compare the measurements obtained by the eVOG application to the measurements collected by the standard method in a sample of patients with multiple sclerosis. This study showed that the detection of different anomalies by eVOG is correlated with classic VOG.\n\nIn view of these encouraging preliminary results, a prospective study could be set up with the objective of evaluating the value of digital VOG in the diagnostic process in patients referred to a tertiary center for white matter signal abnormalities on MRI.\n\nthe hypothesis is that subclinical oculomotor disorders will be found more frequently in the group of patients with MS spectrum disease due to the presence in this pathology of diffuse inflammatory and degenerative damage to brain tissue, unlike the others inflammatory or non-inflammatory pathologies.",[28,29,30],"Multiple Sclerosis","Radiologically Isolated Syndrome","White Matter Lesions","RECRUITING","2026-06-15",{"date":34,"type":35},"2026-06-16","ACTUAL",{"date":37,"type":35},"2023-04-07",{"date":39,"type":22},"2027-04-01",{"name":41,"class":42},"Centre Hospitalier Universitaire de Nice","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":17,"sex":18,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":43},"100596221","mechanism-of-gamma-oscillation-synchronization-in-the-prefrontal-hippocampal-circuit-for-memory-dysfunction-in-patients-with-white-matter-lesions-of-cerebral-small-vessel-disease-100596221","NCT07042633","Mechanism of Gamma Oscillation Synchronization in the Prefrontal-hippocampal Circuit for Memory Dysfunction in Patients With White Matter Lesions of Cerebral Small Vessel Disease","Inclusion Criteria:\n\n* \\- Individuals with cerebral small vessel disease, normal cognition or mild cognitive impairment subjects;\n* Participants with complete demographic data, neuropsychiatric scale assessments, imaging data, and EEG data.\n\nExclusion Criteria:\n\n* Severe aphasia, physical disability, or other conditions preventing completion of neuropsychological assessments;\n* History of cerebrovascular stroke with documented neurological deficits during onset and corresponding lesions on neuroimaging;\n* Neurological disorders that may cause cognitive impairment, including alcohol abuse, drug addiction, traumatic brain injury, epilepsy, encephalitis, or normal-pressure hydrocephalus;\n* Systemic diseases potentially contributing to mild cognitive impairment (e.g., hepatic\u002Frenal insufficiency, endocrine disorders, vitamin deficiencies);\n* Current diagnosis of major depressive disorder or psychiatric disorders.","55 Years","75 Years",{"count":21,"type":22},"OBSERVATIONAL","The mechanism underlying memory impairment caused by white matter lesions of cerebral small vessel disease is still unclear. The disrupted synchronization of gamma oscillations in the prefrontal-hippocampal circuit is a potential key mechanism. Our study has demonstrated that white matter lesions lead to demyelination of the connection tracts between the prefrontal lobe and hippocampus, which is closely related to memory dysfunction. However, further studies are required to explore if these microstructural changes in white matter tracts influence memory function by affecting gamma oscillations. Thus, this project will use the previously established episodic memory task and event-related potential to determine the changes in gamma oscillations in the prefrontal-hippocampal circuit and the effects on memory encoding and retrieval. Combining multimodal imaging, we will explore the mediating role of white matter microstructure damage, and establish a machine learning prediction model for memory impairment. In addition, transcranial alternation current stimulation (tACS) will be used to investigate the mechanisms of memory improvement by regulating the prefrontal-hippocampal gamma oscillations. This project will clarify the neural oscillation mechanism underlying memory impairment caused by white matter lesions of cerebral small vessel disease, with the expectation of providing new predictive indicators and interventions.",[56,30,57],"Vascular Cognitive Impairment","Gamma Oscillation","2025-06-26",{"date":60,"type":35},"2025-06-29",{"date":62,"type":35},"2024-03-07",{"date":64,"type":22},"2027-12-31",{"name":66,"class":42},"Xuanwu Hospital, Beijing"]