[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"white-spot-lesion-of-tooth\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:white-spot-lesion-of-tooth":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,47,83,107,130,157,187],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100643564","artificial-intelligence-versus-clinical-examination-in-white-spot-lesions-detection-identification-and-scoring-100643564",false,"NCT07639749","Artificial Intelligence Versus Clinical Examination in White Spot Lesions Detection, Identification, And Scoring","Diagnostic Accuracy of Artificial Intelligence Analysis Using Intraoral Photographs Versus Clinical Examination in White Spot Lesions Detection, Identification, And Scoring.","Inclusion Criteria:\n\n1. Adult patients aged 20 - 60 years\n2. Males or Females\n3. Patients with white spot lesions of teeth 4 - Co-operative patients with interest in participation in the study\n\nExclusion Criteria:\n\n1. Patients with orthodontic appliances or bridgework that might interfere with evaluation and assessment\n2. Patients with no white spot lesions\n3. Patients with systematic diseases that might affect participation\n4. Patients refusing to sign the informed consent or not willing to be part of the study","ALL","20 Years","60 Years",{"count":20,"type":21},329,"ESTIMATED","1 Year","OBSERVATIONAL","The goal of this observational study is to compare the diagnostic accuracy of Clinical examination as a standard for detection, identification and scoring of White Spot Lesions Versus Artificial intelligence analysis of intraoral photographs. The photographs are examined by experienced dental professionals to maintain diagnostic accuracy. Machine learning models YOLO and Mask-RCNN will analyze these images in three phases: pre-analytical, analytical and post-analytical. A dataset of 329 labelled photographs, annotated by experts, is used to train these models. Data augmentation methods enhance model performance, and accuracy is assessed against clinical examination results to confirm reliability.\n\nThe main question it aims to answer is:\n\n\\- Is artificial intelligence analysis of intraoral photographs as accurate as clinical assessment in the detection, identification, and scoring of white spot lesions among adult Egyptian patients attending Cairo University Dental Hospital?",[26],"White Spot Lesion of Tooth",[28,29,30,31,32,33,34],"white spot lesions","dental","caries","intraoral","photography","diagnostic accuracy","artificial intelligence","NOT_YET_RECRUITING","2026-06-08",{"date":38,"type":39},"2026-06-10","ACTUAL",{"date":41,"type":21},"2026-07-01",{"date":43,"type":21},"2027-11-01",{"name":45,"class":46},"Cairo University","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":16,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":78,"leadSponsor":80,"locationsCount":82},"100599971","a-split-mouth-clinical-trial-evaluating-the-bond-failure-rate-of-a-new-etch-free-orthodontic-adhesive-100599971","NCT07091422","A Split-Mouth Clinical Trial Evaluating the Bond Failure Rate of a New Etch-Free Orthodontic Adhesive","Inclusion Criteria:\n\nPatients aged 14 to 35 years\n\nRequiring comprehensive fixed orthodontic treatment with brackets on both arches\n\nGood general health with no contraindications to orthodontic treatment\n\nPresence of at least 10 permanent teeth per arch suitable for bracket bonding\n\nAbility and willingness to comply with study visits and follow-up for at least 12 months\n\nParent\u002Fguardian consent and child assent obtained as appropriate\n\nExclusion Criteria:\n\nPresence of systemic diseases or conditions that affect oral health or healing (e.g., uncontrolled diabetes, immunosuppression)\n\nTeeth with significant enamel defects, restorations, or caries in bonding areas\n\nPatients currently undergoing or who have undergone orthodontic treatment previously\n\nHistory of allergy or sensitivity to dental adhesives or related materials\n\nPatients with poor oral hygiene or active periodontal disease\n\nUse of medications known to affect tooth enamel or oral tissues (e.g., long-term corticosteroids)\n\nInability to attend follow-up visits or anticipated lack of compliance\n\nParticipation in another clinical trial that could interfere with study outcomes",true,"14 Years","35 Years",{"count":57,"type":21},20,"INTERVENTIONAL",[60],"NA","This randomized, split-mouth clinical trial will evaluate a new orthodontic adhesive that eliminates the need for acid etching before bracket bonding. Conventional orthodontic bonding requires etching enamel with phosphoric acid, which can weaken the outer enamel layer and increase the risk of white spot lesions and enamel damage. The etch-free adhesive under investigation is designed to simplify the bonding procedure while preserving enamel integrity.\n\nTwenty orthodontic patients starting treatment with braces will participate. For each patient, one side of the mouth (left or right) will be randomly assigned to receive the etch-free adhesive, while the opposite side will receive the conventional adhesive with acid etching. This intra-patient design allows a direct comparison under identical oral conditions.\n\nParticipants will be followed for 12 months. Bracket failures, bonding time, ease of adhesive removal, enamel surface condition after debonding, and the presence of white spot lesions will be recorded. If effective, the etch-free adhesive may reduce enamel damage without compromising bond strength, providing a safer and more efficient bonding option for orthodontic patients.",[63,64,65,26],"Bracket Bonding","Orthodontic Treatment","Dental Adhesives\u002FRestorations Performance",[67,68,69,70,71,72],"Etch-Free Adhesive","Orthodontic Bonding","Bracket Failure","Split-Mouth Trial","White Spot Lesions","Orthodontics Clinical Trial","RECRUITING","2025-11-05",{"date":76,"type":39},"2025-11-10",{"date":74,"type":39},{"date":79,"type":21},"2026-12-01",{"name":81,"class":46},"University of Maryland, Baltimore",1,{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":53,"sex":16,"minAge":90,"maxAge":55,"enrollmentInfo":91,"targetDuration":4,"studyType":58,"phases":93,"briefSummary":94,"conditions":95,"keywords":96,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":4},"100602657","color-stability-of-s-prg-resin-based-light-cure-varnish-and-prophylaxis-paste-on-white-spot-lesions-100602657","NCT07126366","Color Stability of S-PRG Resin-Based Light-Cure Varnish and Prophylaxis Paste on White Spot Lesions","COLOR STABILITY OF S-PRG RESIN-BASED LIGHT CURE VARNISH AND PROPHYLAXIS PASTE ON WHITE SPOT LESIONS: A 12-MONTH RANDOMIZED CLINICAL TRIAL","Inclusion Criteria:\n\n* Patient consulting in the outpatient clinic.\n* Enamel caries in anterior permanent teeth according to ICDAS-1 and ICDAS-2.\n* Good oral hygiene.\n* Provide informed consent.\n* Cooperative and willing to participate in the trial.\n* Male or female.\n* Adult patients aged 16 to 35 years.\n\nExclusion Criteria:\n\n* Spontaneous or elicited pain from caries.\n* Tooth mobility.\n* Signs of pulpal infection.\n* Severe medical conditions that would not allow management in the clinic.\n* Hereditary developmental defects such as amelogenesis imperfecta or dentinogenesis imperfecta.\n* Known allergies or sensitivities to dental materials, including fluoride\n* Inability to return for recall visits.\n* Poor oral hygiene.\n* Refusal to participate in the study.","16 Years",{"count":92,"type":21},58,[60],"The aim of the study is to evaluate and compare the long-term color stability of two bioactive materials used in the management of white spot lesions: Surface Pre-Reacted Glass (S-PRG) containing resin-based light-cured varnish and S-PRG containing prophylaxis paste. The study will assess color changes over a 12-month period to determine which material better maintains aesthetic integrity while providing therapeutic benefits for demineralized enamel surfaces.",[26],[97,98],"S-PRG","White spot lesion","2025-08-10",{"date":101,"type":39},"2025-08-17",{"date":103,"type":21},"2025-09-21",{"date":105,"type":21},"2026-10-21",{"name":45,"class":46},{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":114,"enrollmentInfo":115,"targetDuration":4,"studyType":58,"phases":117,"briefSummary":118,"conditions":119,"keywords":4,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":82},"100601508","clinical-evaluation-of-remineralizing-potential-of-remineralizing-agents-on-wsls-managment-100601508","NCT07111403","Clinical Evaluation of Remineralizing Potential of Remineralizing Agents on WSLs Managment","Remineralization Potential of Different Remineralizing Agents on Initial Enamel Caries: Laboratory Evaluations and Two-year Randomized Clinical Trial","Inclusion Criteria:\n\n* Participants should have at least one visible initial enamel caries in the permanent teeth\n* Only lesions with ICDAS II score of 1 or 2 could be included\n* The patients must have good oral hygiene\n\nExclusion Criteria:\n\n* patients receiving tetracyclines, any other medication known to stain teeth - Patients had fluoride application less than 3 months before the study\n* Teeth which have microcavities or dentinal involvement due to loss of enamel - Teeth that have discoloration, enamel hypoplasia or fluorosis.","26 Years",{"count":116,"type":21},120,[60],"To evaluate and compare the clinical effect of four different remineralizing agents on initial enamel caries after a two years follow up.",[120,26],"Initial Dental Caries","2025-08-07",{"date":123,"type":39},"2025-08-13",{"date":125,"type":39},"2024-09-10",{"date":127,"type":21},"2026-09-17",{"name":129,"class":46},"Mansoura University",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":16,"minAge":138,"maxAge":54,"enrollmentInfo":139,"targetDuration":4,"studyType":58,"phases":141,"briefSummary":142,"conditions":143,"keywords":145,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":82},"100591909","remineralization-potential-of-prg-barrier-coat-versus-fluoride-varnish-in-white-spot-lesions-in-permanent-anterior-teeth-of-children-100591909","NCT06986551","Remineralization Potential of PRG Barrier Coat Versus Fluoride Varnish in White Spot Lesions in Permanent Anterior Teeth of Children","Remineralization Potential of PRG Barrier Coat Versus Fluoride Varnish in White Spot Lesions in Permanent Anterior Teeth of Children (A Randomized Controlled Trial)","PRG Barrier","Inclusion Criteria:\n\n* Children aged 8-14 years with good health according to the American Society of Anesthesiologists (ASA-I).\n* Have at least one white spot lesion with International Caries Detection and Assessment System (ICDAS II) score one or two\n* Has not used any remineralizing agent in the former three months.\n* Parents who accept to sign informed consent.\n* Cooperative patients\n\nExclusion Criteria:\n\n* Patients have caries or restorations in the labial surface.\n* Extrinsic or intrinsic stains.\n* patients under active orthodontic treatment.\n* Uncooperative patient.\n* Parents refuse to sign informed consent.\n* Medically unfit (other than ASAI).","8 Years",{"count":140,"type":21},78,[60],"To evaluate the remineralization potential of PRG Barrier Coat versus fluoride varnish in white spot lesions in permanent anterior teeth of children.",[26,144],"Demineralization",[146,147,148],"PRG Barrier Coat","white spot lesion","Fluoride Varnish","2025-05-22",{"date":151,"type":39},"2025-05-28",{"date":153,"type":21},"2025-09",{"date":155,"type":21},"2026-11",{"name":45,"class":46},{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":4,"eligibilityCriteria":163,"healthyVolunteers":53,"sex":16,"minAge":164,"maxAge":4,"enrollmentInfo":165,"targetDuration":4,"studyType":58,"phases":167,"briefSummary":169,"conditions":170,"keywords":174,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":82},"100577406","phase-2-preventive-effects-of-silver-diamine-fluoride-on-early-enamel-caries-100577406","NCT06797882","Preventive Effects of Silver Diamine Fluoride on Early Enamel Caries","The Effectiveness of Silver Diamine Fluoride (SDF) in the Prevention of Early Enamel Caries Among Patients With Fixed Orthodontic Appliances: A Randomised Controlled Trial","Inclusion Criteria:\n\n* Subjects about to undergo fixed orthodontic treatment at the Faculty of Dentistry, UKM.\n* Subjects must be aged 18 years and above.\n* Consented for treatment. Patients will be informed of the risk and benefit of the study for each treatment group through the patient information sheet given to them before obtaining their consent.\n* Orthodontic brackets placed at least on the upper incisors.\n* Patients undergoing orthodontic treatment with conventional orthodontic brackets placed on the labial surface.\n* Any degree of malocclusion\n* Fit and healthy patient\n* Non-smoker\n* Subjects can understand and possessed basic command in English\n\nExclusion Criteria:\n\n* History of fixed orthodontic treatment\n* Presence of any dental anomalies or developmental defects of enamel (DDE) on labial surfaces of teeth, such as preexisting fluorosis or enamel hypoplasia.\n* Presence of any or direct\u002Findirect restorations on the labial surface of teeth\n* History of long-term antibiotic usage\n* Presence of untreated cavitated lesions, especially on upper and lower incisors and canines\n* Plaque levels \\>30%.\n* Patient allergic to any of the content of the intervention material (sodium fluoride, silver diamine fluoride, potassium iodide).\n* Patients with lingual brackets.","18 Years",{"count":166,"type":21},99,[168],"PHASE2","Fixed orthodontic patients are at risk of developing dental caries. Topical application of fluoride varnish (FV) around the orthodontic brackets and using fluoridated mouth rinses have been suggested to prevent the formation of white spot lesions (WSLs) on enamel. Recent studies have shown that silver diamine fluoride (SDF) demonstrated better outcomes in dental caries prevention as compared to FV. However, the caries preventive effects of SDF application around the orthodontic brackets have not been established yet.\n\nThis study will be conducted to evaluate the effectiveness of SDF in preventing WSLs formation in patients undergoing fixed orthodontic treatment. This study will use a randomised-controlled double-blinded design with three parallel arms. Ninety-nine eligible participants will be recruited. Using their registration number, a random list of patients will be generated using computer software. Each patient will be assigned randomly to three groups: SDF, FV, or placebo. Digital photographs of upper anterior teeth (frontal view) will be taken as a baseline and repeated at every review appointment. The materials will be applied around the orthodontic bracket of upper incisors and canines every 6 months. The formation of WSLs around the bracket will be evaluated at 1, 3, 6, and 12 months using three parameters: the ICDAS scoring system, the laser fluorescence caries detector, and digital photographic analysis using the Gorelick score. The patients' perception of the colour changes of the enamel will be evaluated through patient-reported outcomes. The difference in ICDAS and Gorelick scores and the patients' perceptions will be reported through descriptive statistics. The Kruskal-Wallis or one-way ANOVA statistical test will be used to compare the changes in fluorescence intensity between treatment groups.\n\nThe investigators believe that the results of this study will provide insight into the caries preventive protocol among fixed orthodontics patients and subsequently reduce the incidence of WSLs during orthodontic treatment.",[171,26,172,173],"Demineralization, Tooth","Fixed Appliances","Early Caries Lesions",[173,175,176,177,148,71],"Silver Diamine Fluoride (SDF)","Fixed Orthodontic Appliances","Caries Prevention","2025-01-28",{"date":180,"type":39},"2025-01-30",{"date":182,"type":21},"2025-01-31",{"date":184,"type":21},"2026-12-31",{"name":186,"class":46},"National University of Malaysia",{"id":188,"slug":189,"hasResults":11,"nctId":190,"briefTitle":191,"officialTitle":192,"acronym":4,"eligibilityCriteria":193,"healthyVolunteers":53,"sex":16,"minAge":194,"maxAge":138,"enrollmentInfo":195,"targetDuration":4,"studyType":58,"phases":197,"briefSummary":199,"conditions":200,"keywords":201,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":82},"100553669","early-phase-1-remineralizing-effect-of-different-silver-containing-agents-on-initial-caries-lesions-in-primary-teeth-in-children-100553669","NCT06489093","Remineralizing Effect of Different Silver-containing Agents on Initial Caries Lesions in Primary Teeth in Children","Evaluation of the Effect of Green Synthesized Nano-silver Fluoride and Silver Diamine Fluoride on Carious Lesions in Children","Inclusion Criteria:\n\n* Age: 3 - 8 years\n* Signed informed consent from parents to participate in the study. Verbal consent from the child for the upcoming manipulations.\n* Enrolled patients do not have any common diseases or conditions associated with decreased salivation and are not taking medications that suppress salivary flow. Study participants have no cognitive or behavioral impairment. The absence of disease will be confirmed by a history-taking interview with the parent.\n* Presence of incipient carious lesions (white spots) reaching the enamel interior, assessed with ICDAS system values 01 (first visible enamel change) and 02 (localized visible enamel change) and laser fluorescence values up to 20. The diagnostic threshold of the included lesions is defined as D1 A (active enamel lesion visible after drying) or D2 A (active enamel lesion visible without drying). Criteria for active lesions: under plaque, loss of gloss, loss of smoothness, diffuse borders of the lesion, opaque appearance, white colour, at pre-selection sites (in the cervical third of the enamel). The lesions are located on tooth surfaces with no preceding obturations.\n* Study participants had not performed remineralization or topical fluoride therapy on the included lesions within six months prior to study inclusion.\n* Children with no history of allergy to the medications administered.\n\nExclusion Criteria:\n\n* Children who are considered medically compromised or medically complex patients. The presence of a medical condition is confirmed by a history interview with the child's parent or guardian and involves common diseases or conditions associated with decreased salivation and intake of medications that suppress salivary flow, cognitive and behavioral disorders.\n* Patients who underwent remineralizing or topical fluoride therapy to the included lesions in the last six months prior to study inclusion.\n* Patients with a history of allergy to the administered medication.","3 Years",{"count":196,"type":21},30,[198],"EARLY_PHASE1","The aim of the present work is to study the effect of the application of Silver diamine fluoride (SDF) and a novel green synthesized Nano-silver fluoride (NSF) on early enamel lesions in primary teeth. Proving their positive effect would be the basis for the development of innovative dental materials and hygienic agents to combat the carious process, which is a critical prerequisite for improving the quality of dental services and reducing dental anxiety and fear.",[26],[202,203,28],"sdf","nano silver fluoride","2024-07-03",{"date":206,"type":39},"2024-07-05",{"date":208,"type":21},"2024-07-29",{"date":210,"type":21},"2025-06",{"name":212,"class":46},"Plovdiv Medical University"]