[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"white-spot-lesion\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:white-spot-lesion":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,40,66,108,132,154,182],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":4},"100639436","remineralization-potential-of-bioactive-varnish-100639436",false,"NCT07602660","Remineralization Potential of Bioactive Varnish","Remineralization Potential of Bioactive Varnish Versus Sodium Fluoride Varnish in Management of White Spot Lesions: Randomized Controlled Trial","Inclusion Criteria:\n\n1. Patients within 16-35 years of age.\n2. Each patient has 4 or more WSLs\n3. Mild and moderate WSLs.\n4. Good oral hygiene and willing patients who can attend study visits.\n5. Symmetrical number of permanent teeth in each arch (mesial to second molars).\n\nExclusion Criteria:\n\n1. Active carious lesions.\n2. Labial surface restorations.\n3. Intrinsic and extrinsic stains.\n4. Patients who have a significant medical history or if they are smokers.\n5. Patients who participated in clinical study during the preceding six months of the start of this trial.\n6. Criteria for discontinuation; Mortality and acquiring severe debilitating disease.","ALL","16 Years","35 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized controlled trial is held to investigate the effectiveness of two remineralizing agents surface pre-reacted glass-ionomer (S-PRG) filler and fluoride in management of white spot lesions.",[27],"White Spot Lesion","NOT_YET_RECRUITING","2026-05-16",{"date":31,"type":32},"2026-05-22","ACTUAL",{"date":34,"type":21},"2026-06",{"date":36,"type":21},"2026-12",{"name":38,"class":39},"Future University in Egypt","OTHER",{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":48,"sex":16,"minAge":49,"maxAge":17,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":65},"100515303","air-polishing-with-erythritol-during-orthodontic-tretament-100515303","NCT05989750","Air-polishing With Erythritol During Orthodontic Tretament","Air-polishing With Erythritol on Prevalence of White Spot Lesions and Gingivitis During Orthodontic Treatment With Fixed Appliances: a Randomized Clinical Trial of 2-years Duration","AirPort","Inclusion Criteria:\n\n* Subjects about to undergo fixed orthodontic treatment will be invited to participate.\n* Age between 12 and 16 years only participants\n* Informed written consent obtained by the parents\n\nExclusion Criteria:\n\n* Clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, etc.),\n* Known or suspected non-compliance, drug or alcohol abuse\n* Inability to follow the procedures of the investigation, e.g. due to language problems, psychological disorders, dementia, etc. of the subject\n* Participation in another investigation with an investigational drug or another MD within the 30 days preceding and during the present investigation\n* Previous enrolment into the current investigation\n* Enrolment of the PI, his\u002Fher family members, employees and other dependent persons\n* History of fixed orthodontic treatment\n* Defects on enamel on labial surfaces of the teeth\n* Untreated cavitated lesions\n* Plaque levels \\>25%\n* Periodontitis\n* Multiple missing teeth\n* Cleft lip and\u002For palate or other craniofacial anomalies or syndromes\n* Patients taking any regular medication\n* Patients with asthmatic problems",true,"12 Years",{"count":20,"type":21},[24],"Patients with multi-bracketed fixed orthodontic treatment are at increased risk of developing white spot lesions (WSL) and gingivitis. Various preventive strategies have been examined to prevent the development of WSLs. During initial non-surgical periodontal therapy, the use of subgingival air-polishing with erythritol powder has shown promising results in reducing deep pockets and gingival inflammation. The efficacy of its use as monotherapy in preventing WSLs and gingival inflammation in patients during orthodontic treatment, has not yet been tested.\n\nThe primary objective of the present study is to compare the effectiveness of an air-polishing device used as monotherapy versus ultrasonic instrumentation (the current gold standard procedure) in preventing white spot lesions (WSL) and gingivitis among young patients undergoing multi-bracketed fixed orthodontic treatment.",[54,27],"Inflammation Gum","RECRUITING","2026-04-28",{"date":58,"type":32},"2026-05-05",{"date":60,"type":32},"2023-09-11",{"date":62,"type":21},"2028-09-01",{"name":64,"class":39},"Catherine Giannopoulou",1,{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":11,"sex":16,"minAge":74,"maxAge":17,"enrollmentInfo":75,"targetDuration":4,"studyType":22,"phases":77,"briefSummary":78,"conditions":79,"keywords":84,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":65},"100620261","comparison-of-a-3-step-bonding-system-transbond-xt-and-a-2-step-system-gc-ortho-connect-on-demineralization-around-maxillary-orthodontic-brackets-100620261","NCT07355322","Comparison of a 3-step Bonding System (Transbond™ XT) and a 2-step System (GC Ortho Connect™) on Demineralization Around Maxillary Orthodontic Brackets","Comparison of a 3-step Bonding System (TRANSBOND™ XT) Versus a 2-step System (GC ORTHO CONNECT™) on Demineralization Around Maxillary Orthodontic Brackets: a Randomized Split-mouth Clinical Trial.","ORTHOCOLLAGE","Inclusion Criteria:\n\n* Patient aged 10 to 16 years included,\n* Patient attending their first dentofacial orthopedics consultation at the Montpellier Dental Care Center, in adolescent or young adult dentition (according to Démogé classification),\n* Patient requiring the placement of a bimaxillary multi-bracket treatment and opting for a metallic vestibular technique.\n\nExclusion Criteria:\n\n* Syndromic patient (all syndromes included, e.g., cleft lip) or with a severe long-term condition (ALD),\n* Patient previously treated with a multi-bracket orthodontic treatment using a mixed, lingual, or vestibular technique,\n* Any medical condition deemed incompatible with bracket placement by the investigator,\n* Patient with severe MIH (molar-incisor hypomineralization) and\u002For severe demineralization on one or more teeth (including severe amelogenesis imperfecta or dentinogenesis imperfecta),\n* Patient with restorations such as metal crowns, ceramic crowns, porcelain-fused-to-metal crowns, inlays, onlays, or amalgam on one or more vestibular surfaces,\n* Patient with oral hygiene incompatible with orthodontic treatment,\n* Agenesis of lateral incisors,\n* Subject already participating in another interventional clinical trial that could interfere with this study,\n* Uncontrolled psychiatric disorder,\n* Lack of written informed consent from a legal representative after a reflection period,\n* Lack of cooperation or difficulty in communication\u002Fcomprehension, or refusal of participation by the minor,\n* Subject with a dependency or employment relationship with the sponsor or investigator,\n* Subject participating in another research study with an ongoing exclusion period,\n* Subject not affiliated with the French social security system or not a beneficiary of such a system,\n* Protected populations according to the French Public Health Code:\n\nPregnant or breastfeeding women Subjects deprived of liberty (by judicial, administrative decision, or involuntary hospitalization) Subjects under guardianship or curatorship","10 Years",{"count":76,"type":21},34,[24],"White spot lesions (WSLs) are one of the most common adverse effects of fixed orthodontic treatments, affecting up to 97% of patients treated with labial appliances. These early enamel demineralizations, caused by microleakage between enamel and adhesive, can appear as early as the fourth week of treatment. They not only pose aesthetic concerns but also increase the risk of bracket failure.\n\nThis randomized split-mouth clinical trial compares two bonding systems : the traditional three-step system (Transbond™ XT) and the simplified two-step system (GC Ortho Connect™) to assess their impact on enamel demineralization around orthodontic brackets. The degree of demineralization will be measured using the Enamel Decalcification Index (EDI) based on intraoral photographs and confirmed with a fluorescence camera (C50 Acteon).\n\nThe aim of the study is to determine whether the simplified bonding protocol can reduce clinical time and saliva contamination risk without increasing enamel demineralization, thus offering a potentially more efficient and conservative approach for orthodontic bonding procedures.",[80,27,81,82,83],"Tooth Demineralization","Demineralization","Orthodontic Appliance Complication","Dental Braces Complication",[85,86,87,88,89,90,91,92,93,94,95,96,97,98],"White spot lesions","Orthodontic bonding","Enamel demineralization","Transbond XT","GC Ortho Connect","Split-mouth trial","Orthodontic Brackets","Fixed Orthodontic Appliances","Adolescents","Oral Hygiene","Dental Plaque","Orthodontic Adhesives","Bracket detachment","Bracket debonding","2026-01-12",{"date":101,"type":32},"2026-01-21",{"date":103,"type":21},"2026-01",{"date":105,"type":21},"2028-04",{"name":107,"class":39},"University Hospital, Montpellier",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":48,"sex":16,"minAge":115,"maxAge":116,"enrollmentInfo":117,"targetDuration":4,"studyType":22,"phases":119,"briefSummary":121,"conditions":122,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":4},"100587787","phase-2-remineralization-effect-of-egg-shell-versus-fluoride-varnish-on-early-carious-white-spot-lesions-in-primary-teeth-100587787","NCT06932926","Remineralization Effect Of Egg Shell Versus Fluoride Varnish On Early Carious White Spot Lesions In Primary Teeth","Remineralization Potential Of Egg Shell Hydrogel Versus Fluoride Varnish On Early Carious White Spot Lesions In Anterior Primary Teeth: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Children aged 3 to 5 years, in good general health, and medically free.\n2. Prescence of at least one WSL on anterior primary teeth with an ICDAS II score of one or two.\n3. Cooperative patients who will comply with follow-ups.\n4. Parents who accept to sign informed consent.\n\nExclusion Criteria:\n\n1. Uncooperative children.\n2. Children with a physical disability or medical disability.\n3. Children with teeth that shows enamel hypoplasia.\n4. Children that have received a fluoride supplement or professional topical fluoride application at least 3 months before the study.\n5. Parents refuse to give written formed consent.","3 Years","5 Years",{"count":118,"type":21},66,[120],"PHASE2","The goal of this clinical trial is to to assess the remineralization potential of Egg shell hydrogel versus fluoride varnish in early carious white spot lesions in anterior primary teeth.\n\nThe main question it aims to answer is:What is the remineralization potential of egg shell hydrogel on early carious white spot lesions compared to fluoride varnish in anterior primary teeth? Researcher will compare egg shell hydrogel with fluoride varnish to see if it is able to promote lesion remineralization.\n\ninterventions that will be given to participasnts: egg shell hydrogel \\& five percent sodium fluoride varnish",[27],"2025-05-13",{"date":125,"type":32},"2025-05-15",{"date":127,"type":21},"2025-09",{"date":129,"type":21},"2026-03",{"name":131,"class":39},"Cairo University",{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":16,"minAge":139,"maxAge":140,"enrollmentInfo":141,"targetDuration":4,"studyType":143,"phases":4,"briefSummary":144,"conditions":145,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":4},"100583897","prevalence-of-white-spot-lesions-in-enamel-after-orthodontic-treatment-in-young-adults-100583897","NCT06882304","PREVALENCE OF WHITE SPOT LESIONS IN ENAMEL AFTER ORTHODONTIC TREATMENT IN YOUNG ADULTS","PREVALENCE OF WHITE SPOT LESIONS IN ENAMEL AFTER ORTHODONTIC","Inclusion Criteria:\n\n1. Patients whose age between 18-30 years old consulting in the outpatient clinic.\n2. Provide informed consent.\n3. Co-operative patients approving to participate in the trial.\n4. Both sexes are included\n5. Egyptian -\n\nExclusion Criteria:\n\n1. Patients under or over this age group.\n2. Patients with other developmental defect, such as; fluorosis, amelogenesis imperfecta and syndromes associated with enamel formation defects.\n3. Patient with MIH .\n4. Refuse to participate in the study.","18 Years","30 Years",{"count":142,"type":21},368,"OBSERVATIONAL","The aim of the study is to measure prevalence of enamel white spot lesions in enamel in young adults after orthodontic treatment.",[27],"2025-03-12",{"date":148,"type":32},"2025-03-18",{"date":150,"type":21},"2025-08-01",{"date":152,"type":21},"2027-10-01",{"name":131,"class":39},{"id":155,"slug":156,"hasResults":11,"nctId":157,"briefTitle":158,"officialTitle":159,"acronym":160,"eligibilityCriteria":161,"healthyVolunteers":48,"sex":16,"minAge":49,"maxAge":162,"enrollmentInfo":163,"targetDuration":4,"studyType":22,"phases":165,"briefSummary":167,"conditions":168,"keywords":172,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":65},"100529360","phase-4-a-randomized-controlled-trial-of-vitamin-d-supplementation-on-salivary-biomarkers-and-cariogenic-oral-microbiome-100529360","NCT06172764","A Randomized Controlled Trial of Vitamin D Supplementation on Salivary Biomarkers and Cariogenic Oral Microbiome","Effect of Vitamin D Supplementation on Salivary Biomarkers; Certain Proteins and Cariogenic Oral Microbiome for Medical Management of Dental Caries: A Randomized Controlled Trial","Incipient","Inclusion Criteria:\n\n* Patients of all genders and ages ranging from 12-50 years, having at least two teeth with clinically diagnosed Initial Carious Lesions at Moderate Risk of Dental Caries, after written informed consent.\n* Patients having vitamin D deficiency.\n\nExclusion Criteria:\n\n* Patients who have heavy calculus, gingivitis, or periodontitis.\n* Patients using desensitizing toothpaste or mouthwash up to six weeks before the study.\n* Patients who have severe intestine or kidney disease, malabsorption syndrome, or any other conditions affecting vitamin D metabolism.\n* Patients on antibiotics or probiotics therapy for the last month\n* Pregnant females.\n* Patients with poor oral hygiene and with excessive dietary exposure to acids and carbohydrates.","50 Years",{"count":164,"type":21},90,[166],"PHASE4","The goal of this clinical trial is to compare the treatment effect of vitamin D supplementation and topical fluorides in the population having vitamin D deficiency and Initial Carious Lesions (ICL) on the progression of ICL in teeth. This study aims to observe the changes in the International Caries Detection and Assessment System (ICDAS) scores, the concentration of salivary proteins, and cariogenic microbes, six months after the interventions.\n\n* Group A will get vitamin D supplements and oral hygiene instructions (OHI).\n* Group B will get vitamin D supplements, topical fluorides, and OHI.\n* Group C (Control), the vitamin D sufficient group will get topical fluorides and OHI.",[169,27,170,171],"Dental Caries","Initial Caries","Incipient Enamel Caries",[169,27,170,171],"2025-03-08",{"date":175,"type":32},"2025-03-11",{"date":177,"type":32},"2023-12-12",{"date":179,"type":21},"2025-12",{"name":181,"class":39},"Dow University of Health Sciences",{"id":183,"slug":184,"hasResults":11,"nctId":185,"briefTitle":186,"officialTitle":187,"acronym":4,"eligibilityCriteria":188,"healthyVolunteers":48,"sex":16,"minAge":189,"maxAge":190,"enrollmentInfo":191,"targetDuration":4,"studyType":22,"phases":193,"briefSummary":195,"conditions":196,"keywords":197,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":206,"locationsCount":65},"100570533","early-phase-1-resin-infiltration-vs-self-assembling-peptide-p11-4-in-treating-white-spot-lesions-100570533","NCT06708481","Resin Infiltration Vs Self-Assembling Peptide (P11-4) in Treating White Spot Lesions","Clinical Outcome of Resin Infiltration Vs Self-Assembling Peptide (P11-4) in Treating White Spot Lesion - a Randomized Clinical Trial","Inclusion Criteria:\n\n* Age (a range from 7-14 years of age was determined)\n* Good general health (absence of disease\u002Fno handicaps, to ensure oral care at home)\n* Preserved pulp vitality of the teeth.\n* Consolidated oral care daily.\n* Agreement by patient and parents (or guardians) to participate in the study\n\nExclusion Criteria:\n\n* Patients with periodontal diseases (periodontal pockets or dental mobility) or radiologically identified pathologies (periapical radiolucency).\n* Teeth revealing any restorations were excluded from the current study.\n* Any previous or planned WSL treatment.","7 Years","14 Years",{"count":192,"type":21},150,[194],"EARLY_PHASE1","Clinical assessment of the effectiveness of two treatment modalities (self-assembling peptide (P11-4) (alone or combined with fluoride) and resin infiltration) for treating white spot lesions",[27],[198],"Resin Infilteration , white spot lesions , Self assembling peptide, remineralization","2024-11-25",{"date":201,"type":32},"2024-11-27",{"date":203,"type":32},"2024-08-30",{"date":205,"type":21},"2025-02",{"name":207,"class":39},"October 6 University"]