[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"white-spot-lesions-initial-caries-on-smooth-surface-of-tooth\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:white-spot-lesions-initial-caries-on-smooth-surface-of-tooth":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":4},"100579453","orthodontic-treatment-on-oral-microbiota-and-salivary-proteins-100579453",false,"NCT06824493","Orthodontic Treatment on Oral Microbiota and Salivary Proteins","Inclusion Criteria:\n\n* No carries and White spot\n* No missing teeth\n* No history of oral treatment\n* No malocclusion\n* No systemic diseases\n\nExclusion Criteria:\n\n* Antibiotic use in the past three months\n* A history of long-term medication use\n* A history of dental fillings\n* Unable to attend regular follow-ups",true,"ALL","6 Years","18 Years",{"count":20,"type":21},150,"ESTIMATED","2 Years","OBSERVATIONAL","Study on the changes in oral microbiota during orthodontic treatment in patients aged 8-18 years. Orthodontic patients treated at Stomatology Hospital of Xi'an Jiaotong University from March 2025 to March 2027 will be recruited. Prior to orthodontic treatment, routine preoperative examinations will be conducted, informed consent forms will be signed, baseline oral conditions will be recorded, and oral and psychological-related questionnaires will be completed. Patients will be informed of the need for regular oral hygiene check-ups, caries risk assessments will be performed, and plaque, saliva, and intraoral photographs will be collected. During orthodontic treatment, plaque samples will be collected every 3 months, and saliva samples will be collected every 6 months until the treatment is completed to evaluate the changes in oral microbiota throughout the orthodontic process.",[26,27,28],"Orthodontics","White Spot Lesions [Initial Caries] on Smooth Surface of Tooth","Caries, Dental",[30],"microbiota","NOT_YET_RECRUITING","2025-05-28",{"date":34,"type":35},"2025-06-04","ACTUAL",{"date":37,"type":21},"2025-07-01",{"date":39,"type":21},"2027-09-01",{"name":41,"class":42},"Xi'an Jiaotong University","OTHER",{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":15,"sex":16,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100585670","remineralization-efficacy-of-moringa-oleifera-varnish-vs-mi-varnish-in-initial-carious-lesions-over-6-months-follow-up-a-randomized-controlled-clinical-trial-100585670","NCT06905379","Remineralization Efficacy of Moringa Oleifera Varnish Vs MI Varnish in Initial Carious Lesions Over 6 Months Follow Up: a Randomized Controlled Clinical Trial","Inclusion Criteria of participants:\n\n* Presentation with at least one active WSLs on the study teeth at the start of the study.\n* Good oral hygiene.\n* Co-operative patients approving to participate in the trial.\n* Have sufficient cognitive ability to understand consent procedures Inclusion criteria of teeth.\n* Active non-cavitated initial carious lesions (ICDAS 1\\&2)\n* DIAGNOdent score between (8-15)\n* Vital teeth with no signs or symptoms of irreversible pulpitis.\n* No signs of clinical mobility.\n* Teeth with healthy periodontium.\n\nExclusion Criteria of participants:\n\n* Participants with parafunctional habits or bruxism.\n* Participants with dry mouth.\n* Participants with systemic diseases or disabilities that may affect participation.\n* Heavy smoking.\n* Pregnancy.\n* Lack of compliance.\n* Severe or active periodontal disease.\n* Cognitive impairment\n\nExclusion criteria of teeth:\n\n* DIAGNOdent score less than 8 and more than 15\n* Untreated cavitated lesions or extensive restorations on the facial surfaces of the study teeth\n* Intrinsic or extremely heavy extrinsic staining\n* Periapical pathosis or signs of pulpal pathology.\n* Non-vital tooth.\n* Signs of pathological wear.\n* Endodontically treated tooth.\n* Severe periodontal affection or tooth indicated for extraction.","25 Years","35 Years",{"count":52,"type":21},40,"INTERVENTIONAL",[55],"NA","This randomized clinical trial aimed to test the remineralization effect of laboratory prepared Moringa Oleifera based varnish compared to MI varnish (CPP-ACP) on incipient carious lesions. The study could include any of the following participants: age: 25-35 years, males or females, presentation with at least one active WSLs on the study teeth at the start of the study, good oral hygiene, co-operative patients approving to participate in the trial, have sufficient cognitive ability to understand consent procedures. The main question it aims to answer is in patients with initial caries lesions will Moringa Oleifera varnish have same remineralization efficacy as MI Varnish after 6 months follow up? MI varnish will be used as a comparator as it has been shown in many studies to be superior to fluoride varnish with NaF alone in arresting early caries lesions. The active ingredient, CPP-ACP can slowly release, localize and stabilize amorphous calcium, phosphate, and fluoride on the enamel surface which aids in deep mineralization of white spot lesions.",[27,58],"Moringa Oleifera",[58,60,61,62,63,64],"MI varnish","white spot lesions","remineralization","DIAGNOdent","Nyvad criteria","2025-03-25",{"date":67,"type":35},"2025-04-01",{"date":69,"type":21},"2025-05-01",{"date":71,"type":21},"2026-01-01",{"name":73,"class":42},"Cairo University",1]