[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"white-spot-lesions\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:white-spot-lesions":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,50,79,105,133],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100495628","comparison-of-mi-paste-plus-and-resin-infiltration-in-white-spot-lesions-following-orthodontic-treatment-100495628",false,"NCT05733676","Comparison of MI Paste Plus and Resin Infiltration in White Spot Lesions Following Orthodontic Treatment","Comparison of MI Paste Plus and Resin Infiltration in Improvement of White Spot Lesions Following Fixed Orthodontic Treatment: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Individuals in the age range of 12-21 years who had undergone fixed orthodontic appliance therapy for a duration of 12-36 months.\n* Should have at least one white spot lesion on the labial surface of either maxillary or mandibular anterior teeth after debonding. Lesion visible with or without drying the lesion surface.\n* Patients with mild to moderate plaque accumulation. Fair oral hygiene. With a simplified Oral Hygiene Index of no more than 1.3-3.0\n\nExclusion Criteria:\n\n* Poor oral hygiene Simplified Oral Hygiene Index of 3.1-6.0 or more\n* Patients with hypoplasia or any developmental defects on the buccal of upper or lower incisors\n* Patients with any restorations on the buccal of upper or lower incisors\n* Patients that have presented WSL on the buccal of upper or lower incisors before orthodontic treatment was initiated.\n* Patients that have received any re-mineralizing agent other than regular toothpaste during the last three months\n* Patient with allergy to milk or any of their products\n* Patient with any medical \u002F oral or mental condition\n* Patients or legal guardians that does not speak or read English",true,"ALL","12 Years","21 Years",{"count":21,"type":22},62,"ESTIMATED","INTERVENTIONAL",[25],"NA","Dental cavities are among the most frequent diseases that affect teeth, particularly in patients who are treated with braces due to the difficulty in maintaining good oral hygiene in the presence of the mouth appliances. The white spot lesion (WSL) is the first clinical sign of cavities that presents itself as a milky-white opacity when located on the front face of the tooth. The aim to manage these early lesions focuses on promoting natural remineralization and preventing further demineralization. Various materials have been introduced for management of WSLs including MI paste and MI paste combined with fluoride (MI paste plus). Recently, a new material called resin infiltration has been found to treat these lesions with high esthetic results and great performance. According to the few numbers of in-vivo studies investigating the effectiveness of remineralization products, the aim of the current study is to clinically compare the outcome of the resin-infiltration and etching + MI paste plus to stop and improve the appearance of the WSL on front teeth in patients after treatment with braces.",[28,29,30,31],"White Spot Lesions","Orthodontic Appliance Complication","Caries Arrested","Smooth Surface Caries",[33,34,35,36],"White spot lesion","caries","arrested","orthodontic","RECRUITING","2026-06-25",{"date":40,"type":41},"2026-06-30","ACTUAL",{"date":43,"type":41},"2023-05-30",{"date":45,"type":22},"2028-10-01",{"name":47,"class":48},"University of Alberta","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":62,"conditions":63,"keywords":67,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":4},"100639870","qlf-and-digital-imaging-for-caries-activity-assessment-after-orthodontic-treatment-100639870","NCT07608471","QLF and Digital Imaging for Caries Activity Assessment After Orthodontic Treatment","Diagnostic Performance of Smartphone, 3D Imaging, QLF-D, and ICDAS Clinical Criteria for Non-Cavitated Caries Activity Assessment in Post-Orthodontic Patients Under a Preventive Program","Inclusion Criteria:\n\n* Participants aged 11 to 46 years\n* Completed fixed orthodontic treatment\n* Presence of at least four active non-cavitated caries lesions (ICDAS 1-3)\n* Lesions located on vestibular surfaces of anterior teeth and\u002For premolars\n* Ability to attend follow-up visits during the three-month study period\n* Signed informed consent and\u002For assent form\n\nExclusion Criteria:\n\n* Systemic conditions affecting salivary flow or enamel structure\n* Extensive cavitated lesions requiring restorative treatment\n* Ongoing orthodontic treatment\n* Use of medications that significantly affect oral conditions\n* Inability to cooperate with imaging procedures or follow-up visits","11 Years","46 Years",{"count":60,"type":22},30,"OBSERVATIONAL","This prospective longitudinal observational study aims to evaluate the diagnostic performance and agreement of Smartphone photography, intraoral 3D imaging, Quantitative Light-Induced Fluorescence Digital (QLF-D), and ICDAS clinical criteria for assessing non-cavitated caries lesion activity in post-orthodontic patients under a preventive follow-up program. Thirty participants aged 11 to 46 years with active initial caries lesions will be followed for three months. Clinical examinations, QLF-D imaging, smartphone photographs, and intraoral 3D scans will be obtained at baseline and follow-up visits combined with professional prophylaxis and oral hygiene reinforcement. The study will analyze changes in lesion activity, fluorescence parameters, and surface characteristics over time, as well as the agreement and diagnostic performance among the evaluated methods.",[64,28,65,66],"Dental Caries","Caries Lesion Activity","Post-Orthodontic Enamel Demineralization",[64,68,65,66],"Dental Caries White Spot Lesions","NOT_YET_RECRUITING","2026-05-20",{"date":72,"type":41},"2026-05-27",{"date":74,"type":22},"2026-07-21",{"date":76,"type":22},"2027-04-22",{"name":78,"class":48},"Universidad El Bosque, Bogotá",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":23,"phases":89,"briefSummary":90,"conditions":91,"keywords":93,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":49},"100615378","a-novel-remineralizing-self-etch-primer-for-orthodontic-bracket-bonding-100615378","NCT07291830","A Novel Remineralizing Self-Etch Primer for Orthodontic Bracket Bonding","Clinical Effectiveness of a Remineralizing Self-Etch Primer for Orthodontic Bracket Bonding: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Full permanent dentition including incisors, canines, premolars, and molars (excepting 3rd molars;\n* Teeth with sound, non-carious buccal enamel and no pretreatment with chemical agents such as hydrogen peroxide,\n* No previous orthodontic treatment with fixed appliances.\n\nExclusion Criteria:\n\n* Participants unable to give informed consent,\n* Had craniofacial anomalies,\n* Require orthognathic surgery as part of their treatment,\n* Had congenital enamel defects.","35 Years",{"count":88,"type":22},45,[25],"This randomized clinical trial aims to evaluate the clinical effectiveness of a remineralizing self-etch primer used for orthodontic bracket bonding. The study compares bonding performance, enamel surface effects, and clinical outcomes between the experimental primer and the conventional bonding protocol,verify the potential remineralization effect, and examine the amount of adhesive remnants left on enamel over a period of 6 months.",[28,92],"Enamel Demineralization",[94,95],"Orthodontic Bracket Bonding","Self-Etch Primers","2026-05-01",{"date":98,"type":41},"2026-05-07",{"date":100,"type":22},"2026-05-15",{"date":102,"type":22},"2026-12-30",{"name":104,"class":48},"University of Baghdad",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":16,"sex":17,"minAge":112,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":23,"phases":116,"briefSummary":117,"conditions":118,"keywords":121,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":4},"100585028","ai-generated-whatsapp-reminders-vs-no-reminders-impact-on-oral-health-in-young-adults-100585028","NCT06897033","AI-Generated WhatsApp Reminders vs. No Reminders: Impact on Oral Health in Young Adults","Effect of Artificial Intelligence-Generated WhatsApp Reminders Compared to No Reminders on Oral Health Among Young Adults: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Received a non-surgical periodontal treatment and oral hygiene instructions.\n* Own a smartphone with WhatsApp installed.\n* Willing and able to provide informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Individuals with pre-existing oral health conditions requiring specialized care.\n* Patients who received surgical periodontal interventions.\n* Participation in another oral health or diet-related study.\n* Individuals who do not use WhatsApp or are unwilling to receive messages through the platform.","20 Years","40 Years",{"count":115,"type":22},60,[25],"This randomized controlled trial aims to evaluate the effectiveness of artificial intelligence-generated WhatsApp reminders on improving oral hygiene practices among individuals aged 20-40 years visiting the periodontal clinic at El-Qasr El-Ainy Dental Hospital. Participants will be randomly assigned to either receive health education followed by AI-generated WhatsApp reminders over a 3-month period or to a control group receiving health education only. The primary outcome is the presence of white spot lesions, assessed using the modified Gorelick White Spot Lesion (WSL) index. Secondary outcomes include the presence of dental plaque, measured by the Plaque Index (PI). This study seeks to determine whether AI-generated reminders can enhance oral hygiene adherence compared to standard health education alone.",[28,119,120],"Dental Plaque","Oral Hygiene, Oral Health",[122,123],"Oral hygiene","Reminders","2025-03-27",{"date":126,"type":41},"2025-04-02",{"date":128,"type":22},"2025-05",{"date":130,"type":22},"2025-09",{"name":132,"class":48},"Cairo University",{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":4,"eligibilityCriteria":139,"healthyVolunteers":16,"sex":17,"minAge":140,"maxAge":141,"enrollmentInfo":142,"targetDuration":4,"studyType":23,"phases":144,"briefSummary":146,"conditions":147,"keywords":149,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":49},"100563441","phase-2-topical-10-povidone-iodine-in-preventing-white-spots-100563441","NCT06616207","Topical 10% Povidone-Iodine in Preventing White Spots","Efficacy and Safety of Topical 10% Povidone-Iodine in Preventing White Spots During Orthodontic Treatment","Inclusion Criteria:\n\n* Healthy children and teens (10-17 years old)\n* Transitional or permanent dentition of at least 4 permanent anterior teeth in each arch\n* Full fixed appliance orthodontic treatment is expected to last at least one year\n\nExclusion Criteria:\n\n* Allergies to iodine\n* Chronic prophylactic use of antibiotics\n* Diagnosis of thyroid disease\n* Conditions that could impair routine oral hygiene procedures.\n* Pregnant at enrollment","10 Years","17 Years",{"count":143,"type":22},80,[145],"PHASE2","The goal of this clinical trial is to learn if topical application on the all surface of 10% Povidone Iodine (Povi-One) in healthy participants in transitional or permanent dentition (10-17 y) prevents new white spot lesions in the maxillary anterior teeth at 1 year of follow-up.\n\nResearchers will compare Povi-One to a placebo to see if Povi-One works to prevent new white spot lesions.\n\nIt will also learn about the safety of topical 10% Povidone Iodine.\n\nThe main questions it aims to answer are:\n\n1. Does Povi-One prevent the development of any white spot lesion on the surface of maxillary anterior teeth?\n2. Does Povi-One lower the probability of any International Caries Detection and Assessment System (ICDAS) score greater than 0 and mean modified Löe-Silness Gingival Index (GI) in the intervention group?\n\nResearchers will\n\n1. Score GI without cleaning participants teeth, then score ICDAS of maxillary and mandibular incisors after participants brush and floss their teeth and take a photograph of maxillary 6 anterior teeth\n2. Apply Povi-one (or control) at the consultation appointment before placing fixed orthodontic appliances and 3, 6, and 9 months after appliance placement\n\nResearchers will\n\n1. Recall using Zoom 24-48 hours after the first application of Povi-One and examine the participant's mouth for oral lesions using a structured paper checklist\n2. Interview the caregiver to complete a paper questionnaire on adverse effects\n\nResearchers will\n\n1. Score GI, and then score ICDAS of maxillary and mandibular incisors in 6, 12 months after appliance placement\n2. Evaluate the development of white spot lesions on maxillary central and lateral incisors in 6, and 12 months after appliance placement",[28,148],"Gingival Inflammation and Bleeding",[150,33,151,152],"Povidone-Iodine","Topical application of 10% Povidone- Iodine in preventing white spots","Topical 10% Povidone-Iodine In Preventing White Spots During Orthodontic Treatment","2024-09-24",{"date":155,"type":41},"2024-09-27",{"date":157,"type":41},"2024-09-13",{"date":159,"type":22},"2027-03-31",{"name":161,"class":48},"University of Washington"]