[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"withdrawal-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:withdrawal-syndrome":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":5},"100507128","kratom-use-disorder-management-using-clonidine-andor-buprenorphine-100507128",false,"NCT05883358","Kratom Use Disorder Management Using Clonidine and\u002For Buprenorphine","Inclusion Criteria:\n\n* adult patients\n* Kratom dependence\n* Kratom withdrawal syndrome\n* Kratom withdrawal therapy\n* good treatment compliance\n* reliable Subjective Opiate Withdrawal Scale (SOWS) diary\n* reliable Clinical Opiate Withdrawal Scale (COWS) diary\n* informed consent for diary review\n* consent for clinical record quality assurance review\n\nExclusion Criteria:\n\n* poor treatment compliance\n* cognitive disorder\n* inability to provide consent\n* major neuropsychiatric disorder\n* unreliable diary\n* cannabis use\n* excessive alcohol intake\n* previous adverse\u002Fallergic reactions to clonidine\n* previous adverse\u002Fallergic reactions to buprenorphine",true,"ALL","20 Years","99 Years",{"count":20,"type":21},50,"ESTIMATED","OBSERVATIONAL","Kratom is used for stimulant, analgesic, anxiolytic, and sedative effects. There is inadequate knowledge about Kratom addiction. Kratom withdrawal may be treated like opioid withdrawal.\n\nProspective observational crossover study of consenting adults who are undergoing Kratom withdrawal management. On alternate weeks, each patient receives treatment using Buprenorphine 5cmg\u002Fhr patch; or Clonidine tablet 0.1mg 4hourly; or combined Clonidine tablet 0.1mg 4hourly + Buprenorphine 5cmg\u002Fhr patch. Each patient will undergo treatment for 12 weeks.\n\nPatients will use Subjective Opiate Withdrawal Scale (SOWS) to collect data on daily basis. SOWS is a patient-administered tool that is used to record the severity and presence of opiate withdrawal. The physician will also use Clinical Opiate Withdrawal Scale (COWS) to collect data on weekly basis. COWS is a clinician-administered tool that is used to record the signs of opiate withdrawal. A change in the COWS and SOWS scores by 6-points is considered significant.",[25],"Withdrawal Syndrome",[27],"Kratom","RECRUITING","2025-01-23",{"date":31,"type":32},"2025-01-27","ACTUAL",{"date":34,"type":32},"2018-07-02",{"date":36,"type":21},"2025-12-31",{"name":38,"class":39},"Salem Anaesthesia Pain Clinic","OTHER"]