[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"women-of-reproductive-age\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:women-of-reproductive-age":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,50,84],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":27,"conditions":28,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100631210","phase-2-virtual-menstrual-pain-approaches-in-females-100631210",false,"NCT07497711","Virtual Menstrual Pain Approaches in Females","Virtual Auricular Acupressure and Baduanjin Qigong Exercise for Preventing Menstrual Pain in Females: A Randomized Clinical Trial","AABQ","Inclusion Criteria:\n\n* 16 - 35 years of age\n* Regular menstrual cycles (28 days ± 7 days) in 3 months prior to enrollment\n* Two or more episodes of menstrual cramps in the past 2 months, scored at least 4 points on the worst pain item of the Brief Pain Inventory (BPI)\n* Stated willingness to comply with all study procedures and availability for the duration of the study\n* Ability to download, install, and navigate the study-specific digital content and use its core functions for training, self-guided intervention administration, and data entry\n* Ability to understand the nature of the study and willingness to give informed consent.\n\nExclusion Criteria:\n\n* Uncontrolled neurological diseases, immunodeficiency, bleeding disorders, and allergies\n* The presence of another Axis I disorder not in remission\n* Lactating or pregnant, or those planning to become pregnant in the coming half year\n* Undergoing other trials for pain management during the study period\n* Plan to initiate other pain therapies for menstrual pain management in the proceeding 3 months","FEMALE","16 Years","35 Years",{"count":21,"type":22},145,"ESTIMATED","INTERVENTIONAL",[25,26],"PHASE2","PHASE3","This research study is testing two self-care approaches that may help prevent or reduce period pain in young females with recurrent painful menstrual cramps. Participants will be placed by chance into 1 of 3 groups: auricular acupressure, Baduanjin qigong, or a self-care education comparison group. The auricular acupressure and Baduanjin groups will receive online training and then practice the treatment on their own for 12 weeks. The main question is whether these two approaches can reduce the severity of menstrual pain. The study will also look at whether they can improve other symptoms that often happen with period pain, such as tiredness, poor sleep, anxiety, low mood, trouble concentrating, and reduced physical function. Researchers will also study stool and blood-related biological markers to better understand whether changes in gut bacteria and body metabolism may be linked to symptom improvement. A total of 145 participants will take part in the study at NTU, and any side effects or other safety concerns will be checked every week.",[29,30,31,32,33,34,35,36],"Pain (Visceral, Somatic, or Neuropathic)","Women of Reproductive Age","Mental Disorder","Digital Health","Acupressure","Traditional Exercise","Host-Gut Microbiota Interaction","Metabolomics","RECRUITING","2026-06-18",{"date":40,"type":41},"2026-06-23","ACTUAL",{"date":43,"type":41},"2026-04-15",{"date":45,"type":22},"2029-03-20",{"name":47,"class":48},"Nanyang Technological University","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":17,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":23,"phases":62,"briefSummary":64,"conditions":65,"keywords":69,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":49},"100630591","indigenous-nutritional-supplements-for-pregnancy-to-improve-resilience-in-environmental-heat-100630591","NCT07489664","Indigenous Nutritional Supplements for Pregnancy to Improve Resilience in Environmental Heat","INSPIRE","Inclusion Criteria:\n\n1. Women aged 18-45 years belonging to a low to middle socioeconomic status, residing in Mithi, Districts in Sindh.\n2. Planning to conceive within the study time frame and expect to become pregnant within four months of starting nutritional intervention.\n3. Women who confirm their pregnancy during the first trimester i.e., before 8 weeks of gestational age.\n\nExclusion Criteria:\n\n1. Women using long-lasting contraceptives such as IUDs, implants, and injectable methods like Depo-Provera.\n2. Women with a history of multiple miscarriage or stillbirths.\n3. Women with known chronic diseases, such as cardiovascular disorders, hepatic disorders, renal disorders, and infectious diseases.\n4. Women suffering from severe malnutrition (WHO: Underweight i.e., having BMI \\\u003C 16 Kg\u002Fm2 or obese having BMI ≥ 30 Kg\u002Fm2).\n5. Women having severe anemia (WHO: Severe anemia i.e., Hb \\\u003C 7g\u002FdL).\n6. Women currently enrolled in BISP supplementation programs or taking any supplements other than iron and folic acid (IFA) will be excluded from the study.\n7. Those who do not become pregnant within three months of supplementation during pre-conception.",true,"18 Years","45 Years",{"count":61,"type":22},292,[63],"NA","The purpose of this study is to learn whether a simple, traditional, and balanced meal made from local foods, eaten once a day during pregnancy, can help women in rural Pakistan stay healthier in hot weather and give birth to healthier babies. Climate change has made heat a serious challenge for pregnant women, especially in areas with limited resources. This study will explore whether an indigenous meal that is culturally acceptable and easy to prepare can improve resilience to heat stress and support better outcomes for both mothers and newborns.\n\nThe study will focus on two main questions:\n\n* Can this daily balanced meal reduce the harmful effects of heat stress during pregnancy?\n* Does it improve newborn health, especially birth weight?\n\nResearchers will compare women who eat the balanced local meal every day with women who continue their usual meals. They will check changes in women's health, levels of key vitamins and nutrients, and their babies' birth outcomes.\n\nDuring the study, participants will:\n\n* Either eat the balanced local meal daily or continue their usual meals.\n* Share information on their health, diet, and heat exposure.\n* Provide small samples, such as blood and stool, to study nutrient levels and gut health.\n* Have their newborns' health and growth measured at birth.",[66,67,30,68],"Heat Stress","Pregnancy","Nutrition Status",[70,71,72,73],"Local Food-Based Diet to Improve Birth Outcomes and Heat Resilience in Pregnant Women","maternal depression","placental transcriptomics","microbiome","NOT_YET_RECRUITING","2026-03-19",{"date":77,"type":41},"2026-03-24",{"date":79,"type":22},"2026-03",{"date":81,"type":22},"2028-12",{"name":83,"class":48},"Aga Khan University",{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":4,"eligibilityCriteria":90,"healthyVolunteers":57,"sex":17,"minAge":58,"maxAge":19,"enrollmentInfo":91,"targetDuration":4,"studyType":23,"phases":93,"briefSummary":94,"conditions":95,"keywords":100,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":49},"100505513","the-maternal-eed-study-100505513","NCT05862363","The Maternal EED Study","Small Intestinal Microbiota of Low Body Mass Index (BMI) & Normal BMI Women of Reproductive Age and Microbiota-directed Balanced Energy Protein (MD-BEP) Supplementation in Maternal Environmental Enteric Dysfunction (EED)","Inclusion Criteria:\n\nInclusion criteria for pregnant low-BMI women\n\n1. Bangladeshi female, age 18-35 years\n2. BMI 20-24.9 kg\u002Fm2\n3. Middle-upper socioeconomic class (≥ $11\u002Fday family income)\n4. Functional dyspepsia\n5. Willing to sign the consent form\n6. Willing to provide biological samples during the study period of 6 months\n\nInclusion criteria for non-pregnant low-BMI women 1. Bangladeshi female, age 18-35 years\n\n1. BMI \\\u003C18.5 kg\u002Fm2\n2. No antibiotics for 1 month\n3. Willing to sign the consent form\n4. Willing to undergo endoscopy and biopsy\n5. Willing to provide biological samples during the study period of 6 months\n6. Willing to receive food supplementation for 3 months\n\nInclusion criteria for normal-BMI non-pregnant women\n\n1. Bangladeshi female, age 18-35 years\n2. BMI 20-24.9 kg\u002Fm2\n3. Middle-upper socioeconomic class (≥ $11\u002Fday family income)\n4. Functional dyspepsia\n5. Willing to sign the consent form\n6. Willing to provide biological samples during the study period of 6 months\n\nInclusion criteria for normal-BMI pregnant women\n\n1. Bangladeshi female, age 18-35 years\n2. BMI 20-24.9 kg\u002Fm2\n3. Middle-upper socio-economic class (≥ $11\u002Fday family income)\n4. Enrolled at the end of first-trimester of pregnancy (before 14 weeks of gestation)\n5. Willing to sign the consent form\n6. Willing to undergo endoscopy and biopsy\n7. Willing to provide biological samples during the study period\n8. Willing to let anthropometry and biological sample collection from her newborn for the first 6 months of life\n\nExclusion Criteria:\n\nExclusion criteria for pregnant low-BMI women\n\n1. Received antibiotics during the last one month\n2. Presence of any chronic disease including diabetes mellitus or any congenital disorder or deformity\n3. Ongoing episode of diarrhea, history of persistent diarrhea in the past month or history of acute diarrhea in the past 7 days\n\nExclusion criteria for non-pregnant low-BMI women\n\n1. Severe anemia (\\\u003C8 g\u002Fdl), TB and other chronic diseases, including diabetes mellitus, urogenital infections or any congenital disorder or deformity\n2. Pregnancy, lactation, drug abuse, known psychiatric disorders\n3. High clinical suspicion of cancer or other chronic or acute diseases that may cause malnutrition. Adult participants who fulfill the inclusion criteria and are not excluded through history and clinical examination will undergo following screening tests based on clinical judgement:\n\n   1. Chest x-ray\n   2. Urine for R\u002FE\n   3. Ultrasonography of whole abdomen\n   4. Fasting blood glucose\u002F HbA1c\n   5. Stool for OBT (occult blood test)\n   6. Cancer markers (ie. CEA, CA 15.3, CA 19.9)\n4. Known allergy to any components of nutrition intervention\n5. Nugent Score\u002FAmsel Criteria to exclude bacterial vaginosis: A Nugent score 3-4 is consistent with Bacterial vaginosis (BV). The modified Amsel criteria with a cut-off value of 2 (pH+VD; sensitivity 71%, specificity 90%, accuracy 88% or KOH+VD; sensitivity 75%, specificity 91%, accuracy 89%) might be considered for this purpose20.\n6. Ongoing episode of diarrhea, history of persistent diarrhea in the past month or history of acute diarrhea in the past 7 days\n\nExclusion criteria for non-pregnant normal-BMI women\n\n1. Received antibiotics during the last one month\n2. Presence of any chronic disease including diabetes mellitus or any congenital disorder or deformity\n3. Ongoing episode of diarrhea, history of persistent diarrhea in the past month or history of acute diarrhea in the past 7 days\n\nExclusion criteria for pregnant normal-BMI women\n\n1. Multiple pregnancy (carrying two or more fetuses)\n2. Threatened abortion, persistent pervaginal bleeding, or cervical incompetence\n3. History of three or more consecutive abortions\n4. History of gestational diabetes, macrosomia, gestational hypertension, preeclampsia\u002Feclampsia in a prior pregnancy\n5. Active disease\u002Fcomplications requiring acute phase treatment in a hospital\n6. Tuberculosis\n7. Severe anemia (Hb concentration \\\u003C 8 mg\u002Fdl)\n8. Antibiotic use (ongoing or within last two weeks before the onset of intervention)\n9. Taking medications such as insulin, thyroid hormones, glucocorticoids\n10. Chronic diseases, such as hypertension, heart disease, chronic obstructive pulmonary disease, chronic kidney disease, chronic liver disease, pancreatic diseases, Crohn's disease, ulcerative colitis, diabetes mellitus, thyroid dysfunction, immunological diseases, malignancy, or any congenital disorder or other diseases which could impede compliance with the study protocol\n11. Known case of serious psychiatric or behavioral disorders, such as schizophrenia, bipolar disorder\n12. Having known history of allergy to the therapeutic agents\n13. Having a plan to move or deliver outside the study area\n14. Known allergy to any components of nutrition intervention.",{"count":92,"type":22},180,[63],"Undernutrition among women of reproductive age is more common in South Asia than in any other region. In South Asia, the prevalence of maternal undernutrition varies between 10 and 40%. There is a scarcity of data on the contribution of small intestinal (SI) microbiota to pathogenesis of Environmental Enteric Dysfunction (EED) of malnutrition, as it is difficult to obtain gut biopsy specimens from malnourished individuals, especially children. The Bangladesh Environmental Enteric Dysfunction (BEED) study, involving participants who live in an urban slum (Mirpur) in Dhaka, provided an opportunity to examine the role of the duodenal microbiota in the pathogenesis of EED in children and also performed esophagogastroduodenoscopy (EGD) on thirty-eight 18-45-year-old malnourished (BMI\\\u003C18.5 kg\u002Fm2) women residing in the same resource-poor setting of Mirpur, Dhaka who failed to respond to an egg\u002Fmilk\u002Fmicronutrients- based nutritional intervention comparable to that given to children. In this intervention component, beginning at the end of the first trimester, low-BMI (\\\u003C18.5 kg\u002Fm2) pregnant women (aged 18-35 years) will be randomly assigned to receive either Microbiota-directed Balanced Energy Protein (MD-BEP) or Ready-to-Use-Supplementary Food Balanced Energy Protein (RUSF-BEP) for the duration of their pregnancy and during the first 3 postnatal months, in addition to standard antenatal care. A parallel cohort of age-matched normal-BMI pregnant women who will not receive any nutritional intervention will serve as a reference control group.",[96,97,30,98,99],"Environmental Enteric Dysfunction (EED)","Malnutrition","Gut Microbiota","Balanced Energy Protein (BEP)",[101,102,103,97,104],"Balanced energy protein (BEP)","Environmental enteric dysfunction (EED)","Gut microbiota","Women of reproductive age","2025-05-12",{"date":107,"type":41},"2025-05-14",{"date":109,"type":41},"2023-01-02",{"date":111,"type":22},"2026-12-31",{"name":113,"class":48},"International Centre for Diarrhoeal Disease Research, Bangladesh"]